Psychotic disorder

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This early-stage trial is testing a long-acting injectable form of the drug cariprazine, called AX251, in 48 adults with stable schizophrenia. The study aims to see how the drug moves through the body and whether it is safe when given as a single shot at different doses. If resul…

This Phase 2 study tests an investigational drug called emraclidine in about 268 adults with schizophrenia. The trial has two parts: Part A looks at how the drug moves through the body and its safety at different doses, while Part B measures whether it improves symptoms like hall…

This phase 3 trial tests whether KarXT (a combination of xanomeline and trospium chloride) can prevent relapse in people with schizophrenia. Participants who have had a recent hospitalization for schizophrenia and still have symptoms will receive KarXT or a placebo. The study mea…

This study is testing the long-term safety of a new medication called LB-102 for adults with stable schizophrenia. About 900 participants will take the drug for 52 weeks to see what side effects occur. The goal is to make sure the drug is safe enough for ongoing use to control sc…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This early-stage study is testing a long-acting injectable form of the drug KarXT in 116 people with schizophrenia. The main goal is to check the drug's safety and how the body processes it. Researchers hope this injectable version could offer a more convenient treatment option t…

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …

This trial is testing the safety of a medication called lumateperone in children and teenagers who have schizophrenia, bipolar disorder, or autism spectrum disorder. Participants take the drug once daily for 26 weeks, and researchers monitor for side effects. The goal is to see i…

This early-stage trial tests whether the experimental drug aticaprant is safe and tolerable when added to standard antipsychotic treatment for schizophrenia. About 64 clinically stable outpatients will receive either aticaprant or a placebo. The main goals are to see if the study…

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up…

This phase 2 trial tests whether ublituximab, an immune-modulating drug, can reduce symptoms in people with treatment-resistant schizophrenia. Participants receive the drug by IV infusion, and researchers measure changes in symptom scores over time. The goal is to see if targetin…

This trial tests whether people with schizophrenia or schizoaffective disorder can safely switch from taking clozapine twice a day to once a day. Participants currently stable on a twice-daily regimen will be randomly assigned to continue that schedule or switch to once-daily dos…

This trial tests whether deep brain stimulation—implanting electrodes in specific brain areas—can help people with severe, treatment-resistant mental disorders like OCD, schizophrenia, depression, anorexia, gambling addiction, and autism. The study involves 18 participants and me…

This study tests whether tracking smartphone activity and offering extra support from peer specialists can help veterans with serious mental illness avoid emergency room visits and hospital stays. About 400 veterans who are at high risk will take part. The goal is to catch early …

This study is tracking 300 adults with schizophrenia in the U.S. who are prescribed a new drug called xanomeline and trospium chloride (X/T). Researchers want to know if patients prefer this drug over their previous treatment and how satisfied they are with it. The study will als…

This study tracks 1,500 adults with schizophrenia who start taking KarXT (xanomeline and trospium chloride) in routine clinical care across the U.S. Researchers will monitor how doctors adjust doses, side effects, weight changes, and relapses over time. The goal is to understand …

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This early-stage study tests a new drug called VV119 in healthy adults and people with schizophrenia. The main goal is to check if the drug is safe and how the body processes it. About 40 participants will take multiple doses to find the right amount for future studies.

This study compares a new, lower-energy seizure therapy (LAP-ST) to standard electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression, bipolar disorder, or schizoaffective disorder. The goal is to see if the gentler approach works just as w…

This study tests a program called LAGOM designed to improve heart health and quality of life for people with psychotic disorders. 644 adults from six clinics in Gothenburg will either receive the LAGOM program or standard care. The program includes regular check-ups, motivational…

This study tests whether combining yoga with a mild electrical brain stimulation technique, called tDCS, can improve thinking and memory in people with psychosis. Participants will be randomly assigned to receive either active tDCS during yoga or a sham (inactive) version, and re…

This trial tests whether a single dose of levetiracetam, a drug used for epilepsy, can reduce overactivity in the hippocampus — a brain area linked to thinking and memory problems in psychosis. People aged 18–40 who are at risk of psychosis will take either the drug or a placebo …

This expanded access program offers continued treatment with OLZ/SAM, a combination of olanzapine and samidorphan, to adolescents with schizophrenia or bipolar I disorder who have already completed a year-long study of the drug. The goal is to provide ongoing access to the medica…

This study tests whether combining aerobic exercise with computerized cognitive training, both delivered via telehealth, can improve thinking and motivation in people who have recently experienced a first episode of schizophrenia. About 100 participants will receive cognitive tra…

This study tests whether the diabetes drug metformin can prevent blood sugar increases caused by statins in people with schizophrenia. Researchers will give 400 patients either metformin or a placebo alongside atorvastatin for six months. The goal is to see if metformin helps kee…

This study is for people aged 18-35 experiencing their first episode of psychosis. Researchers will use genetic tests and MRI brain scans to see if certain markers can predict which antipsychotic drug (aripiprazole, risperidone, or clozapine) will work best. The goal is to improv…

This study tests a new drug called Ulotaront (SEP-363856) to see if it can reduce symptoms like hallucinations and delusions in people with schizophrenia. About 522 adults experiencing an acute episode will receive either the drug or a placebo for 6 weeks. The main goal is to mea…

This trial tests whether a 'link work' intervention can help people with severe mental health difficulties attend routine dental appointments. 480 participants will be assigned to either the link worker support plus usual care, or usual care alone. The study measures whether they…

This study tests a new drug, LB 102, to see if it helps reduce schizophrenia symptoms better than a placebo. About 456 adults with acute schizophrenia will take either the drug or a placebo for 6 weeks while staying in the hospital. The main goal is to measure changes in symptoms…

This phase 3 study tests whether KarXT, a new drug, can safely reduce schizophrenia symptoms in 250 Japanese adults experiencing acute psychosis. Participants first receive either KarXT or a placebo for 5 weeks, then all may receive KarXT for a year. The goal is to see if KarXT i…

This study tests a new drug called NBI-1117570 in 120 adults with schizophrenia who need hospital care. The goal is to see if it improves symptoms like hallucinations and disorganized thinking better than a placebo. Participants take the drug or a placebo daily for 35 days, and r…

This study tests a Transition Care Team (TCT) designed to help people with first episode psychosis successfully move from hospital to outpatient mental health services. The TCT provides short-term support including therapy, case management, and coordination with community program…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in people with schizophrenia. Thirty participants receive both real and sham stimulation in separate sessions while pe…

This study tests whether adding a four-week aerobic exercise program to a new antipsychotic medication (olanzapine-samidorphan) can prevent the early weight gain often seen with these drugs. Thirty adults with schizophrenia, schizoaffective disorder, or bipolar disorder will take…

This study looks at whether stopping unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can improve thinking, quality of life, and brain function in people aged 40-70 with schizophrenia or schizoaffective disorder. Participants will either stay on their medication…

This study tests whether personalized nutrition counseling can lower inflammation in adults with schizophrenia who are on long-term antipsychotic medication. Participants receive either a tailored diet plan or standard hospital meals. The goal is to see if better nutrition can re…

This study tests whether a type of talk therapy called Mentalization-Based Treatment (MBT) can help young people (ages 14–30) who are at high risk for psychosis avoid developing the condition. Participants will receive either MBT plus standard care or standard care alone for 24 w…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve the brain's wiring and connectivity in people with schizophrenia. Participants receive multiple sessions of rTMS using a special coil designe…

This study tests whether combining a non-invasive brain stimulation technique called rTMS with computer-based cognitive training can strengthen brain connections in people with schizophrenia. Participants will receive up to 10 sessions over two weeks, and researchers will use bra…

This early-stage study is testing a single injection of a long-acting form of the drug brexpiprazole in healthy volunteers and people with schizophrenia. The main goal is to check if the injection is safe and tolerable, and how the body processes the drug. The trial involves 56 p…

This study tests whether deep brain stimulation (DBS) can help people with schizophrenia whose symptoms haven't improved with medication. First, doctors map the brain using electrodes to find the problem areas. Then, they implant a device that delivers mild electrical pulses to t…

This pilot study explores whether computer-assisted music remediation can improve memory, attention, and thinking in young people aged 18 to 30 who have had a first psychotic episode. Participants attend weekly group sessions using music software to practice memory and executive …

This study tests whether adding sodium benzoate—a substance that affects brain glutamate—to standard antipsychotic medication can improve symptoms and thinking in people with treatment-resistant schizophrenia. About 90 adults who have not responded well to at least two antipsycho…

This study is testing an experimental drug called MT1988 in 150 people aged 17 to 30 who are at high risk of developing psychosis. Participants take either a low dose, high dose, or placebo pill twice daily for 8 weeks. The main goal is to see if certain tests (like memory and sy…

This pilot study is testing a brain implant called deep brain stimulation (DBS) for people with schizophrenia that hasn't improved with standard treatments. The device delivers electrical pulses to specific brain areas to try to reduce psychotic symptoms. Ten participants will be…

This Phase 3 trial tests whether the experimental drug NBI-1117568 can delay relapse of schizophrenia symptoms compared to a placebo. About 560 adults with stable schizophrenia will first receive the drug openly, then be randomly assigned to continue it or switch to placebo. The …

This phase 3 trial is testing the long-term safety of the drug NBI-1117568 in 600 adults with schizophrenia. Participants will receive the drug and be monitored for side effects over time. The study is open-label, meaning everyone knows they are getting the drug, and it focuses o…

This study is testing how the drug KarXT affects bladder function and overall safety in 60 adults with schizophrenia over 12 months. Participants will stop their current antipsychotics and take KarXT to see if it causes any urinary problems. The goal is to ensure the drug is safe…

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study tests whether adding lumateperone (Caplyta) to clozapine can reduce common side effects like weight gain and high blood sugar in people with schizophrenia or schizoaffective disorder. Fifty participants will take either lumateperone or a placebo for 12 weeks while cont…

This Phase 3 trial tests whether a new drug called NBI-1117568 can improve schizophrenia symptoms like hallucinations and disorganized thinking. About 284 adults with schizophrenia who need hospital care will receive either the drug or a placebo for 5 weeks. The study measures sy…

This study tests a smartphone app that uses motion-sensing cognitive games and interactive stories to help people with schizophrenia improve their thinking, mood, and daily skills. 84 hospitalized adults will be randomly assigned to use the app or receive standard care. The goal …

This study compares clozapine and risperidone in people with schizophrenia, schizoaffective disorder, or bipolar I disorder with psychosis. Researchers want to see if a specific brain biotype (Biotype-1) responds better to clozapine. About 320 participants will be randomly assign…

This study is testing whether clozapine, a medication for schizophrenia, can reduce violent acts better than other antipsychotic drugs. Researchers will enroll 280 people with schizophrenia or schizoaffective disorder who have been violent in the past six months. Participants wil…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study tests a long-acting injection of cariprazine given once a month, instead of daily pills, for people with schizophrenia, bipolar I disorder, or major depression. The trial involves 24 clinically stable adults and will check safety, side effects, and how well the drug wo…

This Phase 3 trial tests a personalized care plan for 500 young people aged 15-30 with early psychosis. The plan combines cognitive training (using apps and virtual reality) with supplements (vitamin B12, folinic acid, Omega 3, NAC) tailored to each person's needs. The goal is to…

This study looks at whether taking antipsychotic medication every other day is as effective as taking it daily for people with schizophrenia. 120 participants will be randomly assigned to either daily dosing or every-other-day dosing for one year. The goal is to see if extended d…

This pilot study tests whether metformin, a diabetes drug, can help protect brain white matter in young adults (18-25) with early psychosis who use cannabis. Participants will take metformin for 6 months and undergo brain scans and questionnaires. The goal is to see if this appro…

This study is testing whether a daily synbiotic supplement (a mix of probiotics and prebiotics) can reduce symptoms of schizophrenia when taken alongside standard antipsychotic medications. Researchers are enrolling 68 adults with schizophrenia or schizoaffective disorder who hav…

This study tests whether ocrelizumab, a drug that suppresses certain immune cells, can reduce psychosis symptoms in people whose schizophrenia or bipolar disorder may be caused by auto-antibodies attacking brain receptors. Forty participants aged 18–35 will receive either ocreliz…

This study tests whether a new generic version of a 3-month schizophrenia injection works the same as the brand-name drug Invega Trinza. About 260 Chinese adults with stable schizophrenia will receive multiple doses of either the test or reference drug. The goal is to see if the …

This study tests whether adding an anti-inflammatory drug to an NMDA-enhancing agent can improve thinking and memory in people with ultra-resistant schizophrenia. About 80 adults who have not responded well to clozapine will receive the combination or a placebo. The goal is to se…

This study tests whether matching specific weight-loss medications (Wegovy, Contrave, or Qsymia) to a person's obesity type (e.g., 'hungry brain' or 'emotional hunger') helps people with bipolar disorder lose weight safely. One hundred adults with bipolar or schizoaffective disor…

This study tests whether adding five extra services—like peer support, digital outreach, and group therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants will either receive standard care or the enhanced program. Researchers wi…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give weekly injections of tirzepatide or a placebo to 108 participants for 16 weeks, tracking heavy drinking d…

This study tests whether adding empagliflozin, a diabetes drug, can reduce weight gain and other metabolic side effects caused by olanzapine in people with schizophrenia. Forty adults aged 18 to 60 who take olanzapine will receive either empagliflozin or a placebo for several wee…

This study compares Magnetic Seizure Therapy (MST) to standard Electroconvulsive Therapy (ECT) in 80 people with treatment-resistant schizophrenia or schizoaffective disorder. MST uses magnetic pulses to trigger a controlled seizure, aiming to ease symptoms like hallucinations an…

This study looks at whether maintenance electroconvulsive therapy (ECT) can prevent relapse in people with schizophrenia that doesn't respond to the strongest medications. About 140 participants who improved after a course of ECT will either continue with maintenance ECT or recei…

This study tests whether giving stronger medications earlier can help people with schizophrenia, major depression, or bipolar depression who did not get better with their first treatment. Over 1,200 participants will receive either standard second-line treatment or an intensified…

This phase 3 trial is testing the long-term safety of a daily pill called SEP-363856 for adults with schizophrenia. Researchers will monitor 100 Japanese participants for side effects over 52 weeks. The goal is to see if this drug can be a safe option for ongoing disease control.

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This pilot study tests a structured program to help young adults (ages 18-35) recently diagnosed with bipolar disorder transition from hospital to community care. The program includes group education sessions and one-on-one peer support over several months. Researchers want to se…

This study tests whether a long-acting injection of iloperidone can delay or prevent the return of schizophrenia symptoms compared to a placebo injection. About 400 adults with schizophrenia who need ongoing treatment will receive either the drug or a placebo and be monitored for…

This study tests a special clinic designed to help people with severe mental illness (like schizophrenia or bipolar disorder) lose weight and improve their metabolic health. About 84 participants will either receive care at this clinic or standard care for 12 months. The main goa…

This study tests whether regular, personalized follow-up by a trained case manager can reduce the chance of another psychotic episode over three years in people aged 16 to 30 who have just had their first episode. 256 participants will be randomly assigned to either standard care…

This study tests a program called Taking Action, where trained peers help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia learn to manage their condition. About 300 students will be randomly assigned to either the program or just…

This pilot study tests whether a portable, at-home brain stimulation device (tDCS) can help people with depression maintain the improvements they achieved during hospital treatment with esketamine, rTMS, or ECT. Thirty adults will use the device for 30 minutes a day, five days a …

This study tests a new treatment called magnetic seizure therapy (MST) for people with psychotic disorders like schizophrenia. MST uses magnetic pulses to trigger a controlled seizure in the brain, aiming to improve symptoms when added to standard antipsychotic medications. The t…

This study tests a 10-week cognitive training program called SCORES for teens at high risk for psychosis. The program aims to improve processing speed (how fast the brain handles information) through game-like tasks, group coaching, and rewards. Researchers hope better processing…

This Phase 1 trial tests the safety and tolerability of a new extended-release tablet called LY03020 in 40 Chinese adults, including healthy volunteers and people with stable schizophrenia. The drug is also being explored for psychosis related to Alzheimer's disease. Participants…

This study tests whether cariprazine, a daily medication, can safely reduce schizophrenia symptoms in teenagers aged 13 to 17. About 330 participants will receive either cariprazine or a placebo for 6 weeks. The main goal is to see if symptoms improve compared to a placebo.

This study tests whether a six-month program of dietary counseling and group exercise can reduce heart disease risk in adults with severe mental illnesses like schizophrenia or bipolar disorder. Around 70 participants will either receive the lifestyle program plus usual care, or …

This study tests whether MitoQ, an antioxidant supplement, can improve thinking and memory in people with early schizophrenia who have signs of mitochondrial dysfunction. Researchers will give 50 participants either MitoQ or a placebo daily for 12 weeks, alongside their usual med…

This study looks at whether giving a more powerful medication sooner can help people with schizophrenia who did not get better on their first treatment. About 418 adults will either receive the usual second-line treatment or an early intensified approach. The goal is to see if th…

This study tests different ways to start taking olanzapine, a common schizophrenia medication, to see if a slower dose increase can reduce side effects while still controlling symptoms. About 120 adults with schizophrenia will receive one of several dosing schedules or a placebo.…

This study is testing a short, 6-session group program called Resilience Training for Teens. The goal is to see if it can help high school students who have mild symptoms of depression, anxiety, or unusual feelings avoid developing more serious mental illnesses. The study will in…

This study tests if a daily probiotic powder can prevent or reduce weight gain, high blood sugar, and high cholesterol caused by certain antipsychotic drugs. About 112 adults starting or recently starting olanzapine, quetiapine, risperidone, or clozapine will take either the prob…

This study tests whether a 4-week Resilience Training program can prevent serious mental illness in college students who already have mild psychotic experiences. 192 students aged 18-30 will be randomly assigned to either Resilience Training or a general Life Skills program. The …

Researchers at Hannover Medical School are testing whether intermittent theta-burst stimulation (iTBS), a non-invasive brain stimulation technique, can reduce negative symptoms and improve thinking in people with schizophrenia. The trial enrolls 60 adults aged 18 to 65 with a sch…

This trial tests an experimental drug called LTX-001 in adults with schizophrenia who are experiencing a sudden worsening of symptoms. Participants stay in a research unit for about five weeks and receive either LTX-001 or a placebo. The main goal is to see if the drug is safe an…

Researchers test whether a non-invasive brain stimulation called tACS can help people with schizophrenia better tell themselves apart from others. The trial delivers 10 Hz current to the medial prefrontal cortex for 20 minutes daily over five days. Participants include patients w…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

Researchers are testing a once-weekly tablet of brexpiprazole against placebo in adults hospitalized for an acute episode of schizophrenia. The trial enrolls about 450 people aged 18 to 74 who need hospital care for a relapse. Over seven weeks, participants receive either the act…

People with treatment-resistant schizophrenia often take clozapine, a drug that can cause serious weight gain and metabolic problems. This pilot study tests whether a daily infusion made from the leaves of the Nitraria retusa plant can reduce those side effects. Thirty patients w…

This study tests an experimental drug called evenamide for people with schizophrenia that hasn't improved with standard antipsychotics. About 400 adults will receive either evenamide or a placebo added to their current medication for 12 weeks. The goal is to see if evenamide redu…

This study tests whether a 4-week mindfulness group therapy program, added to usual care, can reduce symptoms in 252 young people (ages 16-35) hospitalized for early psychosis. Participants are randomly assigned to either the mindfulness program plus standard treatment or standar…

This study tests whether a smartphone app can help people with schizophrenia in Ghana feel better. Researchers will compare usual care to two app-based programs. The goal is to see if the apps reduce symptoms like depression, anxiety, and paranoia.

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication can improve symptoms in people experiencing their first episode of psychosis who haven't responded well to initial treatment. About 250 participants aged 16-40 will receive either CBD or a plac…

This study tests an experimental drug, ITI-1284, to see if it can safely reduce psychosis symptoms like hallucinations and delusions in people with Alzheimer's disease. About 370 participants will receive either the drug or a placebo, and doctors will track changes in symptom sev…

Researchers at the University of Alabama at Birmingham are testing whether short online activities can change mood and attitudes. The study includes 200 adults aged 18 to 65, some with a psychotic disorder such as schizophrenia and some healthy controls. Participants complete the…

This trial tests whether an accelerated form of brain stimulation, called intermittent theta burst stimulation (iTBS), is safe and feasible for young people at clinical high risk for psychosis. Participants receive either active or sham stimulation over five days, targeting a bra…

This study tests whether an oxytocin nasal spray, given before mindfulness-based group therapy, can reduce negative symptoms in people with schizophrenia. Negative symptoms include lack of motivation, social withdrawal, and reduced emotional expression. The trial will compare two…

This trial tests whether a smartphone app called AffectUs can help people with schizophrenia or schizoaffective disorder better recognize emotions and interpret social situations. Participants use the app for 10 weeks, five times a week, while continuing their usual treatment. Th…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can reduce negative symptoms (like lack of emotion or motivation) and cognitive problems in people with schizophrenia. 62 participants will receive either real or sham sti…

This study tests a quick, 5-day brain stimulation treatment for the 'negative symptoms' of schizophrenia, like low motivation and social withdrawal. 75 adults with stable schizophrenia will get either real or fake (placebo) stimulation. The goal is to see if this approach is safe…

This study compares standard metacognitive training (MCT) with a personalized version (P-MCT) for people with schizophrenia spectrum disorder. The goal is to see which approach better improves daily functioning and reduces symptoms. Fifty-one adults with stable psychosis will tak…

This study tests whether a talking therapy called Compassion Focused Therapy (CFT) can help people with conditions like depression, bipolar disorder, or schizophrenia feel less shame and self-stigma. Participants will be randomly assigned to receive CFT, a standard psychoeducatio…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people with early bipolar disorder. Fifty participants will follow either the ketogenic diet or standard dietary guidelines for 12 weeks. Researchers will me…

This early-stage trial tests BXCL501, a dissolving film placed under the tongue, to quickly reduce agitation in children and teens aged 10-17 with schizophrenia or bipolar disorder. About 140 participants will receive either the drug or a placebo. The study measures changes in ag…

This study tests whether a noninvasive brain stimulation technique called iTBS can improve working memory in people with early-stage schizophrenia. Researchers will use magnetic pulses and EEG to measure brain activity before and after stimulation. The goal is to see if iTBS can …

This study tests SloMo, a digital therapy that helps people with psychosis who fear harm from others. It combines face-to-face sessions with a mobile app to help users notice worries and slow down fast thinking. 150 participants across three NHS trusts will try the therapy, with …

This study tests whether a brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help ease depression in people with schizophrenia. Researchers will give up to 20 sessions of active or sham rTMS to 120 participants and use brain scans to see h…

This study tests an experimental oral drug called GXV813 in 142 hospitalized adults with schizophrenia. The goal is to see if it safely reduces symptoms like hallucinations and withdrawal during an acute episode. Participants are randomly assigned to receive GXV813 or a placebo, …

This study tests a new drug called roluperidone for treating negative symptoms of schizophrenia, like lack of motivation and social withdrawal. About 380 adults with schizophrenia will take the drug or a placebo for 12 weeks to see if symptoms improve. Then, for 40 more weeks, re…

This trial tests whether a six-week online group program, combining cognitive behavioural therapy with family support, can help people with schizophrenia and their caregivers. Researchers will measure changes in symptoms, expressed emotion, and caregiver mood. The study includes …

This early-stage trial is testing whether the drug MDMA (commonly known as ecstasy) is safe and tolerable for people with schizophrenia. The goal is to see if it can help with social withdrawal, a common and hard-to-treat symptom. Twenty stable participants will receive three dif…

This study tests a new, non-invasive brain stimulation method called time interference stimulation (TIS) to see if it can improve thinking and memory problems in people with schizophrenia. Fifty adults aged 18-50 with schizophrenia will receive either real TIS or a fake (sham) tr…

This early study tests if a gentle brain stimulation technique called time interference stimulation (TIS) can help with thinking and memory problems in people with schizophrenia. Ten adults aged 18-50 will receive TIS twice a day for two weeks. Researchers will measure changes in…

This small study will test if a culturally-adapted form of cognitive-behavioural therapy (CBT) is practical, acceptable, and safe for Black Sub-Saharan African and Caribbean people who experience psychosis. Six participants will attend up to 16 therapy sessions and complete quest…

This study tests a program called SUPPORT, where trained peer specialists (fellow veterans) help veterans with serious mental illness (like schizophrenia or bipolar disorder) who are at high risk for suicide. Together, they create a personalized recovery plan that includes coping…

This study tests whether acetazolamide, a drug currently used for altitude sickness and glaucoma, can reduce positive symptoms (like hallucinations or delusions) in people with treatment-resistant schizophrenia. Sixty adults aged 18-55 who still have significant symptoms despite …

This study tests whether recreational fishing (angling) can help people with schizophrenia feel better and improve their quality of life. Participants will take part in a structured fishing program alongside their usual care. Researchers will measure changes in symptoms, loneline…

This study tests whether yoga-based exercises can help veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder improve their ability to function in daily life—like socializing, working, and managing leisure activities. About 112 veterans will be randomly assi…

This Phase 3 trial tests whether the drug combination KarXT + KarX-EC can safely reduce psychosis symptoms (like hallucinations and delusions) in people with Alzheimer's disease. About 325 participants aged 55-90 will receive either the drug or a placebo. The study is currently r…

This study tests a new medicine called KYN-5356 to see if it can help with thinking and memory problems in people with schizophrenia. About 150 adults who are stable on their current schizophrenia treatment will take either a low, medium, or high dose of the drug or a placebo for…

This study tests whether training mental health professionals to deliver a short psychoeducational program (BREF) can reduce the burden on caregivers of people with schizophrenia or first psychotic episode. The trial will include 206 caregivers, comparing those who receive the pr…

This study tests whether a virtual reality mindfulness app can help people with schizophrenia or schizoaffective disorder control impulsive aggression. About 58 participants will use the VR app or do distraction tasks, and have their brain activity measured with fMRI. The goal is…

This study tests whether infliximab, an anti-inflammatory drug used for arthritis, can improve motivation and brain activity in people with schizophrenia who have high inflammation. Sixty adults with schizophrenia will receive either infliximab or a placebo, and researchers will …

This study tests whether low-intensity ultrasound, aimed at the brain, is safe and could help with schizophrenia symptoms. Eighty adults with schizophrenia will receive the non-invasive treatment. Researchers will check safety and look for any improvements in mood, thinking, and …

This study tests whether bazedoxifene, a drug that mimics estrogen, can help reduce schizophrenia symptoms in women when added to their usual antipsychotic medication. 160 women aged 18-65 with schizophrenia or related disorders will receive either bazedoxifene or a placebo daily…

This study tests whether people with schizophrenia who hear voices that medication doesn't help can learn to quiet them using a special brain-training technique. Participants get real-time feedback from an fMRI scanner to help them shift their brain activity away from the halluci…

This study tests whether learning music—rhythm, singing, and body movements—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part. The goal is to see if music-based training is a more engaging and effective way …

This study tests whether playing specially designed somatosensory video games for 2 months can improve thinking skills in people with schizophrenia. The games train five cognitive functions like memory and attention using body movements. Researchers will enroll 84 stable patients…

This study tests a 6-week group therapy program for adults with schizophrenia or related disorders. The therapy focuses on changing negative core beliefs (like feeling worthless or that others are dangerous) using compassion-focused techniques. The goal is to see if this approach…

This study tests whether a low dose of buprenorphine (0.15 mg) can improve social motivation in 40 people with schizophrenia. Participants will take either the drug or a placebo and complete tasks that measure their drive to seek or avoid social interaction. The goal is to see if…

This study tests whether a 24-week supervised exercise program (aerobic, strength, and flexibility) can improve physical fitness, mood, and quality of life in 44 adults with psychosis who are on long-acting injectable medication. Participants are randomly assigned to either the e…

This study tests whether estradiol patches can improve anhedonia (loss of pleasure) and psychosis symptoms that start during perimenopause. About 100 women aged 44-55 will receive either estradiol or a placebo patch for three weeks, plus a short course of progesterone. Researcher…

This study tests whether adding a trauma-focused therapy called EMDR to usual care can help reduce trauma symptoms in people with schizophrenia spectrum disorders. Many people with these conditions have experienced trauma, which can make their illness worse, but trauma treatment …

This study tests a virtual reality program designed to help people with psychosis improve their thinking and social skills. The program was created with input from patients and doctors. Researchers will see if it is practical and helpful for daily life. The study involves 52 adul…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study tests a drug that boosts NMDA activity as a standalone treatment for schizophrenia. It is for people who refuse or cannot tolerate standard antipsychotics. The trial will measure changes in symptoms like hallucinations and social withdrawal in 80 participants over seve…

This study tests whether adding a second drug that boosts NMDA receptors to a sigma-1 receptor agonist can better reduce schizophrenia symptoms than the sigma-1 drug alone. About 90 adults with schizophrenia who did not improve on at least two antipsychotics will take the combina…

This study tests if a non-invasive brain stimulation technique called rTMS can improve negative symptoms (like lack of motivation or emotion) in people with schizophrenia. About 20 adults will receive either real or sham stimulation to different brain areas. The main goal is to s…

This study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum can improve cognitive deficits and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's…

This study tests whether cromoglicate, a nasal spray used for allergies, can improve symptoms in people with schizophrenia or schizoaffective disorder. Researchers will give 160 adults either the active spray or a placebo, in addition to their usual medication. The goal is to see…

This study explores whether a yoga-based group program is practical and helpful for outpatients with schizophrenia. Sixty participants will be randomly assigned to yoga, strength training, or standard care. Researchers will measure stress, symptoms, and well-being over 12 weeks a…

This study tests an experimental drug, NBI-1117568, to see if it improves schizophrenia symptoms like hallucinations and delusions better than a placebo. About 284 adults with schizophrenia who need hospital care will take the drug or a placebo for 5 weeks. The main goal is to me…

This study tests whether a non-invasive brain stimulation technique called high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive problems like memory and attention in people with schizophrenia. One hundred participants will receive either rea…

This study tests whether a smartphone app called Kiso Mind is acceptable and helpful for people with schizophrenia or schizoaffective disorder. Sixty participants will either use the app plus their usual treatment, or just usual treatment alone, for 12 weeks. Researchers will mea…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This study tests a new virtual reality job training program for people with schizophrenia who want to work. About 40 adults aged 20 to 55 will practice job interviews and other skills in a safe VR environment. The goal is to see if this training helps improve symptoms and makes i…

This study tests a smartphone app called mSITE that encourages people with schizophrenia or schizoaffective disorder to have more social interactions. Researchers will track participants' social activity and symptoms over time. The goal is to see if the app helps reduce social wi…

This study tests whether breathing extra oxygen (normobaric oxygen therapy) can improve thinking, quality of life, and daily function in people who have had psychosis for less than 5 years. Twenty participants aged 15-35 will be randomly assigned to receive oxygen or a placebo. T…

This study tests whether a weekly skills group is practical and helpful for teens aged 13-18 who are at clinical high risk for psychosis. The group combines two types of therapy to teach coping and social skills. Researchers will track attendance, satisfaction, and quality of lif…

This study tests whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and pain severity after …

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to improve thinking skills and daily functioning by using EEG brain scans to identify who will benefit most. A…

This study tests a community-based cognitive remediation program for adults with schizophrenia or schizoaffective disorder. Participants do computer exercises and group sessions to improve memory, problem-solving, and social skills. The goal is to see if this helps them function …

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce depression in people with schizophrenia. About 180 adults will receive rTMS to the left prefrontal cortex. Researchers will measure changes in mood, thinking, and other symptoms over time.

This study is testing whether cognitive behavioral therapy (CBT) delivered via telehealth can help young people aged 14 to 25 who are at clinical high risk for psychosis. Participants will receive group, family, or individual CBT sessions online. The goal is to see if this approa…

This study tests a program called 'Need to Be Needed' (N2BN) that uses volunteering to help adults with serious mental illness feel more connected and less lonely. 120 participants will either join the volunteering program or receive weekly listening support. Researchers will mea…

This study tests whether a type of talk therapy focused on sleep (CBT-I) can improve sleep, reduce psychotic symptoms, and enhance quality of life in people with treatment-resistant schizophrenia. About 60 adults with chronic psychosis and long-term sleep problems will receive ei…

This early-stage study tests an experimental oral drug called NTX-253 in healthy volunteers and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. 73 adults aged 18–55 will take single or multiple doses to find the right dose r…

This phase 3 trial tests whether adding cannabidiol (CBD) to standard treatment can improve symptoms, thinking, and inflammation in people with early psychosis. About 120 adolescents and adults will receive either CBD or a placebo for 8 weeks. Researchers will also explore what f…

This study tests a 12-session group program called 'Better Together' for young adults with severe mental illness (like schizophrenia, bipolar disorder, or major depression) who are single and want to improve their romantic relationships. The program teaches communication, emotion…

This study tests whether a personalized form of brain stimulation called iTBS can help reduce schizophrenia symptoms in everyday clinic settings. Forty adults with schizophrenia will receive daily iTBS sessions for two weeks, while continuing their usual medications. Researchers …

This study tests whether brief high-intensity exercise is better than standard high-intensity training for people with schizophrenia or bipolar disorder. Fifty participants will follow one of the two programs for 26 weeks. The main goal is to see which program people stick with l…

This study tests whether a skin patch called ALTO-101 can improve cognitive function in people with schizophrenia who have thinking problems. About 82 participants will receive either the active patch or a placebo, then switch after a period. The main goal is to see changes in br…

This study is testing a mobile app that uses cognitive behavioral therapy (CBT) to help people with depression. Over 8 weeks, participants use the app for weekly AI-guided lessons and homework. The goal is to see if the app reduces depression symptoms and to explore how it affect…

This pilot study tests a new type of talking therapy designed for people with early psychosis who experience 'self-disorders' — a feeling of being disconnected from themselves. Eight adults with schizophrenia or psychosis risk will receive the therapy and then be interviewed abou…

This study tests whether a precise magnetic pulse to a specific brain area can improve negative symptoms like apathy and social withdrawal in people with schizophrenia. Forty participants will receive either real or sham stimulation daily for 10 days. Researchers will measure sym…

This study tests whether computer-based cognitive training, combined with group therapy, can improve thinking skills and daily functioning in Tunisian youth at clinical high risk for psychosis. Fifty-four participants will either receive the cognitive training program or an enhan…

This study tests whether physical activity in green outdoor spaces reduces negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. 45 adults aged 18-55 with persistent negative symptoms will participate. Researchers…

This study tests a new psychological program called 'Feeling Safe' for people with psychosis who have persistent delusions. The program offers personalized modules to improve sleep, reduce worry, boost self-confidence, lessen the impact of voices, and build a sense of safety. Res…

This pilot study is testing a new approach called MI-CBTech that combines in-person counseling with a mobile phone app to help homeless veterans who have serious mental illnesses like schizophrenia. The goal is to help them set and achieve personal goals for community integration…

This study tests a 12-week group therapy program called Motivation Skills Training for people with schizophrenia or schizoaffective disorder. The goal is to see if it improves motivation, goal attainment, and quality of life compared to a control group focused on healthy behavior…

This study is testing a new social skills training program for Veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) who are looking for work. The program teaches skills to better understand social cues and handle workplace relationships. Researcher…

This pilot study tests whether a non-invasive magnetic brain stimulation technique called TMS can improve brain connectivity and thinking skills in people with schizophrenia. Forty adults will receive either real or sham TMS daily for four weeks, and researchers will measure chan…

This study tests whether real-time fMRI neurofeedback can help people with schizophrenia who still hear voices despite medication. Participants learn to control their own brain activity while inside an MRI scanner, aiming to reduce the brain signals linked to auditory hallucinati…

This study is testing whether an NMDA-enhancing drug can improve negative symptoms of schizophrenia (like lack of motivation or social withdrawal) and if it works better in men or women. 90 people with stable schizophrenia will receive either the drug or a placebo for several wee…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study looks at heart electrical patterns (ECGs) in 240 people hospitalized for methamphetamine use, comparing those with and without psychosis. Researchers will check ECGs at admission and before discharge to see if psychosis is linked to more heart strain. The goal is to be…

This study follows 150 people diagnosed with methamphetamine-induced psychotic disorder for one year. Researchers will track factors like medication adherence, social support, and insight into illness to see how they relate to changes in psychiatric symptoms. The goal is to bette…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

This study uses PET and MRI brain scans to see if antipsychotic medication causes lasting changes in dopamine receptors in people with schizophrenia. Researchers will compare three groups: healthy volunteers, patients who have never taken antipsychotics, and patients who have bee…

This study looks at 48 teenagers with autism who were checked for psychotic symptoms 10 years ago. Researchers want to see how their mental health and daily functioning are now. They will compare those who had early signs of psychosis with those who did not, using interviews and …

This study investigates how a person's genetic makeup influences their response to cannabis, including risk for addiction and psychosis. Healthy adults aged 21-60 receive either a very low or medium dose of THC (the active ingredient in cannabis) or a placebo intravenously. Resea…

This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disor…

This study looks at how common sleep apnea is in people hospitalized with schizophrenia and whether it affects their mental health. Researchers will use a special ring and a fiber-optic mat to track breathing during sleep without any wires or uncomfortable equipment. The goal is …

This trial explores whether physical activity, specifically walking in different visual environments, can improve the sense of self in people with schizophrenia, borderline personality disorder, or vestibular syndromes. Participants will complete walking sessions in three environ…

This study explores whether a non-invasive magnetic brain stimulation technique (TMS) can temporarily improve how quickly people with psychotic disorders (like schizophrenia or bipolar) solve problems. About 95 participants will do thinking tasks and get brain scans before and af…

This study investigates why people with schizophrenia or depression often experience apathy—a loss of motivation and goal-directed behavior. Researchers will use cognitive tasks and EEG brain recordings to examine three distinct forms of apathy: executive, emotional, and initiati…

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…

This pilot study will compare the Clubhouse Model—a structured, community-based program where members work together to run the clubhouse—to standard outpatient care for adults with schizophrenia. Researchers will measure changes in thinking, daily functioning, and brain activity …

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study looks at whether brain activity synchronizes differently in people with schizophrenia during social interactions. Researchers will compare 100 participants—some with schizophrenia and some without—as they chat and do tasks together while wearing EEG caps. The goal is t…

This study investigates whether markers of inflammation in the blood could serve as diagnostic or severity biomarkers across several psychiatric conditions, including bipolar disorder, schizophrenia, and depressive episodes with psychotic features. Researchers will collect blood …

This study looks at how mental state, emotional eating, and sleep quality together influence the risk of metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) in people with schizophrenia or bipolar disorder. Researchers will measure these factors …

This study investigates whether reduced sensitivity to social rewards contributes to social anhedonia—a lack of pleasure from social interactions—in people who have recently experienced their first episode of psychosis. Participants, aged 18 to 35, will undergo brain scans while …

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful technique. The goal is to see if the new method wor…

This study looks at whether a single dose of modafinil or D-serine can improve decision-making and thinking in people who have had psychosis for less than five years. Twenty-four participants will play computer brain games and have brain scans before and after taking the drugs. T…

This study investigates whether early-detection programs for psychosis can reduce the time people live with untreated symptoms and whether that leads to better long-term functioning. Researchers will follow adults newly diagnosed with schizophrenia-spectrum disorders in two Danis…

This study investigates whether immune inflammation in the blood and brain is linked to brain structure, function, and symptoms in people with schizophrenia. Researchers will follow 200 participants for three months, collecting clinical data, brain scans, and biological samples. …

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study will use brain scans (PET/MRI) to see how the drug Cobenfy affects dopamine in the brains of 12 people with schizophrenia. Participants will take one of three doses of Cobenfy for 5 weeks and get a brain scan before and after treatment. The goal is to understand how th…

This study investigates whether microRNAs found in brain-derived particles in the blood can serve as biomarkers for schizophrenia. Researchers will compare blood samples from 80 people recently diagnosed with first-episode schizophrenia and 80 healthy volunteers, tracking changes…

This study looks at how alcohol and substance use affect people with severe mental illnesses like schizophrenia and bipolar disorder. Researchers compare those who also have substance use problems with those who do not, measuring things like hospitalizations, medication needs, em…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study aims to create a 'patient library' by collecting blood, stool, and hair samples from 250 people aged 15 to 30 who have had a first psychotic episode or are at high risk. Researchers will track their mental health over 10 years using the CAARMS test. The goal is to bett…

This study follows 178 people who had a first episode of psychosis to see how early treatment choices and relapses affect their thinking, daily life, and mental health over 20 years. Participants attend one interview to assess symptoms, thinking skills, and functioning. The goal …

This observational study follows 74 pregnant individuals with severe mental illness to see how taking antipsychotics (versus other medications or no medication) affects psychiatric stability and infant development. Participants complete psychiatric interviews, donate blood, and h…

This study aims to help 25,000 young people aged 12-29 who are at high risk for psychosis reach out for help sooner. Researchers will use online screening and personalized digital messages to encourage them to schedule assessments and connect with local clinics. The goal is to re…

This study aims to create a French-language memory task that can be used during brain scans to measure source-monitoring—the ability to remember where information came from. Researchers will test the task on 120 people, including those with schizophrenia and healthy volunteers. T…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study will follow 1,200 people with schizophrenia in Shanghai for up to 5 years. Researchers will track symptoms, aggression, and other mental health changes to understand how the disease progresses. The goal is to build a long-term database and biobank to improve future car…

This study looks at brain activity during sleep in people with early-course schizophrenia compared to healthy individuals. Researchers will play soft tones during deep sleep using a wearable headband to see if it can strengthen sleep-related brain waves and improve memory. The go…

This study is testing whether subtle changes in how people speak can predict who will develop schizophrenia. Researchers will record and analyze free speech from 215 young people aged 15-30 who are at ultra-high risk for psychosis. By using computer programs to detect semantic an…

This study explores whether a non-invasive brain stimulation technique called rTMS can reduce cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will compare brain activity changes in 100 participants, including healthy cannabis users. The goa…

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study investigates whether abnormal insulin action in the brain contributes to cognitive and metabolic problems in schizophrenia. Twenty participants (some with schizophrenia, some healthy) will receive either intranasal insulin or a placebo before a PET scan that measures b…

This study looks at 120 people having their first episode of psychosis. They get brain scans and then take either risperidone or aripiprazole for 12 weeks. The goal is to see if brain scan patterns can predict who will respond well to which drug, potentially personalizing treatme…

This study is collecting blood samples and questionnaires from 1,100 people with bipolar disorder or schizophrenia. Researchers are looking for links between genetics, inflammation, and a dormant virus called HERV-W. The goal is to find new biomarkers and pave the way for future …

This study investigates how the brain chemical glutamate relates to memory and attention in people who have recently experienced psychosis. Researchers will use brain scans and a mild electrical stimulation technique called tDCS to see if glutamate levels can predict who responds…

This study looks at how to measure cardiorespiratory fitness in people with severe mental illness, such as schizophrenia or bipolar disorder. Researchers will compare three different fitness tests in 50 patients and 25 healthy volunteers. The goal is to find a simple, accurate wa…

This study looks at how people with schizophrenia-spectrum disorders update their beliefs after treatment for persecutory delusions. Researchers will use therapy, brain scans, and learning tasks to see if treatment changes how the brain responds to uncertainty. The goal is to bet…

This study aims to help 25,000 young people ages 12-29 who may be at risk for psychosis get connected to care sooner. Researchers will use online screening and text-based coaching to understand different types of help-seekers and test which digital strategies work best. The goal …

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study uses powerful 7T MRI scanners and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare brain chemistry and vision in 320 patients and healthy volunteers. The …

This study aims to understand why Black Americans often report higher levels of paranoia than White Americans, even without a mental health diagnosis. Researchers will use an online guided imagery task to see if race-related stress triggers paranoia in 480 Black American particip…

This study looks at how being in a hot room affects the body, thinking, and mood of people with schizophrenia. Ten adults with and without schizophrenia will sit in a warm or very hot room for six hours, doing light activity. The goal is to learn how heat impacts them so we can c…

This study creates a registry of brain scans, thinking tests, and blood samples from 1,000 people with schizophrenia, schizoaffective disorder, or no mental illness. Researchers use MRI to compare brain activity and connections between groups while performing memory tasks. The go…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study explores whether a gentle electrical current applied to the scalp (tDCS) can improve attention, learning, and memory in people with schizophrenia. Researchers will compare stimulation during a task versus rest, and front versus back of the head. They will also measure …

This study looks at language difficulties in people with psychosis, including those at risk, experiencing a first episode, or diagnosed with schizophrenia. Researchers will give a full language test to 90 patients and compare results with a healthy control group. The goal is to b…

This study investigates how people with schizophrenia experience time and sensory information differently. Researchers will use a visual illusion task to see if small timing disruptions affect perception. The goal is to better understand the link between time processing and psych…

This study looks at how people with schizophrenia sense time through touch. Researchers measure finger movements and brain signals to see if problems with timing can help predict who might develop psychosis. The goal is to find early markers for better care.

This study investigates how the immune system influences psychotic symptoms and response to antipsychotic medication. Researchers will collect blood and spinal fluid from 500 participants, including those starting or changing antipsychotics and healthy controls. The goal is to fi…

This study uses brain imaging (fMRI) to investigate why people with schizophrenia or depression often have trouble with memory and managing emotions. Researchers will scan the brains of 90 adults aged 18-60 while they perform tasks and at rest. The goal is to better understand th…

This study uses a special two-way mirror device to see how teenagers and young adults at risk for psychosis recognize themselves versus others. Participants sit opposite a healthy volunteer and report who they see as lighting changes. The goal is to find differences in self-other…

This study looks at how certain psychiatric drugs may change heart rhythms in children and teens. Researchers will track 100 young patients with eating disorders, mood disorders, or psychosis who are starting a new psychiatric medication. They will perform ECGs at the start and a…

This study looks at how attention and thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to healthy volunteers. Participants will use a positive thinking strategy during a gambling task while having t…

This study uses virtual reality games and EEG brain scans to understand how people with schizophrenia or bipolar disorder experience the passage of time. Researchers will compare 120 participants (patients and healthy volunteers) as they perform tasks in virtual environments. The…

This study tests whether a gentle electrical current applied to the scalp (tDCS) can improve how people with schizophrenia recognize emotions in faces. Researchers will use brain scans to see if the stimulation changes activity in motion-processing areas. The goal is to understan…

This study looks at how brain structure and gene activity in the blood are linked in people with early schizophrenia. About 1,899 participants, including healthy volunteers, will have brain scans and blood tests at the start and after one year of regular medication. The goal is t…

This study looks at how people with schizophrenia experience nicotine withdrawal when they stop vaping or smoking for 24 hours. Researchers will compare withdrawal symptoms, mood, and thinking skills between daily vapers and daily smokers. The goal is to understand nicotine depen…

This study looks at 320 people with early psychosis to see if brain scans, eye-tracking, and electrical brain waves can predict how well they respond to treatment. Participants will have four visits over a year, including interviews, memory tests, and optional DNA samples. The go…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study uses a non-invasive brain stimulation technique called TMS to see if it can change brain activity in people with schizophrenia. Researchers will measure brain waves before and after stimulation to understand how the hippocampus works in this condition. The goal is not …

This study tests whether learning to play a music video game like Guitar Hero can strengthen the brain's white matter in people with schizophrenia. White matter helps different brain regions communicate quickly, and it is often impaired in schizophrenia, leading to slower thinkin…

This study looks at whether social isolation contributes to the early health problems seen in people with schizophrenia, who often die 10–20 years earlier than others. Researchers will follow 650 participants (500 with schizophrenia and 150 siblings) aged 40–70, tracking medical …

This study tests whether diroximel fumarate, a drug already used for multiple sclerosis, can increase levels of the antioxidant glutathione in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the …

This study tests whether a type of brain stimulation called repetitive TMS can increase natural brain inhibition in 34 people with schizophrenia. The goal is to see if this change relates to better thinking and memory. Participants will receive five days of treatment and undergo …

This study uses high-resolution 7-Tesla MRI to examine how a part of the brain called the mediodorsal thalamus supports flexible thinking and decision-making. One hundred healthy adults will perform computer tasks while their brain activity is scanned. The goal is to understand w…

This study tests whether analyzing speech recordings with artificial intelligence can help predict when someone with psychosis might relapse. About 360 participants, including people with psychosis and healthy volunteers, will provide weekly voice samples and answer questions via…

This study explores the brain basis of social difficulties in 30 teens with autism and 30 with schizophrenia. Participants take part in a 16-week social skills program called PEERS, and undergo brain scans before and after to see how the intervention affects brain networks. A con…

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study is following 200 children and teens (ages 7-20) who have experienced psychosis to see if they fall into distinct subgroups. Researchers will use interviews, brain scans, and genetic tests to classify participants. The goal is to see if these subgroups predict how well …

This study tests a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants more accurately judge their own skills. Researchers want to see if this improves h…

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to understand how hallucinations work in people with schizophrenia or schizoaffective disorder. Researchers will stimulate a specific brain circuit and measure changes in brain connectivity and…

This study is looking at 200 people with treatment-resistant schizophrenia who are starting clozapine. Researchers will measure immune markers in blood and spinal fluid, brain scans, and other tests before and after 12 weeks of treatment. The goal is to find biological signs that…

This study looks at 55 women who have a chronic (long-term) infection with the Toxoplasma parasite and also have a mental health condition like schizophrenia, depression, or bipolar disorder. Researchers want to see if tiny molecules called microRNAs in the blood can help tell th…

This study looks at 30 adults with psychotic disorders who are stable on long-term antipsychotics and want to reduce or stop their medication. Researchers will describe real-life cases to understand what works, what doesn't, and the risks of relapse. The goal is to learn practica…

This study is testing a new questionnaire called ESSME that is given to people with schizophrenia at their homes. The goal is to see if this home-based assessment can better capture their real-life needs compared to standard methods. 56 participants will be followed for 6 months …

This study looks at how the brain uses ketones and sugar for energy in people experiencing their first episode of schizophrenia. Researchers will use PET scans to compare brain metabolism in 22 patients before and after 4-8 weeks of antipsychotic treatment, and also compare them …

This study is measuring how well people with schizophrenia or bipolar disorder can exercise, breathe, and manage daily life. Researchers will test lung function, breathing muscle strength, and walking ability in 150 adults. The goal is to find physical limitations that could be i…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study is testing whether MRI brain scans can help predict which patients having their first psychotic episode will not respond to standard treatment. Researchers will scan 80 people aged 18-35 with schizophrenia or related disorders who have never taken antipsychotic medicat…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This pilot study uses MRI scans to investigate whether a small brain area called the inferior colliculi plays a role in auditory hallucinations in people with schizophrenia. Researchers will compare brain activity in 40 participants—20 with hallucinations and 20 without—while the…

This pilot study is testing whether two established trauma therapies—Prolonged Exposure and EMDR—can be safely used in young adults with psychotic disorders who also have PTSD symptoms. Twenty participants from the OPUS early-intervention program will receive one of the therapies…

This study tests a program called PRESTO that aims to identify and treat first-episode psychosis sooner. The program educates the public, trains frontline workers like doctors and teachers, and provides a mobile team to connect patients to care. Researchers will measure whether t…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, weakens the immune system over time. Researchers will measure immune markers in 24 patients before and after 6 and 12 months of treatment. The goal is to understand infection risks in th…

This study looks at whether teaching families skills to support young adults with psychosis can reduce stress for caregivers and help patients stay stable. About 113 family members will attend 9 weekly classes led by experts. Researchers will measure family burden, patient sympto…

This study looks at how the brain processes visual information in people with schizophrenia, bipolar disorder, or schizoaffective disorder. Researchers will use a non-invasive EEG cap to measure brain waves while participants view simple visual patterns. The goal is to find early…

This study aims to create brain-based tools to identify which veterans with chronic psychosis are most likely to benefit from cognitive rehabilitation. Researchers will use EEG recordings to measure brain activity and see if these signals can predict improvements in thinking skil…

This observational study will collect genetic and health information from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will link this data to electronic health records to find patterns and risk facto…

This study looks at whether older adults who develop hallucinations or delusions for the first time may have early signs of dementia. Researchers will use special brain scans (tau PET) and blood tests to check for abnormal proteins linked to Alzheimer's. The goal is to better und…

This study looks at tiny particles called exosomes in the blood of people experiencing their first episode of schizophrenia. Researchers want to see if the genetic material inside these particles is linked to problems with thinking and memory. By studying 300 participants, they h…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like working memory, attention, and decision-making—in people with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, ADHD, bo…

This study compares brain energy use, lactate, and glutamate levels in 75 people with schizophrenia and healthy volunteers using advanced MRI and PET scans. Researchers aim to see if brain glucose use is lower and lactate higher in schizophrenia, and if glutamate varies more. No …