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Shock therapy maintenance may keep schizophrenia at bay

NCT ID NCT06456983

Disease control Sponsor: Central Institute of Mental Health, Mannheim Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether maintenance electroconvulsive therapy (ECT) can prevent relapse in people with schizophrenia that doesn't respond to the strongest medications. About 140 participants who improved after a course of ECT will either continue with maintenance ECT or receive usual care. The goal is to see if maintenance ECT delays or reduces the chance of relapse.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), BPRS total score \> 45 and history of clozapine resistant schizophrenia (CRS), which will include treatment-resistant schizophrenia with clozapine intolerance or absolute contraindications for clozapine; Exclusion Criteria: 1. Diagnosis of DSM-5 major neurocognitive disorder ("dementia"), current severe substance-use disorder, affective disorders with psychotic symptoms or any personality disorder; 2. Inability to read/write German 3. Pregnancy or breast-feeding; 4. General medical condition contraindicating ECT.

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Conditions

The condition(s) this trial relates to.

schizophrenia Schizophrenia, Treatment-Resistant treatment-refractory schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Schizophrenia Treatment resistant schizophrenia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clinic for Psychiatry, Saarbrücken

    NOT_YET_RECRUITING

    Saarbrücken, Germany

  • Department of Psychiatry and Psychotherapy, Central Institute of Mental Health (CIMH)

    RECRUITING

    Mannheim, 68159, Germany

  • Departmet of Psychiatry, University Medical Center Göttingen

    NOT_YET_RECRUITING

    Göttingen, Germany

  • Dept. of Psychiatry I, Wiesloch

    NOT_YET_RECRUITING

    Wiesloch, Germany

  • Dept. of Psychiatry, Hannover Medical School

    NOT_YET_RECRUITING

    Hanover, Germany

  • Dept. of Psychiatry, LMU München

    NOT_YET_RECRUITING

    München, Germany

  • Dept. of Psychiatry, RWTU Aachen

    NOT_YET_RECRUITING

    Aachen, Germany

  • Dept. of Psychiatry, University Mainz

    NOT_YET_RECRUITING

    Mainz, Germany

  • Dept. of Psychiatry, University Tübingen

    NOT_YET_RECRUITING

    Tübingen, Germany

  • Dept. of Psychiatry, University of Augsburg

    NOT_YET_RECRUITING

    Augsburg, Germany

  • Klinik für Psychiatrie, Göppingen

    NOT_YET_RECRUITING

    Göppingen, Germany

  • Klinik für Psychiatrie, Siegen

    NOT_YET_RECRUITING

    Siegen, Germany

  • Universitätsklinikum Heidelberg, Klinik für Allgemeine Psychiatrie

    NOT_YET_RECRUITING

    Heidelberg, 69115, Germany

  • Zentrum für Psychische Gesundheit

    NOT_YET_RECRUITING

    Ingolstadt, Germany

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