Brain fuel mystery: new study scans energy use in early schizophrenia

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion criteria for patients with FES 1. Age 18-35 years 2. Diagnosed with FES (ICD-10: F20) 3. Able to give informed oral and written consent. Inclusion criteria for healthy controls 1. Age 18-35 years 2. No mental disorder (ICD-10: F00-99) 3. Able to give informed oral and written consent. Exclusion Criteria: Exclusion criteria for patients with FES 1. Any coercive measure including patients in forensic psychiatry 2. In a clinical condition where the treating clinician evaluates that the patient is not able to attend the research study. 3. Previous use of AP at an antipsychotic dose (except for Risperidone ≤0.5 mg, Abilify ≤2.5 mg, Seroquel ≤50 mg or Zyprexa ≤2.5 mg) for more than 2 continuous weeks in the past year and/or 6 weeks over a lifetime 4. Use of an antipsychotic in the last 3 months before inclusion at a dose greater than: 4.1 Seroquel/Quetiapine 50 mg 4.2 Risperdal/Risperidone 0.5 mg 5. Comorbidity: Borderline intelligence or intellectual disability, autism spectrum disorder, decompensated substance use disorder, psychosis induced by a medical condition or psychosis induced by medication or drug use. 6. Pregnancy, childbirth within the past 6 months, or breastfeeding. Female participants should use an effective contraception. 7. Contraindications to MRI (metal, severe claustrophobia). 8. Acute suicidal thoughts (e.g., resulting in hospitalization) 9. Diabetes mellitus type 1. History of severe head trauma, stroke, chemotherapy or brain surgery. Hypo- or hyperthyroidism. Epilepsy. Systemic glucocorticoid hormone treatment. 10. Other conditions interfering with participation according to the qualified physician's judgment. Exclusion criteria for healthy controls 1. Previous use of an antipsychotic dose (except for Risperidone ≤0.5 mg, Abilify ≤2.5 mg, Seroquel ≤50 mg or Zyprexa ≤2.5 mg) for more than 2 continuous weeks in the past year and/or 6 weeks over a lifetime 2. Use of AP in the last 3 months before inclusion at a dose greater than: 1. Seroquel/Quetiapine 50 mg 2. Risperdal/Risperidone 0.5 mg 3. Pregnancy, childbirth within the past 6 months, or breastfeeding. Female participants should use an effective contraception. 4. Contraindications to MRI (metal, severe claustrophobia). 5. Diabetes mellitus type 1. History of severe head trauma, stroke, chemotherapy or brain surgery. Hypo- or hyperthyroidism. Epilepsy. Systemic glucocorticoid hormone treatment. 6. Other conditions interfering with participation according to the qualified physician's judgment.