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Could zapping the brain boost memory in schizophrenia?

NCT ID NCT06470516

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a non-invasive brain stimulation technique called high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive problems like memory and attention in people with schizophrenia. One hundred participants will receive either real or sham stimulation for 30 days. Researchers will measure changes using cognitive tests and brain imaging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-frequency transcranial alternating current stimulation (Hi-tACS) device
What this could lead to
If it works, this could offer a non-drug way to help with memory and attention problems in schizophrenia.
What could go wrong
This is an early-stage study with only 100 people. The effects may be small or not last, and the stimulation might cause discomfort or side effects like headache.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Meets the diagnostic criteria for schizophrenia according to DSM-5. 2. Age ≥ 18 years old. 3. Right-handed. 4. Willing to participate in this study and sign an informed consent form. If the participant is unable to read and sign the informed consent form due to lack of capacity, a legal guardian must act as a proxy during the informed consent process and sign the form. 5. Clinically stable, receiving antipsychotic medication treatment with a stable dose for 4 weeks without any changes. 6. Montreal Cognitive Assessment score ≥ 10 points. Exclusion Criteria: 1. Psychotic disorders caused by split affective disorder, bipolar disorder, intellectual disability, anxiety spectrum disorders, drugs, alcohol, and other psychoactive substances according to DSM-V diagnostic criteria. 2. Those with severe or unstable organic diseases, with a history of brain tumors or epilepsy. 3. Those who have received MECT or TMS treatment within 1 month before enrollment. 4. Skin integrity at the electrode placement site is compromised. Allergy to electrode gel or adhesive. 5. Implants of metal or electronic devices (such as pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt surgery, etc.). 6. Participation in any other clinical trials within 1 month prior to baseline. 7. Pregnant and lactating women. 8. The investigator believes that there are inappropriate conditions for participating in this study.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Quzhou Third Hospital

    RECRUITING

    Quzhou, Zhejiang, 324003, China

  • Sir Run Run Shaw Hospital

    RECRUITING

    Hanzhou, Zhejiang, 310020, China

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