Nutritional disorder

This study tests whether a pneumococcal vaccine (Pneumosil) can produce a strong immune response in children aged 6-59 months who are hospitalised with severe acute malnutrition. Half the children will receive the pneumococcal vaccine, and the other half will receive a typhoid va…

This trial tests whether mazdutide, an experimental weekly injection, can reduce fat buildup in the pancreas of adults with overweight or obesity. About 194 participants will receive either mazdutide or a placebo, alongside standard lifestyle advice, for 48 weeks. Researchers wil…

This Phase 2 trial tests whether combining the supplement alpha-lipoic acid with the drug mirabegron can improve how the body processes sugar in people with obesity. Sixty adults aged 18 to 65 with a BMI between 30 and 45 will take the combination or a placebo for 4 weeks. The st…

Many people who have bariatric surgery do not lose as much weight as expected or regain it over time. This trial tests whether tirzepatide, a weekly injection that acts on two gut hormones, helps adults with obesity lose more weight after surgery. Participants receive either tirz…

Researchers are testing an experimental drug called MWN117 to see if it is safe and how the body handles it. The trial enrolls 48 healthy and obese Chinese adults who receive a single injection under the skin of either MWN117 or a placebo. Participants are split into groups that …

Researchers are testing an experimental injectable drug called SHR-1179 in obese adults. The trial aims to see how safe and tolerable a single dose is, and how the body processes the drug. About 50 participants with a body mass index between 28 and 35 will receive either SHR-1179…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

Researchers are testing whether a combination of semaglutide (Wegovy), a levonorgestrel-releasing intrauterine device (LNG-IUD), and a structured weight loss program can treat endometrial atypical hyperplasia or early-stage, grade 1 endometrioid endometrial cancer in women who wa…

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

Researchers are testing whether limiting all meals and snacks to a 9-hour window each day improves blood sugar control, insulin levels, and daily metabolic rhythms in adults with obesity and prediabetes. The trial enrolls 26 people aged 35 to 75 who usually eat over 13 hours a da…

This trial investigates whether adding a once-weekly injection of tirzepatide to standard diabetes pills can improve blood sugar control and promote weight loss in obese adults with type 2 diabetes. Over six months, researchers will compare changes in HbA1c and body weight betwee…

Researchers are testing whether tirzepatide, given as a weekly injection, can help children aged 6 to under 12 who have obesity. All participants also receive support for healthy eating and exercise. The trial compares tirzepatide with a placebo and measures changes in body mass …

Researchers in Denmark are testing whether a structured weight loss program can slow the progression of atrial fibrillation in people who are overweight or obese. The trial enrolls 480 adults with symptomatic paroxysmal or early persistent atrial fibrillation and a body mass inde…

Researchers are studying zenagamtide, an experimental drug for overweight and obesity, to see how food and water affect the tablet version. Participants take zenagamtide as either a tablet or an injection, and the tablet group tries different meal timings and water amounts around…

Researchers are testing whether adults with obesity can safely switch from semaglutide (Wegovy) to an experimental drug called zovaglutide. The trial enrolls 210 people aged 18 to 75 with a BMI of at least 28 who do not have diabetes. Participants first receive semaglutide inject…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

Researchers are observing how tirzepatide works in routine care for adults in Pakistan who have obesity, prediabetes, or type 2 diabetes. The study follows 330 people starting the medicine as part of their normal treatment at ten diabetes and endocrinology centres. Doctors decide…

Researchers are running a Phase 1 trial of HRS-1597, an experimental tablet for obesity and metabolic disorders. The study gives single doses to healthy volunteers and multiple doses to obese participants to check safety, tolerability, and how the drug moves through the body. It …

This study tests whether combining two experimental drugs, petrelintide and enicepatide, helps adults with obesity or overweight lose more weight than taking either drug alone or a placebo. About 486 participants will receive different doses or a placebo for several months. The g…

Researchers are testing an experimental injectable drug called IBI3046 in Chinese adults who are overweight or obese. The trial checks the drug's safety, how the body processes it, and how it affects body weight. Participants receive IBI3046 alone, in combination with another dru…

This early-stage study at Yale is testing whether a combination of two medications (naltrexone and bupropion) plus cognitive-behavioral therapy can help people who are considering bariatric surgery lose weight and stop smoking. Twenty participants will receive the treatment for f…

This 52-week trial tests whether combining a structured lifestyle program with a mushroom-based supplement and the drug bupropion helps overweight adults lose weight and lower cardiometabolic risk. About 250 adults aged 18 to 55 with a BMI between 25 and 35 will be randomly assig…

This early-stage trial tests an experimental drug called LY4329090 in adults with obesity or overweight. The main goal is to see how safe and tolerable the drug is, and how the body processes it. Participants receive either the drug or a placebo by injection, and researchers moni…

This trial tests whether two moderate low-carbohydrate diets, one higher in protein and one higher in fat, improve blood sugar, blood fats, and weight more than a standard diet. Adults with type 2 diabetes, high triglycerides, and overweight or obesity will follow one of the thre…

This phase 3 trial tests whether UBT251, an investigational drug given as a weekly injection, can reduce breathing pauses during sleep in adults with moderate-to-severe obstructive sleep apnea who also have obesity. Participants continue their usual positive airway pressure (PAP)…

This study tests an experimental drug called berobenatide, given as a once-monthly injection, to see if it helps adults with obesity lose weight. About 197 participants in Japan will receive either berobenatide or a placebo for roughly 21 months. The trial measures changes in bod…

This Phase 3 trial tests an investigational drug called berobenatide, given as a once-weekly injection, in about 180 adults with obesity in Japan. Some participants may also have type 2 diabetes. Researchers randomly assign participants to receive either berobenatide or a placebo…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

Researchers are testing an experimental injection called SYH2069 in adults who are overweight or obese but do not have diabetes. The study compares the drug against a placebo over 28 weeks to see if it leads to meaningful weight loss. Participants receive either SYH2069 or a plac…

This Phase 3 trial tests whether berobenatide, a once-weekly injection, helps Chinese adults with overweight or obesity lose weight. About 300 participants will receive either berobenatide or a placebo for 48 weeks, with researchers tracking changes in body weight and safety. The…

This early trial tests an investigational pill called IBI3042, which activates the GLP-1 receptor, a target used by many weight-loss drugs. Researchers want to see if single and repeated doses are safe and tolerable in healthy, overweight, and obese adults. The study also tracks …

This early-stage trial is testing an investigational drug called BI 3034701 in people with overweight or obesity who also have at least one weight-related health condition. The main goal is to see how safe and tolerable the drug is when given by injection, and to understand how i…

Researchers are testing whether a gentle electrical stimulation on the ear, called taVNS, paired with mouth and tongue exercises can help infants with severe swallowing difficulties. The trial will include 12 infants in the NICU who have trouble sucking and swallowing. Over three…

This trial tests whether a nutrition program before elective open-heart surgery can reduce blood transfusions in patients with mild anemia. Participants receive a high-protein diet with iron and vitamin supplements, plus educational materials, for 8 to 12 weeks before their opera…

This study tests whether Vibegron, a drug already approved for overactive bladder, can improve metabolism, heart health, and physical and mental function in middle-aged and older adults with obesity. Forty participants will take the drug or a placebo for 12 weeks. The goal is to …

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This trial tests an experimental oral drug called TQF3250, which mimics a natural hormone that helps control appetite and blood sugar. Researchers will give the drug or a placebo to 80 overweight or obese adults who have not had success with diet and exercise alone. The main goal…

This 8-week pilot trial tests whether eating at least 56 grams of almonds daily can raise blood levels of vitamin E and improve overall diet quality in adults taking GLP-1 medications like semaglutide or tirzepatide for obesity or type 2 diabetes. Participants are split into two …

This trial tests whether a daily iron-rich snack bar can improve hemoglobin levels in adolescent girls with mild anemia. Researchers plan to enroll 100 girls aged 16 to 18, with half eating two bars each day for 12 weeks while the other half follows their usual diet. The bars are…

This pilot study tests whether endoscopic sleeve gastroplasty (ESG), a minimally invasive procedure that reduces stomach size, can help obese adults with heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in heart failure symptoms and weight …

This trial tests whether an online weight loss program with specific daily goals, called the 30-30-30 plan, helps people lose more weight than a standard online program. The plan asks participants to eat at least 30 grams of protein per meal, 30 grams of fiber per day, and get 30…

This trial tests whether a 12-week program of respiratory muscle training—using a device that strengthens breathing muscles—combined with exercise can improve lung function and exercise tolerance in obese adolescents aged 10 to 16 who have specific learning disabilities. Half of …

This phase 1 trial tests an experimental drug called TQF6422 in healthy adults who are overweight or obese. The drug is an antibody that blocks certain proteins in the body, which may affect how the body regulates muscle and fat. Researchers give single and multiple doses to see …

This trial tests whether an investigational drug called HDM1005, given as a weekly injection, can help people with obstructive sleep apnea and obesity. Participants will receive either HDM1005 or a placebo for 52 weeks, alongside lifestyle counseling on diet and physical activity…

This trial tests whether adding a second procedure to a standard weight-loss operation leads to greater weight loss and better metabolic health in adults with obesity. The standard procedure, endoscopic sleeve gastroplasty (ESG), uses stitches to make the stomach smaller. The add…

This trial tests whether a daily supplement of calcium-HMB plus vitamin D3 can help adults aged 65 to 85 with type 2 diabetes keep their muscle mass and metabolism while starting semaglutide, a common weight-loss and diabetes medication. Participants take the supplement or a plac…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This trial tests whether giving patients extra protein and saline mist after tonsillectomy helps them heal faster and avoid complications. Tonsil removal is common in children and adults, but it often causes pain, trouble swallowing, and a risk of bleeding. The researchers will c…

This trial tests whether orforglipron, a once-daily oral medication, helps Chinese adults with obesity or overweight and related health conditions lose weight. Participants take either orforglipron or a placebo for about a year. Researchers measure changes in body weight, waist s…

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar levels. Participants will play active video games at home, and researchers will track changes in weight a…

This study tests whether eating one avocado daily for 12 weeks can improve blood flow to the brain and support heart and blood vessel health in adults with prediabetes and overweight or obesity. Researchers will measure brain blood flow using MRI, along with markers of blood vess…

This study tests a 12-week app-based strength training program called PLAN-RT 1.0, designed for midlife women (ages 40-54) who recently started GLP-1 medication for weight loss. The goal is to see if the program is practical and acceptable, and whether it can help preserve muscle…

This trial compares two approaches—electrical muscle stimulation (EMS) and traditional resistance training—to see which better improves cellular health and reduces oxidative stress in overweight and obese women aged 35 to 45. Participants will be randomly assigned to eight weeks …

This phase 3 trial is testing whether an investigational drug called HDM1005, given as a once-weekly injection, can improve obstructive sleep apnea and reduce body weight in people with obesity who do not use positive airway pressure (PAP) therapy. About 200 adults aged 18 to 75 …

This study tests whether gradually reducing the dose of semaglutide can help adults with overweight or obesity maintain their weight loss just as well as staying on the full dose. Participants who have already lost weight on semaglutide will either taper their dose over 24 weeks …

This phase 3 trial is testing whether an investigational drug called UBT251 can reduce the severity of obstructive sleep apnea in people who are obese and do not use positive airway pressure (PAP) therapy. Participants will receive weekly injections of UBT251 or a placebo for 52 …

This trial is testing whether an investigational drug called AZD6234, given as a weekly injection, can help adults with type 2 diabetes and excess weight lose more weight than a placebo. Participants will receive either AZD6234 or a placebo for 68 weeks, and researchers will meas…

This Phase 3 trial will test whether a new drug called zenagamtide helps people with obesity lose more weight than the current treatment semaglutide. About 650 adults will receive weekly injections of either zenagamtide, semaglutide, or a placebo. The main goal is to see how much…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This phase 3 trial is testing whether an experimental once-daily oral drug called zenagamtide can safely help people with excess body weight lose weight. Around 950 adults aged 18 and older with overweight or obesity will be randomly assigned to receive either zenagamtide or a pl…

This pilot trial is testing a digital health program called CHALAANE, which means 'walk' in Hindi and Urdu, for South Asian adults with knee osteoarthritis and obesity. The program combines a smartband, an AI-powered mobile app for tracking diet and activity, and a 12-week superv…

This trial tests whether taking vitamin C, vitamin E, or both daily for 12 weeks can lower markers of brain inflammation and change appetite-related brain signals in Mexican adults with obesity. Participants are randomly assigned to one of the supplements or a combination, and re…

This early-stage trial is testing an investigational injection called MWN110 in healthy volunteers and in people who are overweight or obese. The study aims to see if the injection is safe and tolerable, and how it affects body weight and composition. Participants receive either …

This trial tests whether adding mazdutide, a weekly injection that helps with weight loss, to a hormonal intrauterine device (IUD) can improve treatment for overweight or obese women with atypical endometrial hyperplasia or early-stage endometrioid endometrial cancer who wish to …

This Phase 3 study tests whether a weekly injection called zenagamtide helps Asian adults with overweight or obesity lose weight safely. About 400 participants will receive either the drug or a placebo for several weeks. The main goal is to see how much body weight changes, with …

This trial tests whether a weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can improve blood sugar control and reduce the need for insulin in adults with obesity and type 2 diabetes. Participants have poorly controlled diabetes despite taking standard medication…

This phase 3 trial is testing whether an investigational injection called MWN109 can help non-diabetic adults with overweight or obesity lose weight. About 760 participants will receive either MWN109 or a placebo once a week for a year. The main goals are to see how much weight p…

This early-stage trial is testing an investigational injection called SYH2092 in healthy adults who are overweight or have obesity. The main goal is to see if the drug is safe and tolerable, while also measuring how it moves through the body. Participants receive either the injec…

This phase 3 trial tests whether a single infusion of a new intravenous iron, Ferric Bepectate, can raise hemoglobin as effectively as two infusions of the current standard treatment (ferric carboxymaltose) in adults with iron deficiency anemia. About 1,366 participants will rece…

This trial asks whether GLP-1 receptor agonists, a class of drugs used for weight management, can improve gum health and boost the response to standard deep-cleaning treatment in people with obesity and periodontitis. Adults with both conditions will be split into two groups: tho…

This trial investigates whether semaglutide, a medication used for diabetes and obesity, can help reduce alcohol cravings and drinking in adults with alcohol use disorder and obesity. Participants will receive either a low dose, a high dose, or a placebo for 20 weeks. The study t…

This trial tests whether a single dose of ferric carboxymaltose can treat iron-deficiency anemia after stomach cancer surgery as effectively as multiple doses of iron sucrose. About 160 adults who had curative stomach cancer surgery and developed anemia will be randomly assigned …

This trial compares two approaches to weight loss: a traditional energy-restricted diet versus a personalized dietary plan tailored to each person's metabolism, body composition, eating habits, and preferences. About 800 adults with obesity (BMI 28 or higher) will be followed for…

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This trial compares three different negative-pressure wound dressings (NPseal, PICO, and Prevena) applied after total knee replacement surgery. The study enrolls adults at higher risk for wound problems, such as those with diabetes, obesity, or chronic kidney disease. Participant…

This study explores whether dietary counseling on a low glycemic index diet can reduce blood sugar fluctuations in adolescents with obesity. Participants will receive education and sample menus to help them choose foods that cause a slower, steadier rise in blood glucose. The tri…

This trial investigates whether semaglutide, a medication used for diabetes and obesity, can help adolescents aged 12-18 with autism spectrum disorder (ASD) and obesity reduce their body mass index (BMI). Participants will receive either semaglutide injections or lifestyle counse…

This trial tests whether adding laser acupuncture to a standard acupuncture technique—thread embedding—can enhance weight loss in adults with obesity. Participants receive the same thread embedding treatment, but half also get active laser acupuncture while the other half gets a …

This trial tests whether adding inositol or metformin to either a Mediterranean or low-carbohydrate diet improves insulin resistance in obese women with polycystic ovary syndrome (PCOS). About 90 to 102 participants will be randomly assigned to one of six groups and followed for …

This study tests whether adding cognitive behavioral therapy for insomnia (CBTI) to a flexible time-restricted eating plan helps adults with overweight or obesity and chronic insomnia lose more weight. Participants will either follow the eating plan alone or combine it with CBTI,…

This study tests whether patients can safely go home within 6 hours of bariatric surgery instead of staying overnight. 200 adults with obesity will be randomly assigned to same-day discharge or overnight stay. The main goal is to see how many need emergency care within a week.

This trial tests whether adding semaglutide—a medication used for diabetes and weight management—to standard antipsychotic treatment can lower the 10-year risk of heart attack and stroke in people with schizophrenia who also have metabolic syndrome. The study will measure changes…

This trial tests a new laparoscopic procedure called SIBS, which combines sleeve gastrectomy with a side-to-side connection between the duodenum and ileum, without cutting the duodenum. The goal is to see if the surgery is safe and technically feasible in adults with obesity and …

This trial tests whether gummies containing polydextrose, a type of dietary fiber, can help adults with overweight or obesity lose weight. Participants will take the gummies before meals for 24 weeks, alongside standard diet and exercise advice. The study compares weight loss, ap…

This early-stage trial is testing whether a new drug called macupatide, given alone or with another drug called eloralintide, is safe and well-tolerated in Japanese adults with obesity or overweight who do not have type 2 diabetes. Participants will receive multiple doses and sta…

This trial investigates whether combining oliceridine, a newer opioid, with propofol can provide safe and effective sedation for obese patients undergoing a painless gastroscopy. The study aims to determine the optimal dose of propofol when used with oliceridine, potentially redu…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial tests whether time-restricted feeding—eating all meals within a 16-hour fasting window—helps adolescents with overweight or obesity lose weight, and whether matching meal times to a teen's natural chronotype (early vs. late) makes a difference. About 120 teens aged 12-…

This study tests whether a traditional Chinese herb called Polygonatum sibiricum, or Huangjing, can help reduce visceral fat—the deep belly fat around organs that raises risks for diabetes, fatty liver, and heart disease. Adults with visceral obesity will receive either the herb …

This study tests whether supervised leg exercises can preserve muscle mass in adults with obesity who are starting treatment with incretin-based weight-loss drugs. Participants will train one leg twice a week for 13 weeks, while the other leg serves as a comparison. Researchers w…

This study tests whether eating a daily serving of pecans for 12 weeks can improve cholesterol levels and other markers of heart-disease risk. Adults aged 25–75 who are overweight or have borderline-high cholesterol will either add pecans to their diet or stick with their usual e…

This trial investigates whether a nutrition formula customized daily to each patient's measured energy needs and protein levels can improve outcomes for critically ill adults in the intensive care unit (ICU), including those with sepsis. Participants are randomly assigned to rece…

This phase 2 trial is testing whether adding an experimental oral drug called LUM-201 to the weight-loss medication semaglutide can improve physical function in older adults with obesity. The study enrolls people aged 60 to 85 with a body mass index (BMI) between 30 and 45 who ha…

This study tests a 6-month digital program that combines appetite awareness training with behavioral weight loss techniques, delivered remotely via Zoom. It aims to help Black women with obesity who binge eat at least once a week relearn hunger cues and prevent weight gain. The t…

This clinical trial is investigating whether a traditional Chinese medicine formula called Qingxin Jiaotai Decoction (QXJTD) can help adults who have both insomnia and obesity. Participants will receive either the herbal granules or a placebo, along with personalized diet and exe…

This trial tests whether taking a GLP-1 medication (semaglutide) for at least six months before hip or knee replacement surgery can improve recovery and reduce complications in patients with obesity. Participants will be randomly assigned to receive either the medication plus beh…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This trial tests whether adding a twice-daily nutritional drink to standard care helps adults aged 55 and older regain weight and muscle strength after being hospitalized for an acute illness. Participants are at risk of malnutrition and have low grip strength. Half receive the d…

This trial tests whether switching from one inhaled anesthetic (sevoflurane) to another (desflurane) near the end of weight-loss surgery helps patients wake up just as quickly as using desflurane throughout. Adults with obesity scheduled for laparoscopic gastric bypass will be ra…

This trial tests whether taking antioxidant-rich supplements for 12 weeks can improve skin and blood carotenoid levels, antioxidant status, and cardiometabolic health in overweight and obese adults aged 21-70. Participants maintain their usual diet while adding either LifePak Ele…

This pilot trial tests whether tirzepatide, a once-weekly injection used for diabetes and weight loss, can improve lung function and muscle health in overweight adults with COPD. About 30 participants will receive either tirzepatide or standard care for 12 months, with tests meas…

This study compares how well women with overweight or obesity stick to a 10-week dance-based exercise program versus a clinical Pilates program. Participants, aged 18-60 with a BMI between 25 and 35, will be randomly assigned to one of the two supervised group programs, held twic…

This study tests whether motivational interviewing—a supportive, goal-oriented counseling style—can help overweight and obese adults improve their eating habits, health literacy, and body measurements. Participants will receive either four structured counseling sessions plus rout…

This trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can improve physical function in adults with heart failure and obesity. Participants will receive either tirzepatide or a placebo for six months, while continuing their usual heart failure…

This trial tests whether converting a prior sleeve gastrectomy to a procedure called intestinal transit bipartition can improve stomach emptying, reduce acid reflux, and help with weight control. Forty adults who had sleeve gastrectomy and now have weight regain or reflux will un…

This trial tests whether donepezil, a medication used for memory, can help adults with anorexia nervosa weaken the strong habits that drive restrictive eating. Ten participants will receive the drug for up to 8 weeks while staying in an inpatient unit, with weekly check-ins to mo…

Preterm infants are born with low vitamin A stores and rely on breast milk to meet their needs, putting them at risk for deficiency. This trial tests whether giving mothers of very preterm infants (born before 29 weeks) a daily high-dose vitamin A supplement for four months can i…

This study investigates whether eating two servings of Greek yogurt daily—either whole milk or skimmed—can improve muscle protein synthesis, blood sugar control, and thinking skills in post-menopausal women who are overweight or have obesity. Participants will follow a standardiz…

This trial tests whether a smart ring that continuously tracks sleep, heart rate, and activity can help adults lose more weight during obesity treatment. Adults having weight-loss surgery or starting weight-loss medication wear the Oura Ring. In one group, the care team can see t…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This early-stage trial is testing an experimental oral drug called PF-08642534 in adults with obesity. The goal is to see if different doses are safe and how the body processes the drug. Participants will receive either the drug or a placebo once daily for a set period. The study…

This study tests whether switching to an oral weight-loss medication—either phentermine or orforglipron—can help people maintain weight loss after they stop taking injectable GLP-1 drugs like semaglutide or tirzepatide. Participants must have lost at least 10% of their body weigh…

This trial tests whether a simple saliva test, called MyPhenome, can guide doctors in choosing the most effective anti-obesity medication for each individual. The test sorts people into biological subtypes—like 'hungry brain' or 'hungry gut'—to personalize treatment. About 424 ad…

This trial compares two simple diet strategies — eating only during early hours or cutting staple foods like rice and bread in half — each combined with an app-guided exercise program, against exercise alone. Researchers want to see which approach helps adults with obesity and pr…

This phase 1 trial tests CG-0416, an experimental oral drug that targets thyroid hormone receptors in the liver, in healthy volunteers who are overweight or have obesity. The study aims to evaluate the drug's safety, tolerability, and how the body processes it after single and mu…

This trial compares two intravenous iron treatments—ferric carboxymaltose and iron sucrose—in pregnant women with iron deficiency anemia who need IV iron. Researchers want to see which one raises hemoglobin levels more after four weeks and whether one reduces hospital visits and …

This study tests an experimental drug called HS-20136-2, given as an injection under the skin, to see if it is safe and tolerable in healthy and obese adults aged 18 to 55. The trial also looks at how the drug moves through the body and whether it causes weight changes. Participa…

This trial tests whether adding tirzepatide (Mounjaro) to a structured lifestyle program reduces the return of atrial fibrillation within a year after catheter ablation in obese patients. About 710 participants with symptomatic AF and a BMI of 28 or higher (or 24 with other risk …

This study tests four nutrition programs—meal kits, ready-to-eat meals, cooking classes, and motivational texts—in 400 adults with overweight or obesity who use food pantries. The goal is to see which approach best improves diet quality and food security, with the aim of reducing…

This study tests whether giving teens with obesity and prediabetes a continuous glucose monitor (CGM) — along with nutritional counseling — helps them eat better and keep blood sugar in check. For three months, participants see their glucose levels in real time and learn how diff…

This study looks at whether taking macaúba oil supplements while doing outdoor exercise can improve how the body burns fat and handles mental stress. Researchers will enroll 60 physically active adults aged 35 to 59 who are overweight but not obese. Participants will take either …

This trial tests whether two specific diet plans can help people with obesity or overweight maintain weight loss after stopping semaglutide (Wegovy). Many patients regain weight quickly when they stop the drug. The study compares a special dietary pattern called NutriAct plus wit…

This pilot study tests a personalized lifestyle program called PRISM for adults with metabolic syndrome and insulin resistance. Participants follow a time-restricted eating schedule (eating all meals within an 8-hour window) and are later assigned extra lifestyle changes like phy…

This phase 3 trial tests an injectable drug called ribupatide in people who have both obesity and knee osteoarthritis. The study measures whether ribupatide can reduce knee pain and stiffness, improve joint function, and help with weight loss over 68 weeks. Participants are rando…

This two-part study investigates Lembas Edge, a dietary supplement derived from a peptide. Part 1 tests its safety and tolerability in healthy adults. Part 2 evaluates its ability to control blood sugar after meals in overweight or obese adults with prediabetes. Participants take…

This trial tests whether changing the order of exercise (aerobic before anaerobic, or vice versa) and the order of eating (vegetables and protein first, carbohydrates last) helps overweight children and teens lose weight and improve health. Over 28 days at a weight loss camp, par…

This trial compares adapted taekwondo training with conventional exercise (moderate continuous training and stretching) in women aged 60–65 with abdominal obesity. The goal is to see which approach better reduces belly fat and improves physical function, strength, balance, and fl…

This study tests whether adding hands-on cooking classes to standard Mediterranean diet advice helps adults aged 30-60 with metabolic syndrome improve their health. Participants receive either diet counseling alone or counseling plus culinary training, including recipe booklets a…

This study tests whether a daily 4-gram dose of ajwa seed powder, made from date seeds, can improve blood sugar control (HbA1c) and body composition in overweight and obese adults aged 30–50 with type 2 diabetes. Over 12 weeks, researchers will measure changes in HbA1c, weight, w…

This study investigates whether combining aerobic exercise with blood flow restriction—using a pressure cuff on the thigh—can improve key blood markers in young women with iron deficiency anemia. Fifty participants aged 19-25 with mild to moderate anemia will walk on a treadmill …

This study investigates whether combining early time-restricted eating (eating all daily food within an 8-hour window, e.g., 7 AM to 3 PM) with a structured exercise program can improve bone density, walking, balance, and reduce fall risk in healthy adults aged 60 and older. Abou…

This study investigates whether adding a high-protein diet and supervised resistance training to the weight-loss medication tirzepatide helps preserve muscle mass better than a high-protein diet alone. Adults aged 30–60 with a BMI between 27 and 37 who are about to start tirzepat…

This study tests whether an AI-powered intensive lifestyle program can help people with obesity and newly diagnosed type 2 diabetes lose weight and control blood sugar as well as the drug tirzepatide. Adults aged 18 to 65 with a BMI of 28 to 40 and recent diabetes diagnosis are r…

This study tests whether a 10-week digital mindfulness program, combined with dietary advice, can help people with type 2 diabetes and obesity lose weight and improve blood sugar control. Participants learn mindful eating techniques through videos and home exercises. The trial me…

This study tests whether giving caregivers a weekly bulk container (7-day supply) versus daily single-use sachets (1-day supply) of a nutrient supplement improves how much children actually consume. About 500 caregivers of children aged 6-24 months in northern Ghana will try both…

This study investigates whether a special cooking oil called diacylglycerol (DAG) oil can improve thinking skills and reduce body weight in adults aged 45 to 75 who have both obesity and mild cognitive impairment. Participants replace their usual cooking oil with either regular r…

This pilot study tests a 12-week digital lifestyle program created specifically for gay men and lesbian women with obesity. Participants receive an online, self-paced intervention and provide feedback on how well it meets their needs. The goal is to see if a tailored approach imp…

This phase 2 study tests HRS-4729, a once-weekly injection, for weight loss in adults with obesity who do not have diabetes. About 252 participants will receive either the drug or a placebo. The main goal is to see how much body weight changes after 32 weeks compared to a placebo…

This trial investigates whether giving obese women with polycystic ovary syndrome (PCOS) a GLP-1 receptor agonist (a drug that helps control appetite and blood sugar) along with healthy lifestyle education for 12 weeks before starting fertility treatment can improve their chances…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, reduce hospitalizations, and boost quality of life in adults aged 65 and older who have heart failure with preserved ejection fraction and iron deficiency. Participants receive…

This study evaluates the safety and effectiveness of the Allurion Gastric Balloon System, a swallowable balloon placed in the stomach to help with weight loss. It involves 250 adults aged 22–65 with a BMI between 30 and 40. The balloon is swallowed and later passes naturally, avo…

This study compares two 20-week exercise programs for adults aged 30-65 with both type 2 diabetes and obesity. One group attends supervised, in-person sessions twice a week, while another follows the same plan through a mobile app. A third group receives standard medical care onl…

This study compares the effects of Pilates exercises versus intermittent fasting on physical and metabolic aging in obese perimenopausal women. Participants will be assigned to one of two groups: a Pilates exercise program or a 16:8 intermittent fasting diet. The researchers will…

This study investigates how semaglutide (the drug in Ozempic and Wegovy) changes brain activity related to appetite and eating in people with obesity. Researchers will compare teenagers (ages 12–18) and adults (ages 30–45) using brain scans and meal tests to see if the drug affec…

This study tests whether combining two medications, empagliflozin and finerenone, can lower blood pressure in adults with obesity and stage 1 hypertension. Participants take the drugs or a placebo daily for 12 weeks. The trial also measures effects on kidney function, inflammatio…

This early-stage study tests a small implant placed under the skin that releases semaglutide (the drug in Wegovy) over 4 weeks. It involves 20 otherwise healthy overweight or obese adults. The goal is to see if the implant is safe and how it compares to weekly injections.

This Phase 2 trial tests whether adding LAE102 to the weight-loss drug tirzepatide can improve body composition in 60 adults with obesity. Participants receive weekly injections of either LAE102 plus tirzepatide or a placebo plus tirzepatide. The main goal is to see if the combin…

This phase 4 trial will study 240 adults aged 35-55 with class I/II obesity to see if weight loss from semaglutide (Ozempic/Wegovy) improves brain health. Participants will take the drug weekly for 80 weeks and undergo MRI scans, cognitive tests, and blood work. The study also in…

This study will test whether replacing breakfast and a snack with a diabetes-specific nutritional drink (Glucerna) helps people with type 2 diabetes and obesity keep their blood sugar in a healthy range more often. About 198 adults will be randomly assigned to either the drink-ba…

This study tests whether eating goat liver three times a week can improve anemia in teenage girls in Nepal, compared to standard iron-folic acid pills. Researchers will also look at how gut bacteria affect iron absorption. Sixty girls aged 15-19 with anemia will be randomly assig…

This Phase 2 trial tests whether BGM0504 tablets can help overweight or obese adults without diabetes lose weight. About 200 Chinese participants will take either the drug or a placebo daily for 20 weeks. Researchers will measure changes in body weight, waist size, and blood suga…

This study investigates whether a supervised, adapted physical activity program can improve how the body burns fat during walking in women with overweight or obesity, both with and without polycystic ovary syndrome (PCOS). Researchers will compare changes in fat oxidation and oth…

This pilot study will test whether supplements made from bilberries and olives can reduce inflammation and oxidative stress in people with prediabetes who are overweight. Researchers will collect blood, urine, and stool samples from 60 participants to measure changes in key healt…

This study investigates whether replacing some wheat flour with legume flours (chickpea, pea, or lentil) in Arabic bread can reduce blood sugar spikes after eating. Overweight or obese adults aged 18–65 will consume different breads and have their blood glucose and appetite measu…

This study will test whether taking oral iron supplements every other day works as well as taking them daily for pregnant women with iron deficiency anemia in their second trimester. About 184 women will be randomly assigned to one of two dosing schedules for four weeks. Research…

This trial compares two ways to treat iron deficiency anemia in children aged 1 to 5 years: oral iron syrup taken daily for weeks, or a single intravenous (IV) iron infusion. The goal is to see which approach raises hemoglobin levels faster and with fewer side effects. The study …

This study looks at whether adding lifestyle coaching to a new weight-loss medication (GLP-1) helps teens with obesity lose more weight and feel better. About 1,020 teens aged 12-17 will take the medication and be assigned to either intensive or basic lifestyle support. The goal …

This study looks at whether day hospitalization (going home at night) works as well as full-time hospital stays for teens aged 12-20 with severe obesity. About 126 participants will be followed to see how their weight changes six months after treatment ends. The goal is to find a…

This phase 3 study tests whether a weekly injection called UBT251 can help overweight or obese adults lose weight. Participants receive either the drug or a placebo for 52 weeks. The main goal is to measure the percentage change in body weight, with additional checks on waist siz…

This trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce the return of atrial fibrillation (AFib) after a heart procedure called catheter ablation. Overweight or obese adults with persistent AFib will receive either tirzepatide injections plus st…

This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This study looks at whether improving sleep habits can help teenagers with overweight or obesity better regulate blood sugar and energy. Researchers will enroll 60 teens aged 14-19 who get less than 7 hours of sleep on school nights. For two weeks, participants will follow a slee…

This pilot study tests whether fecal microbiota transplant (FMT) – taking capsules made from healthy donor stool – is a feasible and acceptable treatment for 20 teens (ages 12-17) with anorexia nervosa. Participants will take FMT or placebo capsules twice a day, twice a week for …

This study compares two blood-thinning injections (tinzaparin and enoxaparin) to prevent dangerous blood clots after weight loss surgery. About 180 adults having laparoscopic sleeve gastrectomy or gastric bypass will be randomly assigned to one of the two drugs for 21 days after …

This study looks at whether combining GLP-1 medications (like semaglutide and tirzepatide) with Noom's app-based behavioral program helps people lose weight and improve heart health markers. Over 2,300 adults will be followed for 24 months, tracking weight, blood sugar, cholester…

This study will test whether adding whole-body electrical muscle stimulation (EMS) to a reduced-calorie diet helps people with obesity lose weight and improve metabolic health. Forty adults will be randomly assigned to either diet alone or diet plus EMS for 8 weeks. Researchers w…

This study tests whether a 12-day nutrition education program, called Positive Deviance/Hearth (PDH), can help children aged 6-59 months recover from moderate acute malnutrition. Caregivers learn to prepare nutrient-dense meals using local ingredients, with follow-up support. The…

This pilot study tests whether adding a single dose of fecal microbiota transplant (FMT) to standard psychotherapy can help people with anorexia nervosa. Thirty-six adults starting outpatient therapy will be randomly assigned to receive either therapy alone or therapy plus FMT (v…

This study looks at whether adding exercise to the weight-loss medication tirzepatide helps people lose more weight and improve health markers like blood sugar and cholesterol. Researchers will enroll 24 adults aged 30–65 with overweight or obesity. Participants will take tirzepa…

This pilot study tests whether a home-based high-intensity interval training (HIIT) program can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or co…

This study tests whether a special omega-3-enriched nutritional drink can improve nutrition in people with advanced lung or colorectal cancer who are at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The g…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study looks at whether giving people feedback on their metabolic profile (blood test results) halfway through a 3-month low-starch, low-sugar diet helps them lose more weight. 300 overweight adults (BMI over 25) will follow the diet, and half will learn their metabolic impro…

This study looks at whether metabolic surgery (like gastric bypass) can reduce the severity of atrial fibrillation (AF), a common heart rhythm problem, in people with obesity. About 100 adults with AF and a BMI between 35 and 65 will be randomly assigned to either surgery or medi…

This study tests a minimally invasive procedure called POSE2.0 for weight loss in 186 adults with obesity. The procedure uses stitches placed in the stomach without any incisions, combined with a diet and exercise program. Researchers will compare weight loss and safety between t…

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study tests a nutritional supplement called Redefine in 80 overweight adults who are already taking a weight-loss medication (semaglutide) and following a low-calorie diet. The goal is to see if Redefine is safe and helps preserve muscle mass while losing fat. Participants t…

This study tests whether a 9-month lifestyle coaching program (individual and group sessions with a dietician) helps obese male firefighters lose weight and improve metabolic health. Fifty participants will be randomly assigned to coaching or usual care. The main outcomes are cha…

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in p…

This study tests whether a specific ventilator mode called APRV can improve breathing and oxygen levels in very obese patients after elective heart surgery. 180 adults with a BMI of 40 or higher (or 35 with related health issues) will be randomly assigned to receive either APRV o…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce liver fat in people with alcohol-related fatty liver disease (MetALD). 105 participants will receive either personalized rTMS, standard rTMS, or a sham (placebo) treatment over 20 sessions.…

This study tests whether a structured exercise and nutrition plan can help older patients (70+) avoid losing the ability to care for themselves during a hospital stay. About 360 patients from a geriatric ward will take part. The goal is to see if personalized resistance and mobil…

This study tests whether vericiguat, a drug already used for heart failure, can improve how the body uses sugar and burns energy in Black adults with obesity and insulin resistance. Researchers will give 200 participants either vericiguat or a placebo daily for 12 weeks, measurin…

This study tests the drug tirzepatide (Munjaro) in 30 obese adults with congenital heart disease. Over 6 months, half get the drug and half get a placebo. Researchers will check if it improves exercise ability, heart function, and cholesterol. It is one of the first studies to lo…

This study tests whether adding the weight-loss drug orlistat to standard gout treatment helps obese patients lower uric acid levels and reduce gout attacks. 120 adults with gout and obesity will take either orlistat or a placebo for 24 weeks, along with diet and exercise advice.…

This study tests whether eating meals at times that match your body's internal clock can help people who have had weight-loss surgery keep the weight off and improve their health. About 246 adults who had sleeve gastrectomy at least six months ago will either follow standard diet…

This study tests whether a daily supplement made from mealworm flour can improve the nutritional health of 40 children aged 2-10 with chronic malnutrition in the Democratic Republic of the Congo. One group will receive the mealworm supplement, while the other gets a traditional c…

This study compares an oral iron supplement (sucrosomial iron) to the usual intravenous (IV) iron given to anemic patients before heart surgery. About 75 adults with mild anemia scheduled for heart procedures will be randomly assigned to one of the two treatments. The goal is to …

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or obesity. Participants receive weekly injections for three months. The goal is to see if this drug can help manage weight and …

This study looks at whether giving extra nutrition during dialysis sessions helps people on long-term hemodialysis build muscle and manage blood pressure. Researchers will compare the effects of this special nutrition with usual care in 16 adults who have been on dialysis for at …

This study looks at whether eating more protein can help people on dialysis avoid hospital stays. Dialysis removes nutrients like protein from the blood, and current guidelines are based on old research. The study will give some participants a high-protein diet or supplements and…

This study tests two 2-month programs to help adults with overweight or obesity cut down on ultra-processed foods. One program uses standard diet tips like meal planning, while the other uses a 'dissonance' approach where participants take part in activism against the food indust…

This study tests whether giving tranexamic acid (TXA) through a vein during weight-loss surgery can reduce blood loss in patients with a very high body mass index (BMI over 45). About 128 high-risk adults will receive TXA or a placebo to see if it lowers the need for blood transf…

This study tests whether combining a home exercise program with a daily anti-inflammatory nutritional supplement (Alisenoc™) can improve physical performance in frail, malnourished adults aged 75 and older. Participants will be randomly assigned to receive either the anti-inflamm…

This study tests whether a new oral iron supplement called Sucrosomial iron (Sideral Folico) can effectively treat iron deficiency anemia in pregnant women. Researchers will enroll 82 pregnant women between 24 and 32 weeks of pregnancy with mild to moderate anemia. The goal is to…

This study will compare two types of minimally invasive gastric bypass surgery for people with severe obesity: one done with a robot (DaVinci) and the other done by hand (laparoscopy). Researchers want to see which approach leads to fewer complications and is more cost-effective.…

This study tests whether a simple calculation from a standard blood test—the creatinine-to-body weight ratio—can predict fatty liver disease in people with metabolic syndrome. Metabolic syndrome is a cluster of conditions like obesity, high blood pressure, and high blood sugar th…

This study investigates whether specific proteins found in tiny particles in the blood (called small extracellular vesicles) can help identify obese individuals who are at risk for developing type 2 diabetes. Researchers will measure levels of two proteins, integrin-β2 and ECM1, …

This study tests whether a combination of blood markers, ultrasound, and genetic information can accurately diagnose metabolic dysfunction-associated steatotic liver disease (MASLD) in children aged 8 to 18 with obesity. Each child provides a blood sample, undergoes a liver ultra…

This study is testing a new AI software called Soma that automatically measures muscle and fat from CT scans. Researchers will compare the software's measurements to those made by three expert radiologists using 200 CT scans from public databases. The goal is to see if the AI is …

Researchers at Tufts University are testing whether an interactive, customizable digital comic can help Black and Latino children ages 8 to 12 develop healthier eating and physical activity habits. The comic lets children make choices that change the story and health messages the…

Researchers are testing whether a daily yeast protein supplement can protect lean body mass and muscle function in adults with overweight or obesity who are losing weight with GLP-1 receptor agonist drugs. The trial enrolls 200 adults aged 25 to 50 who are starting or have recent…

This trial tests whether pre-filling online grocery carts with healthy recipe ingredients can help parents with obesity buy and serve more nutritious foods to their young children. Parents of 2-to-5-year-olds receive weekly recipe packets, and some also get carts pre-stocked with…

This study tests whether giving vitamin K2 (MK-7) supplements to breastfed infants or their breastfeeding mothers can prevent vitamin K deficiency at 2 months of age. About 134 healthy, full-term babies who received standard vitamin K shots at birth will be enrolled. Some infants…

Researchers in Lahore, Pakistan are testing whether providing a daily balanced school meal to children aged 6 to 11 can improve their nutritional status and academic performance. Over 12 weeks, some children will receive a meal covering about one-third of their daily energy needs…

This trial tests whether giving semaglutide (Wegovy) to women shortly after a pregnancy affected by gestational diabetes can reduce their risk of developing metabolic syndrome, a cluster of conditions that raise the chance of heart disease and diabetes. About 226 postpartum women…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This trial tests whether structured motivational interviews, based on the Five-Step (5A) model, can encourage healthier habits in adults at high risk of obesity. Participants will attend counseling sessions and be tracked for changes in weight, waist size, and readiness to change…

This study tests whether social media campaigns can improve diet quality in young adults aged 18-29 who frequently consume sugary drinks and snacks. Participants will see one of three Instagram campaigns: counter-marketing that exposes deceptive food industry practices, health ed…

This trial tests a program called HADAS, designed to prevent eating disorders and body image dissatisfaction in adolescent female athletes aged 12 to 16 who compete in aesthetic sports like gymnastics and figure skating. The program works with athletes, their coaches, and their f…

This pilot study tests whether a simple program of brief, frequent movement throughout the day can help reduce cardiometabolic risk in rural women. Participants wear a Fitbit that reminds them to move each hour and complete health assessments before and after the 12-week program.…

This study compares two behavioral programs for young women aged 14-22: a new one called Priorities, which helps build self-worth beyond weight and shape, and The Body Project, an established eating disorder prevention program. Researchers want to see which is more effective at r…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests a special silver-coated mesh placed during emergency abdominal surgery to see if it can prevent surgical site infections and incisional hernias. About 110 adults having urgent open abdominal surgery will take part. Researchers will track infection and hernia rate…

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

This study tests a community-based program to help Black and Hispanic teens aged 15-20 cope with chronic stress and prevent depression. Participants will join peer groups to learn skills and will be tracked for 2 years. The goal is to reduce depressive symptoms and improve physic…

This study tests whether an AI-informed peer-mentoring program can help healthy 12- to 25-year-olds eat better and move more to prevent obesity. Participants will be split into three groups: AI-assisted peer mentoring, traditional peer mentoring, or standard health education. Res…

This study looks at whether using secure digital systems to share information between pediatricians and WIC nutritionists can help mothers get consistent advice on responsive parenting—like how to respond to a baby's needs for healthy eating, sleep, and activity. About 380 pregna…

This study will test a family support model that combines two existing programs: a universal school-based program for all first graders and a targeted program for parents of children with overweight or obesity. Researchers will enroll 126 parents of children aged 6-12 in Sweden t…

Researchers are testing whether mazdutide, a weekly injected drug, reduces the number of gout flares in adults who have both obesity and gout. The study enrolls 30 people aged 18 to 65 with a BMI of at least 30 and at least two gout flares in the past six months. Everyone receive…

Researchers are testing whether a carbohydrate-rich clear drink given two hours before bariatric surgery helps patients with metabolic syndrome recover normal gastrointestinal function faster. About 208 adults scheduled for gastric bypass or sleeve gastrectomy will be randomly as…

Researchers are testing whether adding whole-body electromyostimulation (WB-EMS) to a supervised exercise program improves body composition, heart health, fitness, and quality of life in overweight or obese postmenopausal women. Thirty women aged 48 to 60 will join a 16-week prog…

Researchers at Indiana University are testing whether a food carbohydrate powder made from raw corn and potato starch can raise levels of GLP-1, a gut hormone that helps people feel full. The trial enrolls 62 adolescents aged 12 to 18 with obesity. For two months, participants dr…

Researchers compare two surgical methods for removing an inflamed appendix in obese patients: laparoscopic (keyhole) surgery and traditional open surgery. The trial enrolls 166 obese adults with acute appendicitis, randomly assigning each to one of the two procedures. The main go…

Researchers are testing whether a monthly injection of berobenatide can reduce the severity of obstructive sleep apnea and lower body weight in adults who have overweight or obesity and use a PAP breathing machine. The trial enrolls about 258 adults with moderate to severe sleep …

Researchers are testing a 16-week program for adults aged 60 and older who carry excess body fat and do not exercise regularly. Participants are assigned to one of three groups: resistance training alone, resistance training plus group cognitive behavioral therapy, or both of tho…

This study tests two therapy approaches to help children aged 3-8 with Avoidant/Restrictive Food Intake Disorder (ARFID) eat more foods and have less stressful mealtimes. One group gets a sensory-based feeding program, another adds coaching for parents, and a third group gets sta…

Researchers compare two ways to control pain after laparoscopic sleeve gastrectomy, a weight-loss operation. One method injects a local anesthetic around the surgical port sites. The other uses ultrasound to guide a nerve block that numbs a wider area of the upper belly. The tria…

Anemia from iron deficiency is common in pregnancy and after childbirth, affecting many women. This trial tests whether iron given through a vein can raise hemoglobin levels and improve how women feel and function in everyday life before and after delivery. Researchers will compa…

Researchers are testing whether a weight-loss drug called tirzepatide, given for 16 weeks before a frozen embryo transfer, can improve the chance of a healthy birth in women with obesity. The trial enrolls women aged 20 to 40 with a BMI of 28 or higher who plan to have a frozen e…

Researchers compare two regional nerve block techniques with standard pain relief in adults having laparoscopic sleeve gastrectomy for obesity. The paragastric nerve block targets visceral pain, while the erector spinae plane block is given at the T6 level of the spine. Seventy-t…

Researchers are testing whether a six-week program of breathing-muscle training combined with high-intensity interval exercise improves diaphragm thickness, lung function, and aerobic fitness in boys aged 10 to 12 with obesity. Fifty boys are randomly assigned to the combined tra…

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This trial tests whether a daily ubiquinol supplement, a form of Coenzyme Q10, can reduce fatigue and help maintain muscle strength in adults aged 30-65 who are taking GLP-1 weight loss medications like Wegovy or Mounjaro. About 90 participants will take either ubiquinol or a pla…

This trial tests whether listening to a 15-minute relaxation audio during breastfeeding, twice daily for 12 weeks, can improve weight gain in low-birth-weight newborns and reduce maternal stress and anxiety. Mothers of stable infants born under 2500 grams will be randomly assigne…

This study tests whether a wearable device that delivers mild electrical stimulation to the brain, called transcranial direct current stimulation (tDCS), can reduce appetite and binge eating. Adults with binge eating tendencies will use the device at home twice daily for four wee…

This study tests two 8-week programs in women with overweight or obesity: one focusing on body awareness through yoga, breathing, and relaxation, and the other on mind-based techniques like psychoeducation and cognitive awareness. The goal is to see if these approaches can improv…

This phase 2 trial tests whether semaglutide, a weekly injection already used for weight loss, can reduce chronic low back pain in adults with obesity. Researchers will compare semaglutide to a placebo over 52 weeks in 250 participants, measuring changes in pain severity, disabil…

This trial tests whether adding a structured nutrition and exercise program to the standard appetite-stimulating drug olanzapine can improve quality of life in people with advanced solid tumors who have poor appetite. Participants are randomly assigned to receive olanzapine alone…

This trial tests whether two non-drug programs—targeted physiotherapy or supervised exercise—can reduce bladder and bowel symptoms in adolescents aged 13–18 with obesity. Participants will be randomly assigned to one of the two interventions or to standard obesity care for 12 wee…

This study tests whether a 16-week online mindfulness-based nutrition program is feasible and acceptable for adults with obesity who are taking GLP-1 receptor agonist medications. Participants in the intervention group attend nine live video sessions on mindful eating, practice d…

This study tests whether a trauma therapy program can help children aged 10 to 17 who have been bullied because of their weight. The therapy is based on Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) and aims to reduce emotional distress, improve body image, and address eat…

This study tests whether adding 3D reconstruction and virtual reality to standard body image counselling helps patients feel better about their body after weight-loss surgery. 80 adults on the waiting list for bariatric surgery will be split into two groups: one gets traditional …

This study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…

This study tests whether a temporary catheter placed during laparoscopic sleeve gastrectomy can be used to re-dose nerve-blocking medicine (bupivacaine and dexamethasone) if severe pain or nausea break through after surgery. It includes 30 high-risk patients, such as young women …

This study compares cognitive-behavioral therapy (CBT-AR) to nutrition counseling for children and teens aged 10-18 with Avoidant/Restrictive Food Intake Disorder (ARFID). 70 participants will be randomly assigned to one of the two treatments. The goal is to see which approach be…

This study tests whether light physical activity after meals can improve blood sugar levels in adults with metabolic syndrome and prediabetes. Twenty-five participants will try three routines in random order: sitting, a 15-minute walk, or brief resistance exercises like squats ev…

This study tests whether a daily lutein supplement made from microalgae can slow cognitive decline in postmenopausal women with obesity. 300 women aged 48-60 will take either 6 mg, 14 mg, or a placebo for 180 days. Researchers will measure changes in memory, attention, and inflam…

This study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…

This study tests a new approach called 'snack exercise' for adults aged 65 and older who are overweight. Instead of one long workout, participants do several short bursts of activity throughout the day. The goal is to see if this easier routine helps improve health, fitness, and …

This study compares two types of iron supplements—standard ferrous salt and a newer liposomal form—in adult women with iron-deficiency anemia caused by heavy menstrual bleeding. About 100 women will take one of three treatments daily or every other day for three months. Researche…

This early study tests whether a non-invasive brain stimulation technique called rTMS can help reduce symptoms of anorexia nervosa in 45 people aged 14 to 24. Participants will receive 20 daily sessions of rTMS, which uses magnets to stimulate the brain. Researchers will track ch…

This study tests whether a 10-week camp program can help children and teens (ages 7-14) reduce binge eating. Some parents will also receive special training to see if it adds extra benefit. Researchers will follow participants for up to 5 years to track lasting effects.

This study tests a non-invasive device that stimulates the vagus nerve through the ear in 60 men aged 25-35 with central obesity (waist >94 cm, BMI ≥30). The goal is to see if it lowers inflammation (IL-6 levels) and reduces waist size. Participants must be otherwise healthy, non…

This study looks at whether giving iron through an IV in the emergency department can help children with iron deficiency anemia recover faster than taking iron pills. Researchers will compare how quickly anemia resolves, how many children need blood transfusions or hospital stays…

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study tests if giving the asthma drug salbutamol during weight-loss surgery can improve breathing in obese patients. Researchers will measure lung function during surgery and check for breathing problems afterward. The goal is to see if this simple addition can reduce compli…

This study tests whether a short virtual reality (VR) program is safe and acceptable for adults with anorexia nervosa. Participants will use VR for about 20-30 minutes each weekday for one week, while continuing their usual care. The goal is to see if people are willing to try it…

This study will compare two devices that blow gas into the belly during laparoscopic sleeve gastrectomy (a weight-loss surgery). The goal is to see if one device causes less pain after surgery than the other. About 74 adults aged 22 to 65 having planned sleeve gastrectomy will be…

This study compares two devices used during robotic gastric sleeve surgery to see which causes less shoulder, neck, and chest pain afterward. About 74 adults having non-emergency sleeve gastrectomy will be randomly assigned to receive either the AirSeal or DV5 insufflation system…

This study tests whether a single-session consultation can reduce binge eating in women who struggle with it. About 56 women will be split into three groups: one gets a full talk session, one gets only an assessment, and one gets minimal contact. The goal is to see if even a brie…

This study looks at whether a nerve block (TAP block) given after laparoscopic gastric sleeve surgery can help the gut work normally again sooner. Sixty adults having weight-loss surgery will either get the block or standard pain care. Researchers will track gut symptoms using pa…

This study will test whether a structured education program plus a mobile app can help caregivers of patients with a percutaneous endoscopic gastrostomy (PEG) tube. The goal is to improve caregivers' knowledge, reduce tube-related problems, and lessen their sense of burden. Eight…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study follows 125 pregnant women from 30 weeks of pregnancy through their baby's first year. Researchers want to learn how diet, food access, and other social factors affect mothers' health, breastfeeding success, and baby growth. Participants will complete remote visits and…

This study follows 400 children aged 5 to 7 with obesity or normal weight until age 12. Researchers will track puberty signs, hormones, genes, diet, and chemical exposures to see what predicts early puberty. No treatments are given; the goal is to gather information.

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

Researchers at the University of California, San Francisco are following 100 adolescents and young adults, ages 12 to 21, who are starting GLP-1 weight-loss drugs like Ozempic, Wegovy, or Mounjaro. Over one year, participants answer online surveys about their eating behaviors and…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study will follow 3,000 French patients with severe or complicated obesity who are taking semaglutide (Wegovy) as part of an early access program. Researchers will track weight changes, treatment patterns, and well-being over time using questionnaires. The goal is to underst…

This natural history study looks at how life events during childhood might affect eating behaviors and weight gain in adults. Researchers will observe 110 healthy volunteers aged 18 to 60, measuring food intake, physical activity, blood sugar, and body fat. Participants will also…

This study will measure how the body uses energy and burns fat in 10 people with extreme obesity (BMI of 60 or higher). Participants will spend 23 hours in a special metabolic chamber and drink a labeled water to track energy use over a week. The goal is to better understand meta…

This study will give 28 women with obesity either a calorie-restricted DASH diet or a standard American diet for 4 weeks. Researchers will track weight changes and analyze stool samples to see how diet affects gut bacteria and related health markers. The goal is to understand how…

This study looks at how the brains of women with anorexia nervosa respond to fatty food smells and images. Researchers will use brain scans to compare their reactions to those of healthy women. The goal is to understand why fatty foods cause aversion, which could help improve fut…

Researchers at the University of Texas at Dallas are studying how physical activity, sedentary behavior and self-control relate to loss of control eating in children. The study follows 200 children aged 10 to 12 for three years, using brain scans, activity monitors, and real-time…

Researchers at Kırıkkale University are studying how GLP-1 receptor agonists, drugs prescribed for type 2 diabetes and obesity, affect saliva and oral health. Fifty adults aged 18 to 65 who are newly prescribed these drugs provide saliva samples and undergo dental exams at the st…

Researchers are studying whether three body measurements can help predict how well patients do after one-anastomosis gastric bypass. The measurements are the percentage of a laparoscopic instrument segment covered by fat, the total length of the small bowel, and a calculated abdo…

This study looks at whether using ultrasound to measure neck tissue thickness can better predict difficult airway in obese patients undergoing surgery. Researchers will compare ultrasound measurements with standard tests in 52 adults. The goal is to improve safety during anesthes…

Researchers want to know whether weight loss from laparoscopic sleeve gastrectomy changes neck pain, posture, and neck function. The study follows about 25 adults scheduled for this weight-loss operation at one hospital. Participants complete neck questionnaires, strength and mot…

Researchers at the University of Liverpool are exploring how different menu labels affect food choices and feelings in adults with eating disorders, common mental health conditions like anxiety or depression, and no mental health diagnosis. Participants order a meal from a simula…

This study tests whether giving breastfeeding mothers a daily iodine-containing multivitamin for 6 months helps their babies' brains and thyroid health. Researchers will compare babies' brain activity and development between moms who get the supplement and those who receive stand…

Researchers at a French sleep center are studying adults with obesity who are referred for a sleep study because of suspected obstructive sleep apnea. The team measures how much carbon dioxide builds up in the blood overnight using a skin sensor, then compares that cumulative exp…

This phase 1 trial examines whether eloralintide, an experimental drug for obesity, changes how the body processes a common birth control pill containing levonorgestrel and ethinyl estradiol. Researchers will give the pill to women with overweight or obesity, with and without elo…

This phase 1 trial asks whether a single dose of tirzepatide changes how quickly the stomach empties in adults with type 1 diabetes who are overweight or have obesity. Researchers will give participants either tirzepatide or a placebo injection, then measure stomach emptying usin…

This phase 1 trial examines how severe kidney impairment or end-stage kidney disease affects the levels of ribupatide, an experimental drug, after a single injection. Researchers compare drug exposure in 32 participants: some with normal kidney function and others with severe kid…

This study investigates whether changes in serum phosphate, a blood electrolyte, are linked to respiratory quotient, a measure of how the body uses energy, in critically ill patients during their first week in intensive care. The goal is to see if a rising respiratory quotient co…

This study tests whether polyphenols from whole grapes can improve metabolic flexibility, the body's ability to shift between burning carbohydrates and fat after a meal. Researchers will give 20 adults, half lean and half with overweight or obesity, a single dose of grape powder …

This study investigates what happens when critically ill patients in the intensive care unit (ICU) are not given nutrition for the first 72 hours after admission. Researchers will measure ketone bodies in the blood and examine how immune cells respond, comparing these patients to…

Researchers at Bordeaux University Hospital are studying whether obesity in middle age is linked to memory problems. They plan to enroll 150 adults aged 30 to 50 with a BMI between 30 and 45. Participants will undergo MRI brain scans to measure key brain regions and complete memo…

This study looks at whether a blood protein called asprosin is linked to metabolic syndrome and heart risk in people with rheumatoid arthritis. Researchers will compare asprosin levels in three groups: rheumatoid arthritis patients with metabolic syndrome, those without it, and h…

Researchers at the University of Waterloo are testing whether estrogen, a hormone more common in women, changes how exercise affects blood sugar control, inflammation, and immune function in men. The study will enroll 24 sedentary, overweight men aged 18 to 35. Participants will …

This study looks at elderly patients (60 and older) with COPD who need a breathing machine in the ICU. Researchers will check their nutritional status and measure the thickness of their diaphragm muscle using ultrasound. The goal is to see if these factors can predict how well pa…

This observational study follows people with obesity-related heart failure to see how their heart performs during exercise, using stress echocardiography. It observes those who are taking GLP-1/GIP receptor agonists (like semaglutide or tirzepatide) as part of their routine care,…

This study will compare how vegan, omnivorous, and carnivore diets affect the way LDL cholesterol particles clump together in the blood, which can lead to artery plaque. Researchers will measure blood lipids and other health markers in 90 adults aged 25-60 who have followed their…

This early-phase study looks at whether metabolic syndrome reduces brain blood flow more in women than in men. Researchers will use MRI scans and a drug called indomethacin to test this in 72 healthy adults and those with metabolic syndrome. The goal is to understand sex differen…

This study looks at how having extra body fat and being resistant to insulin can change the way your brain learns to like or want certain foods. Researchers will give 50 adults flavored drinks with sweetener, sometimes with extra calories, to see how their preferences shift. The …

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This trial evaluates a new device called Tasso+ that lets people collect a small blood sample from their upper arm, potentially replacing the traditional finger-prick or venous blood draw for vitamin D testing. Researchers will compare vitamin D levels measured from the Tasso+ sa…

This study looks at how a 12-week aerobic exercise program affects brain activity and stress hormones in veterans with overweight or obesity. Researchers will use brain scans and stress tests to see if exercise changes how participants react to pictures of high-calorie foods and …

This study looks at whether magnesium levels in the blood are related to sleep quality, pain, and quality of life in women with lipedema, a condition that causes abnormal fat buildup in the legs. Researchers will compare women with good sleep versus poor sleep to see if magnesium…

This study asks whether swapping a beef burger for a plant-based pea burger changes how the body handles fats and sugar after a meal. Ten adults with metabolic syndrome (and a BMI of 25 or higher) will eat both types of burgers on separate occasions in a crossover design. Researc…

This trial is testing whether a genetic score can predict how much weight and body fat people lose on a 12-week low-energy, high-protein diet. Obese adults aged 18-40 will follow a personalized diet plan and receive counseling, while researchers track changes in weight, body comp…

This study looks at how bariatric surgery affects the liver's energy processing in people with obesity and fatty liver disease. Researchers will use safe, non-radioactive tracer infusions and MRI scans before, during, and six months after surgery to measure changes in liver metab…

This observational pilot study explores whether adults with obesity in England, France, and Germany can participate in research entirely from home. Participants will authorize access to their medical records and complete an online questionnaire about their health, quality of life…

This study looks at whether nutritional risk and muscle thickness can help predict recovery in adults aged 65 and older after hip fracture surgery. Researchers will measure nutritional status using a standard score and check muscle thickness in the thigh with a quick, painless ul…

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with prediabetes. Researchers will measure insulin release in 10 adults with impaired fasting glucose or impaired glucose tolerance. The goal is to better understand what raises the risk o…

This study looks at how two common medications, rosuvastatin (a cholesterol drug) and losartan (a blood pressure drug), are absorbed in people who have had weight-loss surgery. Sixty adults scheduled for either Roux-en-Y gastric bypass or sleeve gastrectomy will take a single dos…

This study explores whether increasing calorie intake after weight loss can restore normal appetite control. Adults with obesity will follow a 20-week diet and exercise plan, then some will have their calories adjusted upward. The goal is to see if this reduces hunger and helps w…

This study explores whether polycystic ovary syndrome (PCOS) independently contributes to fatty liver disease in adolescent girls, beyond the effects of obesity. Researchers will compare three groups of girls aged 10–18: those with PCOS and obesity, those with obesity alone, and …

This study follows people with severe obesity who are scheduled for bariatric surgery. Researchers will measure changes in body fat, muscle mass, metabolism, and strength before surgery and again at 3 and 6 months after. The goal is to better understand how the surgery affects th…

This study tests a new web-based AI tool designed for older adults in Hong Kong. Users take photos of their Cantonese-style meals, and the AI identifies ingredients and scores how well the meal follows the cMIND diet, a brain-healthy eating pattern. The goal is to see if the tool…

This study examines whether vitamin D levels are linked to asthma control, lung function, and oxidative stress in Egyptian adults with bronchial asthma. Researchers will measure vitamin D in the blood, assess asthma symptoms with a standard test, and check lung function and marke…

This early-phase study will test how insulin given as a nasal spray affects nerve activity and blood flow in the brain and legs. Researchers will compare 64 adults with obesity and insulin resistance to healthy-weight individuals. The goal is to understand how obesity changes the…

This observational study is investigating whether vitamin D levels are linked to cholesterol and other blood fats in obese adults with type 2 diabetes. Researchers will measure vitamin D status and lipid profiles in 150 participants from a diabetes clinic in Cairo. No treatments …

This study tests whether 3D infrared body scanning can better assess malnutrition in adolescents and young adults hospitalized with anorexia nervosa. Researchers will measure body composition and track how organ and tissue stores relate to medical stability, nutritional needs, an…

This trial investigates whether a brief educational video on nutrition can improve diet quality in people recovering from knee or shoulder arthroscopic surgery. Participants are randomly assigned to receive either standard post-operative care or standard care plus a recorded vide…

This study looks at whether brown adipose tissue (brown fat), which burns energy as heat, can predict how well people with obesity respond to the weight loss drug semaglutide (Wegovy). Eighty adults starting semaglutide will have PET/CT scans before and after 24 weeks of treatmen…

This study looks at whether GLP-1 receptor agonists like semaglutide and tirzepatide, used for weight loss, change saliva composition and increase tooth wear. Researchers will measure saliva calcium, pH, flow rate, and dental erosion in 40 adults before and 3 months after startin…

This study investigates how taurine—a natural amino acid linked to inflammation and cell health—differs between metabolically healthy and unhealthy older women with obesity. Researchers will measure taurine levels before and after a 16-week combined exercise program. The goal is …

This study looks at the nutritional health of people aged 65 and older who are hospitalized with mental disorders. Researchers will assess conditions like malnutrition, frailty, and obesity, and use the findings to design a practical care pathway for nutritional support. The goal…

This study investigates how sleeve gastrectomy, a common weight-loss surgery, impacts brain health and cognitive function in adults with severe obesity. Researchers will use brain scans and thinking tests to measure changes in brain age and mental performance over time. The goal …

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This phase 1 study investigates whether ZT002 (zovaglutide), an experimental injectable drug given every two weeks, affects the heart's electrical activity in overweight or obese adults. Researchers compare changes in the QT interval—a measure of heart rhythm—between those receiv…

This study uses advanced MRI and spectroscopy to track how semaglutide therapy changes muscle strength, volume, and quality over six months. Researchers will measure muscle function and fat infiltration in people with type 2 diabetes and obesity. The goal is to understand whether…

This study tracks sleep quality in adults with obesity before and one year after metabolic surgery (gastric bypass or sleeve gastrectomy). Participants wear two sleep-monitoring devices for five nights at home and fill out sleep questionnaires and diaries. The goal is to see whet…

This study explores whether taking a dietary fibre supplement during a 10-day fast can improve gut health and metabolism more than fasting alone. Overweight adults (BMI 25 or higher) will fast at a clinic and then either receive a resistant starch fibre or a placebo. Researchers …

This study investigates whether a brief training task can change how people with anorexia nervosa value food. Participants view food images and focus on attributes like tastiness or healthiness, then make food choices. The goal is to see if this training makes their choices more …

This study looks at whether the exact position of a feeding tube inside the stomach affects how well patients do after the tube is placed. The tube is inserted through the skin into the stomach for people who cannot eat enough by mouth and need long-term nutrition. Researchers wi…

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This phase 1 trial tests a new investigational drug, SCB0020160, for the first time in humans. Healthy adult men aged 18 to 65 receive either the drug or a placebo to evaluate safety, tolerability, and how the drug moves through the body. The study also looks at whether food affe…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study investigates refeeding syndrome, a dangerous metabolic complication that can occur when severely malnourished patients start receiving nutrition again. Researchers will give a mixed-meal tolerance test to 15 adults who need a feeding tube after a month of very low food…

This study looks at how incretin-based therapies (like GLP-1 drugs used for weight loss) affect breathing in people with obesity. Researchers will analyze data from 48 adults aged 25-60 with a BMI of 30 or higher. They will use machine learning to find patterns that predict impro…

This study will test whether a therapeutic patient education program is acceptable and useful for adults living with obesity and related conditions like diabetes or joint problems. About 42 participants will take part in a one-day group session and follow-up workshops, then answe…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study follows 307 adolescents and young adults (ages 12-22) with eating disorders who receive care at a specialized day hospital. Researchers will track changes in body mass index, eating disorder symptoms, and overall well-being over time. The goal is to understand how well…

This study will test whether smelling a pleasant food odor (madeleine scent) before drinking a sugary solution changes how the body handles blood sugar. Twenty adults, some with obesity and mild insulin resistance and some without, will each undergo two sessions: one with the sce…

This study follows 40 adults who recently had laparoscopic sleeve gastrectomy for obesity. Over 6 months, researchers will measure changes in blood sugar, cholesterol, gut barrier markers, and digestive symptoms. The goal is to understand how the surgery affects gut health and me…

This study looks at whether a measurement called Body Roundness Index (BRI), which uses waist size and height, can predict death in adult intensive care unit (ICU) patients. Researchers will measure BRI in 550 adults when they enter the ICU and track their outcomes, including dea…

This study looks at why some older adults lose their appetite while others keep a healthy one. Researchers will measure how taste, digestion, and hormones differ between the two groups. Twenty women aged 65-74 will take part. No treatment is given; the goal is simply to learn mor…

This study follows 40 people who recently had laparoscopic sleeve gastrectomy to see how their eating behavior, nutrition, and appetite-regulating hormones change over 6 months. Researchers will measure hormones like ghrelin, GLP-1, and PYY, along with dietary intake and eating a…

This study follows 120 malnourished adults undergoing major abdominal or pelvic cancer surgery to see how their gut function, nutrition, and risk of confusion (delirium) change in the first week after surgery. Researchers will also check if giving a natural chemical called seroto…

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This study looks at how metabolic health (measured by a simple blood test) relates to artery stiffness and daily blood pressure changes in 800 adults. Researchers will use routine tests and non-invasive measurements to find better ways to identify people at higher risk for heart …

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This study looks at whether taking a calcium butyrate supplement for 4 weeks can improve how immune cells (monocytes) work and change gut bacteria in adults with obesity. Butyrate is a natural substance made by gut bacteria that helps reduce inflammation. The study will compare t…

This study tests a smartphone app called NutriTrack that uses artificial intelligence to help people with obesity or overweight track what they eat and how they feel. About 50 adults will use the app for 4 weeks. The main goal is to see if the app is easy to use and helpful for b…

This 5-year study will follow 2,800 overweight or obese Chinese adults aged 18-60 to see how their health changes over time. Participants will use a smartphone app to track their data and get lifestyle support. The goal is to understand who develops diabetes or complications, and…

This study looks at whether rotating the head 45 degrees to the left improves the view of the vocal cords during video laryngoscopy in obese adults. Fifty patients with a BMI of 30 or higher will be observed. If the maneuver works, it could offer a simple way to reduce airway com…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at vitamin D levels in 63 critically ill children (ages 1 month to 12 years) admitted to the ICU with severe breathing infections. Researchers will measure vitamin D in the first 24 hours and compare it to how severe the infection is and the risk of death. The go…

This study aims to understand how a less invasive stomach procedure called endoscopic sleeve gastroplasty changes digestion, hormones, and gut bacteria compared to traditional weight-loss surgery. Researchers will follow 40 adults with obesity to measure stomach emptying and othe…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This study will check if a routine blood measure called mean platelet volume (MPV) can predict acute coronary syndrome (heart attack or unstable angina) in people with metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare MPV levels between 60…

This study is testing a new physical activity support program called Movámonos for Spanish-speaking adults who are overweight or obese and not very active. The goal is to see if the program is something people like and can stick with. About 20 people will take part to help resear…

This study looks at whether one session of magnetic brain stimulation can temporarily change how the heart and brain communicate in women who have had multiple pregnancy losses and are overweight. Sixty women will receive either real or fake stimulation while their heart activity…

This study will give fecal transplants to 90 people with recurrent C. difficile infection, ulcerative colitis, or metabolic syndrome. Researchers will use advanced tests on stool and tissue samples to track how donor bacteria settle in the gut and interact with the host. The goal…

This pilot study tests whether patients having laparoscopic gastric bypass can safely go home the same day if they use a remote monitoring device. Forty adults will be randomly assigned to either same-day discharge with remote monitoring or an overnight hospital stay. The study w…

This study looks at whether metabolic syndrome (a cluster of conditions like high blood pressure and excess belly fat) makes it harder to recover from a rotator cuff injury. Forty adults with rotator cuff tears will be split into two groups—those with and without metabolic syndro…

This study looks at whether common environmental chemicals like PFAS, bisphenol A, and pesticides are linked to childhood obesity. Researchers will measure levels of these chemicals in blood, urine, and hair samples from 80 children aged 6 to 15—half with obesity and half without…

This study compares how two weight-loss surgeries—gastric bypass and sleeve gastrectomy—affect acid reflux in 128 obese patients. Participants will be randomly assigned to one surgery, and their reflux will be measured before and after using a 24-hour pH test. The goal is to see …

This pilot study tests a self-guided digital program called SOAR that shares science-backed sleep tips with people starting treatment for an eating disorder. The program includes videos on sleep hygiene and setting a regular sleep schedule. Researchers want to see if the program …

This study tests a structured program called TransitionED designed to help youth aged 16+ with eating disorders move from pediatric to adult healthcare. The program includes planning packages, guided meetings, and a personal profile to share with new providers. Researchers will c…

This study will look at medical records of 1700 adults with obesity who took tirzepatide along with lifestyle coaching at several Dutch clinics. Researchers want to see how much weight people actually lose after six months and how doctors prescribe the medication in daily practic…

This study will test whether a simple skin scan can accurately measure how many fruits and vegetables toddlers eat. Researchers will give 150 healthy 2-year-olds either applesauce or a fruit-vegetable puree for 4 weeks, then compare skin carotenoid levels with blood tests and foo…

This study tests whether adjusting ventilator pressure during laparoscopic sleeve gastrectomy can improve lung function and reduce breathing complications. Forty-six obese patients will receive either individualized pressure settings or a fixed setting. The goal is to see if the …

This study will review medical records of 500-800 children aged 2-18 who attended NHS weight management clinics and had genetic tests for obesity. The goal is to see how often these tests find a genetic cause and whether certain traits, like developmental delays or eating behavio…

This pilot study looks at how the diabetes and weight-loss drugs semaglutide and tirzepatide directly affect blood vessels and heart function, beyond their known effects on weight. Researchers will infuse the drugs into the arm or bloodstream of 112 volunteers with different body…

This study will compare a carnivore diet (only animal foods) with a Mediterranean diet (fruits, veggies, grains, legumes) in 30 adults aged 30-60 with high LDL cholesterol. Over 3 weeks, researchers will measure how each diet affects cholesterol clumping, blood fats, and blood ve…

This study will follow 150 mothers and their babies for 6 months to see how a mother's weight and diet affect her breastmilk and her baby's growth. Researchers will measure mom's body fat, diet, and health markers, and analyze breastmilk for nutrients and immune factors. The goal…

This study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…

This study aims to see if two short questionnaires can accurately measure how much dietary fiber and iron people eat, compared to the standard method of keeping detailed food records for five days. About 50 adults aged 18 to 65 will fill out the questionnaires and also complete 2…

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. The goal is to understand why some people gain weight more easi…

This study will analyze medical records of 400 adults with type 2 diabetes or obesity to see how semaglutide affects blood sugar, heart, and kidney health over three years. Researchers will compare those taking semaglutide to those on other diabetes medications. The goal is to un…

This study tests whether giving less therapeutic food and requiring fewer clinic visits can still effectively treat severe acute malnutrition in children aged 6-59 months in Kenya. About 2,274 children will take part across 45 health facilities. The goal is to find a treatment ap…

This study will give 10 overweight men a daily pill called ATR-258 for 8 weeks to see how it changes signaling pathways in their muscles. Researchers will take small muscle samples and measure blood sugar control and body composition. The goal is to understand the biology, not to…

This study looks at how weight loss affects the energy the body uses to digest food (called dietary thermogenesis) in teens with obesity. Researchers will compare 30 obese adolescents before and after weight loss with normal-weight teens. The goal is to understand if losing weigh…

This observational study tracks 100 adults to see how Roux-en-Y gastric bypass surgery changes gut bacteria and related metabolic products over 12 months. Participants include people having surgery, those with obesity on diet alone, and healthy normal-weight individuals. Research…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be randomly assigned to take one sweetener or water for two week…

This study looks at how two different exercise programs affect a protein called Sestrin-2, which is linked to inflammation and metabolism, in women with obesity and high blood pressure. About 42 women aged 30-65 will do either moderate steady exercise or brisk interval exercise f…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …

This study looks at sleep, daytime activity, and body rhythms in 75 adults with anorexia, bulimia, or binge-eating disorder. Participants wear a small device called an actigraph to track movement and sleep for 24 hours. Researchers will also check hormone levels and ask about moo…

This study will compare two devices that measure muscle relaxation during anesthesia in 30 obese patients having weight-loss surgery. One device tracks thumb movement (AMG), the other measures muscle electrical signals (EMG). The goal is to see which is more accurate for guiding …

This study looks at how children's eating behaviors, like eating quickly or eating large portions, are linked to brain activity and body fat. Researchers will follow 420 children aged 7 to 9 for one year, using brain scans and meal observations. The goal is to understand why some…

This study will check the health, nutrition, and daily living abilities of 330 older adults (age 60+) living in a rural village in Assiut, Egypt. Researchers will interview participants and take simple physical measurements like weight and blood pressure. No treatments are given—…

This study looks at whether injecting the blood thinner enoxaparin into the arm or the abdomen works better for preventing blood clots in people with severe obesity (BMI over 40). Researchers will measure drug levels in the blood to see which injection site gives the right amount…

This study tests an online platform called Precare that provides educational content and appointment management for people waiting for bariatric surgery. Researchers want to see if it is easy to use, acceptable to patients, and helps them feel more ready for surgery. About 1,050 …

This study looks at how the body's energy use changes when overweight or obese adolescents walk with simulated weight loss. Researchers will use a special treadmill that reduces the effect of gravity to mimic being at a normal or overweight weight. By measuring energy burned and …

This study looks at whether older adults (70+) with low muscle mass are more likely to have serious bleeding while taking common blood thinners (apixaban or rivaroxaban). Researchers will compare muscle mass in 110 patients who had a bleeding event with those who did not. The goa…

This study will check how common vitamin B12 deficiency is in preterm infants (born before 37 weeks) at the time they go home from the hospital. Researchers will measure B12 and related markers in blood samples from 40 babies. The goal is to understand if these vulnerable infants…

This study will follow 175 children and young adults who had a bone marrow transplant before age 18. Researchers will test their thinking, memory, and attention skills, and check for links to physical health issues like metabolism and fitness. The goal is to find early warning si…

This study looks at how obesity and low iron levels affect iron buildup in the liver and heart, and how weight-loss surgery might help. Researchers will compare people with and without iron deficiency before and after bariatric surgery. The goal is to better understand these conn…

This study will check how common it is for obese people with sleep apnea to still have low breathing at night even when using a CPAP machine. About 139 adults will wear a special skin sensor that measures oxygen and carbon dioxide levels overnight. The goal is to find out how man…