New breathing technique could help obese heart surgery patients avoid ICU complications
NCT ID NCT07409324
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a specific ventilator mode called APRV can improve breathing and oxygen levels in very obese patients after elective heart surgery. 180 adults with a BMI of 40 or higher (or 35 with related health issues) will be randomly assigned to receive either APRV or standard ventilation after surgery. The goal is to see if APRV leads to better lung function, fewer breathing problems, and shorter ICU stays.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Airway Pressure Release Ventilation (APRV) - a mode on a mechanical ventilator
- What this could lead to
- If it works, this could lead to a standard way to help very obese patients breathe easier after heart surgery, potentially reducing ICU stays and breathing complications.
- What could go wrong
- This is an early-stage study (not yet recruiting) with only 180 patients, so results may not apply to everyone. The intervention is a device mode, not a drug, so benefits may be modest and risks include ventilator-related lung injury or discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 180 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Adult patients aged 18-65 year of both sex. Morbidly obese patients (body mass index ≥ 40 kg/m² or ≥ 35 kg/m² with obesity-related comorbidities) Scheduled for elective cardiac surgery (CABG, valve, or combined) requiring cardiopulmonary bypass Planned postoperative admission to the cardiac surgical intensive care unit Patients eligible for mechanical ventilation with planned early extubation within 6-12 hours postoperatively Ability to provide written informed consent Exclusion Criteria: Severe pulmonary disease (e.g., COPD GOLD III/IV, home oxygen therapy, and pulmonary fibrosis). Patients with history of previous spontaneous pneumothorax or postoperative pneumothorax. Intracranial hypertension or contraindication to APRV. Hemodynamically unstable on admission (MAP less than 65 mmHg) Vasopressor/inotropic score (VIS) more than 10 Requirement for postoperative extracorporeal membrane oxygenation (ECMO) or intra-aortic balloon pump (IABP). Inability to obtain informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
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The official record
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