Nutritional disorder

This phase 2 trial tests whether LY3549492, an oral tablet, helps adults who are overweight or obese and have type 2 diabetes lose weight. Participants receive either LY3549492 or a placebo for about 11 months. Researchers measure changes in body weight and the percentage of peop…

This phase 3 trial tests whether metformin, a standard diabetes medication, can prevent or reverse metabolic syndrome in men with prostate cancer who are starting androgen deprivation therapy (ADT). Metabolic syndrome—a cluster of conditions like high blood sugar, high blood pres…

This trial tests whether a single intravenous iron infusion can improve exercise capacity in people with heart failure and iron deficiency. Participants are randomly assigned to receive the infusion or no treatment, then undergo cardiopulmonary exercise testing to measure peak ox…

This study looked at whether a procedure called endoscopic sleeve gastroplasty (ESG) could help people with obesity who stopped taking GLP-1 weight loss drugs because of side effects or poor results. Researchers compared weight loss and safety in 18 adults who either had ESG plus…

This trial tests whether intravenous (IV) iron or oral iron pills work better for adults with congestive heart failure who also have low iron levels. Participants are randomly assigned to receive either a one-time IV infusion of ferric carboxymaltose (with a possible repeat dose)…

This study tests whether a wearable bioimpedance wristband (like a fitness tracker) helps people with severe obesity and knee osteoarthritis improve their body composition—gaining muscle and losing fat—before joint replacement surgery. All participants receive coaching on body co…

This trial investigates whether a remote digital support program, including a connected pedometer and online coaching, can help people aged 30–50 who are scheduled for bariatric surgery become more physically active in the months before their operation. Participants use a digital…

This study tested whether combining weight management (diet and exercise guidance) with a daily hormone pill (megestrol acetate) could help obese patients with early-stage endometrial cancer who want to preserve their fertility. The goal was to see if the cancer would completely …

This study tested whether adding cognitive remediation therapy and emotional skills training to standard obesity treatment could reduce food cravings and improve weight management. It involved 144 obese adults who reported food cravings. The program included weekly group sessions…

This study aimed to see how well semaglutide works for weight loss in everyday medical practice, outside of a strict research setting. It involved 100 adults with obesity who were already planning to take the drug. The study was stopped early, so results are limited, but it may s…

This study tested whether regular phone calls after a first hospital stay for anorexia nervosa could help patients maintain a healthy weight and avoid relapse. Researchers planned to compare phone-based support to standard follow-up care in people over 15. The study was terminate…

This small pilot study tested whether a low-carb diet (50-100 grams of carbs per day) combined with the diabetes drug dapagliflozin could improve blood sugar control in people with chronic kidney disease and prediabetes or type 2 diabetes. Four participants were split into two gr…

This study tested whether the statin drug rosuvastatin, taken daily with supplements, could improve bone density and reduce heart disease risk in adults with long-term spinal cord injury. Only 8 people enrolled before the trial was stopped early. Participants received either rosu…

This small pilot study tested whether nabilone, a synthetic drug similar to cannabis, could help obese adults lose weight. The trial aimed to check safety and feasibility, but it was terminated early, so we don't have clear results. Only 18 people were enrolled, making it too sma…

This study looked at two ways of giving growth hormone to short children who were born small for their age. The goal was to see which dosing method works better for growth and has fewer side effects on metabolism. Only 10 children took part before the study was stopped early.

This phase 2 study tested a weekly extended-release capsule of calcifediol (CTAP101) in 44 adults with chronic kidney disease on hemodialysis who also had vitamin D insufficiency and secondary hyperparathyroidism. The goal was to see if the drug could raise vitamin D levels and l…

This study tested an online program that combined exercise guided by the FITT-VP principle with dietary advice for children and adolescents with obesity. The program included small group exercise sessions three times a week for 16 weeks, plus dietary guidance. Researchers compare…

This study looked at whether a plant-based diet and lifestyle changes could help people with type 2 diabetes, prediabetes, or obesity improve their health. Researchers aimed for diabetes remission (normal blood sugar without medication for at least 3 months) or significant weight…

This study looked at whether using a combination of weight-loss medications could help people with obesity lose weight and improve the health of their blood vessels. It involved 128 adults aged 40-75 who were obese and had at least one heart risk factor. The study was stopped ear…

This study tested a new drug called CK-0045 in 90 adults with type 2 diabetes and overweight or obesity. Participants received weekly injections of CK-0045 or a placebo for 16 weeks to see if it improved blood sugar after meals and reduced body weight. The trial was terminated ea…

This study tested whether a special chewing gum with fiber could help obese children lose weight and improve their metabolism. About 93 children were to take part, but the study was stopped early. The gum aimed to change gut and mouth bacteria to support weight control.

This study aimed to see if a phone-delivered program could help Latino children in rural Nebraska manage their weight. About 76 parent-child pairs were to be assigned to either the program or a waitlist. The study was terminated early, so results are limited.

This early-stage study tested an experimental drug called FT-4101 in 14 overweight or obese adults with NASH, a serious fatty liver disease. The main goals were to check safety and see if the drug could reduce liver fat. The study was stopped early, so results are limited.

This study looked at whether medically tailored meals and a behavioral app (Noom) could help people maintain weight loss after stopping GLP-1 medications like Wegovy. It enrolled 39 adults who had lost at least 10% of their body weight on GLP-1s and had stopped the drug within th…

This study aimed to see if bariatric surgery or medical weight loss (diet and exercise) helps severely obese patients lose enough weight to safely undergo hip or knee replacement. Only 3 people took part before the study was stopped early. The goal was to get patients to a BMI of…

This study aimed to compare a standard sleeve gastrectomy (removing part of the stomach) with a modified version called N-Sleeve, which adds a wrap around the top of the stomach to prevent acid reflux. The trial was designed for people with severe obesity and GERD, but only 2 pat…

This study aimed to see how two antipsychotic drugs, aripiprazole and ziprasidone, affect heart risk in people with schizophrenia, schizoaffective disorder, or bipolar disorder. Researchers measured blood fats and heart electrical changes in 48 adults over 12 months. The trial wa…

This study tested a mobile telerehabilitation program called Telemouv in 50 adults with obesity (BMI over 30). Participants used the app for three months to encourage healthy behavior changes and fat loss. The trial was terminated early, so we don't have final results on whether …

This study looked at whether a specific type of exercise, combining aerobic and resistance training in short bursts, could improve metabolic health in overweight or obese breast and prostate cancer survivors who had finished treatment. The goal was to reduce insulin resistance an…

Researchers are testing a mobile health program that uses web-based comics for children and newsletters for parents to encourage healthier eating and lower obesity risk. The study enrolls 8- to 12-year-old Black and Latino children and a parent, who receive either the comic-and-n…

This trial tests whether giving older adults a high dose of vitamin D before their flu shot can strengthen their immune response. Participants are 65 or older with low vitamin D levels. The study measures changes in infection-fighting proteins and antibody levels after vaccinatio…

This study tests whether pregnant women who eat two eggs daily have babies with longer birth lengths and better development. Researchers in Rwanda are giving eggs to some women and comparing them to those eating their usual diet. The goal is to see if this simple, affordable food…

This study tested a program called Communities for Healthy Living (CHL) that helps families with young children (ages 3 to 5) eat better and be more active. The goal was to prevent childhood obesity by empowering parents and kids in Head Start programs. The study was ended early,…

This early-stage study is testing an experimental drug called LY4064912 in 144 healthy volunteers and people with overweight or obesity. The main goal is to check safety and how the body handles the drug, not yet to prove it works for weight loss. Participants will receive either…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with anorexia nervosa. The treatment targets the insula, a brain region involved in taste and body perception. Forty women aged 18-45 with anorexia will receive either real or sham TMS …

This study tested a special device called the Traxi panniculus retractor, which holds excess belly tissue out of the way during cesarean deliveries. The goal was to see if it could shorten surgery time, improve breathing, and increase satisfaction for both patients and doctors. T…

This pilot study tested whether MitoQ, an antioxidant supplement, could improve bladder symptoms like urgency and frequency in women aged 50 and older with metabolic syndrome. Twenty participants took either MitoQ or a placebo for 4 months, tracking their symptoms through questio…

This study compared two types of non-invasive breathing support for people with sudden breathing failure who are obese or have sleep apnea. One machine automatically adjusts pressure and volume, while the other uses a fixed pressure setting. The goal was to see which method clear…

This study tested whether a 3D ultrasound device (Accuro) helps anesthesiologists place epidural needles for pain relief during labor in women with a BMI of 40 or higher. The device was compared to the standard blind approach using touch. The trial was terminated early, so result…

This study looked at whether switching to a high-energy, high-protein tube feeding formula (Sondalis HP 2 kcal) improves digestive comfort and quality of life in adults who have trouble tolerating their current home tube feeding. Seventeen adults on home enteral nutrition took th…

This study looked at whether showing people with bulimia or binge eating disorder visual graphs of their symptom changes during the first four weeks of cognitive behavioral therapy (CBT) helps them improve faster. About 80 participants were split into groups that either saw these…

This study looks at people who had an endoscopic sleeve gastroplasty (ESG) at least 5 years ago to see if they kept the weight off. Researchers will measure total body weight loss at the 5-year mark. The goal is to understand the long-term success of this weight-loss procedure.

This study investigates whether MRI can detect early signs of pancreatic damage linked to obesity and metabolic syndrome, which are risk factors for pancreatic cancer. Researchers will compare MRI images with tissue samples from patients undergoing pancreatic surgery, as well as …

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide, which stops the pancreas from making insulin. Researchers will then measure their fasting blood su…

This study tests whether a French version of the Leeds Food Preference Questionnaire (LFPQ) accurately measures food reward—the psychological drive to eat certain foods. Researchers will ask lean and obese adults to complete the questionnaire before and after a meal, repeating th…

This study explores whether a 24-hour fast can identify two metabolic types in people with severe obesity: 'thrifty' (whose metabolism slows significantly) and 'spendthrift' (whose metabolism stays steady). Researchers will track weight loss during a 12-week very-low-calorie diet…

This study looked at how being obese as a teenager might affect emotional memory and the connections between two key brain areas: the amygdala and hippocampus. Researchers compared obese and normal-weight adolescents aged 12-17 using MRI scans while they performed memory tasks. T…

This study looked at whether using ultrasound to guide central venous catheter placement reduces complications in obese intensive care unit patients. Researchers planned to include 450 patients, but the study was terminated early. The goal was to compare complication rates betwee…

This study tested a new therapy that combines mindfulness and exposure to body sensations for teens with avoidant/restrictive food intake disorder (ARFID), where eating is very limited. The goal was to see if the therapy was acceptable and could increase the number of foods eaten…

This study looked at whether a gentle, adapted physical activity program could help women with anorexia nervosa during refeeding. Researchers measured changes in a metabolic pathway linked to mood and energy. Only 9 people took part, and the study was stopped early, so the findin…

This pilot study tested whether remote check-ups (using a chatbot questionnaire and video calls) could work as well as in-person visits for people who had weight-loss surgery. Only 7 adults living far from the hospital took part. The goal was to see if this approach could improve…

This study looked at how gas-filled stomach balloons and a procedure called endoscopic sleeve gastroplasty affect stomach emptying, hunger hormones, and appetite in people with obesity. Researchers compared these treatments to a meal replacement program. The goal was to understan…

This study tested if a special measurement called transpulmonary pressure could help obese patients with breathing failure get off ventilators sooner. Only 4 people took part before the study was stopped early. The goal was to reduce time on the ventilator and lower risks like in…

This study aimed to find blood and tissue markers that could predict whether obese patients with type 2 diabetes would go into remission after bariatric surgery. Researchers planned to measure 9 specific molecules in blood samples and also collect fat and muscle tissue during sur…

This study looked at how insulin works in the skin of people with plaque psoriasis who are also overweight or have prediabetes. Researchers took small skin samples from both psoriasis patches and healthy skin to measure insulin activity. The goal was to understand if insulin acts…

This study tested whether a 16-week program of yoga and lifestyle changes could affect gene activity (micro RNA) and heart disease risk factors in 16 adults with coronary artery disease. Participants had either undergone a heart procedure or had non-obstructive heart disease with…

This study looked at how serotonin, a brain chemical, affects circuits involved in avoiding food in people with anorexia nervosa. Researchers used PET and fMRI scans to compare brain activity between 30 women with anorexia and 27 healthy women. The goal was to understand the brai…

This study looked at whether measuring resting metabolic rate (how many calories your body burns at rest) before bariatric surgery can help predict weight loss after the procedure. Researchers planned to enroll 84 adults scheduled for primary bariatric surgery and use a device ca…

This study compared two brands of surgical staplers (Covidien and Ethicon) used in sleeve gastrectomy for people with severe obesity. Researchers wanted to see if one device caused fewer complications like bleeding or leaks. The trial was terminated early and enrolled 62 adults, …

This study looked at how food intake relates to gut bacteria in women with anorexia nervosa compared to healthy volunteers. Researchers analyzed stool samples to measure immune-coated bacteria and dietary habits. The study was terminated early with only 14 participants, so findin…

This early study tested whether a special MRI technique using inhaled xenon gas can detect brown adipose tissue (BAT) in healthy adults. Brown fat burns calories to generate heat, and researchers wanted to see if this imaging method could measure its activity. The study involved …

This study looked at whether weight-loss surgery can lengthen telomeres, which are caps on our DNA that shorten as we age. Researchers compared telomere length in people with severe obesity who had surgery versus those who did not. The goal was to see if rapid weight loss might r…

This study looked at whether blocking certain nerve signals can improve how the body uses insulin and reduce inflammation in people with obesity and high blood pressure. Ten participants took two drugs—moxonidine and amlodipine—to lower nerve activity. The goal was to see if this…