Weight loss and hormone pill tested for fertility-sparing cancer treatment – but trial stopped early
NCT ID NCT05316467
First seen Jun 05, 2026 · Last updated Jun 23, 2026 · Updated 4 times
Summary
This study tested whether combining weight management (diet and exercise guidance) with a daily hormone pill (megestrol acetate) could help obese patients with early-stage endometrial cancer who want to preserve their fertility. The goal was to see if the cancer would completely respond within 28 weeks. However, the trial was terminated early and only enrolled 8 people, so we cannot draw strong conclusions from it.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Obstetrics and Gynecology Hospital, Fudan University
Shanghai, Shanghai Municipality, 200011, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Megestrol acetate (a hormone drug) plus intensive lifestyle intervention (diet and exercise guidance)
What this could lead to
If it had succeeded, this approach could have offered a way to control early endometrial cancer while preserving fertility in obese patients.
What could go wrong
The trial was terminated early with only 8 participants, so results are very limited. It is unclear if the combination works better than standard treatment.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.