ENDOMETRIAL CARCINOMA

This study is testing whether a short, 1-week course of radiation therapy combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The usual radiation takes 5 weeks, so this shorter schedule could be more convenie…

This early-phase study tests an experimental therapy called FT836, a ready-made CAR T-cell treatment, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have not responded to prior treatments. The main goals are…

This early-stage study tests a new drug called HWK-007 in people with advanced solid tumors, including certain ovarian, endometrial, and lung cancers. The drug is designed to target a protein (PTK7) found on cancer cells and deliver a chemotherapy-like payload directly to them. T…

This phase 2 trial tests a personalized cell therapy called lifileucel (TIL) in 60 people with advanced endometrial cancer that has been treated before. Doctors take a sample of the patient's tumor, grow immune cells from it in a lab, and then infuse them back after a short cours…

This study tests a new drug called CR-001 in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if it can shrink tumors. About 290 people will take part in this early-phase trial.

This study tests a new drug called BNT329 in people with advanced solid tumors that have a specific marker (CA19-9). The main goals are to check safety and find the best dose. About 245 participants will take part. The drug works by targeting cancer cells and may help control tum…

This study tests a new drug, FOG-001, in about 595 people whose solid tumors (like colorectal, prostate, or endometrial cancer) have spread or can't be removed by surgery. The main goals are to see if the drug is safe and if it can shrink tumors or slow their growth. Participants…

This study tests a personalized vaccine plus three other drugs in 60 adults with advanced HER2-positive endometrial cancer that returned after treatment. The vaccine is made from each patient's own blood cells and targets the HER2 protein. The goal is to see if this combination c…

This study tests whether adding targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can shrink tumors and stop HER2-positive endometrial cancer from coming back. About 360 people with stage I-IV endometrial cancer will receive either chemo alone or chemo plus the…

This study tests a drug called tegavivint in children, teens, and young adults whose solid tumors have come back or stopped responding to treatment. The goal is to find the safest dose and see if it can shrink tumors by blocking a key growth signal inside cancer cells. About 147 …

This study tests whether a personalized, automated physical activity program using a Fitbit can help women with advanced ovarian or endometrial cancer exercise more and improve their quality of life. Researchers will compare the program to standard exercise advice in 120 particip…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study looks at how people with endometrial cancer currently get medical information and how satisfied they are with it. Researchers also want to know if patients would be interested in using an artificial intelligence (AI) chatbot to help them learn about their care. The goa…

This study looks at DNA methylation patterns in brain, thyroid, and endometrial cancers to better classify tumors and find new markers for diagnosis. Researchers will analyze tissue samples from 180 participants to build predictive models. The goal is to improve how these cancers…

This study at Mayo Clinic tests new AI-based image processing methods (AIR Recon DL and Sonic DL) to see if they can make MRI scans faster and clearer for detecting pelvic cancers like prostate and endometrial cancer. About 60 healthy volunteers and patients will get standard and…

This study looks at the genetics of high-risk endometrial cancer to find out why it sometimes returns after treatment. About 100 adults having surgery at Mayo Clinic will provide tissue and blood samples. Researchers will analyze these samples to build a databank for future studi…