ENDOMETRIAL CARCINOMA

This early-phase study tests a personalized vaccine made using quantum computing for 40 people with high-risk or returning endometrial cancer. The vaccine is designed to train the immune system to attack each person's unique tumor. The main goals are to check safety and see if th…

This study tests a new drug called SKB264 in people with advanced solid tumors that have not responded to standard therapies. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The trial includes over 1,400 participants with various …

This Phase 3 study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy, followed by maintenance durvalumab with or without the targeted drug olaparib, helps people with newly diagnosed advanced or recurrent endometrial cancer. About 805 participants ar…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (with or without radiation) after surgery can help prevent high-risk endometrial cancer from coming back. About 990 participants who had surgery to remove their uterus and ovaries will r…

This early-stage study tests a new drug called NTX-1088, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The goal is to find safe doses and see if the drug shrinks tumors. About 90 adults with cancers l…

This study tests a combination of two drugs, cadonilimab and lenvatinib, in 32 people with advanced endometrial cancer that has spread or come back and no longer responds to standard chemotherapy. The goal is to see if the combination shrinks tumors and how long it keeps the canc…

This early-phase trial is testing whether adding the immunotherapy drug pembrolizumab to standard radiation and chemotherapy is safe and feasible for people with high-intermediate risk endometrial cancer. About 45 participants who have already had surgery to remove the uterus wil…

This study tests a new drug called E7386 combined with other cancer drugs in people with advanced solid tumors, including endometrial, liver, and colorectal cancers. The goal is to find the safest and most effective dose and to see if the combination can shrink tumors. About 300 …

This study tests several drug combinations in women with endometrial cancer that has returned or not responded to treatment. The drugs work by blocking cancer cell growth or helping the immune system attack tumors. The goal is to see if these combinations can slow or stop the can…

This study tests whether adding pterostilbene (an antioxidant from blueberries) to the hormone drug megestrol acetate works better than megestrol acetate alone in shrinking endometrial cancer or precancerous growths before hysterectomy. About 44 participants will take the drugs f…

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition will take one or both drugs before their …

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This study tests the drug pembrolizumab in about 1,600 people with various advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink or control the tumors. Participants receive pembrolizumab and are monitored for tumor respons…

This study aimed to test the safety and effectiveness of combining two drugs, bemarituzumab and bevacizumab, in people with advanced or metastatic endometrial, ovarian, or cervical cancers that have a specific protein called FGFR2b. The trial was withdrawn before enrolling any pa…

This study tests a drug called sacituzumab govitecan in 50 people with endometrial cancer that has returned or not responded to platinum chemotherapy. The drug works by delivering chemotherapy directly to cancer cells. The main goal is to see how many patients' tumors shrink or d…

This study compares two types of radiation therapy—proton therapy and standard intensity-modulated radiation therapy (IMRT)—given after surgery for cervical or endometrial cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 women will fill out …

This trial was designed to test whether an online mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer coming back or getting worse. The study planned to compare the virtual program to standard educational materials. Ho…

This study follows women who have had pelvic exenteration—a surgery removing the lower colon, rectum, and bladder—for gynecologic cancers like cervical or endometrial cancer. Researchers want to see if factors like tumor size or surgery type affect complications, quality of life,…

This study looks back at 700 patients with endometrial cancer who had either laparoscopic (minimally invasive) or open surgery. The goal is to see which approach leads to fewer complications and better long-term survival, especially for those at higher risk of the cancer coming b…

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having a baby after cancer. Researchers will use the results to help future patients make informed decisions about treatment and family planning. About 1,410 participants…

This study follows 72 women with pelvic cancers (like cervical or rectal) to see how radiation therapy changes their pelvic health, sexual function, and quality of life over two years. Researchers measure vaginal changes and collect surveys on symptoms and intimacy. The goal is t…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers had their tumors genetically tested. Those with specific genetic changes received drugs designed to targe…

This study looks at pelvic floor problems and quality of life in people who survived uterine cancer. Researchers will use questionnaires to gather information from about 310 survivors treated with surgery at MD Anderson between 2006 and 2017. The goal is to better understand how …

This study looks at whether long-term inflammation raises the risk of endometrial cancer. Researchers are collecting blood and urine samples from 191 women having hysterectomy for either cancer or non-cancer reasons. They will compare markers of inflammation to better understand …