ENDOMETRIAL CARCINOMA

This study tests a personalized vaccine plus three other drugs in 60 adults with advanced HER2-positive endometrial cancer that returned after treatment. The vaccine is made from each patient's own blood cells and targets the HER2 protein. The goal is to see if this combination c…

This early-phase study tests whether a short course of radiation (1 week instead of the usual 5) combined with chemotherapy is practical for people with stage III endometrial cancer. About 28 participants who have had surgery will receive the treatment. The main goal is to see if…

This study tests whether adding targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can shrink tumors and stop HER2-positive endometrial cancer from coming back. About 360 people with stage I-IV endometrial cancer will receive either chemo alone or chemo plus the…

This study tests a drug called tegavivint in children, teens, and young adults whose solid tumors have come back or stopped responding to treatment. The goal is to find the safest dose and see if it can shrink tumors by blocking a key growth signal inside cancer cells. About 147 …

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if the drug is safe and can shrink or control tumors. The study focuses on cancers like colorectal, prostate, and others linked to …

This early-stage study tests a new cancer treatment called FT836, a type of immune cell that is made in a lab and ready to use (off-the-shelf). It is given to people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers. The goal is to see if home treatment is preferred and just as safe. Participants will receive their usual cancer drugs at home from a specialized team, and researchers will …

This study tests whether a personalized activity program using a Fitbit can help women with advanced ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either get standard care or a tailored plan with activity goals and feed…

This study at Mayo Clinic tests new AI-based image processing methods (AIR Recon DL and Sonic DL) to see if they can make MRI scans faster and clearer for detecting pelvic cancers like prostate and endometrial cancer. About 60 healthy volunteers and patients will get standard and…

This study looks at the genetics of high-risk endometrial cancer to find out why it sometimes returns after treatment. About 100 adults having surgery at Mayo Clinic will provide tissue and blood samples. Researchers will analyze these samples to build a databank for future studi…