ENDOMETRIAL CARCINOMA

This early-phase study tests a personalized vaccine made using quantum computing for 40 people with high-risk or returning endometrial cancer. The vaccine is designed to train the immune system to attack each person's unique tumor. The main goals are to check safety and see if th…

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition will take one or both drugs before their …

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This study tests the drug pembrolizumab in about 1,600 people with various advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink or control the tumors. Participants receive pembrolizumab and are monitored for tumor respons…

This study tests a new drug called SKB264 in people with advanced solid tumors (like lung, breast, or ovarian cancer) that have not responded to standard therapies. The goal is to find the best dose and see if the drug can shrink tumors. About 1,410 participants will receive the …

This study aimed to test the safety and effectiveness of combining two drugs, bemarituzumab and bevacizumab, in people with advanced or metastatic endometrial, ovarian, or cervical cancers that have a specific protein called FGFR2b. The trial was withdrawn before enrolling any pa…

This study tests a drug called sacituzumab govitecan in 50 people with endometrial cancer that has returned or not responded to platinum chemotherapy. The drug works by delivering chemotherapy directly to cancer cells. The main goal is to see how many patients' tumors shrink or d…

This study tests whether adding pterostilbene (an antioxidant from blueberries) to the hormone drug megestrol acetate works better than megestrol acetate alone for people with endometrial cancer or precancerous changes. About 44 participants take the drug(s) for a few weeks befor…

This study compares two types of radiation therapy—proton therapy and IMRT—given after surgery for endometrial or cervical cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 women will fill out quality-of-life questionnaires to track their sym…

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having children after treatment. Researchers will use the survey results to better understand fertility concerns and help future patients make informed decisions about ca…

This study looks back at 700 patients with endometrial cancer who had either laparoscopic (minimally invasive) or open surgery between 2000 and 2020. The goal is to compare complications and long-term outcomes like survival and cancer return, especially for patients at higher ris…

This study looks at whether matching cancer treatment to a patient's unique tumor genes works better than standard care. Over 6,400 adults with advanced cancers that no longer respond to treatment will have their tumors genetically tested. Based on the results, they receive a tar…

This study follows 72 women with pelvic cancers (like cervical or rectal cancer) who are getting radiation therapy. Researchers measure vaginal health, symptoms, and sexual function before and up to 2 years after treatment. The goal is to better understand the physical changes an…

This study looks at pelvic floor problems and quality of life in people who survived uterine cancer. Researchers will use questionnaires to gather information from about 310 survivors treated with surgery at MD Anderson between 2006 and 2017. The goal is to better understand how …

This study looks at whether long-term inflammation raises the risk of endometrial cancer. Researchers are collecting blood and urine samples from 191 women having hysterectomy for either cancer or non-cancer reasons. They will compare markers of inflammation to better understand …

This study follows women who have had pelvic exenteration—a surgery removing the lower colon, rectum, and bladder—for gynecologic cancers like cervical or endometrial cancer. Researchers compare different surgical techniques to see which lead to fewer complications and better qua…

This study was designed to see if a virtual mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer coming back or getting worse. The program would have been compared to standard educational materials. However, the study w…