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Can a diabetes drug help prevent uterine cancer?

NCT ID NCT04576104

First seen Sep 30, 2025 · Last updated May 24, 2026 · Updated 27 times

Summary

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition took part. The goal is to see if the combination reduces abnormal cell growth more than the hormone drug alone.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cedars Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Northwestern Medicine Central DuPage Hospital

    Winfield, Illinois, 60190, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Colorado

    Denver, Colorado, 80217-3364, United States

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

Conditions

Explore the condition pages connected to this study.