ENDOMETRIAL CARCINOMA

This study is testing whether a shorter course of radiation therapy (1 week instead of the usual 5 weeks) combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The goal is to see if most participants can comple…

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or not responded to standard therapy. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest dose, un…

This study tests a mix of two approved drugs plus an experimental vaccine and an immune booster for people with advanced HER2-positive endometrial cancer that has returned or worsened. The vaccine is made from each participant's own blood cells and targets the HER2 protein. The g…

This study tests whether adding two targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can shrink tumors and stop HER2-positive endometrial cancer from coming back. About 360 people with stage I to IV cancer will receive either chemo alone or chemo plus the targ…

This early-phase study tests two experimental drugs (M1774 and ZEN-3694) together in people whose ovarian or endometrial cancer has returned. The goal is to find the safest dose and see how well the combination works. About 65 participants will take part to help determine if this…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This early-stage study tests a new cancer treatment called FT836, a ready-made immune cell therapy, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers. The treatment is given alone or with chemotherapy and/or antibod…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study compares two types of radiation therapy—proton therapy and standard IMRT—given after surgery for endometrial or cervical cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 participants will fill out quality-of-life questionnaires to…

This study tests whether a personalized activity program using a Fitbit can help women with advanced ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either get standard care or the automated program. Researchers will also…

This study aims to learn why high-risk endometrial cancer comes back by analyzing genetic information from 100 participants. Researchers will collect tissue and blood samples to find inherited and cancer-specific genetic changes. The goal is to build a databank for future studies…

This study at Mayo Clinic tests new AI image-processing methods (AIR Recon DL and Sonic DL) to see if they can improve MRI quality and shorten scan times for people being screened for prostate or endometrial issues. Sixty adults will receive standard and AI-enhanced scans, which …