ENDOMETRIAL CARCINOMA

This early-phase trial tests a personalized vaccine made using quantum computing for 40 people with high-risk or returning endometrial cancer. The vaccine is designed to train the immune system to attack each person's unique tumor. The main goals are to check safety and see if th…

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition took part. The goal is to see if the comb…

This study tests a new antibody drug, acasunlimab, in people with advanced solid tumors that have not responded to standard treatments. The first part checks safety and finds the best dose, while the second part tests how well it works alone or with other cancer drugs. About 429 …

This study aimed to test the safety and effectiveness of combining two drugs, bemarituzumab and bevacizumab, in people with advanced or metastatic endometrial, ovarian, or cervical cancers that have a specific protein (FGFR2b). The trial was withdrawn before enrolling any partici…

This study tests the drug pembrolizumab in about 1,600 people with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink tumors and to identify biomarkers that predict response. Participants receive pembrolizumab and are m…

This early-phase study tests the safety and best dose of the drug veliparib when given with standard chemotherapy (carboplatin and paclitaxel) in adults with advanced solid tumors that also have liver or kidney dysfunction. The goal is to find out how the body processes the drugs…

This study tests whether adding pterostilbene (an antioxidant from blueberries) to the hormone drug megestrol acetate works better than megestrol acetate alone in shrinking or slowing endometrial cancer. About 44 women scheduled for hysterectomy will receive one of the two treatm…

This study tests a drug called sacituzumab govitecan in 50 people with endometrial cancer that has come back or not responded to chemotherapy. The drug works like a guided missile, delivering chemotherapy directly to cancer cells. The main goal is to see how many patients' tumors…

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having children after cancer. Researchers will use the results to help future patients make informed decisions about treatment and family planning. The study involves foc…

This study looks at whether long-term inflammation raises the risk of endometrial cancer. Researchers collect blood, urine, and tissue samples from women having hysterectomy for either cancer or non-cancer reasons. They compare inflammation markers to better understand how to pre…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study was designed to see if an online mental health program could help women with advanced gynecologic or breast cancer cope with the fear of their cancer coming back. It planned to compare the program to standard educational materials. However, the study was withdrawn befo…

This study looks at pelvic floor problems and quality of life in people who survived uterine cancer. Researchers will use questionnaires to gather information from about 310 survivors treated with surgery at MD Anderson between 2006 and 2017. The goal is to learn more about sexua…

This study follows 79 women with gynecologic cancers (cervical, endometrial, vaginal, or vulvar) who had a pelvic exenteration—a surgery removing the lower colon, rectum, and bladder. Researchers track complications, quality of life, and cancer recurrence over time to learn which…