ENDOMETRIAL CARCINOMA

This early-stage study aims to find safe doses of a three-drug combination for treating advanced solid tumors in patients who also have kidney or liver problems. Researchers are testing a new drug called veliparib, given with two standard chemotherapy drugs, to see how the body p…

This study is testing an experimental drug called sacituzumab govitecan for women whose endometrial (uterine) cancer has returned or continued to grow after standard platinum-based chemotherapy. The trial aims to see if the drug can shrink tumors, control the disease, and extend …

This study tested pembrolizumab, an immunotherapy drug, in people with advanced solid tumors who had already tried standard treatments that stopped working. Researchers enrolled 1,609 participants with various cancers including anal, cervical, lung, and thyroid cancers to see how…

This early-phase trial is testing a personalized vaccine for people with high-risk or recurrent endometrial cancer. The vaccine is custom-made for each patient based on the unique genetic markers of their tumor, with the goal of training their immune system to fight the cancer. A…

This study is testing if adding a common diabetes drug, metformin, to the standard hormone therapy (megestrol acetate) works better to control a uterine pre-cancer condition. It involves 51 women who are already scheduled for a hysterectomy or IUD placement. The goal is to see if…

This large national trial is testing whether choosing cancer drugs based on the specific genetic changes found in a patient's tumor is more effective than standard approaches. It is for adults with advanced solid tumors, lymphoma, or multiple myeloma that have progressed after at…

This study is testing whether adding a natural antioxidant found in blueberries, called pterostilbene, to a standard hormone therapy (megestrol acetate) can better slow the growth of endometrial cancer. It involves 44 patients who are already scheduled for a hysterectomy. The goa…

This early-stage trial is testing a new antibody drug called acasunlimab (GEN1046) for people with advanced solid tumors. The study first aims to find safe doses, then tests how well those doses work when given alone or combined with other cancer drugs. All 429 participants will …

This study aimed to test an online mental health program designed to help women with advanced breast or gynecologic cancers manage their fear of the cancer returning or getting worse. It planned to compare this virtual program to standard educational resources. The goal was to se…

This study aims to understand the long-term recovery and quality of life for women who have undergone a major surgery called pelvic exenteration for gynecologic cancers. Researchers are observing 79 women to see how different surgical techniques affect complications, survival, an…

This Mayo Clinic study aims to understand if long-term inflammation in the body increases a woman's risk of developing endometrial (uterine) cancer. Researchers are collecting blood, urine, and tissue samples from 191 women who are having a hysterectomy, either for cancer or for …

This study aims to understand how common pelvic floor problems are and how they affect quality of life in women who have been treated for uterine cancer. Researchers are comparing survivors who had different treatments (like surgery with or without radiation) to a group of women …

This study is a survey designed to understand the experiences of women who have survived breast or gynecological cancers when it comes to family planning and fertility. Researchers are asking over 1,400 survivors about their decisions, challenges, and use of fertility services af…