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New pill may keep endometrial cancer at bay longer

NCT ID NCT05611931

Disease control Sponsor: Karyopharm Therapeutics Inc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 2 times

Summary

This study tests whether the drug selinexor can help keep advanced or recurrent endometrial cancer from growing back after initial chemotherapy. About 276 adults whose cancer has a normal p53 gene and who responded to platinum-based chemo will receive either selinexor or a placebo as long-term maintenance. The goal is to see if selinexor extends the time before the cancer progresses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

257 people

The number who actually took part.

Started

Apr 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients must meet all of the following inclusion criteria in order to be eligible to participate in this study: * Adults (Aged ≥ 18 years) * Histologically confirmed endometrial cancer (endometrioid, serous, undifferentiated, or carcinosarcoma sub-types) that is TP53 wild type by central NGS * Must have completed at least 12 weeks of platinum-based chemotherapy (with or without immune checkpoint inhibitors), with a confirmed partial or complete response according to RECIST v1.1 * Must be able to initiate C1D1 within 3-8 weeks after last platinum dose * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Adequate bone marrow function and organ function Exclusion Criteria: Patients meeting any of the following exclusion criteria are not eligible to participate in this study: * Uterine sarcomas, clear cell or small cell carcinoma with neuroendocrine differentiation * Palliative radiotherapy administered within 14 days of intended C1D1 * Any gastrointestinal dysfunction that could interfere with the absorption of oral study therapy * Serious psychiatric or medical conditions that could interfere with study participation or would make study involvement unreasonably hazardous * Previous treatment with an XPO1 inhibitor * Stable disease or disease progression after platinum-based chemotherapy * Pregnancy, breastfeeding, or other legal/ethical restrictions to trial participation * Known dMMR/MSI-H EC tumors that are medically eligible to receive an immune checkpoint inhibitor

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrial carcinoma endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometrial cancer

Contacts and locations

Locations

  • "Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" - NAPOLI Struttura Complessa Oncologia Medica Uro-Ginecologica"

    Naples, 20133, Italy

  • AO Ordine Mauriziano

    Torino, 10128, Italy

  • ASST Spedali Civili Di Brescia

    Brescia, 25123, Italy

  • AZ Sint Lucas

    Ghent, 9000, Belgium

  • Acibadem Atakent Hospital

    Istanbul, 34303, Turkey (Türkiye)

  • Adana Baskent Hospital

    Adana, 34920, Turkey (Türkiye)

  • Advent Health

    Orlando, Florida, 32804, United States

  • Alexandra Hospital

    Athens, 11528, Greece

  • Allegheny Health Network - West Penn Hospital

    Pittsburgh, Pennsylvania, 15224, United States

  • Alliance Cancer Specialists

    Langhorne, Pennsylvania, 19047, United States

  • Ankara Baskent Hospital

    Çankaya, Ankara, 34093, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, 88, South Korea

  • Atrium Health Levine Cancer Institute

    Charlotte, North Carolina, 28209, United States

  • Avera

    Sioux Falls, South Dakota, 57105, United States

  • Border Medical Oncology & Haematology

    Albury, New South Wales, 2640, Australia

  • Box Hill Hospital - Eastern Health (Oncology)

    Box Hill, Victoria, 3128, Australia

  • Broward Health Medical Center

    Fort Lauderdale, Florida, 33316, United States

  • CHA University/Bundang CHA General Hospital

    Seongnam-si, 59, South Korea

  • CHU Ambroise Pare

    Mons, 7000, Belgium

  • CHU UCL Namur, Site Sainte-Elisabeth

    Namur, 5000, Belgium

  • Cabrini Health

    Malvern, Victoria, 3144, Australia

  • California Pacific Medical Center

    San Francisco, California, 94109, United States

  • Cancer and Blood Specialty Clinic

    Los Alamitos, California, 90720, United States

  • Caucasus Medical Centre

    Tbilisi, 0186, Georgia

  • Center Of Hope

    Reno, Nevada, 89511, United States

  • Central Coast LHD - Gosford & Wyong Hospitals

    Gosford, New South Wales, 2250, Australia

  • Centre Hospitalier de l'Université de Montréal

    Montreal, Quebec, H2X 0C1, Canada

  • Cerrahpasa University

    Istanbul, 34098, Turkey (Türkiye)

  • Chang Gung Memorial Hospital

    Taoyuan City, 333, Taiwan

  • Charite Berlin Universitatsmedizin

    Berlin, 13353, Germany

  • Chi Mei Medical Center

    Tainan, 71004, Taiwan

  • Chris O'Brien Lifehouse

    Camperdown, New South Wales, 2050, Australia

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • City of Hope at Irvine Lennar

    Irvine, California, 92618, United States

  • Cliniques Universitaires St. Luc

    Brussels, 1200, Belgium

  • Cork University Hospital

    Cork, T12 DC4A, Ireland

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Duke Cancer Center

    Durham, North Carolina, 27710, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Euromedica General Clinic

    Thessaloniki, 54645, Greece

  • Fondazione Policlinico Universitario Agostino Gemelli - ROMA

    Roma, 00168, Italy

  • Frankston Hospital

    Frankston, Victoria, 3199, Australia

  • Galway University

    Galway, H91 YR71, Ireland

  • General University Hospital in Prague

    Prague, 12851, Czechia

  • Georgia Cancer Center at Augusta University

    Augusta, Georgia, 30912, United States

  • Goshen Health

    Goshen, Indiana, 46526, United States

  • Grady Hospital

    Atlanta, Georgia, 30303, United States

  • H 12 de Octubre

    Madrid, 28041, Spain

  • Hacettepe University Oncology Hospital

    Ankara, 06230, Turkey (Türkiye)

  • Hadassah Medical Center

    Jerusalem, 91120, Israel

  • Helios Klinikum Krefeld

    Krefeld, 47805, Germany

  • High Technology Hospital Medcenter

    Batumi, 6000, Georgia

  • Hillel-Yaffe Medical Center

    Hadera, 38100, Israel

  • Honor Health

    Phoenix, Arizona, 85016, United States

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clínico Universitario Lozano Blesa

    Zaragoza, Zaragoza, 50009, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital LaFe Uacenlia

    Valencia, 46026, Spain

  • Hospital Maisonneuve-Rosemont

    Montreal, Quebec, Canada

  • Hospital Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Na Bulovce

    Prague, 18100, Czechia

  • Hospital Universitari Vall d' Hebrón

    Barcelona, 08035, Spain

  • Hospital Universitario Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Universitario Donostia

    Donostia / San Sebastian, Gipuzkoa, 20014, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Reina Sofía

    Córdoba, 14004, Spain

  • Hospital Universitario Virgen de las Nieves

    Granada, 18014, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, 41013, Spain

  • Hospital Universitatrio Virgen de la Victoria

    Málaga, 29010, Spain

  • Houston Methodist

    Houston, Texas, 77030, United States

  • Humanitas San Pio X Hospital

    Milan, 20159, Italy

  • Hygeia Hospital

    Athens, 15123, Greece

  • IASO Hospital

    Marousi, Athens, 151 23, Greece

  • ICO Badalona

    Badalona, 08916, Spain

  • ICON Cancer Centre Southport

    Southport, Queensland, 4215, Australia

  • IRCCS Azienda Ospedaliero Universitaria di Bologna

    Bologna, 40138, Italy

  • IRCCS Istituto Romagnolo Per Lo Studio Del Tumori "Dino Amadori" - IRST S.R.L.

    Meldola, 47014, Italy

  • Illinois Cancer Specialists

    Arlington Heights, Illinois, 60005, United States

  • Institut Catala d'Oncologia Hospitalet

    Barcelona, 08908, Spain

  • Institut Catala d'Oncologia de Girona

    Girona, 17007, Spain

  • Instituto Europeo di Oncologia

    Milan, 20141, Italy

  • Instituto Valenciano de Oncología

    Valencia, 46009, Spain

  • Intermountain Health St. Vincent Regional Hospital

    Billings, Montana, 59101, United States

  • Istituto Nazionale dei Tumori IRCCS - MILANO S. C. Ginecologia Oncologica

    Milan, 20133, Italy

  • Istituto Oncologico Veneto

    Padova, 35128, Italy

  • JSC - K.Eristavi National Center of Experimental and Clinical Surgery

    Tbilisi, 0159, Georgia

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 833401, Taiwan

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe GroBhadern

    Munich, 80337, Germany

  • Klinikum Südstadt Rostock

    Rostock, 18059, Germany

  • Korea University Anam Hospital

    Seoul, 73, South Korea

  • LSU Health Sciences Center New Orleans

    New Orleans, Louisiana, 70119, United States

  • LTD Innova Medical Center

    Tbilisi, 0186, Georgia

  • LTD New Hospitals

    Tbilisi, 0114, Georgia

  • Lenox Hill Hospital

    New York, New York, 10075, United States

  • Long Beach Memorial Medical Center

    Los Angeles, California, 90806, United States

  • MD Anderson Cancer Center Madrid

    Madrid, 28033, Spain

  • Macarthur Cancer Therapy Centre

    Campbelltown, New South Wales, 2560, Australia

  • Mackay Memorial Hospital

    Taipei, 104217, Taiwan

  • Magee - Women's Hospital

    Pittsburgh, Pennsylvania, 15213, United States

  • McGill University Health Centre (MUHC)

    Montreal, Quebec, H4A3J1, Canada

  • Memorial Ankara Hospital

    Ankara, 06520, Turkey (Türkiye)

  • Memorial Hospital of South Bend

    South Bend, Indiana, 46601, United States

  • MetroHealth

    Cleveland, Ohio, 44109, United States

  • Midwest Ventures Group HCA MId America Division

    Kansas City, Missouri, 64132, United States

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • Mount Sinai Comprehensive Cancer Center

    Miami Beach, Florida, 33140, United States

  • Multiprofile Clinic "Consilium Medulla"

    Tbilisi, 0186, Georgia

  • NYU Langone Hospital-Long Island

    Mineola, New York, 11501, United States

  • National Cancer Center (NCC)

    Goyang-si, 323, South Korea

  • National Cancer Institute

    Bratislava, 83310, Slovakia

  • Newcastle Private Hospital

    New Lambton Heights, New South Wales, 2305, Australia

  • NorthShore University Health System

    Evanston, Illinois, 60201, United States

  • Northwell Health - Queens Cancer Center

    Rego Park, New York, 11374, United States

  • Northwell Health - Zuckerberg Cancer Center

    New Hyde Park, New York, 11042, United States

  • Northwest Cancer Center

    Dyer, Indiana, 46311, United States

  • Nuovo Ospedale di Prato

    Prato, 59100, Italy

  • Oklahoma Cancer Specialists and Research Institute, LLC

    Tulsa, Oklahoma, 74146, United States

  • Oncology Associates of Oregon

    Eugene, Oregon, 97401, United States

  • Ospedale Ostetrico Ginecologico Sant'Anna

    Torino, 10124, Italy

  • Ospedale San Gerardo - Asst Monza

    Monza, 20900, Italy

  • Our Lady of the Lake Hospital, Inc.

    Baton Rouge, Louisiana, 70808, United States

  • Parkland Health & Hospital System

    Dallas, Texas, 75235, United States

  • Perlmutter Cancer Center at NYU Langone Health

    New York, New York, 10016, United States

  • Petz Aladár University Teaching Hospital

    Győr, 9024, Hungary

  • Princess Margaret

    Toronto, Ontario, M5G 2M9, Canada

  • ProMedica Flower Hospital

    Sylvania, Ohio, 43560, United States

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000, Australia

  • Royal North Shore Hospital

    Saint Leonards, New South Wales, Australia

  • Samsung Changwon Hospital

    Changwon, 51353, South Korea

  • San Raffaele Hospital

    Milan, 20132, Italy

  • Seoul National University Bundang Hospital

    Seoul, 101, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital (Yonsei University Health System)

    Seoul, Seongbuk, 50-1, South Korea

  • Sheba Medical Center

    Ramat Gan, 52621, Israel

  • Soon Chun Hyang University Hospital Cheonan

    Cheonan, Chungcheongnam-do, 31151, South Korea

  • St Vincent Hospital

    Indianapolis, Indiana, 46260, United States

  • St. Dominic's Gynecologic Oncology

    Jackson, Mississippi, 39216, United States

  • St. Elisabeth Cancer Institute

    Bratislava, 81250, Slovakia

  • St. James Hospital

    Dublin, D08 NHY1, Ireland

  • St. Vincent's University Hospital

    Dublin, Elm Park, D04 T6F4, Ireland

  • Stanford University

    Palo Alto, California, 94304, United States

  • Sunnybrook Research Institute

    Toronto, Ontario, M9L 2H9, Canada

  • TaiChung Veterans General Hospital

    Taichung, 407219, Taiwan

  • Taipei Medical University- Shuang Ho Hospital, Ministry of Health and Welfare

    Taipei, 23561, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Tbilisi Cancer Center

    Tbilisi, 0156, Georgia

  • Texas Oncology - Dallas

    Dallas, Texas, 75246, United States

  • Texas Oncology - San Antonio

    San Antonio, Texas, 78240, United States

  • Texas Oncology - The Woodlands

    The Woodlands, Texas, 77380, United States

  • Texas Oncology, PC, Tyler

    Tyler, Texas, 75702, United States

  • The Royal Adelaide Hospital

    Southport, 5000, Australia

  • The University of Alabama at Birmingham

    Birmingham, Alabama, 35205, United States

  • Todua Clinic

    Tbilisi, 0112, Georgia

  • Tom Baker Cancer Centre

    Calgary, Alberta, T3H2G5, Canada

  • Toowoomba Hospital

    Toowoomba, Queensland, 4350, Australia

  • Trials365, LLC

    Shreveport, Louisiana, 71133, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • UC DAVIS

    Davis, California, 95616, United States

  • UCLA - Women's Health Clinical Research Unit

    Los Angeles, California, 90095, United States

  • UH Bratislava

    Bratislava, 82606, Slovakia

  • UH Královské Vinohrady

    Prague, 10034, Czechia

  • UH Trenčín

    Trenčín, 91101, Slovakia

  • USON - Minnesota Oncology Hematology

    Minneapolis, Minnesota, 55404, United States

  • USON - Texas Oncology, Austin Central

    Austin, Texas, 78731, United States

  • UZ Leuven

    Leuven, 3000, Belgium

  • Unit of Gynecol.Oncol., Dept.Obstet.Gynecol., Clinical Center, University of Debrecen

    Debrecen, 4032, Hungary

  • Universita di Pisa

    Pisa, 56127, Italy

  • Universitatsklinikum Schleswig-Holstein

    Kiel, 24105, Germany

  • University Hospital Brno

    Brno, 60200, Czechia

  • University Hospital Dresden

    Kiel, 01307, Germany

  • University Hospital Ostrava

    Ostrava, 70852, Czechia

  • University Hospital Waterford

    Waterford, X91 ER8E, Ireland

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of Cincinnati Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Tennessee Health Science Center

    Memphis, Tennessee, 38103, United States

  • University of Tennessee Medical Center

    Knoxville, Tennessee, 37920, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

  • University of Virginia

    Charlottesville, Virginia, 22908, United States

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin, 53792, United States

  • Universitätsfrauenklinik Mainz

    Mainz, 55131, Germany

  • Universitätsfrauenklinik Ulm

    Ulm, 89075, Germany

  • Universitätsklinik Leipzig

    Leipzig, 04103, Germany

  • Universitätsklinikum Hamburg Eppendorf

    Hamburg, 20246, Germany

  • Universitätsmedizin Mannheim

    Mannheim, 68167, Germany

  • Virgen de la Arrixaca University Clinical Hospital

    Murcia, 30120, Spain

  • Westmead Hospital

    Wentworthville, New South Wales, 2145, Australia

  • Wolfson Medical Center

    Holon, Israel

  • Women's Cancer Care Associates, LLC

    Albany, New York, 12208, United States

  • Women's Cancer Center of Nevada

    Las Vegas, Nevada, 89106, United States

  • Zangmeister Cancer Center

    Columbus, Ohio, 43219, United States

  • Çukurova University

    Adana, 01330, Turkey (Türkiye)

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