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Obesity drug trial using cannabis compound halted early

NCT ID NCT04801641

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small pilot study tested whether nabilone, a synthetic drug similar to cannabis, could help obese adults lose weight. The trial aimed to check safety and feasibility, but it was terminated early, so we don't have clear results. Only 18 people were enrolled, making it too small to draw firm conclusions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nabilone (a synthetic cannabinoid similar to THC)
What this could lead to
If it had worked, this could have pointed toward a new weight-loss treatment using cannabis-like compounds.
What could go wrong
The trial was terminated early and only enrolled 18 people, so we have very little data. Nabilone can cause side effects like dizziness, drowsiness, and mood changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

18 people

The number who actually took part.

Started

Sep 2021

Finished

Aug 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Obese adults (BMI \> 30.0 kg/m2). * For the optional imaging component of the study, a maximum weight (315 lbs) and a maximum girth in line with capacity of the machine (60 cm horizontal and 45 cm vertical; therefore, circumference of scanner is 166.6 cm) * For women of reproductive potential (WORP) and men whose sexual partners are WORP: use of adequate methods of contraception (effective barrier methods such as male condoms, female condoms, cervical caps, diaphragms, or contraceptive sponges; and highly effective methods of contraception such as oral hormonal contraceptives, intrauterine devices (IUDs), vasectomy, or tubal ligation) * AST/ALT, bilirubin, and kidney function tests within normal limits at screening. Exclusion Criteria: * Unstable gastrointestinal, respiratory, endocrinological, cardiovascular or cerebrovascular diseases that would prevent participation in the trial at QI (or its delegate) discretion, * Unstable major psychiatric disorder(s) (i.e. Axis I Disorders) that would prevent participation in the trial at QI (or its delegate) discretion, * Current substance use disorders (DSM-V) (excluding tobacco and caffeine), * History of, or current neurological illnesses, that would prevent participation in the trial, * Current use or use during the previous month of antipsychotic medications, * Learning disability, amnesia or other conditions that impede memory and attention, * Visual impairments that prevent participation in the study, * Personal or family history of schizophrenia, or psychosis (or psychosis-related) disorders, * Antibiotic use in the last 4 weeks, * Previous bariatric surgery, * Current use or use in the past month of other weight-loss pharmaceuticals, * Cannabis use in last 6 months, * Known sensitivity to cannabis or other cannabinoid agents, * Pregnancy or lactation (females), and * For the optional imaging component of the study: * Presence of metal implants or objects unsafe for MRI such as cardiac pacemakers, metal fragments in the eye, and aneurysm clips in your brain * Piercings or jewelry that are unable to be removed * Tattoos inked with metal dyes

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Center for Addiction and Mental Health

    Toronto, Ontario, M5S 2S1, Canada

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