Hyperlipidemia

This study tested whether the drug RDX-002 can lower high blood fat levels in people who recently stopped taking weight-loss medications like semaglutide or tirzepatide. Sixty-eight adults who had lost at least 10% of their body weight on those drugs took either RDX-002 or a plac…

This study tests whether a daily dose of Taiwanese Green Propolis, a natural bee-derived supplement, can improve blood fat levels, reduce fatigue, and enhance quality of life in people who have completed treatment for oral cavity cancer. Participants take either propolis capsules…

This study tested the safety and effectiveness of inclisiran sodium, a cholesterol-lowering injection, in 65 Indian adults with high cholesterol or mixed dyslipidemia. Participants received three doses over 270 days. The goal was to see how well it lowers LDL cholesterol and if a…

This study tested a drug called pegozafermin in 369 adults with severe hypertriglyceridemia, a condition where blood fat levels are dangerously high. Participants received either the drug or a placebo for 26 weeks. The main goal was to see if the drug could safely lower triglycer…

This completed Phase 3 trial tested two new drugs, AG2304T and AG2304R, in 158 adults with primary hypercholesterolemia (high cholesterol). The study compared these drugs to an active control to see how well they lower LDL cholesterol and to check for side effects. Results could …

This study looked at whether two natural herbs, Ashwagandha and Jamun, can help people with high cholesterol. Sixty adults with unhealthy cholesterol levels took one or both herbs for three months. Results suggest the combination may improve cholesterol numbers, but more research…

This early-stage study tested a new drug called BKR-017 in 9 adults already taking statins for high cholesterol. Researchers checked how the body handles BKR-017 and whether it builds up over a week of twice-daily dosing. The main goal was to see if it is safe and how it affects …

This study tested an experimental drug called MGL-3196 (resmetirom) in 116 adults with heterozygous familial hypercholesterolemia, a genetic condition causing very high cholesterol. Participants took either the drug or a placebo daily for 12 weeks. The main goal was to see if the…

This Phase 3 study tested a drug called plozasiran (ARO-APOC3) in 75 adults with familial chylomicronemia syndrome, a rare genetic disorder causing extremely high blood fat levels and risk of pancreatitis. Participants received four injections of the drug or a placebo over severa…

This study tested the drug pravastatin in 21 HIV-positive people with high cholesterol who were already on HIV medications. The goal was to see if pravastatin could safely lower their cholesterol without affecting their HIV treatment. Participants received either pravastatin or a…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This observational registry followed 260 patients with homozygous familial hypercholesterolemia (a severe genetic condition causing very high cholesterol) who were taking lomitapide. The goal was to monitor long-term safety, especially liver problems and gastrointestinal issues, …

This study tested whether drinking a calcium-bicarbonate mineral water called Lete can lower LDL (bad) cholesterol in healthy adults with high cholesterol. 160 participants drank either the test water or a regular low-mineral water for four months. The goal was to see if the mine…

This study looked at the long-term safety of a drug called ARO-APOC3 in adults with dyslipidemia (abnormal fat levels in the blood). Participants who completed a previous 12-month study could continue receiving the drug every 3 or 6 months. The goal was to see if the drug remains…

This completed Phase 3 trial tested whether a single pill combining ezetimibe, rosuvastatin, and amlodipine can safely lower both cholesterol and blood pressure in 163 Korean adults with hypertension and high cholesterol. Participants took the combination pill or a control for 8 …

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study looked at whether eating different amounts of pecans every day for 28 days can improve cholesterol and other heart health markers in adults who are overweight or have high cholesterol. 108 participants were split into groups that ate pecans providing 6%, 13%, or 20% of…

This study looked at whether adding small amounts of cottonseed oil to the diet can improve cholesterol and other heart disease risk factors. 95 adults at increased risk for heart disease drank shakes and ate snacks with different amounts of cottonseed oil for 28 days. Researcher…

This study tested whether a special extract from plants (phytosterols and phytostanols) can help lower cholesterol levels in adults with high cholesterol. 42 people took either the extract or a placebo for a period of time. The main goal was to see if the extract could reduce tot…

This study tested whether taking two drugs (DWC202206 and DWC202207) together is safe and effective for people with both high blood pressure and high cholesterol. 214 adults aged 19 to 80 took part. The goal was to see if the combination lowered blood pressure and LDL ("bad") cho…

This completed Phase 4 trial tested a single pill containing three medicines (telmisartan, amlodipine, and rosuvastatin) in 252 Korean adults with both high blood pressure and high cholesterol. Participants took either the triple pill or a two-drug pill for 8 weeks. The study mea…

This study tested a low dose (10 mg) of the statin drug rosuvastatin in 242 Korean adults with high cholesterol or heart disease risk. The goal was to see how much it lowered 'bad' LDL cholesterol after 8 weeks. Results help guide cholesterol treatment in this population.

This phase 2b trial tested plozasiran, an experimental drug, in 353 adults with mixed dyslipidemia (high triglycerides and cholesterol). Participants received either plozasiran or a placebo, and researchers measured changes in blood fat levels over 48 weeks. The goal is to see if…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This completed Phase 4 trial tested the drug inclisiran (given as a shot under the skin) against a placebo in 1770 adults with high cholesterol who were already on cholesterol-lowering therapy. The goal was to see if inclisiran helps more people reach their LDL cholesterol target…

This study tested a digital quality improvement program to help doctors better manage LDL (bad) cholesterol in patients with heart disease. Over 1,400 adults with established cardiovascular disease participated. The program used smartphone tools to improve treatment and follow gu…

This study tested the drug evolocumab (Repatha) in 81 kidney transplant recipients with high cholesterol. The goal was to see if it could safely lower cholesterol levels, since standard statin drugs often cause side effects in these patients. The results could lead to a better wa…

This study tested whether drinking unsweetened soymilk every day can lower cholesterol in adults with high levels. Twenty-five participants drank two bottles (750 mL total) daily for 8 weeks. Researchers measured cholesterol and other health markers to see if the soymilk helped i…

This study tested whether a probiotic called Lactobacillus mucosae DPC6426 can lower cholesterol in healthy adults with mildly high levels. Over 12 weeks, 94 participants took either the probiotic or a placebo. The goal was to see if this natural approach could offer a heart-heal…

This study tested whether checking your own cholesterol at home and reporting results by phone helps lower LDL (bad cholesterol) more than standard doctor visits. 70 adults with high LDL took part. The idea was that frequent monitoring would improve medication adherence and help …

This study tested two statin drugs, rosuvastatin and pravastatin, in 86 people with HIV who also had high cholesterol. The goal was to see which drug lowered LDL (bad) cholesterol better and was safer when taken with HIV medications. Participants took one of the two statins for 4…

This phase 2 trial tested olpasiran, an injectable drug, in 281 adults with high lipoprotein(a) – a genetic risk factor for heart disease. Participants received either olpasiran or a placebo. The main goal was to see how much the drug lowered Lp(a) levels after 36 weeks. Results …

This study tested a new drug called MK-0616 (enlicitide) to see if it lowers 'bad' LDL cholesterol better than current pills (ezetimibe, bempedoic acid, or both). About 300 adults with high cholesterol and heart disease risk took part. The main goal was to check cholesterol reduc…

This study looked at how well the drug atostazet lowers cholesterol and affects blood sugar in people aged 65 and older with high cholesterol. Over 600 participants took the drug for 6 months, and researchers tracked side effects and changes in glucose metabolism. The goal was to…

This study looked at how a red yeast rice supplement (LipoCol Forte) affects cholesterol in 41 men aged 35-55 with high cholesterol. Researchers checked blood and stool samples to see changes in cholesterol, heart disease risk, gut bacteria, and bile acids. The goal was to see if…

This completed Phase 3 trial tested whether taking two cholesterol-lowering drugs together works better than one alone. 184 adults with high cholesterol or mixed dyslipidemia took either the combo or a single drug daily for 8 weeks. The main goal was to see how much LDL ('bad') c…

This completed study looked at nearly 7,000 adults with high cholesterol who switched from taking a statin alone to a combination pill containing Pitavastatin and Ezetimibe. The main goal was to see how much their LDL (bad) cholesterol dropped after 24 weeks. The study was observ…

This Phase 3 trial tested an oral drug called enlicitide decanoate (MK-0616) in 303 adults with heterozygous familial hypercholesterolemia, an inherited condition causing very high cholesterol. Participants took either the drug or a placebo daily for up to 52 weeks. The main goal…

This study tested a daily pill called ETC-1002 in 130 adults with very high LDL ("bad") cholesterol who either didn't respond well to statins or had side effects from them. Over 52 weeks, researchers checked how safe the drug was and how much it lowered cholesterol. The goal was …

This study tested a new injection called SYH2053 in 156 adults with high cholesterol. The goal was to see if it lowers bad cholesterol (LDL-C) better than a placebo or an existing treatment. Participants followed a low-fat diet and either took their usual cholesterol meds or none…

This study tested a new medicine called SHR-1918, given as multiple shots under the skin, for people whose high cholesterol is not well controlled. About 44 adults with high cholesterol took part. The main goal was to see how much their 'bad' cholesterol (LDL-C) dropped after 24 …

This study looked at how well the drug Livalozet lowers bad cholesterol (LDL-C) in people with high cholesterol, comparing those with and without diabetes. Over 1,500 adults took part for 24 weeks. The main goal was to measure the change in LDL-C levels from the start of the stud…

This study tested a new injectable drug called SHR-1918 in 335 people with high cholesterol that was not well controlled by their current statin therapy. Participants received either SHR-1918 or a placebo alongside their usual cholesterol medications. The main goal was to see how…

This study looked at whether adding elastic band resistance training to waltz dancing could help improve cholesterol levels in women aged 45 to 65 with dyslipidemia (abnormal blood fats). Sixty women participated in a 12-week program of supervised exercise classes three times a w…

This study tested whether a twice-yearly injection (inclisiran) lowers LDL cholesterol better than a daily pill (bempedoic acid) in 402 adults with heart disease who still have high cholesterol despite taking statins. Participants received either inclisiran or bempedoic acid on t…

This study tested a drug called inclisiran in teenagers aged 12 to 18 who have a rare inherited condition that causes extremely high cholesterol. The goal was to see if the drug safely lowers their LDL (bad) cholesterol. Participants received either inclisiran or a placebo for on…

This study tested a drug called inclisiran in teenagers aged 12 to 18 who have a genetic condition that causes very high cholesterol. The goal was to see if the drug is safe and can lower bad cholesterol. Participants received either inclisiran or a placebo for one year, then eve…

This study tested a drug called Cipros 20 in 406 adults with dyslipidemia (abnormal levels of fats in the blood) who also had high or very high heart disease risk. The goal was to see if it lowers triglycerides and LDL cholesterol more effectively than current options. Participan…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This pilot study tested whether adding plant sterols (phytosterols) and/or krill oil to a heart-healthy Brazilian diet can lower cholesterol in people with familial hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Fifty-eight adults with FH were ra…

This early-stage study tested a new medicine called ARO-ANG3 in 93 people, including healthy volunteers and patients with high cholesterol or high triglycerides. The main goal was to check if the drug is safe and how the body processes it. This research helps determine if the dru…

This early-stage study tested a new medicine called ARO-APOC3 in healthy volunteers and people with severely high triglycerides or a rare genetic condition called familial chylomicronemia syndrome. The main goal was to check safety and how the drug moves through the body. The stu…

This early-stage study tested a new drug called HRS-1301 in 82 healthy adults to check its safety and how the body processes it. The goal is to see if it can help control high cholesterol. Participants received either the drug or a placebo, and researchers monitored for side effe…

This early-stage study tested the safety of Atorvo+™, a new drug that combines the common cholesterol-lowering medication atorvastatin with cannabidiol (CBD). The trial involved 24 healthy adults aged 40-75 to see how the body processes the drug and if it causes any side effects.…

This Phase 3 study tested a new injectable drug called SAL003 in 618 adults with high cholesterol or mixed dyslipidemia. Participants received either SAL003 or a placebo every 4 weeks for 12 weeks, then all received SAL003 for another 40 weeks. The main goal was to see if SAL003 …

This Phase 3 trial tested the drug SHR-1918 in 55 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. Participants received either the drug or a placebo, and researchers measured how much their LDL (bad) choles…

This study tested a drug called pemafibrate (K-877) in 71 people with high cholesterol who cannot take statins due to side effects. Participants took either a low or high dose of pemafibrate or a placebo daily for 12 weeks. The goal was to see if pemafibrate safely lowers LDL (ba…

This phase 2b trial tested an experimental drug called ARO-ANG3 in 204 adults with mixed dyslipidemia, a condition with high triglycerides and cholesterol. Participants received injections of the drug or a placebo over several months. The goal was to see if the drug safely lowers…

This Phase 3 trial tested an injectable drug called SAL003 in 720 adults with high cholesterol or mixed dyslipidemia. Participants were already on statins but still had high LDL cholesterol. The study compared SAL003 to a placebo to see if it safely lowers cholesterol further. Th…

This study tested a new extended-release form of pemafibrate (K-877) in 121 adults with high triglycerides, a type of fat in the blood. Participants took the drug once daily for 52 weeks, either in the morning or evening, to see if it safely lowers triglyceride levels and improve…

This completed trial in Taiwan tested whether a digital health program helps middle-aged and older adults manage conditions like high blood pressure, diabetes, and high cholesterol. 199 participants from four communities used smart devices to measure their health data at home, wh…

This study looked at whether eating sunflower seeds every day can lower cholesterol in adults. 28 men with high cholesterol ate a set amount of sunflower seeds for 45 days. Their cholesterol levels were checked before and after. The goal is to see if sunflower seeds can be a simp…

This Phase 2 trial tested an oral drug called HRS-5346 in 120 adults with high lipoprotein(a) levels and a high risk of cardiovascular events. The main goal was to see how well the drug lowers Lp(a) levels compared to a placebo, and to check its safety. The study is completed, an…

This study tested a program to help people with rheumatoid arthritis (RA) get their cholesterol checked and treated. Many RA patients are at higher risk for heart attacks and strokes but often miss out on proper screening. The program used peer coaches and educational materials t…

This study tested a new medicine called olezarsen in 446 people with very high levels of blood fats (triglycerides). The goal was to see if it could lower these fats more than a placebo. Participants received shots under the skin and followed a healthy diet.

This study tested a new medicine called inclisiran in 350 people with high cholesterol who were not taking any other cholesterol drugs. The goal was to see if inclisiran could lower 'bad' LDL cholesterol more than a placebo or another drug called ezetimibe. Participants received …

This study tested whether adding a drug called inclisiran to standard care helps lower 'bad' LDL cholesterol more effectively in people who recently had a heart attack. About 400 participants received either the new care pathway including inclisiran or usual care alone. The goal …

This study tested a new controlled-release version of the drug pemafibrate in 60 adults with dyslipidemia (abnormal levels of fats in the blood). The goal was to see if the new version works as well or better than the current immediate-release tablet, with fewer side effects. Par…

This Phase 3 trial tested a daily pill combining two drugs, obicetrapib and ezetimibe, in 407 people with inherited high cholesterol or heart disease. Participants took the combination or a placebo on top of their usual cholesterol meds. The main goal was to see if the combo lowe…

This completed trial enrolled 2,486 people with asymptomatic high-grade carotid stenosis (narrowing of the neck arteries) to see if adding surgery or stenting to intensive medical management reduces stroke risk more than medical management alone. Participants were randomly assign…

This Phase 3 trial tested whether a single pill combining ezetimibe and rosuvastatin works better than rosuvastatin alone for lowering LDL (bad) cholesterol. The study included 305 Chinese adults whose cholesterol was not well controlled on statin therapy. Participants took eithe…

This study tested a new drug called obicetrapib in over 2,500 people with high cholesterol that wasn't well controlled by their current treatments. Participants took either a 10 mg obicetrapib pill or a placebo daily for about 6 months. The main goal was to see if obicetrapib cou…

This early-stage trial tested a single injection of HRS-7249 in 48 healthy adults with high cholesterol. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigned to receive either the drug or a placebo, and researchers monitor…

This large Phase 3 trial tested an experimental oral drug called enlicitide decanoate (MK-0616) in nearly 3,000 adults with high cholesterol, including those with a genetic form. The goal was to see if the drug safely lowers 'bad' LDL cholesterol more than a placebo over 24 weeks…

This study looked at whether taking fish oil and doing high-intensity interval training (HIIT) could lower inflammation in people who are overweight or obese. Researchers measured changes in blood markers of inflammation and metabolism over 10 weeks. The goal was to see if the co…

This early-phase study tested a single dose of VSA003 in 36 healthy Chinese adults to see if it is safe and how the body handles it. The drug aims to help control high cholesterol and triglycerides. Participants received either VSA003 or a placebo, and researchers monitored for s…

This phase 2 trial tested an investigational drug called SHR-1918 in 26 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. The study measured how much the drug lowered LDL (bad) cholesterol after 12 weeks. All…

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack a…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This study creates a registry for people with familial hypercholesterolemia (FH) in Greece, a genetic condition that causes very high cholesterol and early heart disease. Researchers will screen adults aged 18 to 80 to learn how common FH is and describe the health of those affec…

This completed Phase 1 study tested whether a single tablet combining laroprovstat and rosuvastatin works as well as taking the two drugs separately. 44 healthy adults aged 18 to 55 took part in a crossover design, receiving different formulations. The goal was to measure how muc…

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or mediu…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This study tested whether an educational website helps people who stopped taking statins due to muscle pain make informed decisions about restarting. Nearly 900 participants were randomly assigned to use the website or receive usual care. The goal was to see if the website increa…

This completed study looked at how meals with different amounts and types of fat and carbohydrates affect digestion and blood sugar/fat levels in 12 healthy adults. Participants ate test meals and had blood samples taken over 5 hours. The goal was to understand how meal compositi…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This completed study followed 1868 patients with high cholesterol to see how inclisiran (Leqvio®) and other cholesterol-lowering treatments work in real-world medical practice. Researchers tracked heart events, medication use, and lab results without assigning any treatments. The…

This study explored how teenagers and their parents react emotionally and mentally when they learn about genetic risks for conditions like hereditary breast cancer, Lynch syndrome, or high cholesterol. Researchers surveyed 162 participants using questionnaires and interviews to m…

This study looked at how taking statins (a common cholesterol-lowering drug) along with a structured exercise program affects muscle cells and overall fitness in adults aged 40-65 with high cholesterol. 120 participants were split into four groups: exercise plus placebo, exercise…

This study looked at medical records from over 11,900 adults in China who took either inclisiran or PCSK9 mAbs to lower their high cholesterol. Researchers wanted to see how well these drugs worked in everyday medical practice, not just in controlled trials. The study found that …

This completed study looked at how physical activity, life satisfaction, and medication adherence are related in 82 older Turkish adults (65+) with chronic conditions like high blood pressure or diabetes. Researchers used surveys to measure each factor. The goal was to understand…

This pilot study tested whether taking a low dose of aspirin (81 mg) before niacin (600 mg) could reduce the flushing reaction that niacin often causes. Nine healthy adults with high cholesterol participated, providing urine and blood samples to measure prostaglandin levels. The …

This study looked at how a new drug called HRS-1301 changes the way the body processes rosuvastatin, a common cholesterol-lowering medication. Sixteen healthy adults took both drugs so researchers could measure drug levels in the blood. The goal was purely to gather information, …

This study looked at how an experimental drug called AZD0780 affects the way the body processes metformin, a common diabetes medicine. Fourteen healthy volunteers took both drugs, and researchers measured drug levels in the blood. The goal was purely to gather information on drug…

This early-stage study tested a new drug called DW5124 in 55 healthy adults to see how safe it is and how the body processes it. Researchers also checked whether taking the drug with food changes its effects. The goal was to gather basic information before testing the drug in peo…

This study offered free genetic testing to immediate family members of children found to have a genetic marker for familial hyperlipidemia (FH), a condition that causes very high cholesterol and early heart disease. The goal was to see if large-scale testing can identify at-risk …

This completed trial tested two ways of reminding doctors to prescribe statins to patients who need them. Over 3,300 patients were included. One reminder popped up and required action, while the other was less intrusive. The goal was to see which method works better without overw…

This study looked at 2000 adults with early heart disease to understand how inherited high cholesterol (familial dyslipidemia) contributes to heart attacks. Researchers reviewed medical records to find patterns in cholesterol levels. The goal was to highlight the need for better …

This study looked at 514 people with stable coronary artery disease to see if how their body processes fat after a meal (triglyceride tolerance) is linked to future heart attacks or death. Researchers also checked blood sugar tolerance. The goal was to find a better way to identi…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This pilot study tested a quality improvement process called CUSP to help community mental health staff deliver better care for cardiovascular risk factors like high blood pressure, diabetes, and high cholesterol. The study included 85 staff and patients from psychiatric rehabili…

This study tested whether a whole-food plant-based diet, compared to a standard North American diet, can lower LDL cholesterol in 50 adults with heterozygous familial hypercholesterolemia (HeFH). Participants followed each diet for 28 days in a crossover design. Researchers also …

This completed study tested whether a generic bempedoic acid tablet works the same as the brand-name drug Nilemdo in 32 healthy adults. Participants took a single dose of each under fasting conditions, and researchers measured drug levels in the blood. The goal was to see if the …

This early-stage trial tested whether a single pill containing two medicines (pitavastatin for cholesterol and valsartan for blood pressure) works the same in the body as taking the two pills separately. Fifty-two healthy men took both versions in random order. The study only mea…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…