Aspirin may block Niacin's uncomfortable flush, tiny study hints
NCT ID NCT01275300
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether taking a low dose of aspirin (81 mg) before niacin (600 mg) could reduce the flushing reaction that niacin often causes. Nine healthy adults with high cholesterol participated, providing urine and blood samples to measure prostaglandin levels. The study was small and exploratory, aiming to understand the body's response rather than prove a treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Aspirin 81 mg and Niacin 600 mg
- What this could lead to
- If successful, this could help understand how to reduce the uncomfortable flushing side effect of niacin, potentially making it easier for people with high cholesterol to tolerate the medication.
- What could go wrong
- This is a very small pilot study with only 9 participants, so results may not apply to the general population. It is designed to measure biological markers, not to prove any treatment benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Pennsylvania Hospital
Philadelphia, Pennsylvania, 19104, United States
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