Plant-Based diet may lower cholesterol in genetic heart condition

NCT ID NCT05181553

Completed Knowledge-focused Sponsor: Laval University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a whole-food plant-based diet, compared to a standard North American diet, can lower LDL cholesterol in 50 adults with heterozygous familial hypercholesterolemia (HeFH). Participants followed each diet for 28 days in a crossover design. Researchers also looked for metabolic markers of healthy eating.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: whole-food plant-based diet
What this could lead to: If successful, this could show that a plant-based diet helps lower cholesterol in people with familial hypercholesterolemia and provide a way to measure diet adherence.
What could go wrong: This is a small, completed study (50 participants) that looks at short-term effects only. Results may not apply to everyone with the condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder cholesterol metabolism disease familial hypercholesterolemia Hypercholesterolemia hyperlipidemia Hyperlipoproteinemia Type II metabolic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES CHOLESTEROL, ELEVATED CHOLESTEROL; METABOLIC DISORDER FAMILIAL HYPERCHOLESTEROLEMIA NUTRITION, HEALTHY

Contacts and locations

Locations

Institute on nutrition and functional foods, Laval University

Québec, Quebec, G1V0A6, Canada

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