New pill could tame inherited high cholesterol

NCT ID NCT03038022

Completed Disease control Sponsor: Madrigal Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called MGL-3196 (resmetirom) in 116 adults with heterozygous familial hypercholesterolemia, a genetic condition causing very high cholesterol. Participants took either the drug or a placebo daily for 12 weeks. The main goal was to see if the drug could lower LDL (bad) cholesterol more than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MGL-3196 (resmetirom)
What this could lead to: If it works, this could provide a new oral option to help control high cholesterol in people with familial hypercholesterolemia.
What could go wrong: This is an early Phase 2 trial with only 116 participants, so results may not apply to everyone. The drug may not lower cholesterol enough or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

familial hypercholesterolemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

Contacts and locations

Locations

Madrigal Research Site

Aalborg, Denmark
Madrigal Research Site

Copenhagen, Denmark
Madrigal Research Site

Esbjerg, Denmark
Madrigal Research Site

Herlev, Denmark
Madrigal Research Site

Viborg, Denmark
Madrigal Research Site

Amsterdam, Netherlands
Madrigal Research Site

Apeldoorn, Netherlands
Madrigal Research Site

Goes, Netherlands
Madrigal Research Site

Hoorn, Netherlands
Madrigal Research Site

Nijmegen, Netherlands
Madrigal Research Site

Zwijndrecht, Netherlands
Madrigal Research Site - 1

Oslo, Norway
Madrigal Research Site - 2

Oslo, Norway

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