Can plant sterols and krill oil tame inherited high cholesterol?
NCT ID NCT05695937
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether adding plant sterols (phytosterols) and/or krill oil to a heart-healthy Brazilian diet can lower cholesterol in people with familial hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Fifty-eight adults with FH were randomly assigned to one of four groups: diet alone, diet plus phytosterols, diet plus krill oil, or diet plus both supplements. The study measured changes in LDL cholesterol and lipoprotein(a) after 120 days, along with adherence and side effects, to inform a larger future trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
phytosterols and krill oil (dietary supplements)
What this could lead to
If it works, this could point toward a way to better manage high cholesterol in people with familial hypercholesterolemia using diet and supplements.
What could go wrong
This is a small pilot study (58 people) with no phase, so results are preliminary. The supplements may not significantly lower cholesterol, and the diet may be hard to stick with long-term.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for FAMILIAL HYPERCHOLESTEROLEMIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Hcor
São Paulo, Brazil
-
Hospital Ana Nery
Salvador, Brazil
-
Hospital São José
Criciúma, Brazil
-
Hospital das Clínicas da Universidade Federal de Goiás
Goiânia, Brazil
-
InCor
São Paulo, Brazil
-
Instituto Dante Pazzanese de Cardiologia
São Paulo, Brazil
-
Instituto Nacional de Cardiologia
Rio de Janeiro, Brazil
-
Universidade Feevale
São Leopoldo, Brazil
-
Universidade Regional do Noroeste do Estado do Rio Grande do Sul
Ijuí, Brazil