New drug SHR-1918 targets stubborn high cholesterol in rare disease
NCT ID NCT06723652
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tested the drug SHR-1918 in 55 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. Participants received either the drug or a placebo, and researchers measured how much their LDL (bad) cholesterol dropped after 12 weeks. The goal is to see if SHR-1918 can safely lower cholesterol in patients who already take other lipid-lowering medications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SHR-1918 (a drug that lowers LDL cholesterol)
- What this could lead to
- If it works, this could provide a new treatment option for people with homozygous familial hypercholesterolemia, helping to lower their dangerously high cholesterol levels.
- What could go wrong
- This is a completed Phase 3 trial with only 55 participants, so results may not apply to everyone. The drug may cause side effects or fail to show meaningful benefit over existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
The Second Xiangya Hospital of Central South University Hospital
Changsha, Hunan, 410000, China
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