New drug shows promise for rare High-Cholesterol disease
NCT ID NCT06009393
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial tested an investigational drug called SHR-1918 in 26 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. The study measured how much the drug lowered LDL (bad) cholesterol after 12 weeks. All participants continued their usual cholesterol medications during the trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SHR-1918 (an investigational drug to lower cholesterol)
- What this could lead to
- If successful, SHR-1918 could offer a new treatment option to help control dangerously high cholesterol in people with this rare genetic condition.
- What could go wrong
- This is a small, early-phase trial with only 26 participants and no placebo group. Results may not apply to all patients, and the drug's long-term safety and effectiveness are not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
The Second Xiangya Hospital of Central South University Hospital
Changsha, Hunan, 410007, China
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