New drug plozasiran aims to lower high fats in the blood

NCT ID NCT04998201

Completed Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2b trial tested plozasiran, an experimental drug, in 353 adults with mixed dyslipidemia (high triglycerides and cholesterol). Participants received either plozasiran or a placebo, and researchers measured changes in blood fat levels over 48 weeks. The goal is to see if the drug can safely lower these fats when added to standard diet and statin therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Plozasiran (ARO-APOC3 injection)
What this could lead to: If successful, plozasiran could offer a new option to help control high triglycerides and cholesterol in people with mixed dyslipidemia.
What could go wrong: This is a mid-stage trial with results not yet published. The drug may not prove effective or safe enough for approval, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

hyperlipidemia, familial combined, LPL related

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIXED DYSLIPIDEMIA

Contacts and locations

Locations

Research Site 1

Fort Lauderdale, Florida, 33308, United States
Research Site 10

Montreal, Quebec, H2W2T2, Canada
Research Site 11

Auckland, 2025, New Zealand
Research Site 12

Dayton, Ohio, 45419, United States
Research Site 13

San Antonio, Texas, 78249, United States
Research Site 14

Miami Springs, Florida, 33166, United States
Research Site 15

Concord, Ontario, L4K 4M2, Canada
Research Site 16

Christchurch, 8013, New Zealand
Research Site 17

New Windsor, New York, 12553, United States
Research Site 18

Dunwoody, Georgia, 30338, United States
Research Site 19

Clayton, Victoria, 3168, Australia
Research Site 2

Boca Raton, Florida, 33434, United States
Research Site 20

Balatonfüred, H-8230, Hungary
Research Site 21

Debrecen, H-4032, Hungary
Research Site 22

Nyíregyháza, H-4405, Hungary
Research Site 24

Lodz, 94-048, Poland
Research Site 25

Poznan, 61-655, Poland
Research Site 26

Rzeszów, 35-055, Poland
Research Site 27

Joondalup, Western Australia, 6027, Australia
Research Site 28

Lodz, 93-338, Poland
Research Site 29

Adelaide, South Australia, 5000, Australia
Research Site 3

Beverly Hills, California, 90211, United States
Research Site 30

Morayfield, Queensland, 4506, Australia
Research Site 31

Las Vegas, Nevada, 89121, United States
Research Site 32

Houston, Texas, 77030, United States
Research Site 4

Franklin, Ohio, 45005, United States
Research Site 5

Pembroke Pines, Florida, 33024, United States
Research Site 6

Houston, Texas, 77002, United States
Research Site 7

Greenville, South Carolina, 29607, United States
Research Site 8

Northridge, California, 91325, United States

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