Hyperlipidemia

This trial tests whether an oral drug called HRS-5346 can safely lower elevated lipoprotein(a) — a genetic risk factor for heart attacks and strokes — in adults at high cardiovascular risk. Participants will take one of two doses of the drug or a placebo for 12 weeks, and researc…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This phase 2 trial tests whether a combination of Chinese herbal granules (Dachaihu Decoction and Erzhiwan) can safely lower LDL cholesterol in people with hypercholesterolemia. Participants receive either the herbal formula or a placebo for 8 weeks, followed by 4 weeks of observ…

This early-stage trial is testing an experimental drug called SAL0167 in healthy adults to see if it is safe and how the body processes it. The goal is to gather initial data that could support future studies for treating high cholesterol. Participants will receive either the dru…

This study tests whether a low-dose sugarcane-derived supplement called policosanol, combined with a structured exercise program, can improve physical fitness and blood lipid levels in adults with elevated cholesterol who do not yet need medication. Over 12 weeks, participants ar…

This study looks at two different dosing schedules of the drug tafolecimab—given every two weeks or every three weeks—in people with high cholesterol that isn't controlled by statins alone. Over 12 weeks, researchers will measure how much LDL (bad) cholesterol drops and how safe …

This Phase 3 trial tests an investigational biologic called DR10624, given as a weekly injection, in adults with severe hypertriglyceridemia (very high blood fats) who are already on standard lipid-lowering therapy. The study compares two doses of DR10624 against a placebo to see…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This study tests whether adding a drug called inclisiran to standard cholesterol-lowering therapy (statins) helps people who recently had a heart attack or unstable angina lower their LDL ('bad') cholesterol more than statins alone. About 300 adults in Saudi Arabia will receive e…

This study looks at the best way to manage high cholesterol caused by the targeted therapy lorlatinib in people with advanced ALK-positive non-small cell lung cancer. Some participants receive standard cholesterol-lowering drugs, while others get a more intensive combination. The…

This early-stage trial tests a single injection of MWX205 in 37 adults with high cholesterol or blood fats (dyslipidemia). Researchers will check if the drug is safe, how the body processes it, and how it affects cholesterol levels compared to a placebo. The goal is to find the r…

This Phase 3 trial tests whether a new combination pill containing laroprovstat and rosuvastatin lowers LDL cholesterol better than rosuvastatin alone. About 200 adults with high cholesterol and a history of heart disease or high risk will take either the combo or a placebo plus …

This phase 3 trial tests bempedoic acid, a daily pill, in 222 adults with high cholesterol that statins alone can't control. Participants take the drug or a placebo for 12 weeks while staying on their usual cholesterol meds. The main goal is to see how much LDL ('bad') cholestero…

This study tests a new pill that combines two drugs (laroprovstat and rosuvastatin) to lower LDL or 'bad' cholesterol. About 600 adults with high cholesterol who have never taken cholesterol-lowering medication will receive either the combination, one of the drugs alone, or a pla…

This study tests a new drug called zodasiran in 12 teens aged 12 to 17 with homozygous familial hypercholesterolemia, a rare genetic condition causing very high cholesterol. The drug is given as a shot under the skin. The main goal is to see if it safely lowers bad cholesterol af…

This study tests whether a drug called colesevelam, normally used for high cholesterol, can help lower levels of PFAS (often called 'forever chemicals') in the blood of veterans. About 50 veterans with high PFAS levels will receive either the drug or a placebo for a period, and r…

This small pilot study will test a pharmacist-led program to control high blood pressure and cholesterol in 10 people aged 50-75 who carry the APOE ε4 gene, a major risk factor for Alzheimer's. Participants will take specific medications for six months to see if managing these he…

This early-stage study tests a single dose of BSA204, an experimental injection, in 40 Chinese adults with borderline high lipoprotein(a) – a fatty substance linked to heart disease. The main goal is to check safety and side effects, while also measuring changes in cholesterol le…

This study compares a three-drug combination (atorvastatin, ezetimibe, and bempedoic acid) against the usual two-drug therapy for lowering LDL cholesterol in people who have had a heart attack or unstable angina. About 120 adults will take either the triple or dual therapy for 3 …

This early-stage study tests a new medicine called ISH0688, given as a shot under the skin, for people with high triglycerides (a type of blood fat). The study will involve 104 healthy volunteers and people with high triglycerides to check the drug's safety and how the body proce…

This early study tests a new injection called ART002g1 in 24 adults with a genetic form of high cholesterol (HeFH). The injection uses gene editing to lower a protein that raises cholesterol levels. The main goal is to check safety and how well the drug works at reducing choleste…

This Phase III trial tests QLC7401, a new RNA-based drug, in 120 adults with heterozygous familial hypercholesterolemia (a genetic condition causing very high cholesterol). Participants already on cholesterol medication will receive either QLC7401 or a placebo injection. The stud…

This Phase 3 trial tests a new drug called QLC7401 in about 780 adults with high cholesterol that remains high despite standard therapy. Participants will receive either QLC7401 or a placebo, added to their current cholesterol medications. The main goal is to see if QLC7401 can s…

This study tests whether giving a triple combination of cholesterol-lowering drugs (a high-intensity statin, ezetimibe, and bempedoic acid) right after a heart attack works better than usual care. About 600 adults hospitalized for a heart attack will be randomly assigned to the t…

This Phase 3 trial tests an injection called SYH2053 for people with high cholesterol that isn't controlled by standard pills. About 900 adults aged 18-75 will receive either the drug or a placebo, on top of their usual cholesterol medication. The main goal is to see if SYH2053 s…

This study tests whether a new omega-3 supplement called Ruby-O, made from phospholipids, raises omega-3 levels in the blood more effectively than standard omega-3 supplements. About 105 adults with mixed dyslipidemia (abnormal blood fats) who are already on statin therapy will t…

This study tests a new injectable drug called DNV001 in about 120 adults with high cholesterol that isn't well controlled by statins. Participants will receive different doses of the drug or a placebo as a shot under the skin, while continuing their usual statin pills. The main g…

This study tests whether an AI-powered app called 'Smart family doctor' can help people who have had heart surgery (bypass or stent) better control their blood pressure, blood sugar, and cholesterol. About 951 participants from 10-20 hospitals will use the app for personalized he…

This early-stage trial will test a new drug formulation (AD-117) for mixed dyslipidemia, a condition involving high cholesterol and triglycerides. Sixty healthy adults will receive a single dose of either the new or a reference formulation to compare how the body processes each. …

This pilot study tests whether a natural supplement called 2-HOBA can reduce harmful oxidized fats in people with high lipoprotein(a), a genetic risk factor for heart disease. Ten adults with elevated Lp(a) will take 2-HOBA capsules for 6 weeks. Researchers will measure changes i…

This study is testing a new, non-invasive way to screen for high cholesterol using a person's breath. Researchers will collect exhaled breath samples from 280 healthy adults and those with high cholesterol. They will analyze the breath for unique chemical patterns to see if the t…

This study tests whether an 8-week virtual reality exercise program using the Microsoft Kinect can improve body composition, balance, and daily participation in 32 children aged 8-14 with hyperlipidemia (high cholesterol). The program includes game-based activities like boat navi…

This study investigates how eating three high-fat meals in a row changes vitamin E levels in the blood. Researchers will compare people with normal blood fats to those with high blood fats (hyperlipidemia). The goal is to understand whether fats in the blood can trap vitamin E, p…

This Phase 1 trial is testing two different formulations of an experimental drug called HRS-5346 in healthy adults aged 18 to 45. The goal is to compare how well the body absorbs each version, which helps guide future development. Participants receive both formulations in a cross…

This early-stage trial is testing two experimental oral drugs, AD-236A and AD-236B, in healthy adult volunteers. The goal is to see how the drugs interact when taken together and whether the combination is safe. The study involves 44 participants aged 19 to 55 and will measure dr…

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study compares two approaches to notify relatives of people diagnosed with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. One method lets patients share information themselves; the other has the study team contact relatives directly. R…

This study will follow about 2,500 adults in Italy who have high cholesterol and are at high risk for heart problems. Researchers want to see if their current treatments match official guidelines and how well their cholesterol is controlled over one year. The goal is to find gaps…

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study will look at medical records from 3,600 people in Japan to see how well they follow their prescribed cholesterol-lowering medication. It compares two drugs, inclisiran and evolocumab, over 12 months. The goal is to understand real-world adherence, not to test new treat…

This study tests whether sending an electronic letter to people with heart disease and high cholesterol encourages them to get their cholesterol checked. Researchers will compare those who receive the letter to those who don't, using national health records to track results. The …

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This early-stage study will test three experimental drugs (AD-231A, AD-231B, and AD-231C) in 55 healthy adults to see how they interact in the body and if they are safe. The drugs are being developed for high blood pressure and high cholesterol. Participants must be between 19 an…

This study aims to create an AI system that combines Traditional Chinese Medicine (TCM) body type data with modern technology to give personalized health advice. Researchers will enroll 195 adults who have all three conditions: high blood pressure, high blood sugar, and high chol…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This study compares levels of oxidized LDL (a type of 'bad' cholesterol linked to heart disease) in the gum fluid of people with advanced gum disease versus those with healthy gums. Researchers aim to better understand the connection between gum inflammation and heart health. The…