New shot could help when statins Aren't enough for high cholesterol
NCT ID NCT07391722
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new injectable drug called DNV001 in about 120 adults with high cholesterol that isn't well controlled by statins. Participants will receive different doses of the drug or a placebo as a shot under the skin, while continuing their usual statin pills. The main goal is to see how much DNV001 lowers 'bad' LDL cholesterol after 24 weeks, and to check its safety over about a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DNV001 injection (a lab-made antibody that targets PCSK9 to lower cholesterol)
- What this could lead to
- If successful, this could lead to a new injectable treatment option for people with high cholesterol that isn't fully controlled by statins alone.
- What could go wrong
- This is an early Phase II trial with only 120 people, so results may not apply to everyone. The drug may not lower cholesterol enough or could have side effects not yet seen.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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