New drug shows promise for Long-Term cholesterol control

NCT ID NCT05413135

Completed Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at the long-term safety of a drug called ARO-APOC3 in adults with dyslipidemia (abnormal fat levels in the blood). Participants who completed a previous 12-month study could continue receiving the drug every 3 or 6 months. The goal was to see if the drug remains safe over time and continues to lower triglycerides, a type of blood fat.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ARO-APOC3 injection

What this could lead to

If successful, this could provide a long-term treatment option to lower triglycerides and manage dyslipidemia, reducing heart disease risk.

What could go wrong

This is an early-phase extension study, so long-term safety and effectiveness are not yet proven. Side effects or lack of sustained benefit are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Dyslipidemias hyperlipidemia inherited lipid metabolism disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DYSLIPIDEMIAS

Contacts and locations

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Locations

Clincal Research Site 4

Boca Raton, Florida, 33434, United States
Clinical Research Site 1

Beverly Hills, California, 90211, United States
Clinical Research Site 10

Pembroke Pines, Florida, 33024, United States
Clinical Research Site 11

Port Orange, Florida, 32127, United States
Clinical Research Site 12

Dunwoody, Georgia, 30338, United States
Clinical Research Site 13

Minneapolis, Minnesota, 55455, United States
Clinical Research Site 14

Tupelo, Mississippi, 38801, United States
Clinical Research Site 15

Omaha, Nebraska, 68114, United States
Clinical Research Site 16

Las Vegas, Nevada, 89121, United States
Clinical Research Site 17

Long Island City, New York, 11106, United States
Clinical Research Site 18

New Windsor, New York, 12553, United States
Clinical Research Site 19

New York, New York, 10029, United States
Clinical Research Site 2

Northridge, California, 91325, United States
Clinical Research Site 20

Morehead City, North Carolina, 28557, United States
Clinical Research Site 21

Fargo, North Dakota, 58104, United States
Clinical Research Site 22

Marion, Ohio, 43302, United States
Clinical Research Site 23

Maumee, Ohio, 43537, United States
Clinical Research Site 24

Oklahoma City, Oklahoma, 73135, United States
Clinical Research Site 25

Greenville, South Carolina, 29607, United States
Clinical Research Site 26

Chattanooga, Tennessee, 37421, United States
Clinical Research Site 27

Houston, Texas, 77030, United States
Clinical Research Site 28

Houston, Texas, 77099, United States
Clinical Research Site 29

Houston, Texas, 77002, United States
Clinical Research Site 3

Palm Springs, California, 92292, United States
Clinical Research Site 30

San Antonio, Texas, 78249, United States
Clinical Research Site 31

Manassas, Virginia, 20110, United States
Clinical Research Site 32

Camperdown, New South Wales, 2050, Australia
Clinical Research Site 33

Milton, Queensland, 4068, Australia
Clinical Research Site 34

Sippy Downs, Queensland, 4556, Australia
Clinical Research Site 35

Adelaide, South Australia, 5000, Australia
Clinical Research Site 36

Clayton, Victoria, 3168, Australia
Clinical Research Site 37

Joondalup, Washington, 6027, Australia
Clinical Research Site 38

Nedlands, Washington, 6009, Australia
Clinical Research Site 39

Concord, Ontario, L4K4M2, Canada
Clinical Research Site 40

London, Ontario, N6A 5A5, Canada
Clinical Research Site 41

Chicoutimi, Quebec, G7H 7K9, Canada
Clinical Research Site 43

Montreal, Quebec, H2W 1R7, Canada
Clinical Research Site 44

Québec, Quebec, G1G 3Z4, Canada
Clinical Research Site 46

Balatonfüred, H-8230, Hungary
Clinical Research Site 47

Békéscsaba, 5600, Hungary
Clinical Research Site 48

Debrecen, 4032, Hungary
Clinical Research Site 49

Gyöngyös, 3200, Hungary
Clinical Research Site 5

Fort Lauderdale, Florida, 33308, United States
Clinical Research Site 50

Komárom, H-2900, Hungary
Clinical Research Site 51

Nyíregyháza, 4400, Hungary
Clinical Research Site 53

Amsterdam, 1105 AZ, Netherlands
Clinical Research Site 54

Sneek, 8601 ZR, Netherlands
Clinical Research Site 55

Zwijndrecht, 3331LZ, Netherlands
Clinical Research Site 56

Christchurch, 8011, New Zealand
Clinical Research Site 57

Christchurch, 8013, New Zealand
Clinical Research Site 58

Papatoetoe, Aukland, 2025, New Zealand
Clinical Research Site 59

Bydgoszcz, 85-605, Poland
Clinical Research Site 6

Miami, Florida, 33173, United States
Clinical Research Site 60

Oświęcim, 32-600, Poland
Clinical Research Site 61

Poznan, 61-655, Poland
Clinical Research Site 62

Rzeszów, 35-055, Poland
Clinical Research Site 63

Lodz, 94 046, Poland
Clinical Research Site 64

Lodz, 93-338, Poland
Clinical Research Site 8

Miami, Florida, 33155, United States
Clinical Research Site 9

Miami Springs, Florida, 33166, United States