Acute coronary syndrome

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study looked at whether follow-up visits by phone or video are as safe as in-person visits for people who had a heart attack and received a stent. 88 patients were split into two groups: one had telemedicine check-ups at 1, 3, and 6 months, and the other had standard office …

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This large phase 3 study tested whether milvexian, an oral blood thinner, can reduce the risk of major cardiovascular events like heart attack, stroke, or death in people who recently had an acute coronary syndrome (heart attack or unstable angina). Over 14,000 participants took …

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This study looked at over 17,000 people who had a heart attack to compare two blood thinners: prasugrel and ticagrelor. Hospitals switched from ticagrelor to prasugrel in a stepwise way to see which drug better prevents death, another heart attack, or stroke. The goal is to find …

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This study tested a combination of two drugs, rivaroxaban and ticagrelor, in 40 patients with atrial fibrillation who had a stent placed. The goal was to see if this combo causes less bleeding and prevents heart attacks or strokes better than current treatments. Patients took the…

This study tested whether evolocumab (Repatha), a drug that lowers LDL cholesterol, can reduce inflammation and improve heart function in people who recently had a mild heart attack (NSTEMI). Sixty participants received either evolocumab or a placebo within 24 hours of admission.…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study looked at over 3,400 people with acute coronary syndrome (a heart attack or unstable angina) who received a stent to open blocked arteries. Researchers compared two types of stents (biostable vs. biodegradable polymer) and two doses of the blood thinner prasugrel (5 mg…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested a new, simpler method called JINS for placing drug-coated stents in heart arteries. Researchers wanted to see if it could help achieve better stent placement while reducing extra radiation and complications from balloon inflation. The study involved 161 people w…

This study tested whether a single dose of dantrolene, a muscle relaxant, could reduce the risk of dangerous heart rhythms in 68 people with structural heart disease who were scheduled for a procedure to treat ventricular tachycardia. Participants received either dantrolene or a …

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This trial tested a new type of stent (a small mesh tube) that slowly dissolves after being placed in a heart artery. The stent is coated with a drug to prevent the artery from narrowing again. Over 1600 patients with stable heart disease or a mild heart attack received either th…

This study tested whether monthly text messages with heart-health tips could help people who had a heart attack better control their risk factors and avoid future heart problems. 370 participants received either usual care or usual care plus text messages for one year. The goal w…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed study looked at whether moderate-dose statins work as well as high-dose statins in lowering 'bad' LDL cholesterol after a heart attack. 190 adults aged 25-85 took either a moderate or high dose of atorvastatin or rosuvastatin daily for 3 months. The goal was to see…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study looked at whether the drug vericiguat can help people who have had a heart attack or unstable angina and also have a weak heart (ejection fraction below 45%). The main goal was to see if it lowers the chance of dying from heart problems or being hospitalized for heart …

This study tested whether using cardiac MRI to guide ablation (a procedure that destroys small areas of heart tissue) can improve outcomes for people with ventricular tachycardia, a dangerous fast heart rhythm. 104 adults with structural heart disease were randomly assigned to on…

This study looked at whether a herbal capsule called Xuesaitong (made from Panax notoginseng) can help patients who recently had a heart attack and a stent placed. Sixty adults took the capsule for 4 weeks. Researchers measured changes in platelet genes, proteins, and metabolites…

This completed trial tested whether taking two blood thinners (clopidogrel and aspirin) for 12 months after a heart stent procedure is better than aspirin alone for people with multiple blocked coronary arteries. Over 8,000 patients were enrolled across 100 centers. The main goal…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study looked at whether giving ulinastatin during heart surgery can lower the chance of lung complications like infections or breathing failure. Researchers analyzed data from over 4,500 patients and also used computer models to understand how the drug works. The results sug…

This pilot study tested whether a hybrid cardiac rehabilitation program, combining a few clinic visits with mostly home-based telehealth sessions, is feasible for heart attack survivors. Ten participants were enrolled to see if they would join and stick with the program. The stud…

This study tested whether adding evolocumab, a drug that lowers bad cholesterol, to standard care helps people who recently had a heart attack. The goal was to see if it reduces cholesterol and inflammation in the heart and blood vessels. 100 adults aged 25 to 90 who had a specif…

This study tested whether adding a drug called inclisiran to standard care helps lower 'bad' LDL cholesterol more effectively in people who recently had a heart attack. About 400 participants received either the new care pathway including inclisiran or usual care alone. The goal …

This study tested whether adding a special pressure wire measurement (FFR) to standard angiography helps doctors decide the best treatment for people with multiple blocked heart arteries. Over 900 patients were randomly assigned to get either angiography alone or angiography plus…

This completed study tested whether SGLT2 inhibitors (dapagliflozin or empagliflozin), taken daily, can reduce heart failure hospitalizations, repeat heart attacks, and death in 450 non-diabetic patients who had a heart attack treated with stenting. Participants received the drug…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack a…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This study tested whether an AI-powered smart stethoscope can accurately detect structural heart disease in over 6,600 students aged 10-18 in China. Trained staff used the device to listen to heart sounds, and the AI flagged potential issues. Students with positive results, plus …

This study tested a new contrast agent called NH002 in 36 adults with heart disease. The agent is used during heart ultrasound to make the heart's chambers and borders clearer. The main goal was to check safety by monitoring vital signs, heart activity, and allergic reactions aft…

This study tested a new software program that analyzes heart angiogram images to measure blood flow blockages without needing to insert a pressure wire into the artery. Researchers reviewed the records of 100 patients who had both an angiogram and an invasive pressure measurement…

This study tested a portable, unshielded magnetocardiography (MCG) device in the emergency department to see if it could reliably detect heart attacks. 124 patients with symptoms of acute coronary syndrome participated. The main goal was to see if the device could collect usable …

This study tested whether a clinical decision rule, combining a 5-question heart score with a rapid blood test, could safely reduce unnecessary hospital referrals for chest pain. Nearly 950 adults with new chest pain were seen by their general practitioner. The goal was to see if…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested whether a non-invasive procedure called remote ischemic preconditioning (RIPC) can prevent kidney damage caused by contrast dye in diabetic patients undergoing coronary angiography. The procedure involves using a blood pressure cuff to briefly restrict blood flo…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study tested whether acupressure, a technique that applies pressure to specific points on the body, can reduce anxiety and improve vital signs like blood pressure and heart rate in people hospitalized with acute coronary syndrome (ACS). Sixty-eight adults with a first-time A…

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested whether wearing an eye-ear sleep band, which blocks light and noise, could improve sleep quality in 100 adults admitted to a coronary care unit with acute coronary syndrome. Each patient spent one night with the band and one night with standard care, in random o…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested whether adding a tramadol injection to a continuous local anesthetic (levobupivacaine) delivered through a wound catheter can reduce the need for morphine after heart surgery via sternotomy. 160 adults undergoing various heart surgeries were enrolled. The goal w…

This study tested a breathing exercise called the active cycle breathing technique in 120 adults who had just had heart surgery. The exercise combines controlled breathing, deep breaths, and huffing or coughing to help clear the lungs and improve breathing. Researchers measured w…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study tested whether specially designed educational videos, sent through a mobile messaging app, could help people with coronary heart disease improve their fitness and heart health knowledge during a 12-week home-based cardiac rehabilitation program. Twenty-one participants…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looked at how well two types of stents (small mesh tubes) placed in heart arteries after a heart attack become covered by the body's own cells. 22 people who had a heart attack were randomly assigned to get either a SYNERGY stent or a bioresorbable scaffold. Doctors us…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This study looked at whether certain cells and substances in the blood can help predict if a person who has had a heart attack or unstable angina will have another heart problem within a year. Researchers took blood samples from 180 patients and tracked their health for one year.…

This study aimed to make heart rate monitors more accurate for people with heart conditions. Researchers collected data from 138 participants, including cardiac patients and athletes, using Fitbit and Polar devices over 13 weeks. The goal was to remove false readings and develop …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looked at how well hospitals follow the standard protocol for giving heparin, a blood thinner, to patients with blood clots or heart issues. Researchers checked 100 patients to see if their heparin doses were adjusted correctly based on blood test results. The goal was…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study combined data from over 5,000 people to see if a simple blood test (troponin) and risk scores used by paramedics can accurately identify those having a heart attack before they reach the hospital. The goal is to improve how patients are triaged and treated early. No ne…

This study tested whether giving heart attack patients remote monitoring devices to use at home could reduce the need for hospital readmissions. 337 participants with high cardiovascular risk took part. The goal was to see if telemedicine could safely provide necessary diagnostic…

This study reviewed medical records of 139 people with advanced chronic kidney disease who had a heart attack. Researchers wanted to see if getting a coronary angiogram (a special X-ray of the heart arteries) soon after the heart attack was linked to living longer and needing dia…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at 552 people hospitalized with acute coronary syndrome, a serious heart condition. Researchers calculated a value called the leukoglycemic index (LGI) from routine blood tests and compared it to the SYNTAX score, which measures how complex the coronary artery d…

This study tested a new combination of very low-dose aspirin (20 mg twice daily) plus a blood thinner called rivaroxaban (2.5 mg twice daily) in 48 adults with chronic coronary syndromes. Researchers compared this new regimen to standard aspirin alone (75 mg once daily) and stand…

This study followed over 1,000 people who had a heart attack and were given a quick-acting intravenous blood thinner called cangrelor during a procedure to open blocked arteries. Researchers wanted to see how often bleeding occurred when patients then switched to a different oral…

This study tested whether a computer-based decision support system (DSS) helps doctors start or intensify cholesterol-lowering treatments earlier in patients who have had a heart attack. Over 1,100 patients from multiple hospitals took part. The DSS provided risk estimates but di…

This study looked at how long people who had a heart attack should take two blood-thinning medicines (aspirin plus a second drug). About 5,000 patients were randomly assigned to shorter or longer treatment. The goal was to find the best balance between preventing another heart at…

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This study looked at how Chinese Americans talk about advance care planning—decisions about end-of-life care—with their families. Researchers interviewed religious leaders, patients with chronic diseases, and family caregivers in Chicago to understand their needs and readiness. T…

This study looked at how different blood-thinning drugs are used in Italian hospitals for patients having a heart attack. Researchers collected information from over 2,800 patients to see which drug combinations and timing doctors actually use. The goal was to describe current pr…

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study combined data from over 1,700 patients who had a heart attack or unstable angina and underwent a special imaging test (OCT) of their heart arteries. Researchers aimed to find factors that predict plaque erosion, a common cause of heart attacks. The goal is to better un…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study looked at whether a 6-minute stepper test (ST6) can accurately measure exercise tolerance in people with heart conditions undergoing rehabilitation. Researchers compared the stepper test results with the standard 6-minute walk test and a cardiac stress test in 60 patie…

This study looked at 1,655 people who had a heart attack or unstable angina (acute coronary syndrome) to create a personalized risk model. Researchers used medical tests, genetic information, and other health data to predict who might have worse outcomes or complications from tre…

This completed study of 88 heart attack patients looked at why some develop kidney injury after receiving contrast dye during a procedure to open blocked arteries. Researchers analyzed medical records to find which factors—like age, lab results, or procedure details—were linked t…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at 10,000 people who came to the emergency room with chest pain. Researchers tested new blood markers to see if they could diagnose heart attacks faster than current methods. The goal is to help doctors quickly rule out or confirm a heart attack, especially in t…

This study looked at 2000 adults with early heart disease to understand how inherited high cholesterol (familial dyslipidemia) contributes to heart attacks. Researchers reviewed medical records to find patterns in cholesterol levels. The goal was to highlight the need for better …

This study looked at whether using a thin, 7-French sheath through a small artery in the wrist is safe and effective for opening blocked heart arteries. 100 adults with heart disease took part. The goal was to see if this approach causes fewer bleeding or artery problems while st…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study looked at 207 older adults (65+) who came to the emergency room with a heart condition called acute coronary syndrome. Researchers measured their usual physical activity levels using a questionnaire and tracked their heart health over time. They found that people who w…

This study looked at 407 people with a type of heart attack called NSTEMI to see if getting a heart procedure (coronary angiography) within 24 hours leads to better outcomes. Researchers checked how well following this timing guideline predicted death, another heart attack, strok…

This completed study looked at how levels of C-reactive protein (CRP), a marker of inflammation, change in 35 patients having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points up to 30 days after. The goal was…

This completed study looked at 1,000 heart attack patients to understand why some have no standard risk factors like smoking, high blood pressure, or diabetes. Researchers compared these 'SMuRF-less' patients to those with risk factors, examining their medical history, lab tests,…

This completed study looked at 1029 patients who had a heart attack or unstable angina and quit smoking. Researchers checked for certain gene mutations (called CHIP) in their blood. They wanted to see if these mutations are linked to a higher chance of future heart problems, like…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a machine called ECMO (which pumps and oxygenates blood). Researchers measured how well the heart was pumping at 28 days and 90 days after the arrest. The goal was to understand if…

This completed study looked at how different doses of aspirin, given with or without another drug called ticagrelor, affect the body's immune response. Healthy volunteers took the medications for 10-14 days, then received an injection that causes temporary flu-like symptoms to te…

This study monitored brain oxygen levels and electrical activity in 15 children aged 6 to 36 months during open heart surgery. Sensors placed on the forehead measured oxygen and brain waves every 5 minutes. The goal was to understand how these measurements relate to each other, w…

This early-stage study tested two blood-thinning drugs, vicagrel and clopidogrel, in 18 healthy adults with a specific gene type (CYP2C19 normal metabolizers). The goal was to compare how the body absorbs and processes each drug. Researchers measured drug levels in the blood and …

This study looked at 362 adults who had a heart attack to understand why they waited before going to the hospital. Researchers collected information on symptoms, travel time, and other barriers. The goal is to find patterns that can help doctors and communities reduce delays and …

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…