New pain combo could cut morphine use after Open-Heart surgery

NCT ID NCT02851394

Completed Symptom relief Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a tramadol injection to a continuous local anesthetic (levobupivacaine) delivered through a wound catheter can reduce the need for morphine after heart surgery via sternotomy. 160 adults undergoing various heart surgeries were enrolled. The goal was to see if this approach lowers morphine consumption and related side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tramadol and levobupivacaine
What this could lead to: If it works, this could provide a better way to manage pain after heart surgery, reducing the need for morphine and its side effects.
What could go wrong: This is a small, single-center Phase 4 trial, so results may not apply broadly. The combination might not significantly reduce morphine use or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART SURGERY VIA STERNOTOMY POST OPERATIVE ANALGESIA

Contacts and locations

Locations

CHU Dijon Bourgogne

Dijon, 21079, France

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