Could a simple injection cut morphine use after Open-Heart surgery?
NCT ID NCT02851394
First seen Feb 06, 2026 · Last updated Jun 23, 2026 · Updated 20 times
Summary
This study tested whether adding a tramadol injection to a continuous local anesthetic (levobupivacaine) delivered through a wound catheter could reduce the need for morphine after heart surgery. 160 adults undergoing sternotomy were enrolled. The goal was to see if this combination lowers morphine consumption and related side effects.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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CHU Dijon Bourgogne
Dijon, 21079, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tramadol and levobupivacaine
What this could lead to
If it works, this could lead to a better way to manage pain after heart surgery, reducing the need for morphine and its side effects.
What could go wrong
This is a completed Phase 4 trial, so results are known. The benefit may be small, and tramadol carries its own risks like nausea or dizziness.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.