ANXIETY

This study tests a program called Project YES+ for youth aged 15-21 living with HIV in Zambia. It combines peer mentoring with a mental health approach to reduce stigma from HIV, violence, and mental health issues. The goal is to help them stick with their HIV treatment and impro…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Participants will have at least one risk factor for dementia, such as high blood pressure or memory concerns. The goa…

This study tests a pharmacy-led program to help low-income patients with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to help with follow-up care. …

This study tests a 9-week online program designed to help families of LGBTQ+ youth of color become more supportive and less rejecting. Researchers will measure changes in depression, anxiety, drug use, and other risks in 180 youth aged 14-25 and their caregivers. Half the familie…

This study tests a new way to train youth mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. About 96 teens aged 12-17 and their parents, along with mentors and supervisors, will take part. The goal is to see if the trai…

This study tests a virtual reality game called E-Emotio to help children aged 10 to 16 improve how they manage their emotions. The goal is to prevent anxiety and depression by making emotional control training fun and engaging. About 160 kids will either play the emotion-training…

This study tests a program called FOREST that teaches positive emotion skills to staff at a violence prevention agency. The goal is to reduce burnout, depression, and anxiety while boosting well-being and job retention. About 100 employees will learn these skills over nine months…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience to prevent substance abuse, intima…

This study explores whether reading specially designed storybooks can teach kindergarteners coping skills to prevent anxiety. About 56 children in Singapore will participate, and researchers will measure changes in coping and anxiety levels. The goal is to see if this simple, non…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, or stressed. About 68 students will either use the app plus standard campus care, or just standard care alone. The app includes daily mood check-ins, weekly surveys…

This study tests an online group therapy program (cognitive behavioral therapy) for people with cystic fibrosis and their caregivers. The goal is to see if it helps reduce symptoms of depression, anxiety, and other mental health challenges. About 52 participants will be randomly …

This study tests a two-week smartphone app program designed to help people who have trouble feeling pleasure (anhedonia), along with symptoms of depression, anxiety, and stress. Participants will do three short daily exercises, such as savoring positive moments or practicing grat…

This study looks at whether a procedure called a cervical sympathetic block can reduce PTSD, anxiety, and other trauma-related symptoms in Special Operations Veterans. About 75 veterans will receive the block alone or with added therapy. The goal is to see if this approach provid…

This study tests whether a single session of cardiac coherence—a slow, paced breathing technique—can reduce anxiety in patients before an MRI scan. Researchers will enroll 60 adults who are very nervous about their MRI and measure their anxiety levels and scan quality. The goal i…

This study tests an online self-help program for current or former public safety personnel (like police, firefighters, paramedics) who experience depression, anxiety, or post-traumatic stress. About 164 participants will use a web-based cognitive behaviour therapy course from hom…

This study tests whether taking high doses of vitamin B6 can change brain activity and reduce symptoms of anxiety and depression. Researchers will compare a group taking vitamin B6 to a group taking a placebo. The study involves 44 adults aged 18 to 40 with mild to moderate anxie…

This study looks at whether a specific breathing practice called SKY breath meditation can help college students manage stress and anxiety. About 53 students will be split into two groups: one learns SKY breathing, the other does general yoga without special breathing. Over 8 wee…

This study explores whether using virtual reality (VR) can lower anxiety and improve the treatment experience for cancer patients receiving radiotherapy. About 150 adults with cancer who are getting radiation at the University of Miami will be randomly assigned to watch a standar…

This study tests whether a nasal spray containing midazolam can quickly reduce sudden anxiety in adults receiving palliative care. About 36 participants will receive either the drug or a placebo, and their anxiety levels will be measured before and after treatment. The goal is to…

This study tests a free, online single-session therapy for teens aged 12-17 in Hong Kong who are waiting for mental health care. The goal is to quickly reduce symptoms of depression and anxiety, and help teens feel more ready for future in-person therapy. About 124 participants w…

This study looks at whether mindfulness-based treatments can help first-generation college students in rural areas feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or psychoeducation. Researchers will …

This study looks at whether doing relaxation exercises with a therapeutic clown can help lower fear and anxiety in children before they have surgery. The study includes 162 children aged 6 to 10 who are getting circumcision. Some children will do the exercises with a clown, some …

This study tests whether a mobile app called JoyPop can help 110 youth aged 12-17 who are on a waitlist for mental health services. Participants will either use the app or continue with usual care while they wait. The goal is to see if the app improves emotion regulation and redu…

This study tests whether a probiotic called Clostridium butyricum can improve anxiety and depression in people with functional dyspepsia (a stomach disorder with no clear cause). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach med…

This study is testing whether listening to specially chosen music every day for 4 weeks can help reduce anxiety and depression in people who have recently had a stroke. About 132 participants will either receive the music therapy plus standard care, or standard care alone. The go…

This study tests two types of online therapy for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of PTSD, anxiety, or depression. Participants can choose which therapy they prefer. The goal is to see if online therapy helps reduce sy…

This study tests a noninvasive, personalized brain stimulation treatment (TMS) for people aged 18-65 with chronic symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will have a 66% chance of receiving active TMS and …

This study tests whether wearing a virtual reality headset during a common kidney stone procedure (ESWL) can lower pain and anxiety. About 72 adults will be randomly assigned to either standard care or standard care plus VR. Researchers will measure pain levels, anxiety, and how …

This study tests whether a natural herb called ashwagandha can help reduce stress, anxiety, and improve sleep in LGBTQ+ adults who face ongoing stress due to stigma or discrimination. About 80 adults aged 18-45 will take either ashwagandha capsules or a placebo for 8 weeks, and r…

This study compares two ways to help children aged 5 to 7 feel less anxious during dental numbing shots. One group gets the standard tell-show-do explanation from the dentist, while the other watches a short AI-generated avatar video that explains the procedure in a kid-friendly …

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue in people with sarcoidosis. It also looks at effects on anxiety and depression. About 100 adults with sarcoidosis and fatigue will either join the MBSR program or a mon…

This study looks at whether music therapy can improve mental health and social connections in university students who are feeling depressed, anxious, or stressed. Twenty students will be randomly assigned to either a music therapy group (writing songs) or a control group (listeni…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. About 93 adults will be randomly assigned to different treatment combinatio…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty terminally ill patients will receive either two doses of LSD or a very low-dose active placebo. The goal is to improve psycholog…

This study tests if text messages can help people with Generalized Anxiety Disorder worry less. Researchers will compare a text-based program that helps people stop worry-related habits to a relaxation technique. 300 adults with high worry levels will participate.

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants must have poor sleep for at least 2 week…

This study looks at whether playing your own choice of music during wide-awake hand surgery can lower anxiety more than standard relaxation music. About 170 adults having hand surgery with only local anesthesia will be randomly assigned to one of two music groups. Researchers wil…

This study tests a 10-week online group program for adults with spina bifida. Participants join weekly video sessions to build self-esteem, social skills, and reduce anxiety or depression. The goal is to improve quality of life and emotional well-being. About 35 people aged 18-75…

This pilot study looks at whether a telehealth program can help family members of ICU survivors cope with anxiety, depression, and PTSD. About 150 participants will use an online platform and have health check-ins. The goal is to see if this approach is practical and helpful for …

This study tests whether personalized music playlists can lower stress, anxiety, and depression in adults. 2000 participants will be randomly assigned to either listen to custom playlists or receive no music intervention. The goal is to see if music can be a simple, non-drug tool…

This study tests a coaching program that helps young adults who have finished cancer treatment talk more easily with their friends. The goal is to reduce feelings of anxiety, depression, and loneliness. Ten survivors will try the program, and researchers will see if it works and …

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain drug) for reducing pain and anxiety after spine surgery. About 105 adults aged 21-60 having elective spine surgery will be randomly assigned to receive one of the two medicines.…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in women undergoing breast biopsies. About 600 women will be randomly assigned to one of three groups: VR, music, or usual care. Researchers will measure anxiety and pain …

This study looks at whether reducing social media use and replacing it with exercise, or practicing mindfulness, can help college students feel less anxious and depressed. About 300 students who use social media heavily will be split into three groups: one that does nothing diffe…

This study tests whether an 8-session group therapy program, adapted for Turkish culture, can reduce anxiety in university students. About 40 students from Bogazici University will take part. The program uses cognitive behavioral techniques in a group setting to help students man…

This study tests if press needle acupuncture can reduce anxiety in adults before ear surgery. 32 participants will receive either real or sham needles placed on the skin a day before surgery and left in for 3 days. Researchers will measure anxiety levels and heart rate changes to…

This study tests whether a 4-week digital program that sends activity prompts can increase physical activity and reduce depression, anxiety, and stress in adults with moderate depressive symptoms. About 50 participants will be randomly assigned to receive the program or just have…

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will use the app for 8 weeks, and researchers will track their sleep, mood, fatigue, and signs of inflammation. The goal …

This study looks at whether listening to music for 10 minutes while in labor can lower anxiety and pain and boost satisfaction. About 106 women in labor will either listen to music or have no music. They will rate their anxiety and pain and answer questions about how satisfied th…

This study tests whether an artificial intelligence (AI) program can help people on dialysis feel less anxious and better cope with stress. Sixty adults will use personalized relaxation techniques guided by AI during their dialysis sessions. Researchers will measure changes in an…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health in women waiting for IVF treatment. 120 participants will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no treatment. The goal…

This study is testing an online educational program called On-Trac (Online Training After Cancer) to help adult cancer survivors cope with anxiety. The program teaches strategies based on cognitive-behavioral therapy and acceptance commitment therapy. Researchers will enroll 80 p…

This study looks at whether a 15-minute Emotional Freedom Technique (EFT) session can lower anxiety in mothers waiting for their newborn's first hearing test. About 70 parents will be randomly assigned to either do a structured tapping sequence or just wait. Anxiety levels are me…

This study tests whether listening to binaural beats (special sound patterns) or your favorite music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. Fifty adults having these surgeries will be randomly assigned to one of the two listening options.…

This study tests a simple, 3-session expressive writing program to help sexual minority veterans cope with stress related to their identity and reduce symptoms of depression and anxiety. Researchers will enroll 85 veterans who identify as gay, lesbian, bisexual, or queer and have…

This study tests a group therapy method called I-Reconstruction to see if it helps adults with anxiety feel better. About 36 people will take part in 10 weekly online sessions with breathing exercises and group discussions. Researchers will compare them to people getting usual ca…

This study tests a virtual program called MOVIN that helps pregnant people and new parents manage depression and anxiety. About 570 participants will use an online platform to work with a care coordinator and get personalized treatment plans. The goal is to see if this approach i…

This study tests whether letting children aged 3 to 5.5 years watch a 3-minute virtual reality video of the clinic before their checkup can reduce their anxiety and stress. About 100 children will either use VR goggles or wait as usual. Researchers will measure crying, pain, and …

This study tests an online sleep course for adults who have trouble falling or staying asleep, and feel tired or distressed during the day. About 56 people from Saskatchewan will take part. The course teaches healthy sleep habits and thinking patterns, and researchers will check …

This study looks at whether coloring nature or geometric shapes can help adults feel less pain and anxiety while waiting in the emergency department. About 168 people with moderate pain or anxiety will be asked to color and then report how they feel. The goal is to find a simple,…

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania who are dealing with depression, anxiety, or stress. About 40 teens aged 13-18 will take part. The goal is to provide a low-cost, ac…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can help cancer survivors who feel depressed or anxious. Twenty adults who have finished cancer treatment and have no brain tumors will receive the drug in a controlled setti…

This study tests a new type of talk therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults (ages 18-35) with anxiety or depression. The therapy focuses on how a person sees themselves and others, aiming to be more engaging and personalized than standard tre…

This study tests whether using a virtual reality headset (REALICA) can lower pain and anxiety in people having common urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults will use the VR device during their procedure and report their anxiety and p…

This study tests two resilience-building programs for cardiac arrest survivors and their caregivers. The goal is to reduce anxiety, depression, and emotional distress while improving quality of life. About 84 pairs (survivor plus caregiver) will participate in a series of session…

This study tests if teachers can be trained to provide mental health support to teenagers in rural India. About 216 students from 60 low-cost private schools will take part. The goal is to see if this approach can reduce depression and anxiety symptoms and be a sustainable way to…

This study looks at whether Parent-Child Interaction Therapy (PCIT) can help parents of children aged 2-7 who have behavioral concerns. Researchers will measure changes in anxiety, depression, stress, and even oxytocin levels using surveys and saliva samples. The goal is to see i…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical and mental health in women veterans aged 18-45. Participants will play VR games that involve physical movement, and researchers will measure changes in depression, anxiety, PTSD, …

This study tests whether using a stress ball can lower pain, anxiety, and changes in heart rate and blood pressure during chest tube removal after open heart surgery. About 46 adults who have one chest tube will be randomly assigned to either squeeze a stress ball or receive stan…

This study tests whether using a virtual reality (VR) headset before surgery can reduce anxiety, stress, and pain. About 172 adults having elective surgery will either use VR or receive standard care. Researchers will measure anxiety through questionnaires and brain activity to s…

This study tests whether a probiotic called Bacillus coagulans can improve anxiety and depression in people with functional dyspepsia (a stomach disorder with no clear cause). About 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach …

This study tests whether a free online program from the World Health Organization, called Doing What Matters in Times of Stress, can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with elevated stress will either get t…

This study looks at whether giving both poverty relief and depression treatment helps low-income rural women in Bangladesh more than depression treatment alone. About 680 women aged 18-45 with depression and financial hardship will take part. Researchers will check depression lev…

This study tests a 6-week group program called Emotion Focused Family Therapy (EFFT) for parents of children aged 7-15 with anxiety, depression, or behavior challenges. The program teaches parents skills to support their child's emotions and behavior. Researchers will compare par…

This study tests a group therapy program designed to help young adults (ages 18-29) who struggle with uncertainty and anxiety. The therapy combines cognitive-behavioral techniques with an ecological systems perspective. Researchers will measure changes in intolerance of uncertain…

This study looks at whether adding nuts to the diet can improve mental health in young adults. Researchers will measure changes in depression, anxiety, stress, memory, and thinking skills in 135 university students aged 18 to 25. Participants will eat nuts or follow their usual d…

This study looks at whether giving a small amount of the sedative midazolam during surgery can help prevent confusion (delirium) and anxiety in older patients. About 612 people aged 65 to 85 having non-heart, non-brain surgery will be randomly assigned to receive either midazolam…

This study tests a program called M-O-M-S for pregnant women living in areas hit by natural disasters. The program uses group classes led by experienced mothers (mentors) to help reduce anxiety and depression during pregnancy. Researchers will enroll 240 women and measure changes…

This study tests whether using a virtual reality (VR) headset with a guided meditation program can reduce pain, anxiety, and distress in men during a vasectomy. About 90 adult men will be randomly assigned to either use VR during the procedure or receive standard care. Researcher…

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds extra support from a care manager to usual neurology care, aiming to improve emotional well-being and quality of life. Participants must be 18 o…

This study tests two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep. The goal is to find the best way to improve recove…

This study tests whether a short hypnosis session before a cardiac MRI can improve image quality in patients who feel anxious. Researchers will compare scans from 90 anxious and non-anxious adults. The goal is to see if calming patients with hypnosis reduces movement and artifact…

This study looks at whether painting mandalas during chemotherapy can help reduce anxiety, nausea, and improve comfort. It involves 120 adults receiving chemotherapy for the first time. Half will color mandalas for at least 30 minutes during treatment, while the other half will r…

This study looks at whether a low dose of oral ketamine can help reduce anxiety in people with pancreatic cancer. About 20 participants will receive either ketamine or a placebo in a crossover design, meaning everyone gets both treatments at different times. The main goal is to s…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method works better at getting patients to start a telehealth program that offers counseling and support. About 30 adults being treat…

This study tests a new digital therapy program designed to help people with anxiety or depression return to work. The program combines mental health support with work-focused strategies. Researchers will enroll 400 adults who are on sick leave and receiving mental health care. Th…

This study tests a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults aged 40-79 who have had a stroke and are dealing with anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. Ten participants will us…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face depression, anxiety, and PTSD, but mental health care is hard to access. The app aims to reduce these symptoms and improve quality of…

This study tests a new group program called BEAR for women who have experienced trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Researchers want to see if it's possible to run this…

This study tests whether adding special content about loneliness to an internet-based therapy program (the Wellbeing Course) helps people with depression and anxiety feel better. About 494 adults in Saskatchewan who often feel lonely will take part. Over 8 weeks, they will comple…

This study tests whether an online recovery education and support program, led by trained teen peers and support specialists, can help teens aged 15-18 who were recently hospitalized for suicidal thoughts, depression, or anxiety. Participants are split into two groups: one gets t…

This study is testing whether watching a short animated video about a nail biopsy procedure can help people feel less anxious, understand the procedure better, and be more satisfied with their care. About 30 adults who need a nail biopsy will take part. Half will watch the video …

This study tests a 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce anxiety, depression, and stress while improving quality of life and coping skills. About 160 students will participate, and the program is free.

This study tests whether a psychedelic drug called psilocybin, given in a group retreat setting, can safely reduce anxiety and depression in people with incurable cancer. The drug is thought to help by resetting brain patterns that cause distress. The trial will enroll 18 adults …

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can better reduce cravings, withdrawal symptoms, and anxiety in psychiatric patients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be rand…

This study tests a manual technique called cutaneous resonance stimulation (RESC) to reduce anxiety in 62 people awaiting heart surgery. Participants will receive either real RESC or a fake version, and researchers will measure changes in stress-related body signals like heart ra…

This study tests whether a marijuana-based drug (mostly CBD with a small amount of THC) can reduce anxiety in adults with autism. About 108 participants will take the drug or a placebo daily for 8 weeks, tracking their feelings in a diary. Researchers will check for changes in an…

This early-stage trial tests a generative AI chatbot called Therabot-CALM to see if it is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen adults will use the app for 4 weeks and give feedback through interviews and surveys.…

This study is tracking 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep problems, anxiety, depression, or epilepsy. Researchers will use standard questionnaires to measure changes in symptoms over 24 weeks. The goal is to see how well medical cann…

This study tests a 6-week internet-based mindfulness program for adults with chronic tinnitus (ringing in the ears) who feel distressed by it. Researchers will compare the program to a waitlist group and measure changes in tinnitus distress, anxiety, and depression. The goal is t…

This study tests whether a 6-week group training in nonviolent communication (NVC) can improve mental well-being and reduce stress, anxiety, and depression in parents of primary-school-age children. About 172 parents with mild to severe symptoms will be randomly assigned to take …

This study looks at whether listening to low-intensity, calming music can reduce anxiety in teenagers. Researchers will measure changes in anxiety symptoms, heart rate, and brain activity in 60 participants aged 18-25. The goal is to find a gentle, side-effect-free way to help te…

This study looks at whether combining neurofeedback (a brain training technique) with mindfulness can lower anxiety and stress in nursing students. About 36 students will try this approach for 4 weeks. The goal is to see if it helps them feel better and do better in school.

This study tests an online program called MY-CHOICE for adults with ischemic heart disease who also have anxiety or depression. The program includes personalized online modules and optional video or phone calls with a therapist over 6-12 weeks. Researchers want to see if the prog…

This study tests whether a guided mental health app called SilverCloud can help teens with depression or anxiety. About 120 high school students will either use the app or get usual care. Researchers will check if symptoms improve and if the app is easy to use in schools.

This study looks at whether watching animated films or reading storybooks can lower fear and anxiety in children ages 7-12 who have just been diagnosed with type 1 diabetes. About 64 children will take part, and researchers will measure their anxiety and fear levels using special…

This study is testing a 7-week online program called My Wellbeing Guide to see if it can reduce depression and anxiety in cancer patients. About 6,500 adults with cancer and high depressive symptoms will be randomly assigned to use the program or a control app with resource links…

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study tests a mobile app program called PRISM to help teens and young adults (ages 12-25) who have finished cancer treatment learn skills to manage stress and build resilience. Participants will use the app for six sessions and complete surveys about their well-being. The go…

This study tests a telemedicine program called RxWell that teaches coping skills to manage mood and pain after knee or hip replacement. About 150 adults with anxiety or depression symptoms will use the program before and after surgery. The goal is to see if it reduces the need fo…

This study tests whether a mindfulness program delivered through a mobile app can help reduce anxiety in older adults (60+) with serious illnesses like cancer or heart disease, and their caregivers. About 162 participants will use the app at home. The goal is to find a simple, ac…

This study tests whether an online, therapist-guided therapy for chronic insomnia can also reduce anxiety symptoms and improve emotional health. About 98 adults with both insomnia and anxiety will be randomly assigned to start the therapy immediately or after a delay. Participant…

This study tests an online parenting program for 500 Filipino families in California. Parents take a virtual class to learn positive discipline, while children report their depression and anxiety symptoms. The goal is to see if the program improves parenting and reduces kids' emo…

This study tests whether a nutritional supplement called 'Think Tank' can help middle-aged women (40-60 years old) think better after experiencing stress. Forty healthy female daily caffeine drinkers will take either the supplement or a placebo and then complete thinking and memo…

This study compares two group therapies for university students aged 18-28 who have moderate anxiety and depression. One therapy, Acceptance and Commitment Therapy (ACT), teaches skills to handle difficult feelings and live by personal values. The other is a supportive group that…

This study tests whether a short virtual reality hypnosis session during a coffee break can lower anxiety in nurses working day shifts. Fifty-six nurses will either use VR or take a regular break, and their anxiety levels will be compared. The goal is to see if this simple, drug-…

This study tests if adding a short therapy for fear of uncertainty to standard firearm safety counseling helps military members store guns more safely. About 100 active or recently discharged service members who own an unlocked, loaded firearm will take part. They will attend two…

This study looks at whether showing children an interactive movie while they wait for anesthesia can lower their anxiety. About 70 kids aged 2 to 6 will either get the movie distraction or standard care. Researchers will measure anxiety levels using a special scale.

This study looks at whether adding an antidepressant (escitalopram) to standard psoriasis medication (methotrexate) works better than methotrexate alone for people who have both psoriasis and depression or anxiety. About 40 adults with moderate-to-severe psoriasis and mood issues…

This study tests an internet-delivered therapy course designed to help new and expecting parents manage symptoms of anxiety and depression. Over 8 weeks, 60 participants will review online materials and complete questionnaires. The goal is to see if this approach is practical and…

This study compares two types of exposure therapy for spider phobia: in-person (live spider) and videochat (watching someone else handle a spider). About 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting list. The goal is to see which me…

This study tests whether natural supplements (lavender oil, PEA, and OEA) can improve sleep and reduce stress in adults with moderate sleep problems and stress. About 240 generally healthy adults will take a daily capsule for 8 weeks, comparing three active supplements to a place…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teenage refugees. About 80 participants aged 14 to 18 will be randomly assigned to either the START NOW program or standard care. Researchers will compare c…

This study tests whether using virtual reality (VR) can help patients feel calm before heart surgery, reducing their need for anxiety medication. About 40 adults who request medication for pre-surgery nerves will try VR instead. The goal is to see if VR can provide comfort while …

This study tests a computerized anxiety sensitivity treatment (CAST) in 388 older adults with mild cognitive impairment or mild Alzheimer's disease and their care partners. Participants attend two treatment sessions and are followed for six months. The goal is to see if CAST redu…

This study tests whether the JoyPop app can help Indigenous youth aged 18-25 in Northwestern Ontario manage emotions, depression, and anxiety while they wait for mental health services. About 110 participants will use the app or continue with usual care. The goal is to see if the…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) works better when combined with virtual reality (VR) for burn survivors. About 34 adults who have had a burn injury for at least 6 months and still have symptoms like pain, itch, or sleep p…

This pilot study tests a wearable brain stimulation device (tACS) for anxiety in up to 40 veterans under age 70. Participants use the device at home after an in-office training session. The study measures whether the treatment is practical, safe, and helps reduce anxiety, depress…

This study tests whether combining foot reflexology with a cold pack before chest tube removal can lower pain and anxiety in heart surgery patients. About 108 adults who had bypass surgery will be randomly assigned to receive the combined treatment or standard care. The goal is t…

This study tests whether a tonic called Feel Free® Classic can help healthy adults feel less stressed. About 165 people aged 21-55 with mild to moderate stress will take the tonic or a placebo for 29 days. Researchers will measure stress levels and how the body processes the toni…

This study tests a brief group therapy program (ACT-i) for adults with chronic insomnia who also have mild depression or anxiety. About 76 people will be randomly assigned to either the therapy or a control group. Researchers will check sleep quality, mood, and thinking before tr…

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study looks at whether a type of therapy called cognitive analytic therapy guided self-help (CAT-GSH) works as well as the standard cognitive behavioural therapy guided self-help (CBT-GSH) for people with anxiety or depression who are coming back for more help. About 100 par…

This study tests whether a non-invasive brain-training technique called neurofeedback can reduce anxiety in women who have had multiple pregnancy losses. Sixty-two women will either receive real or sham neurofeedback while listening to a slow pulsing tone, plus standard counselin…

This study looks at whether a multimedia education program (like videos and interactive materials) can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to receive either standard instructions or the multi…

This study tests a short, guided self-help program called Self-Help Plus for university students who are behind on at least 3 exams and feeling significant distress. About 210 students will be randomly assigned to the program or usual support. The goal is to see if the program re…

This study tests whether buspirone, a medication used for anxiety, can reduce withdrawal symptoms and cravings in people with opioid use disorder. About 100 adults will stay in a clinic for 10-12 days while their opioid dose is slowly reduced. The goal is to see if buspirone make…

This study tests a group mental health program delivered by phone or video for adults 55 and older who feel lonely, isolated, or have anxiety or depression. About 128 participants across four Canadian provinces will either join the program or continue their usual community activi…

This study tests a new online, self-guided course based on dialectical behavior therapy (DBT) for adults with mild-to-moderate depression or anxiety. Up to 40 participants in Ontario will use the 8-week program and complete surveys to see if it is easy to use and helpful. The goa…

This study tests if a four-week internet-based cognitive behavioral therapy (iCBT) program can reduce anxiety in people who struggle with MRI scans. Sixty adults who have trouble with MRIs will be randomly assigned to receive the therapy either before or after a simulated MRI ses…

This study compares music therapy using Music Care tablets to a gas mixture (EMONO) for reducing anxiety in 128 people with low back pain undergoing a CT-guided spinal injection. Participants will be randomly assigned to listen to music or inhale the gas during the procedure. The…

This study tests whether a special, soothing way of talking called hypnotic communication can help patients feel less anxious and stressed during a heart catheterization. About 306 adults will be randomly assigned to receive either this calming talk plus usual care, or usual care…

This study tests whether a smartphone app called JoyPop can help young adults (ages 18-25) better manage their emotions, anxiety, and depression while they wait for mental health services. About 110 participants from Northwestern Ontario will either use the app or continue with u…

This study tests three versions of internet-delivered cognitive behaviour therapy (ICBT) for college and university students with mild to moderate depression or anxiety. About 200 students in Saskatchewan can choose a 5-week, 8-week, or flexible course, all with optional therapis…

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which one works better for autistic adults with depression or anxiety. About 300 participants from North Carolina and Virginia will receive therapy sessions …

This study looks at two ways to decide the best treatment for anxiety and depression in 1,000 community college students. Participants will be placed into one of three care levels: self-guided online help, coach-guided online therapy, or care from a clinician. The goal is to see …

This study tests whether an online therapy program can help children aged 8-17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. About 30 children and their parent…

This study looks at whether showing children a short animated video of the pin removal procedure can reduce their pain and anxiety. About 120 children aged 4 to 12 who had surgery for a broken elbow will be randomly assigned to watch the video or receive standard care. Researcher…

This study looks at whether watching a short AI-generated story video at home can reduce fear and anxiety in children aged 4 to 10 before their first skin prick test for allergies or asthma. About 100 children will be randomly assigned to either watch the video or receive standar…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help adult children of genocide survivors who suffer from depression or anxiety. One hundred participants will receive the treatment in a controlled setting. The goal is to se…

This study compares two breathing techniques (cyclic sighing and box breathing) with hypnosis and listening to an audiobook about stress. Researchers want to see if these practices can lower anxiety right away and after four weeks of daily use. About 80 adults will participate, a…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study tests a mental health support program for 150 people who recently left the ICU. The program includes digital tools, coaching, and psychiatric help to reduce anxiety, depression, and PTSD symptoms. Participants are compared to those receiving usual care over six months.

This study tests if a non-invasive brain stimulation technique called rTMS can improve heart rate regulation in women who have had multiple pregnancy losses and also suffer from anxiety. 46 women will receive either real or fake (sham) stimulation in a single session. Researchers…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study tests whether art therapy, delivered through virtual reality glasses or in person, can help reduce anxiety and improve sleep and well-being in people with colorectal cancer who are receiving chemotherapy. 78 patients will be split into three groups: virtual art therapy…

This study is testing a 10-week online psychological treatment program for cancer survivors who are struggling with anxiety, depression, or fear of their cancer returning. It aims to find out which parts of the therapy are most helpful. The program involves 400 survivors in Swede…

This study looks at whether online cannabis ads that claim to help with anxiety or depression make people buy more or stronger products. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. The goal is to se…

This study tests a program called FRAME that helps heart failure patients talk about mental health with their doctors and family. About 7,300 adults with heart failure or at risk for it will take part. The goal is to see if the program makes it easier for patients to get mental h…

This study looks at whether community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to see if this approach works in real-wo…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, including depression, anxiety, and PTSD. Participants will lear…

This study looks at whether patients who are more anxious before surgery are more likely to have a sudden drop in heart rate or blood pressure (vasovagal event) during spinal anesthesia. Researchers will measure anxiety levels in 1500 adults and watch for these events. No treatme…

This study is testing whether a smartphone app can help firefighters improve their sleep, thinking, and overall health. About 50 firefighters will use the app and report on their sleep habits. The goal is to see if the program is easy to use and helpful for this group.

This study compares two web-based apps to see which one better helps Latinas with anxiety or depression start mental health treatment. One app uses an interactive story with a character who gives treatment advice, while the other provides standard information and resources. The g…

This study looks at how fear and anxiety about anesthesia change in people who have never had it before. About 40 adults scheduled for low-risk surgeries will fill out surveys before their procedure and answer follow-up questions a few days later. The goal is to understand if the…

This study is developing and testing a family program adapted for Lakota 2SLGBTQ+ youth (ages 13-18) and their caregivers. The program includes 8 weekly group sessions to improve family relationships and reduce depression, anxiety, and other risks. The main goal is to see if the …

This study looks at how women's feelings about artificial intelligence relate to their anxiety levels and quality of life while undergoing infertility treatment. About 191 women aged 18-45 with infertility will answer questionnaires. The goal is to understand these connections to…

This study looks at whether cognitive remediation (brain exercises with coaching) can improve thinking skills and reduce problem behaviors in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take part. Th…

This study looks at how a park-based afterschool program called Fit2Play affects children's physical fitness and mental health. Researchers will analyze data from about 5,000 kids to see changes in weight, blood pressure, fitness tests, and feelings of anxiety or depression. The …

This study looks at whether analyzing the weekly written stories of people in rehab for drug or alcohol addiction can help track their emotional and mental progress. About 35 adult men in a residential treatment center in Mexico will write about their feelings and challenges, and…

This observational study looks at how controlled sensory stimulation, such as music, affects brain function in people with epilepsy and healthy volunteers. Researchers will map brain networks and measure changes in anxiety and depression. No treatment is given; the goal is to bet…

This study looks at how common sexual problems are in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. Researchers will survey 140 women with relapsing-remitting MS who have a regular partner and are s…

This study looks at what 'visual frailty' means for people aged 60 and older who have age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to create a new assessment tool. The goal is …

This study looks at how people with anxiety or depression react to uncertain situations. Researchers will use a one-time mental exercise to see if it changes decision-making and brain activity. About 140 adults aged 25 to 60 who struggle with uncertainty will take part. The goal …

This study tests a new, non-invasive way to measure brain waves linked to anxiety using a device placed in the outer ear canal. Researchers will give healthy volunteers two different drugs that lower these brain waves to see if the ear device can detect the changes. If successful…

This study looks at whether having control over a virtual environment can change how people experience pain and anxiety. Researchers will test 20 healthy adults by giving them mild heat pain while they are in different virtual settings—some safe, some controllable, and some not. …

This study watches 100 adults with treatment-resistant depression who are taking esketamine nasal spray as part of their normal care. Researchers want to see how well it works, who responds best, and how it affects daily life, work, and mood. They will also look at genetic and br…

This study is a health check for about 363 students and employees at Constructor University Bremen and HAW Hamburg. Researchers will use questionnaires and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects well-being, not…

This study looks at whether teaching parents to interpret ambiguous situations less negatively can reduce anxiety in their children. Researchers will enroll 300 parents and their children (ages 7-12). Parents will use a smartphone app for four weeks to practice thinking in a less…

This study aims to validate a questionnaire (Surgical Anxiety Questionnaire) for Italian cancer patients awaiting surgery. Researchers will enroll 180 adults to test how well the tool measures anxiety. The goal is to help nurses better understand patients' worries and improve car…

This study looks at whether thinking about a supportive person can help people with social anxiety disorder feel less fear. Researchers will show pictures of a loved one or a stranger while giving mild electric shocks to see if the loved one's image reduces fear. The goal is to u…

This study looks at whether a training program that teaches emotional intelligence can help secondary school teachers and students in Dhaka feel less anxious and depressed and improve their overall well-being. About 80 participants will be split into two groups: one gets the trai…

This online registry tracks 550 pregnant women with migraines to see if a nerve-stimulation device (CEFALY) is safe and helpful during and after pregnancy. Participants keep their usual treatments and fill out six short surveys over 12 months. No clinic visits are needed.

This study aims to help families with food insecurity and mothers with depression. Researchers will provide resources like food, rent help, and mental health support to see if it improves the bond between mother and child. The study includes 2,000 caregivers of young children in …

This study tests whether group music training, designed like a game, can help low-income children aged 8-12 who are at risk for depression and anxiety. Over 12 months, researchers will measure changes in resilience, mood, and self-esteem. The goal is to see if a fun, musical acti…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety unlearn fear. Researchers will compare how healthy volunteers and those with social anxiety respond to fear cues paired with either a support figure's image or a stranger's smi…

This study looks at how memory, attention, and other thinking skills relate to work performance and sick leave in people with depression or anxiety. Researchers will give metacognitive therapy with a work focus to 200 patients at risk of sick leave. The goal is to understand if i…

This study observes 1,000 teens aged 12-17 in Miami-Dade County who join a park-based afterschool program. Researchers will track changes in mental health, physical fitness, and resilience over time. The goal is to understand if community park programs can improve overall well-be…

This study looks at whether providing meal kits and nutrition education can improve diet, mental health, and quality of life for adults aged 40 and older with lower incomes. About 120 participants will receive either meal kits plus classes or standard nutrition materials. Researc…

This study tests two school-based programs designed to help teenagers sleep better, with the goal of improving mental health and school performance. About 3000 students aged 13-19 in Swedish high schools will take part, and their results will be compared to students who receive u…

This study tests whether a temporary, non-invasive brain stimulation technique called TMS can change how healthy people respond to stress. About 55 participants will complete tasks during MRI scans, then receive both real and sham TMS on different days to compare effects. The goa…

This study explores whether dream yoga practices, like lucid dreaming, can improve sleep and reduce anxiety. About 70 adults with mild anxiety will learn techniques using virtual reality and home sleep monitors. The goal is to understand how these practices affect brain activity …

This study is testing a mobile phone app called TrueBlue that helps monitor depression and anxiety. It includes 125 adults who are at least 12 weeks pregnant or up to 12 weeks after giving birth. The goal is to see if the app is safe, easy to use, and agrees with standard mood qu…

This study looks at 100 dental students to see if teeth grinding (bruxism), anxiety, and gum health are linked. Participants fill out anxiety questionnaires and get a gum exam. No treatment is given—just observation to understand possible connections.

This study aims to build a system called CAMERA that uses signals from the brain, body, and behavior to measure and predict anxiety and memory. About 40 adults with epilepsy who are already undergoing brain monitoring will participate. The goal is to create a tool that can contin…

This study aims to understand how the brain processes negative emotions and test whether personalized brain stimulation can disrupt these patterns. Researchers will use brain scans to create a map of each participant's negative emotions, then test different types of magnetic stim…

This study looks at how having social support (like a romantic partner nearby) changes how people watch for danger. Researchers will track eye movements and pupil size in 45 adults who have experienced trauma or discrimination. The goal is to understand how past experiences affec…

This study interviews 30 adults who are anxious about their upcoming elective surgery. Researchers want to learn what specifically worries patients, because those concerns can predict long-term pain after surgery. The goal is to use this information to create better, personalized…

This study watches how anxiety levels change in children aged 2 to 12 who are getting radiation therapy for cancer. Researchers at MD Anderson Cancer Center will track safety and emotional responses over time. The goal is to better understand and support young patients during tre…

This study follows 540 adults with solid cancers to track how anxiety and depression change over time. Researchers will look at factors like age, cancer type, and coping style to predict who needs extra support. No new treatment is given—the goal is to learn and improve care.

This study tracks 100 men aged 30-75 who had a heart procedure (stent placement) to see how their erectile function changes over 6 months. Half had a recent heart attack, half had stable chest pain. Researchers will use a standard questionnaire to compare the two groups and under…

This study looks at whether mindfulness and meditation techniques can help mothers of premature babies in the NICU produce more breastmilk and feel less stressed. About 40 mothers will learn mindfulness practices and researchers will measure milk volume, stress hormones, and bond…

This study looks at whether thinking about death can increase feelings of depression and anxiety in healthy adults. Researchers will ask some participants to write about their own death and others to write about dental pain, then compare their emotional responses. The goal is to …

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered online. It aims to help adults in New York State who struggle with worry, rumination, or self-criticism. The study will track changes in attention, emotional control, and mood over 6 th…

This study looks at a telephone service called SUSTAIN that helps older adults (65+) manage depression, anxiety, or chronic pain. Researchers want to find out what factors make the program more effective and whether its benefits last over time. About 4,000 participants will be fo…

This study looks at how getting older and feeling stressed can change the way we remember and find our way around. Researchers will have 85 adults aged 65-80 do a virtual navigation task while their brains are scanned. Some will be put under mild stress to see if it makes them re…