ANXIETY

This study looks at whether adding cognitive behavioral therapy (a type of talk therapy) to standard medication can improve symptoms and daily functioning for people with conditions like anxiety, depression, OCD, PTSD, bipolar disorder, schizophrenia, and personality disorders. A…

This study tests whether a nurse-led program can help women aged 45-64 in Hong Kong better manage their health and use medical resources wisely. Over 1,700 participants will either receive personalized nurse guidance or general health advice. The goal is to improve health confide…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter trainees. About 480 recruits will take part in either an emotion regulation workshop or a standard education session during their aca…

This study looks at the best ways to prevent anxiety and depression in older Latino adults (age 60+) who have mild symptoms but not a full disorder. About 240 participants will join either a health promotion program or a healthy lifestyles education class. Researchers will track …

This study looks at whether a mindfulness program called Mindfulness-Based Childbirth and Parenting (MBCP) can help lower anxiety in pregnant women. About 60 pregnant women with elevated worry will be randomly assigned to either MBCP or a standard childbirth class. Researchers wi…

This study tests a therapy called FIRST, which uses five key principles to help youth manage negative emotions. Researchers will compare FIRST to usual care in 212 youth aged 7-15 with anxiety, depression, trauma, or behavior problems. The goal is to see if FIRST improves mental …

This study tests a small vibrating device held near the needle site to see if it reduces pain and anxiety during blood draws or IV placement. Researchers will compare how children and adults react with and without the device. The goal is to find a simple, drug-free way to make th…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults aged 18-24 who faced early life hardships find it helpful and easy to use. The main goal is to reduce symptoms of anxiety and depression. 44 p…

This pilot study explores whether laughter yoga can reduce depression and anxiety in children with autism spectrum disorder (ASD) and lower stress for their parents. About 66 families with children aged 8-12 will either practice laughter yoga or be placed on a waitlist. The goal …

This study looks at whether two Akashic Records sessions can improve mental health in adults who have felt stressed, anxious, or down in the past year. Participants attend private video sessions with a licensed therapist and complete surveys about their mood and resilience. The g…

This study looks at whether writing about future scenarios (best-case, worst-case, or neutral) can help people with high social anxiety feel better. About 270 adults will do three writing sessions over three weeks online. Researchers will track changes in anxiety and mood to see …

This study tests whether an 8-week virtual music-based relaxation program can help reduce anxiety in teens and young adults who have finished cancer treatment. About 50 participants aged 15-39 with anxiety will take part. The program involves 45 minutes of tailored music relaxati…

This study tests if gentle sound waves aimed at the brain can help manage anxiety. 44 people with high or low anxiety will receive the ultrasound or a fake treatment before a stressful task. Researchers will measure things like heart rate and startle reflexes to see if the sound …

This study looks at whether an 8-week mindfulness program (MBSR) can improve anxiety, depression, stress, and quality of life in people with COPD. About 44 adults with COPD who are already in a pulmonary rehab program will take part. They will attend weekly group sessions, a sile…

This study tests whether a new type of group therapy, called Cognitive Evolutionary Therapy, can help reduce symptoms of depression and anxiety. 64 adults with mild to severe depressive symptoms will either receive two 8-hour therapy sessions over two days or be placed on a waitl…

This study is testing a group-based therapy program for adults with generalized anxiety disorder (GAD) who have trouble dealing with uncertainty. The program uses cognitive-behavioral techniques to help participants manage worry and anxiety. About 12 to 20 people will take part i…

This study tests whether using a mindfulness app on a smartphone for about 10-15 minutes a day over 8 weeks can help older Korean immigrants aged 60 and older feel less stressed, anxious, or depressed. Participants will use the app and have weekly check-ins. The goal is to see if…

This study tests whether a special patch that uses gentle vibrations can help reduce stress and anxiety. About 150 adults who feel stressed or anxious will either get the active patch or a fake patch (sham) for two weeks. Researchers will measure changes in stress levels and qual…

This study looks at whether breathing in aromatherapy scents can help pregnant women feel less pain, anxiety, and nausea during labor. About 128 women in labor will be invited to try it. Researchers will compare their symptoms before and after using the scents to see if it helps …

This study looks at whether progressive relaxation exercises and planned education can help menopausal women reduce their symptoms, stress, and anxiety. About 144 women going through menopause will take part. They will learn relaxation techniques and receive education, and resear…

This study looks at whether one art therapy session can improve mood and reduce symptoms like pain and anxiety in adults receiving palliative care. Twenty patients in a Canadian hospital will fill out short questionnaires before and after a 30-60 minute art session. The goal is t…

This study tests whether using virtual reality (VR) goggles during the placement of a thin tube (PICC line) can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to se…

This study aimed to see if having a parent on a video call during anesthesia could calm children as well as a sedative medicine (midazolam). It was designed for kids aged 4 to 8 having outpatient surgery. However, the study was withdrawn before any participants were enrolled, so …

This study tests whether a device that gently stimulates a nerve in the ear (called TaVNS) can reduce anxiety and distress in healthcare workers. About 90 participants will use the device and have their brain activity measured with MRI scans. The goal is to see if this simple, no…

This study is testing an accelerated version of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, to see how well it reduces symptoms of depression and anxiety. Researchers will treat 70 adults and track changes in mood using standar…

This study tests a 7-week group program led by trained peers (not doctors) to help cancer survivors reduce anxiety and depression after finishing curative treatment. 234 adults in Denmark who completed cancer treatment within the past year and have mild to severe symptoms are tak…

This study looks at whether adding 10 grams of fibre to your daily diet for two weeks can improve mental wellbeing, including anxiety, stress, sleep, and mood. About 40 healthy adults aged 18-40 will take part. Researchers will measure changes using questionnaires before and afte…

This study looks at whether watching a virtual reality (VR) video of what happens during electroconvulsive therapy (ECT) can reduce anxiety and improve understanding for first-time patients. About 64 adults will be randomly assigned to either a VR experience or a standard talk wi…

This study looks at whether a 20-second hug from a family member right before surgery can lower a patient's anxiety and pain afterward. About 160 adults having planned surgery will either hug or not hug their family. Researchers will measure anxiety levels before surgery and pain…

This study tests whether group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in 171 teens and young adults aged 12-20. Participants receive either CBT for anxiety or CBT for insomnia in group sessions. The goal is to see which approach better improves sleep a…

This study looks at whether laughter yoga can lower exam anxiety and improve feelings of spirituality in nursing students. About 36 students will do laughter yoga twice a week for 4 weeks, while another group does nothing special. Researchers will compare anxiety and spirituality…

This study tests whether a short, acceptance-based behavioral therapy can help LGBTQ+ adults who have mild or worse anxiety or depression. About 240 participants will either receive this therapy or their usual care. The goal is to see if the therapy reduces symptoms and improves …

This study planned to test whether virtual reality guided mindfulness meditation could help adults with anxiety, depression, stress, and pain. Participants would have used a VR headset to meditate, and researchers would measure changes in their symptoms. However, the study was wi…

This study tests a program called RESET, led by community health workers, to help older adults in Detroit improve their physical and mental health. About 456 African American adults aged 50 and older with symptoms like depression, anxiety, chronic pain, or loneliness will take pa…

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. 90 adults aged 20-60 participated. Researchers measured anxiety levels before surgery and pain up to 24 hours after, along with vital …

This study is developing and testing a program that combines physical activity coaching with mental health support for veterans who have COPD, depression, or anxiety. The goal is to see if the program is practical and helpful for improving daily function and mood. About 45 vetera…

This study looks at whether using a stress ball during a prostate biopsy can help lower anxiety and pain. About 66 men having their first prostate biopsy will be asked to squeeze a stress ball during the procedure. Researchers will measure their pain, anxiety, and vital signs to …

This study aimed to compare three different nose sprays (dexmedetomidine, fentanyl, and midazolam) for reducing pain and anxiety in young children (ages 2-6) getting stitches in the emergency room. The goal was to see which spray worked best and was safest. However, the study was…

This study tests a program to help teens born in the U.S. to refugee parents deal with emotional and behavioral problems like PTSD, depression, and anxiety. About 308 teens and their parents will join weekly group sessions and virtual peer mentoring to learn coping skills. Resear…

This study tests whether a therapy called Positive Affect Treatment (PAT) is helpful for Spanish-speaking adults who feel low pleasure or interest (anhedonia) along with depression or anxiety. Twelve participants will attend up to 15 therapy sessions over about 4 months. The goal…

This study looks at whether watching an immersive video before open-heart surgery can lower anxiety and improve recovery. About 200 adults scheduled for elective heart surgery will take part. Researchers will measure anxiety using questionnaires and vital signs before and after t…

This study aimed to see if a sphenopalatine ganglion (SPG) block—a numbing shot inside the nose—could quickly reduce anxiety in adults at electronic dance music festivals. Participants would have received either lidocaine or a saltwater placebo. The study was withdrawn before enr…

This study aims to help mothers of babies in the hospital cope with depression and anxiety while strengthening their bond with their baby. It also connects families to resources for food, housing, and other household needs. About 200 English- or Spanish-speaking caregivers of inf…

This study looks at whether kava, a plant-based supplement, can safely help reduce anxiety and stress in people who have finished cancer treatment. About 43 cancer survivors with mild anxiety will take either kava or a placebo for 14 days, then switch after a break. The goal is t…

This study tests a therapy program delivered remotely via a software platform to help reduce anxiety in people with mild cognitive impairment or dementia. About 70 participants will receive the therapy, and researchers will measure changes in anxiety and quality of life. The goal…

This study tests a relaxation tool called Cereset on 40 nurses from a hospital orthopedic unit. The goal is to see if using Cereset can reduce stress, anxiety, and insomnia, and possibly improve their work performance. Participants will use the device in sessions and researchers …

This study tests a new therapy called Emotional Resolution (EmRes) to see if it can reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or practice mindfulness-based gratitude. The goal is to find a simple, effe…

This study tests whether watching a calming nature video with virtual reality glasses can lower pain and anxiety in people recovering from colorectal surgery. Sixty adults will be randomly split into two groups: one group uses the VR glasses before and after surgery, while the ot…

This study tests a 2-week treatment that combines gentle brain stimulation (tDCS) with virtual reality meditation to reduce anxiety. About 52 adults with generalized anxiety disorder will receive either real or fake stimulation while watching calming VR scenes. Researchers will c…

This study tests a device called CES that sends a tiny, painless electrical current through the ears to help calm anxiety. It involves 200 active-duty military members and their families who have significant anxiety symptoms. Half will get the real device, half a sham (placebo) d…

This study looks at two simple methods—watching a video or having a gentle acupressure point stimulated—to help children aged 5 to 8 feel less anxious and experience less pain when getting a baby tooth pulled. Researchers will measure anxiety using a heart rate monitor and a pict…

This study looks at whether interacting with a therapy dog can reduce anxiety and stress in graduate students. Thirty first-year grad students will have their stress levels measured through saliva tests and pain sensitivity checks before and after spending time with a dog. The go…

This early-stage study tests a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to people with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. 17 adults currently in tre…

This study looks at whether a simple, non-invasive ear acupressure technique can help women aged 20-45 who are undergoing IVF and feeling anxious or having trouble sleeping. Participants will either receive standard IVF care or standard care plus ear acupressure. Researchers will…

This study tests whether a fruit compote made with maqui berry, prebiotics, and probiotics can lower anxiety and inflammation in young adults. Thirty university students will eat the compote and have their anxiety levels, stress hormones, and inflammatory markers measured before …

This study tests whether a 5-week heart rate variability biofeedback program can reduce stress and anxiety in 50 dental students moving from classroom to clinic. Participants practice slow breathing while recalling a positive memory, guided by a device that gives real-time feedba…

This study tests whether a 1-month meditation app can help juvenile justice officers and others working with court-involved youth feel less stressed, anxious, or burned out. About 57 adults who work directly with these youth will use the app and report how acceptable and helpful …

This study looks at whether laughter yoga or emotional freedom technique (EFT, a tapping therapy) can lower anxiety in pregnant women. About 120 women with moderate to high anxiety will be randomly assigned to one of these two methods or standard care. The goal is to see if these…

This study tests two non-invasive devices that stimulate the vagus nerve (one on the neck, one on the ear) to see which better reduces physical discomfort and health-related anxiety in people with Somatic Symptom Disorder. About 60 adults will try both devices in random order, ea…

This study tests whether a therapist-guided online program (TG-iConquerFear) can help colorectal cancer survivors who have finished treatment reduce their fear of cancer coming back. About 200 participants will be randomly assigned to either the online therapy or standard care. T…

This study tests a 12-session group therapy program for active duty military personnel who are having suicidal thoughts or have recently attempted suicide. The therapy teaches coping skills and emotion regulation to reduce suicide risk. Researchers will compare it to a standard t…

This study tests whether using a virtual reality hypnosis headset (HypnoVR) can lower pain and anxiety during labor. About 70 women giving birth at hospitals in Tunis will use the headset, and researchers will measure their pain, anxiety, and satisfaction. The goal is to find a n…

This study tests a culturally tailored mobile health program for 150 Black pregnant women to see if it reduces symptoms of depression, anxiety, and stress. Half of the participants receive the app, which teaches communication and self-advocacy skills and offers a support network.…

This study tests a telephone-based, computer-aided care program for adults with depression, anxiety, or risky drinking. Participants receive extra support from a Mental Health Technician who helps their primary care provider manage treatment. The goal is to see if this approach r…

This early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who had significant anxiety or agitation. The goal was to see if it could reduce these behavioral symptoms safely. The stud…

This study tests whether a 4-month anti-inflammatory diet can reduce symptoms of anxiety and depression in 60 adults. Participants will be assigned to either the special diet or their usual eating habits. Researchers will also use AI to analyze speech and facial expressions to se…

This study looks at whether cancer patients can use meditation on their own to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or movement for two weeks. The goal is to see if this approach is practical and helps improve emotional well-bei…

This study looks at whether having a licensed counselor available can improve the mental well-being of medical residents. About 21 internal medicine residents will take part. Researchers will measure changes in well-being, depression, and anxiety to see if this support model help…

This study looks at whether specific brain wave patterns can be a biological sign of social anxiety. Researchers will measure the brain activity of 30 people with social anxiety disorder while they wait to give a speech. The goal is to better understand the brain's role in anxiet…

This study tests an 8-week school program called INSPIRE designed to improve mental health knowledge and resilience in Indonesian teens aged 13-15. About 680 adolescents and their parents will take part, with school counselors leading the sessions. The goal is to see if the progr…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study looks at whether using social media apps too much can make anxiety worse. About 100 adults with mild anxiety or depression will change how they use their smartphones to see if it helps their mental health. The goal is to find healthier ways to use phones, not to stop u…

This pilot study is testing whether adults with acute psychiatric conditions like psychosis, anxiety, or depression can receive hospital-level care at home instead of in a hospital. The study will enroll about 41 people to see how many are eligible and willing to try this approac…

This study looks at whether a self-guided video program on a smartphone can help reduce stigma and mistrust around mental health care for Black adults who have depression or anxiety. About 90 people aged 18-45 who haven't seen a therapist or psychiatrist in the past year will tak…

This study aimed to see if holistic education could help people manage stress and related conditions like anxiety, fatigue, and PTSD. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who agreed to a smoke-free, drug-free, and alcohol-free lifestyle. The …

This study looks at whether viral infections can trigger or worsen mental health conditions like anxiety, depression, bipolar disorder, and schizophrenia. Researchers will analyze health records from about 100,000 people in Israel to compare those with many past infections to tho…

This study looks at whether physiotherapists in private practice check for anxiety and depression in patients with long-term neck, shoulder, or back pain. Researchers will interview 18 physiotherapists to understand what helps or hinders them from screening and referring patients…

This study looks at how jaw surgery (orthognathic surgery) affects not just your bite and appearance, but also your emotions, jaw muscles, sleep quality, and pain. Researchers will follow 100 patients before and after surgery using scans, muscle tests, and questionnaires. The goa…

This study tests a short, web-based mental health program for people on waiting lists for psychological treatment. About 80 participants will try one of two versions of the program or a control activity, and fill out questionnaires over 5 weeks. The goal is to see if the study pr…

This study tests if painting roofs with a special reflective coating can lower indoor temperatures and improve mental health. 800 people in Ahmedabad, India, will have their roofs treated or not, and researchers will track changes in depression, anxiety, and well-being. The goal …

This study follows 2,000 Stanford undergraduates over their college years to understand how social connections, daily moods, and brain activity relate to anxiety, depression, loneliness, and stress. Participants fill out surveys and some undergo brain scans. The goal is to learn,…

This study looks at how stuck or rigid thinking patterns change over time in 35 people getting residential treatment for substance use disorders, anxiety, or depression. Participants fill out weekly surveys about their thoughts and behaviors, and researchers also analyze their th…

This study was designed to see if a drug called LY-2940094 could protect healthy people from developing depression or anxiety after stress. Researchers planned to measure brain responses to rewards and fear using tasks and questionnaires. However, the study was withdrawn before a…

This study planned to test whether scheduled video or audio calls could improve communication and reduce anxiety and depression for family members making medical decisions for hospitalized older adults with Alzheimer's or other cognitive impairments. The study was withdrawn befor…