Can acupuncture ease teen anxiety and depression?
NCT ID NCT06638450
First seen Jun 25, 2026 · Last updated Aug 21, 2026 · Updated 6 times
Summary
This study tests a special type of acupuncture—dense cranial electroacupuncture plus body acupuncture—in 148 teens aged 15-22 with mild to moderate anxiety or depression. Participants receive treatment twice a week for 8 weeks, and researchers measure changes in anxiety, depression, sleep, and quality of life, along with saliva stress hormones. The goal is to see if this approach can reduce psychological distress and improve well-being.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dense cranial electroacupuncture stimulation plus body acupuncture
- What this could lead to
- If it works, this could offer a non-drug option to help teens manage anxiety, depression, and sleep problems.
- What could go wrong
- This is a small, early-stage trial with no blinding for participants, and results may not apply to all teens. Acupuncture effects can be influenced by placebo response.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 148 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2026
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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15 to 22 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Participants will be eligible for this study if they: 1. are experiencing anxiety as evidenced by a BAI-C score of at least 8 (no symptoms = 0-7; mild = 8-15; moderate = 16-25; severe = 26-63), and/or a C-BDI-II score of at least 14 (no symptoms = 0-13, mild = 14-19; moderate = 20-28; severe = 29-63); 2. have symptoms that have persistent for more than 3 months; 3. are able to provide informed consent for participation, and complete treatments and questionnaires as scheduled; and 4. have no suicidal ideation, as evidenced by "no" answers or a score of \<3 for all questionnaires of the Columbia-Suicide Severity Rating Scale (C-SSRS). Exclusion Criteria: Participants will be excluded if they: 1. have unstable systemic medical conditions that may limit their participation in the study, for example, severe liver, cardiovascular, or kidney impairment; gastrointestinal or endocrine dysfunction; malignancy; autoimmune disease; acute infectious disease; or any conditions with unstable vital signs or require intensive hospitalization; 2. have bipolar or psychotic disorder (e.g. schizophrenia); 3. have a history of brain injury or surgery; 4. have alcohol abuse or substance abuse; 5. are pregnant or in lactation, or intend to conceive; 6. have heart pacemaker or other metal devices implanted in the body; 7. have concurrent or use of drug treatment for anxiety/depression in the previous 6 months; 8. have treatment with acupuncture or brain stimulation in the previous 6 months; 9. have a history of epilepsy; 10. have a condition of bleeding tendency, or coagulopathy, or currently receiving anti-coagulant treatment; or 11. involved in other interventional clinical studies in the last 3 months or any relevant condition potentially interfering with study evaluation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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School of Chinese Medicine University of Hong Kong
RECRUITINGHong Kong, Hong Kong, 000000, Hong Kong
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