Urinary system disorder

This phase 2 trial is testing whether a single infusion of a patient's own genetically modified immune cells, called C-CAR168, can safely and effectively treat lupus nephritis that has not responded to standard therapies. The cells are designed to target and eliminate specific im…

This early-phase trial tests whether a single infusion of CD19 CAR-T cells, called TranspoCART19, is safe and can push severe lupus nephritis into remission. Lupus nephritis is a serious kidney complication of lupus that often resists standard treatments. Ten adults with refracto…

Researchers are testing a radiopharmaceutical called 161Tb-PSMA-1 in adults with metastatic clear cell renal cell carcinoma that has worsened after at least two prior treatments, including immunotherapy and drugs that block blood vessel growth. The trial has two parts: a dose-esc…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

Researchers are testing whether drug testing in patient-derived organoids can guide chemotherapy for low-grade non-muscle invasive bladder cancer. Adults with primary or recurrent low-grade bladder cancer receive one of four chemo drugs, epirubicin, mitomycin C, gemcitabine, or d…

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

Researchers are testing whether an oral drug called vepugratinib can clear low-grade, intermediate-risk bladder cancer that has not invaded muscle, or low-grade upper tract urothelial cancer. The trial enrolls adults whose tumors carry a specific change in the FGFR3 gene. Partici…

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

People with end-stage kidney disease need a reliable blood vessel connection, called a fistula, for hemodialysis. This study tests a device called the ePATH System, which creates that connection from inside the blood vessels rather than through open surgery. Researchers will foll…

This study looks back at the experiences of 35 adults with a rare kidney disease called C3G who received the drug iptacopan through a special early access program in Spain. Researchers will collect information on patient health, lab results, and how the disease responds to treatm…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This phase 2 trial is investigating whether an experimental drug called ARGX-121 can improve outcomes for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants will receive either ARGX-121 or a placebo, while continuing their usual care. The …

This study tests whether a citrate-based dialysis fluid with extra magnesium can slow or prevent blood vessel hardening in adults on long-term hemodialysis. Eighty stable patients will receive either the new fluid or a standard one for 12 months. Researchers will measure blood ma…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

Researchers are testing whether combining enfortumab vedotin and pembrolizumab can shrink muscle-invasive bladder cancer enough to avoid removing the bladder or using radiation. The trial enrolls 25 adults with confirmed muscle-invasive urothelial carcinoma that has not spread. P…

Researchers are running a first-in-human study of MGC030, an antibody-drug conjugate, in people with advanced solid tumors that have come back or stopped responding to standard treatment. The trial includes participants with urothelial, colorectal, gastric, gastroesophageal, esop…

Researchers are testing whether adding atrasentan to standard supportive care improves kidney structure and function in adults with IgA nephropathy, a condition where the immune system damages the kidneys. About 20 participants will take atrasentan 0.75 mg once daily for 52 weeks…

This phase 2 trial is testing an experimental drug called RAG-01, either alone or combined with chemotherapy, in people with a type of bladder cancer that hasn't spread into the muscle layer. The study aims to see if the drug can improve how long patients go without their cancer …

When a kidney stone blocks urine flow and causes a severe infection, doctors must quickly relieve the blockage and control the infection. They can place a stent through the urinary tract, insert a drainage tube through the skin, or start antibiotics alone. This study observes 1,6…

Researchers are testing two drugs, toripalimab and axitinib, in adults with advanced non-clear cell kidney cancer or renal medullary carcinoma who have not received prior treatment and still have their primary kidney tumor. Everyone receives the drugs for about 12 weeks. Then a t…

This phase 2 trial tests a combination of two drugs, enfortumab vedotin and pembrolizumab, given before surgery to people with muscle-invasive bladder cancer or upper tract urothelial carcinoma. The goal is to see if the drugs can shrink or eliminate the cancer enough that some b…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

People with advanced chronic kidney disease often avoid nuts because of concerns about phosphorus and potassium. Researchers at Shahid Beheshti University of Medical Sciences are testing whether a daily 30-gram serving of pistachios, added to a standard kidney diet, changes level…

Researchers are testing an experimental drug called VSA012 against eculizumab in adults with paroxysmal nocturnal hemoglobinuria (PNH) who have not received complement inhibitor therapy. The trial enrolls about 70 participants and compares how well each treatment controls hemolys…

This early-phase trial is testing a new cell therapy called GT719 for several immune-mediated kidney diseases, including IgA nephropathy and membranous nephropathy. The therapy uses specially engineered immune cells to target and potentially control the disease. The study will en…

Researchers are testing whether a multidisciplinary care model helps people with type 2 diabetes and chronic kidney disease start and adjust five classes of heart and kidney protective medicines within four months. The trial enrolls about 570 adults at high or very high risk of k…

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This phase 2 trial tests a combination of two drugs, envafolimab and lenvatinib, as a first treatment for people with clear cell kidney cancer that has spread to the liver. The study will enroll 30 participants and measure how well the drugs shrink liver tumors. It is not yet rec…

This trial tests whether using a wearable cuffless blood pressure monitor to guide treatment can help more hemodialysis patients achieve target blood pressure than standard office-based measurements. Adults on maintenance hemodialysis with high blood pressure will be randomly ass…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This phase 2 trial tests whether combining the immunotherapy drug toripalimab with the chemotherapy drug gemcitabine, given directly into the bladder, can reduce the chance of high-risk non-muscle-invasive bladder cancer returning after surgery. Adults aged 18 to 85 who have had …

This study tests whether adding chemotherapy drugs (gemcitabine and mitomycin C) directly into the bladder alongside an immune-boosting drug (toripalimab) works better than toripalimab alone for people with a high-risk bladder cancer that did not respond to standard BCG therapy. …

This trial tests whether injecting platelet-rich plasma (PRP) around the urethra can safely reduce stress urinary incontinence in postmenopausal women. PRP is made from each participant's own blood and contains growth factors that may help repair tissue. About 70 women will recei…

This trial tests the long-term safety and effectiveness of povetacicept, an investigational drug given as a subcutaneous injection, in adults with immunoglobulin A nephropathy (IgAN), a kidney disease that can lead to kidney failure. Participants who completed the earlier parent …

This early-stage trial tests an experimental drug called STRO-006 in adults with advanced solid tumors, including head and neck, lung, esophageal, gastric, colorectal, endometrial, bladder, and breast cancers that have not responded to standard treatments. The study has three par…

This Phase II trial tests an experimental drug called SGB-9768 in adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder where red blood cells break apart too early. The study gives the drug by injection under the skin and measures how well it lowers a marke…

This phase III trial tests whether giving the drug Alpha1H directly into the bladder before standard surgery lowers the risk of cancer returning in adults with low- to intermediate-risk non-muscle-invasive bladder cancer. Participants are randomly assigned to receive either six A…

This trial tests two disposable mini-flexible ureteroscopes, one thinner than the other, for removing kidney stones up to 15 mm. Researchers randomly assign adults to receive surgery with either the 6.3Fr or the 7.5Fr scope. They compare how completely stones are cleared, whether…

This trial tests whether sitting in a special electromagnetic chair can reduce urinary incontinence episodes in women with mixed urinary incontinence, a condition combining stress and urge leaks. Half of the 58 participants will receive 12 sessions of electromagnetic chair therap…

This study tests whether medically tailored meals, prepared to support kidney and heart health, can improve blood pressure and kidney function in Veterans with chronic kidney disease. About 100 participants will be randomly assigned to receive these meals or usual care for three …

This trial tests whether adding the drug mirogabalin to a structured educational and behavioral program improves symptoms for adults with interstitial cystitis or bladder pain syndrome. Participants receive either the behavioral program alone or the program plus mirogabalin for 1…

This trial tests a surgical technique that uses a tissue graft from the inside of the cheek to repair long strictures, or narrowings, in the upper or middle part of the ureter, the tube that carries urine from the kidney to the bladder. The procedure aims to widen the narrowed ar…

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This trial tests a new feature called FlexPoint on a peritoneal dialysis machine used at home. The feature adjusts fluid volume and dwell time during treatment. Researchers will compare three different settings in 24 adults with chronic kidney disease to see which works best for …

This Phase 3 trial tests NDV-01, a sustained-release combination of two chemotherapy drugs (gemcitabine and docetaxel), given directly into the bladder. It aims to prevent cancer from coming back in people with non-muscle invasive bladder cancer, including those who have not resp…

This early-phase trial tests whether a genetically modified pig kidney combined with thymus tissue can work as a transplant in 4 adults with end-stage kidney disease. The goal is to see if the organ can keep them off dialysis safely for at least 6 months. Participants must be on …

This study tests an experimental daily pill called zanzalintinib in 44 adults with advanced bladder cancer that has continued to grow after previous treatments. The goal is to see if the drug can shrink tumors or slow the cancer's progression. Participants will take the pill once…

This early-stage trial tests an experimental medicine called BI 3822971 in adults with advanced or metastatic solid cancers, such as lung, head and neck, breast, esophageal, bladder, vulvar, or cervical cancer, who have no standard treatment options left. The goal is to find out …

Researchers are testing whether personalized nutrition, including special milk formulas, can improve growth, body composition, and muscle strength in children with chronic kidney disease. The study will enroll 128 children aged 6 to 12 with any stage of the disease. The goal is t…

This trial compares three approaches for treating painful diabetic neuropathy: oral medications, topical treatments, and cognitive behavioral therapy. Researchers will enroll 600 adults with diabetes and nerve pain, randomly assigning them to one of these options for four months.…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This phase 3 trial is testing a wearable device that stimulates a nerve in the calf to see if it can reduce the sudden, urgent need to urinate that defines overactive bladder. About 290 adults with overactive bladder symptoms will be randomly assigned to use the device daily or t…

This trial tests whether apixaban, a blood thinner, can reduce the risk of stroke or blood clots in adults on dialysis who also have atrial fibrillation (an irregular heartbeat). Participants are randomly assigned to receive either apixaban or no oral anticoagulant, while continu…

This clinical trial aims to find the safest and most effective hepatitis C treatment for people with chronic kidney disease (CKD). Researchers will compare two drug combinations based on how well the kidneys are working: one for patients with moderate kidney function and another …

This phase II trial is testing whether giving toripalimab (an immunotherapy) plus axitinib (a targeted therapy) for about 12 weeks before a possible delayed kidney removal can help control advanced clear cell kidney cancer. The study enrolls adults whose primary kidney tumor is s…

This trial tests whether a daily maqui berry supplement can improve gut health, reduce inflammation, and lower oxidative stress in people with stage 3-4 chronic kidney disease. Half of the 30 participants will take the maqui powder, while the other half receives a placebo, for th…

This trial tests whether finerenone, a drug already used for chronic kidney disease, is safe and tolerable for people hospitalized with acute kidney injury (AKI). About 72 adults with moderate-to-severe AKI will receive either finerenone or a placebo once daily for up to 45 days,…

This Phase 2 study will test whether empagliflozin (Jardiance), a drug already used for diabetes, can improve blood vessel health and exercise tolerance in 52 veterans with non-diabetic chronic kidney disease. Participants will take either the drug or a placebo for a period, and …

This early study tests a new medicine called TNX-1500 in 5 people who get a kidney transplant. The goal is to see if it is safe and can help prevent the body from rejecting the new kidney. Participants will be followed for one year to check for side effects and signs of rejection…

This study tests whether people on hemodialysis can safely eat a diet that includes more potassium-rich whole foods like fruits, vegetables, and nuts, instead of the usual strict low-potassium diet. Half of the 148 participants will follow this 'liberalized' diet for 12 weeks, wi…

This trial tests whether sending a letter and fact sheet to adults in Manitoba who are at high risk for kidney failure can encourage them to see a kidney specialist. The goal is to catch advanced chronic kidney disease earlier and reduce the number of people who progress to dialy…

This trial tests a new tool called CURTIS, designed to safely remove bladder tumors in one intact piece after they are cut out during surgery. The goal is to see how often the device can successfully retrieve the tumor without breaking it apart, and what the largest tumor size is…

This study tests whether a single dose of tranexamic acid (TXA), a drug that helps blood clot, can reduce blood loss during urethral reconstruction surgery. Forty adults having this surgery will be randomly assigned to receive TXA or standard care. Researchers will compare change…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests whether providing fruits and vegetables along with cooking and nutrition education can improve kidney health in adults with chronic kidney disease. Participants are randomly assigned to receive either fruits and vegetables alone or fruits and vegetables plus a 12…

This early-stage trial tests whether giving kidney transplant recipients a special treatment made from their donor's cells, combined with a light-based therapy called photopheresis, can safely reduce the risk of organ rejection. About 24 adults receiving their first kidney transp…

This trial is testing whether adding the nerve pain medication pregabalin to a structured educational and behavioral program can better ease the symptoms of bladder pain syndrome (also called interstitial cystitis) than the program alone. Adults with this condition will be random…

This study tests a new device that combines a camera and suction in one tool for kidney stone removal surgery. About 75 adults with kidney stones between 0.5 and 2.0 cm will undergo the procedure to see if the device safely clears stones and reduces leftover fragments. The goal i…

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunother…

People on maintenance hemodialysis face a high risk of heart disease, and standard cholesterol drugs often fail to help. This trial tests whether high-dose fish oil (4 grams daily for 8 weeks) can improve the function of HDL, the 'good' cholesterol, which may become faulty in kid…

This study tests whether elderly patients starting dialysis for kidney failure can receive treatments twice a week instead of the usual three times, without increasing hospitalizations or death. The goal is to see if fewer sessions allow patients to spend more days at home and im…

This trial tests whether an artificial intelligence system can help surgeons better see and remove bladder tumors during a standard procedure called TURBT. The AI analyzes the live video from the surgical camera and highlights suspicious areas and recommended cutting edges on the…

This study tests whether a drug called Angiotensin II works better than the usual treatment (norepinephrine) for people with septic shock, a life-threatening condition where blood pressure drops dangerously. About 78 adults with septic shock will receive either Angiotensin II or …

This study is testing whether a new antibiotic combination, cefepime/enmetazobactam, works as well as the best current treatments for complicated urinary tract infections that have spread to the bloodstream. These infections are caused by bacteria resistant to many common antibio…

This study tests whether bempedoic acid, a drug already approved for high cholesterol, can safely slow the progression of autosomal dominant polycystic kidney disease (ADPKD). About 120 adults with rapidly progressing ADPKD will receive either the drug or a placebo for two years.…

This phase II trial tests whether obinutuzumab, a B-cell targeting antibody, can alone achieve complete kidney response in people with pure class V lupus nephritis—a form of lupus kidney disease with no approved treatments. Participants receive up to four infusions over seven mon…

This phase 2 trial tests an experimental drug called sacituzumab tirumotecan in people with two rare types of cancer: papillary renal carcinoma and less common forms of bladder cancer. The drug is given by IV every two weeks for up to three years. The main goal is to see how many…

This trial tests whether reducing the dialysate flow rate during hemodialysis from the standard 500 mL/min to 400 mL/min can maintain adequate blood cleansing while cutting water use. About 250 adults on chronic hemodialysis will each try both flow rates for one month. The main g…

This phase 2 trial is testing whether a combination of an antibody-drug conjugate (disitamab vedotin), an immunotherapy (toripalimab), and targeted radiation can improve outcomes for people with high-risk upper tract urothelial carcinoma. Participants receive the drug and immunot…

This study tests whether giving a daily antibiotic (pivmecillinam) to kidney transplant patients at high risk of bloodstream infections can reduce those infections. 150 participants will receive either the antibiotic or a placebo for 5 months after transplant. The goal is to see …

This study tests two common methods to treat metabolic acidosis—a condition where blood becomes too acidic—in people on long-term hemodialysis for kidney failure. One group takes oral sodium bicarbonate capsules, while the other gets a higher bicarbonate concentration in their di…

This study compares two common medications for overactive bladder (OAB): solifenacin, which blocks nerve signals in the bladder, and mirabegron, which helps the bladder muscle relax. Researchers want to see if a person's 'anticholinergic burden'—the combined effect of other medic…

This trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…

This study tests a smart computer system that helps primary care doctors screen for and manage diabetic kidney disease in adults with type 2 diabetes. The tool automatically calculates kidney function, reminds doctors to order urine tests, and gives personalized treatment advice.…

This trial tests four different breathing strategies during kidney stone surgery to see if reducing kidney motion helps surgeons remove stones more completely and lowers the risk of complications. Eighty adults undergoing the procedure will be randomly assigned to standard ventil…

This study tests whether a dietary supplement called nicotinamide riboside (a form of vitamin B3) can be safely taken by adults with moderate chronic kidney disease. The main goal is to see if it's feasible for participants to take the supplement daily and complete study procedur…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This trial tests whether a prehabilitation program — combining exercise, nutrition advice, and psychological support — can improve fitness and recovery in people with advanced chronic kidney disease awaiting a kidney transplant. Researchers compare an in-person, hospital-based pr…

This study tests whether a supplement called Ketosteril, added to the usual diet, can help people who are starting hemodialysis (a treatment for kidney failure) stay on a less frequent schedule longer. The trial includes 70 adults beginning incremental hemodialysis, where session…

This trial investigates whether adding Naoxintong Capsule, a traditional Chinese medicine made from 16 herbal and animal ingredients, to standard therapy can slow the progression of diabetic nephropathy in people with type 2 diabetes. The study involves 410 participants who will …

This trial tests whether a new flexible and navigable suction ureteral access sheath (FANS) works better than the standard sheath for removing kidney stones smaller than 2 cm in children. Sixty children will be randomly assigned to one of the two devices during a procedure called…

This early-stage trial tests whether a personalized vaccine, made from each patient's unique tumor mutations, can safely boost the effects of the immunotherapy drug pembrolizumab in people with advanced kidney cancer. The vaccine is designed to train the immune system to recogniz…

This study compares two treatments—albumin and fresh frozen plasma—for children with idiopathic nephrotic syndrome who have fluid buildup that doesn't respond to standard diuretics. The goal is to see which approach resolves swelling faster and more safely. Fifty-six children age…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This trial tests whether a vacuum-assisted ureteral access sheath (ClearPetra) removes kidney stones more completely than a standard rigid sheath (Navigator) during flexible ureteroscopy. About 156 adults with stones 1-3 cm will be randomly assigned to one sheath. The main goal i…

This phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…

This phase 2 trial tests whether a combination of two drugs—enfortumab vedotin (Padcev) and pembrolizumab (Keytruda)—can help people with muscle-invasive bladder cancer avoid bladder removal. About 56 participants will receive the drugs first, and those who respond well may get r…

This phase 2 trial tests whether dapagliflozin, a drug used for diabetes and heart failure, can reduce harmful antibodies and prevent relapses in people with membranous nephropathy, an autoimmune kidney disease. The study enrolls 20 adults who have had a recent rise in anti-PLA2R…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This trial tests a one-time treatment called CAR-T cell therapy for people with systemic lupus erythematosus (lupus) that hasn't improved with standard medications. The therapy uses a patient's own immune cells, which are modified in a lab to find and destroy the B cells that dri…

This study looks at whether changing the filter in a kidney dialysis machine more often than usual can lower the chance of new infections in critically ill patients with severe acute kidney injury. About 100 adults in intensive care will be randomly assigned to have their filter …

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This study is testing a new device called ARTUS® that acts like an artificial muscle to control urine leakage in women with severe stress urinary incontinence. Six women who have not gotten better with other treatments will get the device implanted and be followed for two years. …

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This early-stage trial tests a new drug called ATO-101 for a type of bladder cancer that hasn't responded to standard treatments. The drug delivers a short-range radioactive particle directly into the bladder to kill cancer cells while sparing healthy tissue. About 24 patients wi…

This Phase 2 trial tests whether giving two drugs (anlotinib and benmelstobart) before surgery can improve outcomes for people with localized kidney cancer. About 144 participants will either receive the drug combo followed by partial nephrectomy, or surgery alone. The main goal …

This large Phase 3 study tests whether the drug HRS-7535 can help people with chronic kidney disease (CKD) avoid serious outcomes like kidney failure, dialysis, or heart-related death. About 3690 adults with CKD will receive either the drug or a placebo, added to their usual care…

This study compares two blood thinners used during continuous dialysis in adults with sepsis and acute kidney injury. About 1,162 participants will receive either nafamostat mesylate or standard citrate anticoagulation. The main goal is to see which approach reduces death, ongoin…

This study tests whether a combination of disitamab vedotin (a targeted drug) and toripalimab (an immunotherapy) works better than standard chemotherapy plus immunotherapy for people with HER2-positive muscle-invasive bladder cancer. About 240 participants will receive treatment …

This study looks at whether giving more protein (1.5-1.7 grams per kilogram per day) to critically ill patients with acute kidney injury who need continuous dialysis can reduce muscle wasting compared to standard protein intake (1.0-1.2 g/kg/d). About 56 adults will be randomly a…

This study tests whether giving a combination of three drugs (pembrolizumab, belzutifan, and lenvatinib) before surgery can shrink kidney tumors in people with localized clear cell renal cell carcinoma. About 150 participants will receive the drugs for 12 weeks before surgery, th…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This study tests whether using a special ultrasound technique (mVExUS) to guide how much fluid is removed during dialysis can improve outcomes for critically ill patients with acute kidney injury. 126 adults in the ICU will be randomly assigned to either standard care or the ultr…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This study tests a treatment called HIVEC, which delivers heated chemotherapy directly into the bladder. It is for people with a type of bladder cancer that has not responded to standard therapy and who cannot have their bladder removed. The goal is to see if this approach is saf…

This study tests whether covered stents are better than bare metal stents for people with narrowed kidney arteries caused by atherosclerosis. About 150 participants will be randomly assigned to one stent type and followed for 12 months to see changes in kidney function and blood …

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study looks at people with narrowed kidney arteries and high blood pressure. It uses a special pressure measurement (FFR) to decide who gets a stent and who gets only medication. The goal is to see which approach better protects kidney function and controls blood pressure ov…

This early-stage trial tests a procedure called calcium electroporation for bladder tumors. Doctors inject calcium into the tumor and then apply short electric pulses to destroy cancer cells. The study will include 20 patients who cannot have standard surgery or other treatments.…

This pilot study tests whether using a cap containing chlorhexidine on dialysis catheters can reduce infections compared to standard caps. Sixty adults with kidney failure who need dialysis through a central line will be randomly assigned to one of the two caps. The main goal is …

This study compares two ways to drain urine in men with blocked bladders before prostate surgery: self-catheterization (done by the patient several times a day) versus a permanent tube. The goal is to see if self-catheterization leads to fewer infections. About 106 men over 50 wi…

This study will follow 50 adults with IgA nephropathy who are taking sparsentan. Researchers want to see how the drug affects protein in the urine (albuminuria), a key sign of kidney damage. The study is observational, meaning it just watches what happens in real-world use, witho…

This Phase 1 trial tests a new drug called HLX05-N, which is a biosimilar (a copy) of the cancer drug Erbitux, in 387 people with metastatic colorectal cancer. Participants will receive either HLX05-N or Erbitux (from the US or EU) along with standard chemotherapy. The study aims…

This study tests a new pre-mixed fluid that contains phosphate for patients in the ICU who need continuous kidney replacement therapy (CRRT). The standard fluid often washes out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the…

This study tests whether adding pea fiber to the daily diet of people on dialysis can lower harmful waste products in their blood. 72 adults on dialysis will eat baked goods with or without pea fiber for 8 weeks. Researchers will measure changes in toxin levels and heart health m…

This study tests a new treatment for people with a rare cancer of the upper urinary tract (UTUC) that has spread beyond the kidney. Participants must have had surgery and cannot take standard chemo due to health reasons. They will receive either a targeted drug (disitamab vedotin…

This study tests whether regularly measuring the amount of mycophenolate mofetil in the blood helps more people with lupus kidney disease achieve kidney remission. One hundred adults with active lupus nephritis will be split into two groups: one gets standard dosing, the other ge…

This study looks at whether giving vitamin C through a vein can help very sick patients with liver failure and severe infections recover from kidney injury. About 110 patients will get either standard care alone or standard care plus vitamin C. The goal is to see if vitamin C hel…

This early-stage trial tests whether treating a donor kidney with a drug called SYN002 before transplant can safely reduce the risk of passing cytomegalovirus (CMV) to the recipient. About 12 adults waiting for a kidney transplant will receive a treated organ. The main goal is to…

This study tests whether a combination of a controlled diet, structured exercise, and a symbiotic supplement can reduce inflammation and harmful gut toxins in young people with early chronic kidney disease (stages 1-3). Two hundred participants will receive either the multimodal …

This study watches 226 adults with small kidney tumors (stage T1a) who get radiofrequency ablation, a treatment that uses heat to destroy cancer cells. Researchers will track how well the procedure works and any side effects. No extra treatments or tests are given—just normal car…

This Phase 2 trial tests an experimental drug called HS-10542 in 90 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants will receive either a high dose, low dose, or placebo for a set period. The main goal is to see if the drug reduces prot…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can help people with advanced kidney cancer (clear cell type) whose cancer returned after prior immunotherapy. About 108 adults will receive the combination to see if it shrinks tumors or delays cancer gr…

This study tests whether the drug avelumab can help keep metastatic urothelial carcinoma (a type of bladder cancer) from growing after patients have already received two lines of chemotherapy. About 144 adults whose cancer has not worsened after second-line chemo will receive ave…

This study looks at whether giving the drug rituximab early, when signs of the disease reappear in the blood, can prevent relapses in people with certain types of vasculitis (GPA and MPA). About 70 adults who have been on maintenance rituximab for at least 18 months will be rando…

This study tests whether giving amino acids (protein building blocks) through a vein can help prevent or reduce acute kidney injury in adults on ECMO life support in the ICU. About 40 participants will receive either amino acids or a placebo. The goal is to see if this simple tre…

This study tests whether a daily synbiotic supplement (probiotics plus prebiotics) can lower inflammation and improve digestive symptoms in adults with chronic kidney disease stages 3 to 5 who are not yet on dialysis. One hundred participants will receive either the supplement or…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study compares two drugs—tranexamic acid and vasopressin—to see which works better at reducing blood loss during planned C-sections in women with placenta previa, a condition where the placenta covers the cervix. 58 women will be randomly assigned to receive one of the drugs…

This study tests whether giving two drugs (toripalimab and 9MW2821) before surgery can improve outcomes for people with localized upper tract urothelial carcinoma, a type of cancer in the kidney or ureter. About 40 adults will be randomly assigned to either the drug combo followe…

This study tests whether the investigational drug QRX-3 can help hospitalized children and adults with acute tubular necrosis, a type of sudden kidney failure. About 500 participants will receive either QRX-3 or a placebo alongside standard care. The main goal is to see if QRX-3 …

This study tests whether adding a low-dose blood thinner (apixaban) to the standard heparin lock can help dialysis catheters stay functional longer. Fifty-four adults with end-stage kidney disease and a new catheter will be followed for up to 24 months. The goal is to see if this…

This study looks at whether veterans with early-stage high-grade bladder cancer can have fewer follow-up exams (cystoscopies) without harming their health. About 2,500 participants will be randomly assigned to either a low-intensity or high-intensity surveillance schedule. The go…

This study compares two treatments for muscle-invasive bladder cancer: radiation combined with chemotherapy versus surgery to remove the bladder. About 336 adults with this cancer will be randomly assigned to one of the two groups. The goal is to see if the non-surgical approach …

This pilot study tests whether an AI-based system can help doctors choose the right doses of immunosuppressant drugs for kidney transplant patients. The goal is to protect the new kidney from damage and rejection. The study will enroll 34 adults who have received a deceased donor…

This study will compare two laser power settings (high vs low) during a minimally invasive surgery called mini-percutaneous nephrolithotomy for removing kidney stones larger than 20 mm. Seventy adults will be randomly assigned to one of the two laser groups. The main goal is to s…

This study tests whether giving amino acids through the dialysis machine twice a week for a year can help protect the heart and blood vessels in people with kidney failure. About 120 adults on stable dialysis will receive either amino acids or a placebo (saline). Researchers will…

This study tests whether cooling the dialysis fluid slightly can help preserve memory and thinking in people with kidney failure who need hemodialysis. Many patients on dialysis experience a decline in brain function, possibly due to drops in blood flow during treatment. The tria…

This early study tests whether a personalized mix of viruses (called phages) can safely treat urinary tract infections caused by drug-resistant bacteria. Six adults aged 18–65 will receive the phage cocktail through a catheter every 12 hours for 2–3 days. Researchers will monitor…

This study tests imlifidase, a drug that temporarily disables the immune system's antibodies, allowing highly sensitized patients to receive a kidney from a deceased donor they would otherwise reject. The trial will follow 450 patients in France to see how many get transplanted a…

This study tests whether a 12-month diet low in salt, caffeine, protein, and carbs, but high in potassium and water, can slow kidney cyst growth in 30 adults with ADPKD. Participants are split into diet and regular diet groups. The goal is to see if the diet reduces cyst progress…

This Phase 3 trial tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis and serious kidney damage. About 130 participants will receive either avacopan or a placebo alongside usual care. The goal is to see if more patients recover kidney fun…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This study tests a drug called obinutuzumab in 10 adults with a kidney condition called nephrotic syndrome that keeps coming back despite standard treatments. The goal is to see if a single course can keep patients relapse-free for at least 12 months by deeply depleting certain i…

This early-phase trial is testing a new treatment called CRC01 for people with severe lupus nephritis, a serious kidney complication of lupus. The therapy uses a patient's own immune cells, which are modified in a lab to target and destroy certain immune cells that drive the dise…

This phase 2 trial tests a virus-based drug given directly into the bladder for people with high-risk non-muscle invasive bladder cancer. The virus is designed to attack cancer cells and trigger the immune system. About 18 participants will receive increasing doses to find the sa…

This study tests whether taking a laxative (bisacodyl) for two days before getting a peritoneal dialysis catheter can prevent blockages. About 398 adults needing dialysis will be randomly assigned to receive the laxative or usual care. The goal is to see if this simple step reduc…

This study follows 159 Chinese patients with triple-class exposed relapsed/refractory multiple myeloma who are taking elranatamab in routine care. Researchers will track how well the drug controls the cancer, including response rates and survival. The goal is to see if elranatama…

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This study will compare two minimally invasive surgeries for kidney stones that are 2-3 cm in size. About 280 adults across nine hospitals will be randomly assigned to either FANS-based flexible ureteroscopy or suction-assisted mini-PCNL. The main goal is to see which method remo…

This study compares two intravenous fluids—human albumin and saline—to see which better resolves acute kidney injury in people with decompensated cirrhosis. About 114 adults with moderate to severe kidney damage will receive either treatment. The goal is to improve kidney functio…

This study tests a highly precise type of radiation called SBRT for people with kidney cancer who cannot undergo surgery. The treatment uses a robotic system (CyberKnife) to deliver high-dose radiation directly to the tumor while sparing healthy tissue. Researchers will track 60 …

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or obesity. Participants receive weekly injections for three months. The goal is to see if this drug can help manage weight and …

This phase 3 trial compares radiotherapy with a radiosensitiser to the standard BCG immunotherapy for high-risk non-muscle invasive bladder cancer. About 328 patients will be randomly assigned to one of the two treatments after tumor removal. The goal is to see which approach bet…

This clinical trial is for adults with metastatic clear cell kidney cancer. It compares having surgery to remove the kidney tumor either before or after starting immunotherapy drugs (ipilimumab and nivolumab). The goal is to see which timing helps people live longer without the c…

This study looks at whether giving extra nutrition during dialysis sessions helps people on long-term hemodialysis build muscle and manage blood pressure. Researchers will compare the effects of this special nutrition with usual care in 16 adults who have been on dialysis for at …

This study looks at whether eating more protein can help people on dialysis avoid hospital stays. Dialysis removes nutrients like protein from the blood, and current guidelines are based on old research. The study will give some participants a high-protein diet or supplements and…

This study tests whether adding ganagliflozin tablets to standard care can slow kidney disease progression in 1,244 adults with type 2 diabetes and chronic kidney disease. Participants will take either ganagliflozin or a placebo daily for 120 weeks. The main goal is to measure ch…

This phase 2 trial tests whether combining dapagliflozin (a diabetes drug) with SC0062 (a blood vessel drug) can better protect kidneys in adults with type 1 diabetes and chronic kidney disease. Thirty-six participants will try each treatment alone and together in a cross-over de…

This study tests a weekly injection called survodutide in 120 people with chronic kidney disease and high protein in their urine. The goal is to see if the drug can lower protein levels and protect kidney function over 36 weeks. Participants must be on stable standard treatments …

This early study will test a new type of immune cell therapy in 20 people with advanced bladder cancer that hasn't responded to standard treatments. The therapy uses the patient's own γδ-T cells, which are grown in a lab and then infused back to attack the cancer. The main goal i…

This study tests whether injecting the chemotherapy drug gemcitabine directly into the bladder wall can prevent cancer from coming back in people with intermediate- or high-risk non-muscle-invasive bladder cancer. About 320 participants will receive either the new injection or th…

This phase 2 trial tests a dose-dense (faster) schedule of two chemotherapy drugs, gemcitabine and cisplatin, given before surgery for muscle-invasive bladder cancer. The goal is to see if this approach can completely eliminate the tumor in the bladder and lymph nodes. Thirty eli…

This study compares a new surgical tool called VISOR to a standard scope for removing kidney stones. VISOR combines suction, pressure control, and laser to break up and remove stones in one step. About 100 adults with stones up to 3 cm will be randomly assigned to get either VISO…

This study tests whether roxadustat, a drug currently used to treat anemia in kidney disease, can also improve sarcopenia (muscle loss) in patients on hemodialysis. Sixty adults with end-stage kidney disease and anemia will receive either roxadustat or standard erythropoietin. Re…

This trial tests a new drug called QRX3 in 3,000 people with chronic kidney disease whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow the need for dialysis. Participants take QRX3 capsules, and researchers measure changes in kidne…

This study tests a new drug called CVL006 combined with standard chemotherapy or other targeted drugs in people with advanced solid tumors that have not responded to previous treatments. The trial has two phases: first, to find the safest dose, and second, to see if the combinati…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

Researchers are studying whether the total time from heart attack symptom onset to balloon inflation during angioplasty helps predict contrast-induced nephropathy, a kidney complication that can occur after the procedure. The trial enrolls 400 adults with ST-segment elevation myo…

Acute kidney injury is a common complication after coronary artery bypass grafting. This observational study examines whether two measurements from kidney Doppler ultrasound, the renal augmented velocity index and the renal resistive index, can predict which patients will develop…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

This trial is testing a new rapid urine test called Jiddu that aims to quickly identify urinary tract infections (UTIs) and determine which antibiotics will work best. The study involves 100 adults with neurogenic bladder who use catheters and suspect they have a UTI. Participant…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

Doctors use iodinated contrast dye during CT scans, and in some patients this dye can stress the kidneys, a condition called contrast-associated acute kidney injury. Current safety checks rely on an estimated kidney function that assumes an average body size, which may not reflec…

Researchers at Assiut University are comparing a newer kidney scan measure called Normalized Residual Activity (NORA) with standard measures from 99mTc-DTPA diuretic renography. The study enrolls 57 children and adults referred for suspected urinary tract obstruction. All partici…

Researchers are testing whether an open-source artificial intelligence model can measure coronary artery calcium on routine chest CT scans that were not originally taken for heart imaging. The study uses existing scans from about 1,950 people at a German hospital, including patie…

This observational study tests whether levels of MPO-DNA complexes in the blood can serve as a reliable biomarker for disease activity in systemic lupus erythematosus (SLE). Researchers will compare MPO-DNA levels in 90 participants with active versus inactive lupus, and check ho…

Peritoneal dialysis uses the belly lining as a natural filter for people with kidney failure, but over time this membrane can scar and stop working. This study tests whether levels of a protein called DKK3 in blood, urine, and dialysis fluid can serve as an early warning sign of …

This study tests whether blood samples collected at home using small capillary devices, like finger pricks, give the same results as traditional blood draws from a vein. Researchers will compare both methods in about 1,000 people with chronic conditions such as kidney disease, au…

This trial tests whether a fluorescent dye called TTP-ICG, which targets a protein found on bladder cancer cells, can help surgeons spot tumors during surgery. People with suspected or confirmed non-muscle invasive bladder cancer will have the dye placed into their bladder before…

This trial tests whether monitoring pressure inside the kidney during a procedure called percutaneous nephrolithotomy, used to remove kidney stones in children, can lower the chance of post-operative infections. Researchers will enroll 80 children under 18 who need this surgery. …

This pilot trial tests whether a structured ultrasound assessment can help doctors manage fluids better in patients recovering from cardiac surgery. Participants are randomly assigned to either standard care or an ultrasound-guided strategy that measures fluid tolerance and respo…

This study is testing whether new biomarkers in urine can more accurately diagnose urinary tract infections (UTIs) in two groups where current tests often fail: young children not yet toilet-trained and adults aged 65 and older. In these groups, standard urine tests can be mislea…

This trial is testing whether a urine test called ProNephro AKI™ (NGAL) can accurately predict which critically ill adults in the intensive care unit (ICU) will develop moderate to severe acute kidney injury within 48 to 72 hours of admission. The study will enroll 800 adults who…

This study tests whether a special PET scan using a drug called 89Zr-girentuximab can detect kidney cancer that remains or comes back after initial treatment. Ten adults with clear cell renal cell carcinoma will receive the drug and then have a PET scan. Some will also have a sec…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This trial tests three ways to manage urinary symptoms in women aged 65 and older who have frequent urinary tract infections. Some participants receive antibiotics right away, while others get treatment only after a urine test or a lab culture. The goal is to find out which appro…

This trial investigates whether a rapid test for antibiotic resistance genes (integrons) can help doctors choose narrower-spectrum antibiotics for hospitalized adults with urinary tract infections (UTIs). Participants must have had a recent infection with a resistant bacterium. T…

This pilot study tests a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow in tiny vessels of transplanted kidneys. The goal is to see if changes in these vessels can predict how well the kidney will work early after transplant, includin…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study explores whether analyzing tumor DNA in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to see if the test can detect cancer mutations and track change…

This study will test whether a kidney ultrasound and a urine test can predict acute kidney injury in people with sepsis. Researchers will measure kidney blood flow and specific urine markers in 130 adults shortly after sepsis diagnosis. The goal is to see if these tests can spot …

This study tests whether a special PET scan using 82-Rb can tell how aggressive a kidney tumor is. Doctors will compare the scan results to the actual tumor grade after surgery. If it works, patients might avoid unnecessary biopsies or surgeries. The study involves 50 adults with…

This study tests a urine test (Xpert Bladder Cancer Detect) to see if it can accurately identify people with hidden blood in their urine who are at higher risk for bladder cancer. About 1,475 adults over 40 will provide a urine sample and answer symptom questionnaires, then under…

This study tests whether a special PET scan (FAPI PET) and simple urine tests can better determine the stage of bladder cancer compared to standard methods. About 262 adults with bladder cancer will receive the scan and provide urine samples before treatment. The goal is to see i…

This study aims to see if a special MRI scan can accurately diagnose invasive upper urinary tract tumors. About 178 adults with suspicious findings on a CT scan will receive an MRI, and the results will be compared to standard biopsy or follow-up CT. If successful, MRI could offe…

This study is developing a blood test called NeutroFlow that measures specific immune cells (neutrophils) to predict whether cancer patients will benefit from immunotherapy. Researchers will collect blood samples from 600 patients with several types of cancer before they start tr…

This study tests a new computer tool that helps doctors figure out the cause of acute kidney injury (AKI) in hospitalized veterans. AKI is common and serious, but its cause can be hard to diagnose quickly. The tool uses rules and artificial intelligence to guide doctors toward th…

Paraffin disease happens when people inject paraffin oil into muscle for cosmetic enlargement, causing chronic inflammation, high blood calcium, kidney stones, and kidney damage. Researchers are testing whether empagliflozin or losartan, two drugs already used for kidney protecti…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

Researchers are testing whether heated saline can be safely given during surgery to remove early bladder tumors. The study enrolls adults with small papillary tumors that have not grown into the bladder muscle. Participants receive either heated saline or room-temperature saline …

Acute kidney injury is a common complication after major liver surgery. This trial tests whether adjusting anesthesia care based on real-time kidney oxygen readings, measured with near-infrared spectroscopy, can reduce kidney injury after elective hepatectomy. About 1,200 adults …

This study looks at whether taking the antibiotic TMP-SMX for a full year after a kidney transplant can prevent urinary tract infections (UTIs) better than stopping after 6 months. Fifty children and young adults who recently had a kidney transplant will either keep taking TMP-SM…

This study looks at whether the position a woman gives birth in (lying on her back, upright, or on her side) can help prevent stress urinary incontinence (leaking urine when coughing or sneezing) after childbirth. Researchers will follow 669 first-time mothers, ages 20-35, who pl…

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests an 8-week health literacy program designed to help people aged 55-74 who take 5 or more medications daily. The goal is to see if the program improves their understanding of medication management and reduces their risk of developing chronic kidney disease. Half of…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participan…

This study tests whether a single dose of the drug disitamab vedotin, given directly into the bladder right after kidney removal surgery, can prevent bladder cancer from coming back. It involves 49 adults with HER2-positive upper tract cancer who are at risk for recurrence. The m…

This study looks at newborn boys with posterior urethral valves (PUV), a rare birth defect that raises the risk of serious kidney infections. It compares circumcision alone versus circumcision plus daily antibiotics to see if the surgery alone is enough to prevent these infection…

This study tests whether electroacupuncture can prevent recurrent lower urinary tract infections in women. Over 300 participants will receive either real or sham electroacupuncture for 6 months, tracking infection episodes and antibiotic use. The goal is to see if this needle-bas…

This study tests whether rinsing the kidney with an antibiotic called dioxidine right after stone-removal surgery can stop infection-related stones from returning. About 95 adults with infection-type kidney stones will get either standard surgery alone or surgery plus the rinse. …

This study compares two treatments—Plazepod and electrical stimulation—to see which better reduces fall risk in people on hemodialysis. Sixty men aged 40 to 50 with end-stage kidney disease will be followed for changes in balance, leg strength, and mobility. The goal is to find a…

This study tests whether a simple home exercise program can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4-5). 124 participants will either do low-intensity walking and strength exercises or receive standard care. …

Researchers test whether adding inspiratory muscle training to a walking program helps adults on hemodialysis who also have atrial fibrillation. Participants do breathing exercises through a mouthpiece and walk for six minutes, while the study tracks heart rate, blood pressure, k…

Researchers test whether a single intravenous dose of anrikefon, given near the end of kidney stone removal surgery, can reduce opioid-related side effects such as nausea, vomiting, itching, oversedation, and breathing problems in the first 24 hours after surgery. All 160 adult p…

This study tests whether adding a non-invasive electromagnetic chair treatment (HIFEM) to standard pelvic floor training can better reduce urine leakage in women aged 65-85 with daily stress incontinence. One hundred participants will be randomly assigned to either pelvic floor t…

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random …

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

People with advanced kidney disease often face fatigue, itching, pain, and sleep problems that disrupt daily life and strain caregivers. Researchers are testing a nurse-led program called COMFORT that helps patients and their informal caregivers recognize and manage these symptom…

Researchers are testing whether a breathing muscle training program done during hemodialysis can improve breathing strength and physical function in adults with advanced kidney disease. Participants train with a handheld electronic device three times a week for 12 weeks while rec…

Researchers compare two minimally invasive operations for adults with bladder stones. One approach, transurethral cystolithotripsy, reaches the bladder through the urethra. The other, percutaneous cystolithotripsy, goes through a small puncture in the lower belly. The trial rando…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study tests whether a structured family conversation program, called Family TIME, can be delivered successfully to adults receiving hemodialysis for chronic kidney disease and their family members. Participants either receive usual care or usual care plus three family conver…

This trial tests whether listening to music or letting numbing medication sit longer can reduce pain during cystoscopy, a procedure that examines the bladder. About 1,740 people undergoing cystoscopy for bladder cancer diagnosis or surveillance will be randomly assigned to differ…

This trial tests a treatment called peroneal electric transcutaneous neuromodulation, or peroneal eTNM, for people with overactive bladder syndrome. The procedure uses mild electrical pulses to stimulate the peroneal nerve near the ankle, which may help reduce the sudden, strong …

This trial tests whether a super high-flux dialyzer, a more efficient filter used during hemodialysis, can remove more middle-molecule toxins from the blood than standard high-flux dialyzers. The study includes 40 adults with end-stage kidney disease who are on maintenance dialys…

This trial tests a personalized home-based supportive care program for people with non-muscle-invasive bladder cancer who receive intravesical perfusion therapy after surgery. The program provides physical symptom relief, psychological support, and education to help patients mana…

This trial tests whether light therapy glasses can reduce depression in people with end-stage kidney disease who undergo hemodialysis three times a week. Participants wear either active glasses (1000 lux) or a sham device (50 lux) for 30 minutes each session over five weeks. The …

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This study tests whether high-intensity focused ultrasound (HIFU) can safely and effectively treat urinary symptoms caused by an enlarged prostate. Seventeen men aged 45 to 80 with moderate to severe symptoms will receive a single HIFU treatment using a probe placed in the rectum…

This study tests two treatments—mirabegron (a drug) and exercise-based behavioral therapy—for overactive bladder in people with Parkinson's disease. Researchers want to see if combining treatments helps those who don't respond to one alone. The trial will involve 146 participants…

This study tests a laser surgery for men with small prostates that still cause bothersome urinary symptoms. It compares three surgical methods to see which best prevents bladder neck scarring and improves urine flow. 426 men aged 40 to 80 will take part. The goal is to find the s…

This trial compares two approaches for adults with interstitial cystitis, a condition causing long-term bladder pain and frequent urination. All participants receive education and behavioral training, while half also take the antidepressant venlafaxine for 12 weeks. Researchers w…

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study tests whether stimulating a nerve near the ankle, called percutaneous tibial nerve stimulation (PTNS), can safely treat overactive bladder in children aged 5 to 21. The treatment uses a device called Urgent PC that sends weak electrical signals through a thin needle to…

This study looks at whether a supportive product called Neuridase can help reduce nerve damage (peripheral neuropathy) caused by a combination of two cancer drugs (enfortumab vedotin and pembrolizumab) in people with advanced bladder cancer. About 40 participants will receive sta…

This early study tests a new device that lets dialysis patients use just one needle instead of two for their blood cleaning treatments. The goal is to see if it is safe and works well for people who already have a mature vein connection (fistula). About 20 adults who need dialysi…

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This study tests whether Anakinra, a drug that reduces inflammation, can prevent dangerous drops in blood sugar after meals in a patient who had his stomach removed. The 52-year-old man also has kidney failure and needs dialysis. Over 10 weeks, he will receive either Anakinra or …

This study tests whether using virtual reality (VR) during arteriovenous fistula surgery—a procedure for dialysis patients—can lower pain, anxiety, and the need for anesthesia. About 64 adults with end-stage kidney disease will be randomly assigned to receive VR or standard care …

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This study compares lidocaine, a numbing drug, to morphine for treating severe kidney stone pain in the emergency room. Researchers will enroll 250 adults whose pain isn't relieved by standard treatment. The goal is to see if lidocaine provides better pain relief at 30 minutes, p…

This study tests a device called VTone that uses gentle electrical pulses inside the vagina to strengthen muscles and reduce stress urinary incontinence (leaking when coughing, sneezing, or exercising). Fifteen women will receive 8 weekly treatments and be followed for 3 months. …

This study compares a new ureteral access sheath with built-in suction (FANS) to the standard sheath used during kidney stone removal surgery. The goal is to see if the suction device helps clear more stone fragments and reduces infections. About 134 adults with kidney stones wil…

This study tests whether combining relaxation exercises with listening to a specific Quran chapter (Surah Ar-Rahman) can reduce anxiety and improve sleep in people undergoing kidney dialysis. 76 adult Muslim patients will be split into two groups: one doing the relaxation and Qur…

This study tests whether adding a special breathing feedback device to standard breathing exercises can reduce symptoms and improve quality of life in adults with chronic kidney disease. Twenty-four participants will practice the exercises three times daily for six weeks. The goa…

This study tests whether adding Huaier Granule to standard care can reduce proteinuria (excess protein in urine) in breast cancer patients who developed it as a side effect of immunotherapy or anti-angiogenic therapy. About 120 women will be randomly assigned to receive either st…

This study compares two nerve block techniques—dual external oblique fascial plane block and erector spinae plane block—for pain control after percutaneous nephrolithotomy (PCNL), a surgery to remove large kidney stones. Ninety adults will be randomly assigned to receive one of t…

This study looks at whether giving standard bladder cancer drugs in the morning or afternoon changes how well they work and how many side effects they cause. About 224 adults with advanced bladder cancer will be randomly assigned to receive their treatment either before 11:30 a.m…

This study compares two types of nerve blocks (ESPB and QLB) to see which provides better pain relief for children aged 2-12 after kidney surgery. One hundred children will be randomly assigned to receive one of the two blocks. The main goal is to see how long it takes before the…

This study will compare two laser surgeries (HoLEP and ThuLEP) for treating an enlarged prostate in 200 men aged 40-90. The goal is to see which procedure better preserves bladder control, avoids urethral narrowing, and maintains sexual function. Researchers will track outcomes l…

This study tests whether doing virtual reality exercise during dialysis can help patients with end-stage kidney disease keep their electrolytes (sodium, potassium, calcium, phosphorus) in a healthier range. Forty adults on regular dialysis will either do 30 minutes of VR cycling …

This study compares taking tamsulosin every day versus every other day in 288 men aged 40 and older with enlarged prostate and moderate-to-severe urinary symptoms. The goal is to see if the every-other-day schedule controls symptoms just as well while possibly causing fewer sexua…

This study tests whether breathing low-oxygen air during exercise (simulated high-altitude training) can improve walking ability and reduce fatigue in people with stage 3-4 chronic kidney disease. Sixty adults aged 40-65 will be split into three groups: simulated altitude trainin…

This study tests whether a smartphone app with artificial intelligence can help people on hemodialysis take better care of themselves. The app provides education on diet, fluid intake, and fistula care, and sends reminders. 76 patients will be randomly assigned to use the app or …

This study tests a newer, more precise radiation method (adaptive radiotherapy) for people with muscle-invasive bladder cancer who cannot have surgery or choose not to. The goal is to see if this technique reduces bowel side effects like diarrhea compared to standard radiation. A…

This study tests if a gentle heat treatment (45-50°C) delivered through the vagina can calm overactive bladder symptoms. The heat targets nerve endings in the bladder muscle to reduce urgency and leakage. About 48 adults with moderate to severe symptoms will receive this office-b…

This study looks at whether a personalized exercise program, started in the hospital and continued at home with video supervision, can help older adults recover after being hospitalized for pneumonia or a urinary tract infection. The goal is to see if this approach is safe, impro…

This study tests whether potassium citrate, a medication that makes urine less acidic, can relieve painful UTI symptoms in women aged 18-50. Fifty participants will take either potassium citrate or the antibiotic nitrofurantoin for 7 days. Researchers will compare symptom scores …

This study tests whether small changes—like playing calming music, showing a relaxing video, or giving numbing gel at the right time—can reduce pain and anxiety during a bladder cancer exam or treatment. About 378 adults with bladder cancer will be randomly assigned to receive on…

This study will test a mobile app called Smart Kidney that helps adults with chronic kidney disease track and manage their symptoms remotely. Sixty participants in Vietnam will use the app for 6 weeks. The goal is to see if the app is easy to use and helpful for symptom managemen…

This trial tests whether a structured training program for ICU nurses, focusing on respiratory and renal care with case-based discussions, improves their clinical reasoning, knowledge, and collaboration with doctors. The study involves 140 participants, including nurses and mecha…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

Researchers at Assiut University Hospitals compare adults with kidney failure who receive hemodialysis twice a week versus three times a week. The study tracks health-related quality of life, dialysis adequacy, urine output, and hospitalizations over time. About 130 participants …

Researchers at Assiut University are studying how common secondary hyperparathyroidism is among people with end-stage kidney disease who receive hemodialysis three times a week. The study also checks whether the quality of dialysis, measured by standard clearance formulas, relate…

This study will compare two types of robot-assisted surgery for prostate or kidney cancer: single-port (one small incision) and multi-port (several incisions). Researchers will track 376 adults to see which approach leads to a shorter hospital stay and better recovery. The study …

This pilot study tests a patient navigation program for people who visited the ER for kidney stones and are at risk of missing their follow-up urology appointment. About 31 participants will get a trained navigator who helps with scheduling, transportation, and other barriers for…

Doctors often see creatinine rise in patients taking vancomycin plus piperacillin-tazobactam, a common antibiotic pair. It is unclear whether that rise means real kidney injury or a harmless lab change. This study follows 304 adults on either that pair or vancomycin plus meropene…

Researchers at Assiut University Hospital survey adults with advanced chronic kidney disease about arteriovenous fistula creation, the surgically connected vein and artery used for hemodialysis. The study includes pre-dialysis patients and people already on maintenance hemodialys…

People with advanced chronic kidney disease often develop calcium buildup in their coronary arteries, which raises the risk of heart problems. Researchers want to know whether a protein called CXCR2 on white blood cells can predict whose arteries will harden fastest. About 100 ad…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

Membranous nephropathy is a rare autoimmune kidney disease where antibodies attack the kidney and can cause nephrotic syndrome. Rituximab is a routine treatment that depletes B cells, but researchers suspect it also boosts regulatory T cells, which help control immune reactions. …

Researchers are testing whether people with rheumatoid arthritis have early, symptom-free kidney problems more often than healthy people of the same age and sex. The study compares kidney function and urine protein levels between 120 participants, including those with rheumatoid …

Researchers are studying how a single injection of the experimental medicine NNC0537-1482 moves through the body in people with different levels of kidney function. About 54 participants with normal, mildly, moderately, or severely reduced kidney function receive one dose under t…

This study will collect information from 100,000 critically ill patients worldwide who receive continuous renal replacement therapy (CRRT), a type of kidney dialysis, in intensive care units. Researchers want to understand how CRRT is used and how it affects patient survival and …

This study looks at how well a specific kidney filter (multiFlux 160) works when used with two different blood thinners—heparin or citrate—during continuous kidney replacement therapy. The goal is to see which approach keeps the filter working effectively while avoiding side effe…

This study looks at how the amount of phosphorus in food affects phosphorus and calcium balance in people with moderate chronic kidney disease (CKD). Fourteen participants will follow two different controlled diets (low phosphorus then high phosphorus, or vice versa) for 19 days …

This study follows 190 adults with chronic kidney disease who are not yet on dialysis. Over 24 months, researchers track clinical and lab measures to see who experiences a rapid drop in kidney function, defined as a sustained decline of more than 5 mL/min per year. The goal is to…

This study asks whether levels of a protein called vascular endothelial growth factor (VEGF) in blood and urine can predict which patients will develop acute kidney injury after heart surgery that uses a heart-lung machine. Researchers will follow 220 adults having planned heart …

This phase 1 trial examines how severe kidney impairment or end-stage kidney disease affects the levels of ribupatide, an experimental drug, after a single injection. Researchers compare drug exposure in 32 participants: some with normal kidney function and others with severe kid…

This study is testing whether a prediction model can accurately forecast how quickly kidney function declines in people with primary membranous nephropathy, a kidney disease that can lead to nephrotic syndrome and kidney failure. Researchers will follow 128 adults with biopsy-con…

This trial tests how the drug PKN605 moves through the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers give a single oral dose and measure drug levels in the blood over time. The goal is to see if reduced kidney function increa…

Researchers at Johns Hopkins are testing whether a blood test called Signatera can reliably detect tumor DNA in people with high-grade upper tract urothelial cancer, a rare cancer of the urinary tract. The study will collect blood samples before, during, and after treatment to se…

This study looks at the well-being and medical care of people in Korea who had their bladder removed (radical cystectomy) for bladder cancer. Using nationwide insurance records, researchers will track complications, hospital stays, readmissions, and survival up to three years aft…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This study looks at whether transcutaneous electrical nerve stimulation (TENS), a treatment for overactive bladder, also affects the autonomic nervous system—the part of the body that controls heart rate and stress responses. Researchers will measure heart rate variability in adu…

This study looks at whether giving antibiotics for just 24 hours before urological surgery works as well as the usual 48-hour course to prevent infections after the procedure. About 894 adults with a positive urine culture who are scheduled for certain types of urological endosco…

This study looks at whether children with chronic kidney disease, especially those on dialysis, have higher levels of PFAS chemicals in their blood. PFAS are found in many everyday products and may interfere with bone development. The study compares PFAS levels in children with k…

This study looks at whether the type of anesthesia used during a common kidney stone procedure affects how much effort the surgeon feels they are putting in. Researchers will observe adults having flexible ureteroscopy and retrograde intrarenal surgery (RIRS), where the anesthesi…

This study tests whether a pop-up alert in electronic medical records helps doctors prescribe more recommended medications for chronic kidney disease (CKD). About 1,000 patients with CKD will be included, and their doctors will either see the alert or not. The goal is to see if t…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether a blood-thinning method called citrate anticoagulation is safe and practical for critically ill patients with acute kidney injury who may not process citrate normally. It follows 50 ICU patients who need kidney replacement therapy and are at risk for c…

This study looks at whether two blood markers—DEL-1, an anti-inflammatory protein, and thromboxane A2, a sign of platelet activity—are linked to diabetic nephropathy, a common kidney complication of diabetes. Researchers will measure these markers in 80 adults, including patients…

This trial is testing whether a connected urine test strip device, called URIKI, can help people with stage 4 or 5 chronic kidney disease monitor their diet from home. Participants will use the device daily for 10 days, logging meals and other health information in a mobile app. …

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study examines how the severity of chronic kidney disease (CKD) affects the breakdown of a protein called FGF23, which is linked to bone health, anemia, and heart problems. Researchers will measure different forms of FGF23 in blood samples from 80 men with CKD stages 3a to 5…

This observational study at Sohag University Hospital will look at children from birth to 18 years old who have congenital anomalies of the kidney and urinary tract (CAKUT). Researchers will collect data from medical records and routine follow-ups to describe the types of anomali…

Acute kidney injury is a common and dangerous complication in intensive care, but current tests often detect it too late. This observational study tests whether a pressure gradient in the veins — the difference between the driving force for blood return and the central vein press…

This study looks at how the drug D-2570 moves through the body in people with reduced kidney function compared to those with normal kidneys. About 40 adults aged 18 to 70 will receive a single dose of D-2570. Researchers will measure drug levels in the blood and monitor for side …

This study examines the treatment costs of acute kidney injury (AKI) in patients who undergo cardiac surgery at a UK hospital. By comparing medical records of patients with and without AKI, researchers aim to calculate the financial burden of each stage of kidney injury. The find…

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study will test whether using a special ultrasound technique called VeXUS to guide fluid treatment can help protect kidney function in 100 ICU patients with acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and lasting kidney damage. Th…

This study looks at how the drug vasopressin affects the heart and blood flow in people with septic shock, a life-threatening condition from severe infection. Researchers want to see if different patients respond differently based on their specific heart and blood vessel status. …

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This study follows 120 adults with ANCA-associated vasculitis, an autoimmune disease, who are receiving rituximab therapy. Researchers will collect blood samples over time to look for immune cell changes that signal a coming relapse. The goal is to find biomarkers that help docto…

This study looks at whether using a patient's permanent dialysis access (a fistula or graft) instead of a temporary catheter is safe and effective for delivering continuous kidney replacement therapy in the ICU. Researchers will enroll 50 adults with end-stage kidney disease who …

This study compares four surgical techniques for removing bladder stones in patients who have a continent catheterizable urinary reservoir, a surgically created pouch that stores urine. The techniques include using a mini-percussion device through the stoma, a flexible scope thro…

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having bypass or valve surgery will be enrolled. Researchers will measure kidney injury markers and track how much fluid is given, ai…

This study looks at whether testing the liquid used to preserve donor livers and kidneys can predict infections in recipients. Researchers will check if bacteria or fungi in that fluid match infections that develop after transplant. The goal is to see if this simple test could he…

This study looks at what changes occur in the kidneys, urine, and blood when people with IgA nephropathy (IgAN) experience loin pain. Researchers will use MRI scans and lab tests to compare findings during a pain episode and when pain-free. The goal is to better understand the ca…

This study will test four different water-drinking plans in 20 healthy women to see which one gives the best bladder filling for a pelvic ultrasound. Participants will drink different amounts of water on different days, and researchers will measure bladder volume and comfort. The…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study explores how Black and Caucasian patients with kidney disease communicate with their transplant doctors during evaluation visits. Researchers will record these conversations and survey patients to find out which communication styles lead to more living donor referrals …

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This pilot study tests whether a structured discharge summary template and a chat-based educational messaging program can improve care transitions for adults leaving the hospital after acute kidney injury (AKI). Researchers will enroll 160 adults with moderate-to-severe AKI and c…

This study looks at two ways to prevent blood clots during dialysis in people with end-stage kidney disease. Twenty adults will try both methods—one using standard heparin and the other using a citrate-based approach—to see which causes less inflammation and removes waste better.…

This study looks at why dialysis patients often have heart problems that are hard to detect. Researchers will use a special heart test during a routine procedure to check for tiny blood vessel issues in 30 adults who have been on dialysis for at least 6 months. The goal is to fin…

This study tests whether a machine-learning tool built into electronic health records can help doctors reduce kidney injury after surgery. Over 25,000 adults having non-emergency surgery will take part. Doctors are randomly assigned to see the tool's risk prediction, see it with …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This study follows 30 people with liver cirrhosis and a history of bleeding from high blood pressure in the liver. They will have surgery to remove the spleen and disconnect certain blood vessels. Researchers will track kidney function for two years to see if the surgery helps or…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This study aims to learn what it's truly like to live with overactive bladder (OAB) by asking 2000 adults in eight European countries about their daily activities, emotional health, social life, and work. Participants complete surveys about their symptoms and quality of life. The…

This study looks at whether a special CT measurement, called the URSL Predictive Angle, can help doctors know ahead of time if a kidney stone surgery might need to switch to a different method during the procedure. Researchers will review records from 2,200 patients who had this …

This study looks at whether reading a short educational flyer helps women learn more about stress urinary incontinence (SUI). About 90 adult women visiting a urogynecology clinic will fill out a quiz before and after reading the pamphlet. The goal is to see if the pamphlet improv…

This study looks at how sex hormones from gender-affirming therapy change kidney function. Researchers will measure kidney performance, blood flow, and insulin sensitivity in 60 transgender people before and after one year of hormone treatment. The goal is to understand why men a…

This study tests whether a short course of belimumab, a drug used for lupus, can improve detection of immune cells that cause transplant rejection. The goal is to help highly sensitized kidney transplant candidates—people whose immune systems are very picky about donor organs—get…

This early-stage study tests whether a new formulation of the antibiotic polymyxin B (VRP-034) is safer for the kidneys than the current version. It involves 48 healthy adult men who will receive one or more doses of either the new or standard drug. Researchers will measure kidne…

This study tests whether shorter or standard-length dialysis sessions using expanded hemodialysis can remove waste products from the blood as well as a more intensive technique called high-volume hemodiafiltration. Fifteen adults with end-stage kidney disease will try three diffe…

This study will follow 290 Mexican adults with advanced chronic kidney disease who are on dialysis (hemodialysis or peritoneal dialysis). Researchers will track how many patients die, how often they are hospitalized, and how many infections they get. The goal is to better underst…

This study surveys 200 adults (patients and caregivers) to learn what matters most when moving from peritoneal dialysis at home to hemodialysis in a clinic. The goal is to improve care and support during this transition. No treatments or medications are tested—only opinions and p…

This study looks at two ways of giving fluids during liver surgery: one that limits fluids and one that gives more. The goal is to see which approach leads to fewer serious problems after surgery, especially kidney injury. About 90 adults having planned liver surgery will take pa…

This study aims to find out what factors help predict a successful outcome after a type of prostate surgery called HoLEP, which treats an enlarged prostate. Researchers will follow 604 men aged 40 and older who are scheduled for HoLEP. They will measure success based on symptom r…

This study will follow 1000 kidney transplant patients for one year to see if monthly blood tests for certain viruses (CMV, BK, and TTV) can help predict and prevent serious infections and kidney damage. The goal is to learn how the body's immune system and virus levels relate to…

This study looks back at how well a combination of two drugs—enfortumab vedotin and pembrolizumab—works as the first treatment for people with advanced bladder cancer that has spread. Researchers will collect data from 361 patients around the world to see how long they live and h…

This study aims to find genetic and protein markers that can predict whether patients with membranous nephropathy, a kidney disease, will respond to the drug rituximab. Researchers will analyze stored blood and tissue samples from 120 patients and healthy volunteers. The goal is …

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study will see if using virtual care technologies in hospital units can reduce problems like patient falls, infections, and readmissions, while also improving patient satisfaction. About 10,000 adults admitted to six hospital units will take part, with three units using the …

This observational study will compare the gut and urine bacteria, as well as metabolic profiles, of 120 people with ureteral stricture (a narrowing of the tube from kidney to bladder) against healthy volunteers. Researchers aim to find differences that could explain why the condi…

This study looks at whether ultrasound can help predict a sudden drop in blood pressure when ICU patients start a type of dialysis. Researchers will monitor 80 adults using heart and body scans before and during treatment. The goal is to find early warning signs to prevent compli…

This study will test a new classification system (BICEP) to grade bladder injuries that happen during a common surgery for bladder cancer called TURBT. Researchers will observe 1,000 patients to see how often injuries occur, how severe they are, and how doctors manage them. The g…

This study tests whether a digital program (videos, texts, and optional phone support) can help people with kidney failure get more inquiries from potential living donors. About 430 adults referred for a kidney transplant will be randomly assigned to get the program with or witho…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with chronic kidney disease (stages 3B-5). Participants will try four different 10-day diets, all provided for free, to see which foods …

This study looks at how the blood thinner enoxaparin works in critically ill ICU patients with kidney failure, some on dialysis and some not. Researchers will measure drug levels in the blood over 24 hours after a daily shot. The goal is to see if current dosing is enough to prev…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at whether people with overactive bladder can be monitored at home after receiving botulinum toxin injections, instead of going to the hospital. About 112 participants will be randomly assigned to either home or hospital follow-up. The goal is to see if home moni…

This study looks at how age and sex influence pain before and after a first-time flexible cystoscopy (a thin tube inserted into the bladder). Researchers will ask 150 adults to rate their expected and actual pain using a simple 0-10 scale. The goal is to better understand who mig…

This study looks at ICU patients with kidney failure who need blood thinners to prevent dangerous clots. Doctors currently use different types of heparin, but it's unclear which is safest and works best when kidneys are weak. The study will track over 1,100 patients to compare bl…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This early study tests a wearable device that listens to the sound of blood flow in the arm of people on dialysis. The goal is to see if the device can accurately measure the same signals as a standard stethoscope. Six adults with mature fistulas will wear the device weekly for 8…

This study will collect data from 300 kidney transplant patients who receive kidneys from older or higher-risk donors. The kidneys are kept on a machine that pumps cold fluid through them before transplant. Researchers will see if the machine's readings (like flow and pressure) c…

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…

This study aims to develop and test artificial intelligence (AI) tools to help doctors prescribe and deliver acute dialysis better for patients in intensive care. Researchers will analyze data from 7,500 patients to create algorithms that can predict the best treatment approaches…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study will follow about 250 adults having a common kidney stone surgery called RIRS. Researchers will collect information before, during, and after surgery to find out which patients are more likely to develop fever or a serious infection called sepsis. The goal is to help d…

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome…

This study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…

This observational study will follow 150 adults with early-stage bladder cancer to see if factors like muscle loss, fat distribution, and nutrition affect the chance of cancer coming back or getting worse. Participants will have standard treatments and extra assessments including…

This study tracks BK virus in saliva, urine, and blood of 100 kidney transplant recipients over one year. The goal is to see if the virus spreads through saliva and how it affects the new kidney. Participants collect their own saliva samples at home, plus give urine and blood at …

This study will use advanced MRI scans and blood tests to explore how SGLT2i medications protect the kidneys in 100 people with diabetic kidney disease who are at risk of worsening. Participants will already be taking SGLT2i as part of their routine care. The goal is to identify …

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will measure levels of lipoprotein A, a type of fat in the blood, in 300 people with stage 4 chronic kidney disease. Researchers want to see if high levels are linked to future heart attacks, strokes, or worsening kidney function over 18 months. The goal is to find a b…

This study will look at 1,100 older women in Hong Kong, including 1,000 with urinary incontinence and 100 without, to better understand the condition. Researchers will explore how common different types of incontinence are, what traditional Chinese medicine patterns appear, and w…

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This study looks at how receiving positive urine culture results impacts stress levels and bladder symptoms in women with recurrent urinary tract infections (UTIs). Researchers will follow 170 women, including those with interstitial cystitis or bladder pain syndrome, using quest…

This study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…

This study looks at whether teaching patients about catheter care can improve their attitudes toward preventing infections and lower their anxiety after urologic surgery. About 70 male patients who go home with a urinary catheter will receive a training booklet based on daily liv…