Can a heart drug shield kidneys during bypass surgery?
NCT ID NCT07617675
First seen Jun 03, 2026 · Last updated Jun 21, 2026 · Updated 4 times
Summary
This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participants receive either the drug or a placebo for about 48 hours, and researchers track kidney function for a week.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Fuwai Hospital, Chinese Academy of Medical Sciences
Beijing, China
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
recombinant human brain natriuretic peptide (rhBNP)
What this could lead to
If it works, this could provide a way to prevent kidney damage during heart surgery, reducing hospital stays and improving recovery.
What could go wrong
This is a Phase 4 trial, but results are not yet available. The drug may not prevent kidney injury as hoped, and side effects like low blood pressure are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.