Urinary system disorder

This expanded access program lets doctors in Texas give banked, partially matched virus-specific T cells to children under 18 who have persistent or recurring EBV, CMV, adenovirus, or BK virus infections after an allogeneic stem cell transplant or CAR T therapy. The cells come fr…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before surgery helps shrink tumors in people with high-grade upper urinary tract cancer. About 131 adults will be randomly assigned to receive either chemo alone or chemo plus durvalumab be…

This trial tests a two-part approach for advanced clear cell kidney cancer that has stopped responding to standard treatments. First, an imaging injection (PD-32766D) lights up cancer cells that have a specific marker (CA9). If the scan shows the marker is present, participants t…

This study tests whether using a hemostatic agent (a substance that stops bleeding) during kidney stone surgery can reduce blood loss compared to standard care. About 92 adults with kidney stones will be randomly assigned to receive either a hemostatic agent or no agent during th…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This study tests a drug called sacituzumab tirumotecan in 20 people with a rare and aggressive kidney cancer (SMARCB1-deficient renal medullary carcinoma) that has worsened after at least one prior treatment. The goal is to see if the drug can shrink or control the cancer. Resear…

This study tests whether giving extra caffeine to very premature babies (born before 30 weeks) can improve kidney oxygen levels and reduce kidney injury. About 114 babies already receiving standard caffeine will get either an extra dose or a placebo. Researchers will monitor kidn…

This large trial is testing whether a blood test that looks for tumor DNA can help decide who needs immunotherapy after surgery for muscle-invasive urothelial cancer. About 992 participants will be assigned to different treatment plans based on their blood test results. The goal …

This phase 2 trial is testing whether a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—can help people with kidney cancer that has spread to the brain. The study will enroll 20 participants who have not had prior treatment for their brain metastases. The main …

This Phase 2 trial tests whether adding belimumab to standard rituximab treatment helps more people with primary membranous nephropathy achieve remission. The study enrolls 58 adults with confirmed disease. Belimumab targets new immune cells, while rituximab depletes existing one…

This study tests a new drug called AU-007 in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug is designed to help the immune system fight cancer. About 159 participants will receive AU-007 alone or with other medicines to find the safes…

This study tests a drug called veverimer in 150 adults with moderate-to-severe chronic kidney disease (CKD) and a condition called metabolic acidosis, where acid builds up in the blood. The goal is to see if the drug can raise blood bicarbonate levels and improve physical functio…

This early-phase trial tests giving radiation therapy before surgery to people whose adrenal cancer has come back. The goal is to find a safe radiation dose and see if it helps shrink tumors before removal. About 32 adults with resectable recurrent ACC will receive daily radiatio…

This phase 2 trial tests an oral drug called ManNAc in 30 adults with primary focal segmental glomerulosclerosis (FSGS), a kidney disease that causes scarring and protein loss. Participants take ManNAc powder dissolved in water twice daily for 14 weeks. The study aims to see if t…

This study is checking how well the Altaviva™ device works over five years for people with sudden, strong urges to urinate (urge incontinence). The device sends mild electrical pulses to a nerve in the ankle to calm bladder signals. Researchers will track 256 adults to see if at …

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This phase II trial tests whether adding precise, high-dose radiation (SABR) to the main kidney tumor improves outcomes for people with metastatic kidney cancer that cannot be surgically removed. Participants receive standard immunotherapy drugs (avelumab, axitinib, or cabozantin…

This phase II trial tests whether adding the immunotherapy cemiplimab to the targeted drug cabozantinib works better than cabozantinib alone for advanced adrenocortical cancer. About 48 adolescents and adults whose cancer has spread or cannot be removed will take part. The study …

This Phase 3 trial tests the drug benralizumab (Fasenra) in children aged 6 to 17 with two rare eosinophilic diseases: EGPA and HES. The study aims to see if the drug is safe, how it works in the body, and whether it can help control the disease. Fourteen children will receive in…

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

Researchers compare empagliflozin and dapagliflozin, two similar diabetes drugs, to see which works better at preventing death, heart problems, and kidney damage in adults with type 2 diabetes, heart failure, or chronic kidney disease. The trial uses electronic health records to …

This trial compares two common diuretics—furosemide and mannitol—given during kidney transplant surgery to see which better prevents delayed graft function, a condition where the new kidney does not work right away and requires dialysis. The study enrolls adults receiving a decea…

This study tests a new drug, povetacicept, against a standard treatment (calcineurin inhibitor) in 176 adults with primary membranous nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the new drug can put the disease into remission more safely a…

Researchers are testing whether a chemotherapy combination called gemcitabine and carboplatin can help people with advanced urothelial cancer whose disease has worsened after treatment with enfortumab vedotin and pembrolizumab. The trial enrolls about 55 participants who receive …

This early-phase study tests a new treatment called GCAR1, which uses a patient's own immune cells (T-cells) that have been modified to recognize and attack cancer cells carrying a specific marker (GPNMB). The study enrolls 30 adults in Canada with advanced alveolar soft part sar…

This study tests whether adding BI 690517 (Vicadrostat) to empagliflozin can slow kidney disease and prevent heart failure hospitalizations or cardiovascular death in people with chronic kidney disease. About 11,000 adults with or without type 2 diabetes will take either BI 69051…

This study tests an oral medication called BI 764198 for people with a kidney condition called focal segmental glomerulosclerosis (FSGS). About 286 adults and teens will take either the study drug or a placebo daily for up to 2 years, while continuing their usual FSGS treatments.…

This study tests a new medicine, PF-08634404, in adults with advanced kidney cancer that has spread. The goal is to see if the drug is safe and can shrink tumors when used alone or with other cancer drugs. About 224 participants who have not had prior treatment for their advanced…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-phase trial tests a combination of three drugs—enfortumab vedotin, pembrolizumab, and quemliclustat—in people with advanced bladder or urinary tract cancer that has spread or cannot be removed by surgery. The goal is to see if the combination is safe and effective. The…

This study tests a new drug called GI-108 in people with advanced or metastatic solid tumors, including lung, head and neck, pancreatic, and kidney cancers. The drug is designed to boost the immune system's ability to fight cancer. The trial will first find the safest dose, then …

This study tests a healthy eating program that encourages people with early-stage bladder cancer to eat more cruciferous vegetables like broccoli, kale, and cabbage. These veggies contain natural compounds that may help fight cancer cells. Researchers want to see if this diet cha…

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This phase 3 trial tests whether the experimental drug sacituzumab tirumotecan helps people with advanced bladder cancer live longer than standard chemotherapy. About 590 participants whose cancer worsened after prior treatments will receive either the new drug or one of several …

This study tests an experimental drug called STL303 for people with IgA nephropathy, a kidney disease. About 15 adults will receive either STL303 or a placebo to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Possible side effects include na…

This study tests whether giving two drugs (enfortumab vedotin and pembrolizumab) before bladder cancer surgery can eliminate cancer in the lymph nodes and shrink tumors. About 23 adults with advanced bladder cancer that has spread to lymph nodes will receive the combination befor…

This study tests a combination of the drug enfortumab vedotin and radiation therapy given before surgery for muscle-invasive bladder cancer. It is for patients who cannot receive standard cisplatin chemotherapy. The trial will test three different schedules of the drug and radiat…

This study tests experimental drug combinations for people with advanced kidney cancer (clear cell type) that came back during or within 2 years of finishing immunotherapy. About 140 participants will receive these combinations to see if they are safe and can shrink tumors. The g…

This early-phase trial tests a new type of cell therapy called BCMA-CD19-IL-15/IL15sushi compound CAR T cells in 20 people with severe lupus that hasn't improved with standard treatments. The therapy aims to reset the immune system by targeting and eliminating faulty immune cells…

When a kidney stone blocks urine flow and causes a dangerous infection called urosepsis, doctors must drain the kidney right away. They can use a stent placed through the urinary tract or a tube inserted through the skin. This study compares how each drainage method affects the l…

This early-phase trial is testing a new radioactive drug that seeks out a protein called Nectin-4 found on many cancer cells. The drug delivers a dose of radiation directly to the tumor, aiming to destroy it while sparing healthy tissue. About 150 adults with advanced bladder, br…

This study is testing the long-term safety and effectiveness of two experimental drugs, pozelimab and cemdisiran, taken together for paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. About 202 participants who completed a prior study will continue treatment to see…

This Phase 3 trial is testing whether adding the drug zanzalintinib to belzutifan helps people with advanced kidney cancer live longer and keep the cancer from growing. About 758 participants who have already tried standard treatments will receive either the combination or belzut…

This study tests whether adding a virus-based drug (pelareorep) to standard chemotherapy can help people with a specific type of advanced colorectal cancer that has stopped responding to initial treatment. About 60 adults whose cancer has spread and has certain genetic features (…

Researchers are testing whether giving lenvatinib and pembrolizumab before surgery can shrink advanced kidney cancer and the tumor clot that extends into the main vein from the kidney. The trial enrolls 30 adults with stage III or IV renal cell carcinoma and a level II to IV infe…

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The trial will include 99 adults with acute respiratory distress syndrome or kidney injury. Half will receive standard care plus the d…

This study tests an experimental drug called VIB4920 in people with active lupus nephritis, a serious kidney complication of lupus. About 74 adults will receive either VIB4920 or a placebo, along with standard medications, to see if the drug helps improve kidney function. The goa…

This Phase 3 trial tests whether mezagitamab, an injectable drug, can reduce protein in the urine and preserve kidney function in adults with IgA nephropathy, a condition where immune complexes damage the kidneys. About 347 participants will receive either mezagitamab or a placeb…

This study tests an experimental tablet, BI 764198, in adults and some teens with four types of kidney disease that cause protein in the urine. Participants take the drug or a placebo daily for 20 weeks while continuing their usual care. The main goal is to see if the drug lowers…

This Phase 2 trial tests whether combining pembrolizumab (an immunotherapy) with aldesleukin (IL-2) can shrink tumors in people with advanced melanoma or kidney cancer that hasn't responded to prior treatments. About 78 adults will receive two cycles of the combo in the hospital,…

This early-phase trial is testing an experimental drug called BMS-986504 alongside standard cancer treatments in 60 people with advanced cancers that have lost a gene called MTAP. The cancers include mesothelioma, stomach/esophageal cancer, and bladder cancer. The main goal is to…

This study tests the long-term safety of finerenone, a drug that helps control a key system involved in kidney damage, in children aged 1 to 18 with chronic kidney disease and proteinuria. All 100 participants will take finerenone alongside their usual ACE inhibitor or ARB medica…

This phase II trial is testing whether a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—can shrink or slow the growth of rare genitourinary cancers that have spread. About 314 adults with these uncommon tumors will receive the drugs. The goal is to see if the …

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

Researchers are testing whether the drug daratumumab can treat kidney diseases caused by monoclonal gammopathy of renal significance (MGRS), a group of conditions where abnormal antibody proteins damage the kidneys. The trial enrolls 30 adults with biopsy-confirmed MGRS. Particip…

This study tests a drug called felzartamab in people with IgA nephropathy, a kidney disease where abnormal antibodies build up and damage the kidneys. The goal is to see if felzartamab can reduce protein in the urine, a sign of kidney damage. About 454 adults will receive either …

Diabetic nephropathy is a common kidney complication of diabetes that current drugs can only slow, not reverse. Researchers are testing human umbilical cord mesenchymal stem cells, given by injection at increasing doses, to see if they are safe and can reduce inflammation and rep…

This study tests whether combining two immune-suppressing drugs, rituximab and cyclosporine, can safely reduce protein leakage in the urine of people with membranous nephropathy, a kidney disease where the immune system attacks the kidneys. About 30 adults with persistent high pr…

This study tests a new way to do stem cell transplants for people with severe aplastic anemia or other bone marrow failure diseases. Doctors give a smaller number of donor white blood cells along with the stem cells to try to reduce serious side effects. Up to 120 patients aged 4…

This study tests whether a combination of belatacept and sirolimus works better than the standard drugs tacrolimus and MMF in children aged 13-20 who receive a kidney transplant. The goal is to reduce the risk of organ rejection and protect kidney function. Participants are rando…

Researchers are testing whether regularly checking a marker called Gd-IgA1 can help doctors adjust treatment for IgA nephropathy, a kidney disease. Adults with biopsy-confirmed IgA nephropathy or IgA vasculitis-associated nephritis receive Nefecon or telitacicept. Half have Gd-Ig…

This study tests whether empagliflozin, a medicine already used for diabetes, can help children aged 2 to 17 with chronic kidney disease. About 120 kids will take either the drug or a placebo for 6 months, then everyone gets the drug for a year. Researchers will check kidney func…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This early-phase trial is testing a gene therapy called nadofaragene firadenovec for people with low-grade upper tract urothelial cancer. The drug is instilled directly into the kidney's renal pelvis. The study aims to see if it is safe and can eliminate the cancer. Twenty adults…

This early-stage trial tests an experimental drug called INCA036873 in about 280 adults with advanced solid tumors or certain blood cancers that have worsened after standard treatments. The main goal is to check safety and find the right dose. Participants receive the drug throug…

After a liver transplant, patients take tacrolimus to stop their immune system from rejecting the new organ, but the drug can cause kidney problems, high blood pressure, diabetes, and other side effects. Researchers at the University of Alberta are comparing a once-daily extended…

People with end-stage kidney disease need a reliable way to connect to a dialysis machine, and their own veins sometimes cannot handle it. This study follows about 100 adults who receive a decellularized human femoral artery graft, a donated blood vessel stripped of living cells,…

This study tests a new drug called dabogratinib in 230 adults with a rare, low-grade cancer in the upper part of the urinary tract. The goal is to see if the drug can make the cancer disappear completely within 6 months. Participants take the drug by mouth and are monitored for s…

This named patient program gives doctors controlled, pre-approval access to a mitomycin gel called JELMYTO for specific patients with cancer of the renal pelvis or ureter. It is for people in select countries where the treatment is not yet approved and who have exhausted other op…

This study tests whether injecting sodium thiosulfate directly into abnormal calcium deposits can shrink them and reduce pain. It includes people with three rare conditions: systemic sclerosis, dermatomyositis, and a genetic disorder called iPPSD2. Participants receive up to 11 i…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This phase 2 trial is testing whether a new drug called obinutuzumab beta, combined with a short course of steroids, can help people with newly diagnosed ANCA-associated glomerulonephritis—a rare autoimmune disease that causes kidney inflammation and damage. The study will enroll…

Researchers are testing two experimental oral drugs, TT-10 and TT-4, in adults with advanced solid tumors such as kidney, prostate, and lung cancers that have worsened after standard treatment or cannot receive it. The drugs block adenosine receptors, which tumors use to quiet th…

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This phase 2 trial is testing a new treatment called FT819 for people with lupus nephritis, a serious kidney complication of lupus. FT819 is made from donor immune cells that are engineered to target and destroy faulty B cells. The study will enroll 53 participants and aims to se…

This early-stage trial is testing two experimental drugs, vonsetamig and odronextamab, in people with lupus nephritis that has not responded to standard treatments. The main goal is to check safety and side effects over the long term. Researchers will also see if the drugs can he…

This study tests whether adding an experimental treatment (V940) to standard BCG therapy helps people with high-risk non-muscle invasive bladder cancer live longer without their cancer returning. About 308 adults will be randomly assigned to get either V940 plus BCG or BCG alone.…

This study is testing a new experimental drug called GI-101, given alone or with pembrolizumab or lenvatinib, in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults w…

This study tests two drugs, durvalumab and monalizumab, given together to people with a type of bladder cancer that has not gotten better with standard treatment. The goal is to see if the combination can make the cancer disappear or stop it from growing. About 60 adults will tak…

This study tests a new drug called pumitamig, alone or combined with ipilimumab or cabozantinib, in 254 people with advanced kidney cancer that cannot be removed by surgery. The goal is to see if the drug is safe and can shrink tumors. Participants must have a confirmed diagnosis…

This study tests a new treatment called LBP-EC01, which uses specially designed viruses (bacteriophages) to attack drug-resistant E. coli bacteria that cause urinary tract infections (UTIs). About 318 adults with a history of UTIs and a current infection will receive either LBP-E…

This pilot phase II trial tests whether giving two immunotherapy drugs, botensilimab and balstilimab, before surgery is safe and feasible for patients with high-risk clear cell kidney cancer that hasn't spread. Sixteen participants will receive the drugs and then undergo surgery …

This study compares two ways of dosing the drug mycophenolate mofetil (MMF) for children with lupus nephritis, a kidney disease caused by lupus. One method uses a standard dose based on body size, while the other adjusts the dose based on drug levels in the blood. The goal is to …

This study is following 55 adults who have an implanted device that stimulates nerves to control overactive bladder. Researchers want to see if the device safely improves quality of life over the long term. Participants must have already tried other treatments without success.

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs …

People with high-grade non-muscle-invasive bladder cancer often receive BCG immunotherapy, but some cancers stop responding. The standard next step is surgery to remove the bladder, which many patients cannot or choose not to have. This trial tests whether radiation to the whole …

This early-stage study tests the safety of a new drug called AZD1613 in 40 adults with autosomal dominant polycystic kidney disease (ADPKD), a condition that causes kidney cysts. Participants receive either the drug or a placebo to check for side effects and how the drug moves th…

Researchers are studying how well benralizumab works in adults with eosinophilic granulomatosis with polyangiitis (EGPA), a rare disease that inflames blood vessels and can affect the lungs, nerves, and sinuses. The study follows about 100 patients at European referral centers wh…

This early-stage trial tests a new drug, REGN15505, alone or with other drugs, in adults with advanced prostate or kidney cancer that has spread. The goal is to help the immune system attack cancer cells. About 265 participants will be enrolled to check safety, side effects, and …

This study tests a new drug called MK-3120 for high-risk non-muscle invasive bladder cancer. After standard tumor removal, 45 participants will receive the drug directly into the bladder. The main goals are to check safety and how well people tolerate it, while also looking at tu…

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

This program provides early access to cretostimogene grenadenorepvec, a virus-based therapy, for patients with non-muscle invasive bladder cancer that has not responded to standard BCG treatment. Eligible participants have a specific type of bladder cancer (CIS with or without hi…

This Phase 3 trial is testing whether a combination of two drugs, balcinrenone and dapagliflozin, works better than dapagliflozin alone to prevent heart failure events and cardiovascular death. About 4,800 adults with heart failure and moderate-to-severe kidney impairment who rec…

This study tests a drug called surovatamig in 43 adults with primary membranous nephropathy, a kidney disease caused by antibodies attacking the kidneys. The drug is given as a shot under the skin. Researchers want to see if it is safe and can reduce protein in the urine, which i…

Researchers are testing whether adding ivonescimab to enfortumab vedotin works better than adding pembrolizumab to enfortumab vedotin in people with locally advanced or metastatic urothelial cancer who have not yet received systemic treatment. The trial enrolls about 800 adults w…

This study tests whether two drugs, enfortumab vedotin and pembrolizumab, can control muscle-invasive bladder cancer without needing to remove the bladder. About 390 adults whose cancer hasn't spread outside the bladder will receive either the drug combo or standard chemoradiatio…

This study tests a home monitoring system called VIEWER for people with advanced chronic kidney disease (stage 5) or end-stage renal disease. The system includes a tablet, blood pressure cuff, scale, oxygen monitor, and motion tracker. Researchers want to see if using this platfo…

This early-stage trial is testing a new biologic drug, GEN1106, in about 103 people with advanced solid tumors, including bladder cancer. The study has three parts: first, finding a safe dose; then refining it; finally, checking how well the drug shrinks tumors. All participants …

Researchers are testing whether pumping donated kidneys with a warm, oxygen-rich fluid before transplant helps them work better than the standard method of cold storage. The trial enrolls adults waiting for a first or second kidney transplant from donors who died after circulator…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a donor to target and calm the overactive immune system. The main goals are to check safety and see if it can impr…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This study tests a drug called DS-8201a (trastuzumab deruxtecan) in children, teens, and young adults whose osteosarcoma, Wilms tumor, or desmoplastic small round cell tumor has come back or not responded to treatment. The drug works like a smart bomb, attaching to cancer cells a…

This study tests a device called the Selective Cytopheretic Device (SCD) in 339 ICU patients with severe acute kidney injury who are already on continuous kidney replacement therapy. The device filters blood to reduce inflammation, and researchers want to see if it improves survi…

This study tests a new treatment called AZD0120 for people with severe lupus that hasn't improved with standard therapies. AZD0120 is a type of CAR T cell therapy that targets two proteins (CD19 and BCMA) on immune cells to calm the overactive immune system. The trial will enroll…

This study tests an experimental drug called VX-147 in adults and children with a genetic form of kidney disease linked to the APOL1 gene. The goal is to see if the drug can reduce protein in the urine and protect kidney function. About 466 participants will receive either VX-147…

This early-stage trial is testing a drug called orellanine, derived from a mushroom, in 75 people with advanced kidney cancer who are also on dialysis. The drug is given intravenously to see if it is safe and can shrink tumors. All participants have end-stage kidney disease and h…

This Phase 2 trial tests an oral drug called TYRA-300 in 90 adults with a low-grade, intermediate-risk bladder cancer that has not invaded muscle. The cancer must have a specific genetic change (FGFR3 alteration). Participants take a daily tablet for up to 2 years. The main goal …

This study tests a new gene therapy, PS-002, for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The therapy aims to control the disease in people who are at high risk of getting worse despite current treatments. Participants receive a single dose a…

This study is testing whether a kidney from a genetically modified pig can safely work in people with end-stage renal disease who cannot get a human kidney. Up to 50 participants will receive the pig kidney and be followed for at least 24 weeks to check survival, kidney function,…

Researchers are testing whether sodium zirconium cyclosilicate (Lokelma) controls high potassium better than the usual approach of reducing or stopping RAASi and MRA medicines in people with chronic kidney disease. The trial enrolls adults with potassium levels between 5.0 and 6.…

This study tests a decision tool to help select women with bladder cancer who can safely keep their reproductive organs during bladder removal surgery. Currently, standard surgery removes the bladder, uterus, ovaries, and part of the vagina, which can harm sexual health, mental h…

This study looks at how well the medication pegcetacoplan works and how safe it is for people with two rare kidney conditions: C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). Researchers will follow about 150 patients who are…

This phase III trial is testing whether an experimental drug called elecoglipron can reduce the risk of serious kidney decline, kidney failure, or death in people with chronic kidney disease. About 7,000 adults with the condition, with or without type 2 diabetes, will receive eit…

This early-stage trial tests a new drug called IAM1363 in adults with advanced cancers that have HER2 alterations, including breast, lung, and stomach cancers that have spread to the brain. The study aims to find the safest dose and see if the drug can shrink tumors. About 383 pa…

This 2-year extension study looks at lupus nephritis patients who finished a previous trial of ianalumab. Some patients who responded well will stop treatment to see if their kidney disease stays under control. Others who did not respond or were already on open-label ianalumab wi…

This early-phase trial is testing a new experimental drug, BNT317, in 39 people with advanced solid tumors who have run out of standard treatment options. The main goal is to check the drug's safety, find the right dose, and see how the body handles it. It is too soon to know if …

This early-stage study is testing a new drug called M0324, a bispecific antibody designed to target cancer cells. The trial will look at M0324 alone, with the immunotherapy pembrolizumab, and with chemotherapy in about 77 people with advanced solid tumors that have not responded …

This study tests an experimental drug called iptacopan in 31 children aged 2 to under 18 with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug reduces protein in the urine, a sign of kidney damage, and to check its safety and how t…

This pilot trial tests whether restarting renin-angiotensin system inhibitors (RASi) — common blood pressure and kidney-protecting medications — early after acute kidney injury is feasible and well-tolerated. Hospitalized adults who were on RASi before admission and stopped due t…

This early-stage trial will test the safety and tolerability of a new drug, cevostamab, in 46 people with systemic lupus erythematosus, some of whom also have active lupus nephritis. The drug is given intravenously, and researchers will monitor side effects and how the drug moves…

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This study tests a new drug called PF-08052667 for adults with a type of bladder cancer that hasn't spread into the muscle layer but is likely to return. The drug is given directly into the bladder, sometimes with other medicines like BCG or sasanlimab. The trial has three parts …

This phase 3 trial is testing whether adding an experimental drug called SHR-1501 to the standard BCG therapy can improve outcomes for people with a high-risk form of bladder cancer that has not spread into the muscle wall. Participants must have had all visible tumors removed be…

This phase II trial compares two treatments for high-grade T1 bladder cancer that hasn't spread. One group gets the immunotherapy drug pembrolizumab plus radiation, while the other gets standard chemotherapy (cisplatin, gemcitabine, 5-fluorouracil, or mitomycin-C) plus radiation.…

This trial tests whether a special filter called oXiris, used during continuous blood purification, can lower endotoxin levels in adults with septic shock and acute kidney injury. Septic shock is a life-threatening condition where infection causes severe organ failure. The filter…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests a stem cell transplant using blood stem cells from a half-matched family donor (haploidentical) for people with severe aplastic anemia, related MDS, or PNH. Participants receive chemotherapy and a single radiation dose before the transplant, plus a drug to preven…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This study tests whether injecting a substance made from donated amniotic membrane into the bladder can reduce pain and urgency in women with interstitial cystitis (painful bladder syndrome). One hundred women who have not gotten better with other treatments will receive either t…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a stan…

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This phase 3 trial tests a gene therapy called nadofaragene firadenovec against simply watching and waiting in people with intermediate-risk non-muscle invasive bladder cancer. The study will enroll 454 participants who have had a tumor removed. The goal is to see if the gene the…

This trial tests an experimental drug called DS-2243a in adults with advanced solid tumors, including sarcoma, that have spread or cannot be removed surgically. The study has two parts: first, researchers find the safest dose by giving increasing amounts to small groups; then, th…

This study tests a new drug called AVZO-1418 in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if it shrinks tumors. About 480 adults will take part, receiving the drug alone or with other treatments.

This phase 2 trial is testing a combination of two drugs, zanzalintinib and nivolumab, given before surgery to people with advanced kidney cancer that is hard to remove. The goal is to shrink the tumor enough so that surgery becomes possible. About 69 participants will receive th…

This study tests three different drug combinations in 120 people with advanced kidney cancer that has spread. The goal is to see which combination works best to shrink tumors. Participants will receive either a new two-drug or three-drug combination, or a standard two-drug therap…

This early-phase study tests an experimental drug called PF-08046876 in about 310 adults with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas that have not responded to standard treatments. The drug is a type of 'antibody drug conjugate' designed to s…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This trial tests whether personalized pharmacological counselling can help manage side effects of the kidney cancer drug cabozantinib. The approach combines blood level monitoring, genetic testing, and drug interaction checks to tailor dosing. Researchers will compare treatment i…

This study tests a special dialysis machine, the MultiFiltratePRO, in children with acute kidney failure. The goal is to see if it can deliver at least 80% of the prescribed treatment within 72 hours while being safe. About 43 children weighing between 8 and 40 kilograms will be …

This study tests a new treatment called HS-10566, a gel that delivers the chemotherapy drug gemcitabine directly into the bladder. It is for people with high-risk non-muscle-invasive bladder cancer who cannot or choose not to have their bladder removed. The trial will check if th…

This Phase 2 trial tests a drug called cretostimogene grenadenorepvec in 325 people with high-risk non-muscle-invasive bladder cancer. The drug is a virus that is put directly into the bladder to attack cancer cells. The study looks at how well it works and how safe it is, includ…

This extension study follows people with von Hippel-Lindau (VHL) disease or advanced solid tumors who are already taking belzutifan in another trial. The goal is to see how long they live and how safe the drug is over the long term. About 450 participants will take belzutifan by …

This early-stage study tests a new drug called MK-4884 in about 120 people with advanced or metastatic solid tumors (colorectal, kidney, lung, or bile duct cancer). The main goal is to check the drug's safety and find the right dose. Researchers will monitor side effects and how …

This Phase 2 study tests a new drug called ADX-038, alone or with another drug (telitacicept), in 30 Chinese adults with kidney diseases caused by an overactive complement system (IgA nephropathy, C3G, or IC-MPGN). The goal is to see if the treatment is safe and can help control …

This study tests if obinutuzumab can help teens and children with lupus nephritis, a serious kidney complication of lupus. About 40 participants aged 5 to 17 will receive either the drug or a placebo. The goal is to see if the drug improves kidney function and reduces protein in …

This study tests a new gel-like drug, UGN-104, placed directly into the upper urinary tract to treat low-grade cancer. About 70 adults with small tumors will receive the treatment to see if it can completely eliminate visible cancer. The goal is to control the disease and avoid m…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This study follows adults with chronic kidney disease who are on dialysis and starting the phosphate binder Nephoxil for high blood phosphorus. Researchers track patients for 48 weeks to see how many reach a target phosphorus level of 3.5 to 5.5 mg/dL, using either a low or stand…

This early study tests a single treatment of EG110A injections into the bladder muscle for adults with spinal cord injury who still have bladder leaks despite standard care. The goal is to see if the treatment is safe and can reduce incontinence. Sixteen participants will be foll…

This study tests a new drug called VEL-101 in 120 kidney transplant patients. The goal is to see if VEL-101 can safely replace the standard drug tacrolimus, which often causes side effects. Researchers will monitor for rejection, side effects, and how the drug behaves in the body…

This trial compares two approaches for people with small, symptom-free kidney stones: immediate surgery versus simply monitoring them over time. Researchers want to know which strategy leads to less disruption in daily life, fewer emergency visits, and better overall well-being. …

This Phase 2 study is testing a new drug called ADX-038 in 45 adults with complement-mediated kidney diseases, such as IgA nephropathy and C3G. The drug is an siRNA that targets the complement system, which is overactive in these conditions. Researchers are checking if it is safe…

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard chemotherapy delivered directly to the liver can help people with colorectal, bile duct, or adrenal cancer that has spread to the liver. About 70 adults will receive the drug combination along with a s…

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This study tests whether adding TAVNEOS to standard treatment helps control ear, nose, and throat symptoms in people with granulomatosis with polyangiitis (GPA). About 30 adults with active ENT disease will receive either TAVNEOS or a placebo for 52 weeks. The goal is to see if m…

This study tests if a new drug called siplizumab can safely prevent kidney transplant rejection better than the current standard treatment. About 120 adults receiving a kidney transplant will be split into three groups: two groups get different doses of siplizumab, and one gets t…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

This study tests whether adding the experimental drug casdatifan to the standard drug cabozantinib can slow cancer growth better than cabozantinib alone in people with advanced clear cell kidney cancer. About 720 adults whose cancer worsened after prior immunotherapy will receive…

This phase 2 trial is testing whether a combination of three drugs—bevacizumab, erlotinib, and atezolizumab—can safely shrink or stabilize advanced kidney cancer in people with hereditary leiomyomatosis and renal cell cancer (HLRCC) or sporadic papillary renal cell cancer. The dr…

This study tests an experimental drug called APL2 for people with a kidney disease called FSGS. The goal is to see if APL2 can reduce protein in the urine, a sign of kidney damage. The trial has two parts: first, adults will receive APL2 openly; then, both adults and adolescents …

This early-phase study tests a new drug, ASP2998, that targets a protein called TROP2 found on many solid tumors. The drug is given alone or with standard treatments like pembrolizumab or carboplatin. The main goals are to check safety and find the right dose. About 428 adults wi…

This study tests an experimental drug called AZD4144 in 124 adults with sepsis who have also developed acute kidney injury. Participants receive either the drug or a placebo daily by IV while in the hospital. The main goal is to see if the drug helps maintain kidney function bett…

This study tests whether a 15-month course of Nefecon can prevent proteinuria relapse in 288 adults with IgA nephropathy who have already achieved remission. Participants must have completed prior Nefecon therapy and have stable kidney function. The goal is to see if maintenance …

This study tests whether adding tivozanib to the standard immunotherapy pembrolizumab works better than pembrolizumab alone to keep kidney cancer from returning after surgery. About 1040 adults with high-risk clear cell renal cell carcinoma will take part. The goal is to see if t…

This phase 2 trial tests a treatment called NDV-01 KIT for people with high-grade non-muscle invasive bladder cancer (NMIBC). The treatment is a gel containing two chemotherapy drugs, gemcitabine and docetaxel, which is placed directly into the bladder through a catheter. Partici…

This study tests a new device that creates a connection between an artery and a vein using a small needle puncture instead of open surgery. The goal is to provide a reliable access point for dialysis in people with kidney failure. About 126 adults will be enrolled and followed fo…

This study follows people with chronic kidney disease who previously received an experimental treatment called REACT, which uses a patient's own kidney cells to try to repair damaged kidneys. Researchers will track participants for years to see if the therapy causes any delayed s…

This study tests whether adding an experimental drug (MK-3120) to the standard treatment (enfortumab vedotin plus pembrolizumab) is safe and effective for people with advanced bladder cancer that has spread. About 55 participants will receive the new combination. Researchers will…

This early-phase trial is testing whether adding an experimental drug called HC-7366 to standard immunotherapy drugs (nivolumab and ipilimumab) can help control advanced clear cell kidney cancer. About 35 adults with stage IV disease will receive the combination. The main goal is…

This early-stage trial tests a new drug called CT-202 in people with advanced triple-negative breast cancer, colorectal cancer, or bladder cancer that has come back or spread. The drug is a bispecific antibody designed to help the immune system attack cancer cells that have a pro…

This trial compares two surgical techniques for removing complex kidney stones: a single-tract approach using a flexible scope versus the traditional multi-tract method. The goal is to see if the less invasive single-tract procedure can achieve similar stone-free rates at three m…

This study tests an investigational drug called ABBV-CLS-628 in adults with autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that causes fluid-filled cysts to grow in the kidneys. About 240 participants worldwide will receive either the drug or a placebo …

This trial investigates whether a 12-week supervised exercise program, done during regular hemodialysis sessions, can improve postural problems like hunched back and forward head posture in adults with end-stage renal disease. Participants will be randomly assigned to either the …

This trial tests whether having clinical dietitians take the lead on nutrition care—rather than waiting for referrals—can help adult medical inpatients at risk of malnutrition. Researchers will compare a dietitian-driven model with usual care on three hospital wards, measuring le…

This study tests a new way to deliver radiation therapy for people with lung cancer, melanoma, or kidney cancer that has started to grow again in a few spots despite treatment. The approach uses a PET scan to find the most active parts of the tumor and delivers a higher radiation…

This phase II trial is testing whether giving the immunotherapy drug pembrolizumab along with radiation therapy after chemotherapy can help patients with muscle invasive bladder cancer avoid bladder removal surgery. About 111 participants who responded well to initial chemotherap…

This study tests whether taking cabozantinib in a pattern that skips some days can keep the same drug levels in the body as the standard daily dose. It involves 34 adults with advanced kidney cancer who are already on a stable dose. Participants will try both the standard and the…

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This early-phase trial is testing whether adding an experimental drug called emavusertib (CA-4948) to the immunotherapy pembrolizumab can help patients with advanced urothelial cancer whose tumors have become resistant to PD-1/PD-L1 blockers. The study will enroll 27 adults and f…

This early-stage study tests a new drug called casdatifan (AB521) alone or combined with other cancer drugs in people with advanced clear cell kidney cancer or other solid tumors. The main goals are to check safety and find the right dose. About 362 participants will take part.

This study looks at whether irreversible electroporation (IRE) can safely and effectively treat recurrent pelvic tumors in people who cannot have surgery, radiation, or other local treatments. IRE uses electrical pulses to destroy cancer cells without cutting or heating tissue. R…

This trial tests whether a blood purification device called LIPOSORBER LA-15 can help people with focal segmental glomerulosclerosis (FSGS), a kidney disease that causes protein to leak into the urine. The study includes adults whose disease did not respond to standard treatments…

This pilot study tests whether Omnisol, a new preservation solution, can keep deceased donor kidneys in better condition during machine perfusion before transplantation. The goal is to reduce delayed graft function, where the kidney takes time to start working, and improve early …

This trial tests whether a blood purification device called the Liposorber LA-15 System can help children with focal segmental glomerulosclerosis (FSGS), a kidney disease that causes protein to leak into the urine and often resists standard treatments. The device filters the bloo…

This study explores whether adding high-intensity interval training (HIIT) to standard immunotherapy (nivolumab plus ipilimumab) helps patients with advanced kidney cancer. Thirty participants are randomly assigned to either a supervised exercise program or usual care. Researcher…

This trial tests whether combining an individualized exercise program, dietary advice, and anti-inflammatory fish oil supplements can help patients with kidney failure who are losing muscle and strength—a condition called kidney cachexia. Participants on hemodialysis at risk of c…

This trial asks whether aggressively lowering blood phosphate levels in people with end-stage kidney disease on dialysis can reduce heart attacks, strokes, and death. Participants are randomly assigned to either a liberal phosphate target or an intensive target aimed at normal le…

This trial is testing whether MRI-guided radiation therapy can treat early-stage kidney cancer with fewer side effects than standard CT-based radiation. The study enrolls adults with kidney cancer who are not candidates for surgery or who decline it. Participants receive a single…

This trial tests whether empagliflozin, a drug already used for diabetes, can protect kidney cells in African American veterans who have chronic kidney disease but do not have diabetes. Participants will take either empagliflozin or a placebo daily for four months. Researchers wi…

This trial explores whether starting dialysis twice a week instead of the standard three times a week, with a gradual increase over a year, can improve quality of life and preserve remaining kidney function in veterans with advanced kidney disease. Participants are randomly assig…

This trial tests whether droxidopa, an oral medication that raises blood pressure, can improve kidney function in people hospitalized with cirrhosis and acute kidney injury. The study will compare droxidopa to a placebo in 75 participants, measuring changes in blood pressure and …

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This trial tests whether a single intravenous dose of mesenchymal stem cells, derived from bone marrow, can safely help adults with active lupus nephritis achieve a complete or partial kidney response. Participants receive either the stem cells or a placebo (saline) in a double-b…

This phase IIa trial investigates whether obinutuzumab, a monoclonal antibody, can effectively treat adults with newly diagnosed minimal change disease, a kidney condition causing protein leakage and swelling. Participants receive either two doses of obinutuzumab or standard gluc…

This study follows people with end-stage kidney disease who need a vascular graft for hemodialysis. The GORE ACUSEAL graft is placed to create a reliable access point for dialysis. Researchers will track how often the graft becomes infected and how long it stays functional, aimin…

This study tests whether low-dose colchicine, an inexpensive anti-inflammatory drug, is safe and acceptable for people on hemodialysis. Researchers will give 100 dialysis patients colchicine for about 3 months, monitoring side effects and how many stick with it. The goal is to se…

This trial tests whether adding voclosporin to standard lupus nephritis treatment (mycophenolate mofetil and prednisolone) reduces kidney inflammation faster and more completely than standard treatment alone. Adults with active lupus nephritis will be randomly assigned to either …

This study tests whether people with advanced kidney cancer can safely pause their medication after one year of treatment. Doctors will use a special PET scan that targets CD70 to decide who qualifies for a treatment break. The goal is to see if patients can stop drugs without th…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This trial tests whether vericiguat, a drug that relaxes blood vessels, can protect the body during heart surgery. About 170 adults scheduled for open-heart surgery will receive either vericiguat or a placebo starting two days before the operation. Researchers will measure blood …

This trial tests two different drug combinations given directly into the bladder for people with a type of bladder cancer that has not responded to the standard BCG therapy. Participants are randomly assigned to receive either gemcitabine plus docetaxel or gemcitabine plus mitomy…

This trial asks whether a lower or medium intensity of continuous kidney replacement therapy (dialysis) is better for critically ill patients with acute kidney injury. It will compare a low dose (12 mL/kg/hr) against a standard medium dose (25 mL/kg/hr) to see which is more effec…

This trial tests whether the direction of the needle bevel (up or down) during fistula puncture affects the risk of complications in people on hemodialysis. About 240 adults with end-stage kidney disease who are starting dialysis with a new arteriovenous fistula will be randomly …

This trial tests whether a set of five kidney-protecting measures — given early to severe trauma patients identified as high-risk by a urine test — can reduce the chance of acute kidney injury. About 500 adults with severe injuries will be randomly assigned to receive either the …

This trial tests whether an oral herbal supplement called LCS103 can help prevent non-muscle invasive bladder cancer from recurring after surgery. Sixty adults who have had their bladder tumors completely removed will take either LCS103 plus standard care or standard care alone f…

This trial tests whether eating 5 grams of wakame seaweed daily for three months can lower levels of harmful AGEs in the blood of people with stage III chronic kidney disease. AGEs are compounds that may speed up kidney damage. The study includes 30 adults who will add the seawee…

This pilot trial tests whether using an ultrasound score (VeXUS) to guide fluid removal with diuretics can help kidneys recover in patients who develop acute kidney injury after cardiac surgery. About 40 participants will be randomly assigned to either VeXUS-guided fluid manageme…

This study tests whether adding a clinical decision support tool to the electronic medical record helps doctors use the furosemide stress test in critically ill children at high risk for acute kidney injury. The furosemide stress test measures how the kidneys respond to a diureti…

This phase 3 trial is testing whether a combination of two drugs—datopotamab deruxtecan and rilvegostomig—given after surgery can prevent cancer recurrence in people with high-risk muscle invasive bladder cancer. Participants who have had their tumor completely removed will recei…

This trial compares two starting doses of the steroid prednisone for children with lupus-related kidney inflammation (lupus nephritis). The standard high dose can cause serious side effects like growth problems and bone thinning. The study asks whether a lower initial dose can co…

This phase 2 trial tests whether adding one of four different drugs to a standard immunotherapy combination can help people with HER2-positive muscle-invasive bladder cancer avoid bladder removal. Participants receive disitamab vedotin and toripalimab plus a sensitizing agent, th…

This study tests a web-based program called Web-SUCCEED that helps veterans with chronic illness and their informal caregivers work together to manage the condition. The program includes three weekly online modules and brief phone calls with staff, focusing on stress coping and c…

This trial tests whether giving two drugs—enfortumab vedotin and pembrolizumab—before surgery can improve outcomes for people with upper tract urothelial cancer (a type of bladder cancer in the kidney or ureter). Participants receive the drugs intravenously, then undergo surgery …

This study tests whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard rate for patients with advanced kidney disease hospitalized due to severe fluid overload. Participants are randomly assigned to receive either a…

This trial compares two surgical techniques for removing large or complex kidney stones: a modified mini version using a smaller access sheath (20 Fr) versus the standard approach (24 Fr). The goal is to see if the mini procedure causes less bleeding and pain while still clearing…

This study tests whether a structured arm exercise program can help arteriovenous fistulas (AVFs) mature properly in people with chronic kidney disease who need hemodialysis. AVFs are surgically created connections between an artery and a vein that allow for dialysis, but up to h…

This trial compares a new aspiration-enabled access sheath to a conventional one during retrograde intrarenal surgery (RIRS) for kidney stones. The new sheath continuously removes irrigation fluid to control pressure inside the kidney, potentially reducing temporary kidney injury…

This trial investigates whether pioglitazone, a drug used for diabetes, can help protect the kidneys in people with ANCA-associated vasculitis—a rare autoimmune disease that causes inflammation of blood vessels, often damaging the kidneys. Participants receive either pioglitazone…

This study tests whether a carefully controlled low protein diet (about 0.6 grams of protein per kilogram of body weight each day) can help people with advanced chronic kidney disease delay the need for dialysis or a kidney transplant. The study enrolls adults with stage 4-5 or f…

This study tests whether adding targeted radiation or heat-based ablation to ongoing drug therapy can control genitourinary cancers (prostate, bladder, or kidney) that have started growing in only a few new areas. Participants continue their current systemic treatment while recei…

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a personalized care plan at hospital discharge helps people who survived acute kidney injury recover better. Depending on their risk level, patients get education, a primary care visit, or specialist monitoring. The goal is to see if this approach increas…

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This study tests a special cartridge (pHA130) added to regular dialysis to remove toxins that standard dialysis misses. One hundred adults with kidney failure on maintenance dialysis will be split into two groups: one gets the new cartridge once a week plus standard dialysis twic…

This study tests whether the antibiotic rifampin can safely lower high calcium levels in the blood and urine of people with a rare genetic mutation in the CYP24A1 gene. The condition can cause kidney stones and other problems. Sixty participants aged 6 months to 65 years will tak…

This trial tests whether a new robotic system that uses only one small incision (single port) can safely perform common abdominal surgeries in children. The study includes children aged 1 to 17 who need procedures like pyeloplasty or reflux treatment. The goal is to see if the si…

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether giving oxybutynin syrup early (starting at 3-6 months old) can improve bladder function in boys born with posterior urethral valves, a condition that blocks urine flow. Fifty boys who had valve surgery will be randomly assigned to receive either oxybutyni…

This study investigates whether combining the immunotherapy drug durvalumab with a cancer vaccine (S-488210/S-488211) can help people with a type of bladder cancer that has not responded to standard treatment. The trial includes adults with high-risk non-muscle invasive bladder c…

This study tests whether specially grown immune cells (called cytotoxic T lymphocytes) can safely lower BK virus levels in 20 transplant patients with weakened immune systems. Participants have had a stem cell or kidney transplant and show signs of BK virus infection. The goal is…

This study tests a radioactive drug, 177Lu-PSMA-617, in people with advanced kidney cancer that has spread and worsened despite standard treatments like immunotherapy and targeted therapy. The drug targets a protein called PSMA found on kidney cancer cells, delivering radiation d…

This study tests whether hydroxychloroquine, a drug already used for lupus, can slow kidney function decline in people with IgA nephropathy (Berger's disease). About 334 adults with biopsy-confirmed IgA nephropathy and high protein in their urine will receive either hydroxychloro…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

Researchers are testing whether a drug called 5-aminolevulinic acid (5-ALA) can make kidney tumors glow under blue light during surgery. Adults with suspected kidney cancer take the drug by mouth before a partial nephrectomy, a procedure that removes part of the kidney. Surgeons …

This study tests whether a medication called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during surgery. About 10 adults with known or suspected tumors will take 5-ALA before their procedure. The goal is to see if this technique…

Researchers are testing a radioactive tracer called 18F-NY104 to see how well it detects kidney cancer and other tumors that carry a protein called CAIX. About 120 people with known or suspected kidney cancer, or other CAIX-positive cancers, will receive an injection of the trace…

People with lupus can develop kidney inflammation called lupus nephritis, which is easier to treat when caught early. This study enrolls adults with lupus who are at higher risk for kidney problems and assigns them by chance to either standard care alone or standard care plus wee…

This study tests whether a simple urine test (Bladder EpiCheck) can safely replace some of the invasive cystoscopy procedures used to monitor non-muscle invasive bladder cancer. About 240 adults with low-grade intermediate-risk bladder cancer will be followed to compare quality o…

Researchers are testing whether MRI scans can accurately show whether bladder tumors have grown into the muscle wall, a key factor in choosing treatment. The trial enrolls 150 adults with bladder tumors who are scheduled for a transurethral resection (TURB), a surgical biopsy. Do…

IgA nephropathy is a kidney disease where immune proteins build up in the kidney's filtering units. Researchers in China are collecting samples from 600 people aged 16 and older, including those with biopsy-confirmed IgA nephropathy, to study the bacteria living in their mouths, …

The ORACLE study watches people who have finished treatment for early-stage solid tumors, such as lung, breast, colon, and pancreatic cancers. Researchers want to see if a blood test called Guardant Reveal can find tiny traces of tumor DNA that might signal the cancer is coming b…

Researchers are studying whether biomarkers in blood, urine, and stool can predict acute kidney injury in adults scheduled for cardiovascular surgery. The trial follows about 1,500 patients, collecting samples and clinical data before and after contrast dye exposure and surgery. …

Researchers are testing a urine-based fluorescence assay to see if it can detect urological cancers in people who have blood in their urine. The study enrolls 170 adults scheduled for cystoscopy or ureteroscopy. Urine samples are collected before endoscopy and analyzed with the a…

This study collects video recordings and data from 500 patients undergoing blue light cystoscopy, a procedure where a drug makes cancer cells glow. The goal is to train an artificial intelligence (AI) algorithm to detect bladder lesions in real time, helping doctors make more acc…

This trial tests a fluorescent dye called TTP-ICG that may help surgeons identify bladder cancer tissue during removal. Researchers will soak resected tissue samples in the dye and use near-infrared imaging to see if cancer glows differently from healthy tissue. The goal is to re…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This study tests whether a specialized PET/CT scan using a radioactive tracer can more accurately determine the extent of muscle-invasive bladder cancer compared to standard CT scans. It will also explore whether changes seen on a follow-up scan after two cycles of chemotherapy c…

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This study is testing whether a protein called NMAP, measured in a blood sample, can help tell apart people with newly diagnosed kidney cancer from those without cancer. Researchers will compare NMAP levels in about 400 adults — half with kidney cancer and half without — to see h…

This study is testing a new urine test called UroAmp to see if it can accurately detect bladder cancer and monitor for its return. Researchers will collect urine and tumor samples from 2,500 people being evaluated or treated for bladder cancer or related conditions. The goal is t…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This study tests a special PET/CT scan using a radioactive tracer called 68Ga-NYM096 to see if it can accurately detect clear cell kidney cancer in people with complex kidney cysts who are scheduled for surgery. About 70 participants will receive the tracer and undergo imaging be…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

Researchers in Pakistan are testing whether a mobile app that uses artificial intelligence to send personalized heat-risk alerts can reduce heat-related illness symptoms in adults with chronic conditions such as hypertension, diabetes, kidney disease, heart disease, or obesity. T…

Researchers are testing whether adding dapagliflozin to a lifestyle program can normalize blood sugar in people with prediabetes and protect their kidneys. The trial enrolls 170 adults aged 35 to 75 with prediabetes. Participants receive either dapagliflozin or a placebo for six …

This study tests a non-invasive ear stimulation technique (taVNS) to prevent acute kidney injury in 152 adults having heart surgery with a heart-lung machine. Half receive real stimulation before and after surgery; the other half get a sham. The main goal is to see if fewer peopl…

People with end-stage kidney disease who start hemodialysis often use a central venous catheter for access. These catheters raise the risk of bloodstream infections. Researchers are testing whether a daily antibiotic, amoxicillin-clavulanic acid, can prevent these infections comp…

This study tests whether empagliflozin, a drug used for diabetes and heart conditions, can help prevent calcium-based kidney stones. Researchers will give the drug daily for 4 weeks to 32 adults who have had calcium oxalate or calcium phosphate stones. They will measure changes i…

This trial tests whether methenamine hippurate, a non-antibiotic antiseptic, can prevent urinary tract infections (UTIs) as effectively as standard antibiotics in women receiving BOTOX-A injections for overactive bladder. Participants will be randomly assigned to take either meth…

This study tests whether the drug R2R01 can prevent acute kidney injury in people at high risk who are having heart surgery with a heart-lung machine. Participants receive either R2R01 or a placebo before and after surgery. The goal is to see if the drug reduces kidney damage and…

This study tests whether a small, portable nerve stimulation device worn at home can reduce urgent bathroom trips in people with overactive bladder. Sixty adults aged 18 to 65 will either use the device during daily life when they feel urgency or receive standard clinic-based ses…

Researchers are testing whether epidural electrical stimulation can improve bladder function in people with spinal cord injuries. The trial enrolls adults with injuries above T11 who have trouble urinating and rely on catheters. Participants receive an implanted spinal cord stimu…

Researchers are testing whether two kinds of exercise done during hemodialysis are safe and helpful for adults with kidney failure. Participants are assigned to cycle on a stationary bike, use elastic bands for resistance training, or receive standard dialysis care. The study mea…

Researchers at the University of California, San Francisco are running a trial to compare two ways of managing a painful ureteral stone that brings people to the emergency department. One group receives ureteroscopy right away, a procedure that uses a scope to remove or break up …

This study tests a device called the Axonics SNM System, which uses mild electrical pulses to calm the nerves that control the bladder. It is for men with overactive bladder, including those with urgency incontinence or frequent urination. The trial will enroll 150 men and track …

This study is testing a new external device (Axonics ETS-02) to see if it is safe and works for people with overactive bladder or fecal incontinence. About 75 adults will wear the device for a short trial period. The goal is to check if the device stays attached and works properl…

This study tests a device called Tensi+ that uses mild electrical pulses to a nerve in the ankle to treat overactive bladder symptoms like sudden urges and frequent bathroom trips. About 60 adults with these symptoms will use the device at home for 12 weeks. The goal is to see if…

This study looks at whether a single injection of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. Instead of taking pills for several days, participants receive one shot into a muscle or vein. The goal is …

Researchers compare two ultrasound-guided nerve block combinations to numb the arm during surgery for a dialysis fistula. Adults with end-stage kidney disease receive either an intercostobrachial nerve block or an erector spinae block, each added to a standard supraclavicular blo…

This study looks at whether doing simple exercises at home before bladder or upper tract cancer surgery can help patients feel stronger and recover faster. About 128 adults scheduled for surgery will either receive a personalized home exercise plan via a smartphone app or standar…

This study tests whether adding acupuncture to virtual exercise can help manage nerve pain caused by a specific bladder cancer treatment (EV-Pembro). About 50 adults with advanced bladder cancer will be split into two groups: one gets acupuncture plus virtual exercise, the other …

This study tests whether a once-daily pill called orforglipron can reduce stress urinary incontinence (leaking urine during movement) in women with obesity or overweight. About 1000 adult women will receive either the drug or a placebo for about 58 weeks. The main goal is to see …

This study tests whether a specific physical activity program, called the GH Method, can improve physical abilities in people who are frail and on dialysis or have advanced kidney disease. Participants attend two one-hour muscle therapy sessions per week for 12 months. Researcher…

This trial tests a communication tool called 'CKD Jumpstart-Tips' for older adults with advanced chronic kidney disease (stages 4 and 5). Before a clinic visit, patients answer questions about their understanding of their illness, treatment options, and personal goals. During the…

This study looks at whether a simple home-based walking program can boost memory, thinking skills, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, participants will either walk regularly or receive h…

Researchers in Singapore are testing a mobile app that helps people with chronic kidney disease (CKD) choose suitable foods when dining out. The app, called RENDOFOMAP, lets users photograph their meals and provides guidance based on a map of kidney-friendly options. In this pilo…

This study tests whether taking a short chain fatty acid supplement can reduce gut-related side effects in people receiving radiation therapy for cancers in the abdomen or pelvis. About 122 adults will be randomly assigned to receive either the supplement or a placebo. The goal i…

This study tests whether a program that combines gentle walking with progressive muscle relaxation can help reduce the extreme tiredness (fatigue) that many people with end-stage kidney disease feel while on dialysis. Researchers will enroll 40 adults who are on hemodialysis and …

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps the immune system f…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study tests a medicine called difelikefalin in teenagers aged 12 to 17 who are on hemodialysis and have moderate to severe itching. The goal is to see if the drug is safe and how much gets into the blood. About 18 teens will receive the medicine up to 4 times a week for 12 w…

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This study tests whether electroacupuncture (thin needles with mild electrical pulses) can help women with overactive bladder who haven't improved with standard treatments. Thirty-two women will receive either electroacupuncture, a nerve stimulation therapy, or a sham (fake) acup…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This study investigates whether watching a short educational video before a urodynamic test (a procedure that checks how well the bladder works) can lower anxiety in women. Half of the participants will watch the video, while the other half will receive only standard pre-procedur…

This study tests a wearable suit called AquaPass that removes excess fluid through sweat in people with chronic heart failure and fluid overload. Participants wear the suit for up to 5 hours in a hospital or clinic, alongside their usual medications. The goal is to see if the sui…

This study tests a medical device (a perineal probe connected to a mobile app) for women with stress urinary incontinence. Participants use the device at home for 15 minutes, three times a week, plus two sessions with a physiotherapist. The goal is to see if this approach works a…

This study looks at whether adding a small drainage tube in the belly during surgery for large bladder stones (over 2 cm) can make the operation faster and easier. About 140 adults will be randomly assigned to get the standard procedure alone or with the extra tube. The main goal…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study examines how the body processes nemtabrutinib in people with severe kidney impairment compared to healthy volunteers. By measuring drug levels in the blood after a single dose, researchers aim to understand whether kidney function changes how the drug is handled. The r…

This study follows up to 3,000 people who have, are at risk for, or are related to someone with a parathyroid disorder. Researchers will collect medical records, questionnaires, and samples like blood and saliva to learn what causes these conditions and how they change over time.…

This study looks at 50 adults with AL amyloidosis who achieved complete remission after initial chemotherapy. It checks if tiny amounts of remaining disease (called minimal residual disease, or MRD) affect organ recovery and survival. Researchers also test whether a stem cell tra…

This study tests how a single injection of HRS-4729 behaves in people with mild, moderate, or severe kidney impairment compared with healthy people. Researchers measure drug levels in the blood over time to see if kidney function affects how the body processes the drug. The trial…

This study aims to learn more about how lupus (SLE) develops and changes over time by observing patients and their relatives. Up to 2000 people aged 3 and older with known or suspected lupus, along with their family members, will provide medical history, blood and urine samples, …

This study will follow 1000 adults with advanced chronic kidney disease (stage 4-5) to learn why they face higher risks of bone fractures and heart disease. Researchers will track bone turnover markers, calcium and phosphate levels, and kidney function over time. No new treatment…

This study follows people with a rare genetic condition called DICER1 syndrome, which raises the risk of certain childhood cancers like pleuropulmonary blastoma. Researchers will collect medical histories, genetic samples, and tissue from up to 1,500 participants and their relati…

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

This study aims to uncover the genetic causes of hereditary leiomyomatosis renal cell cancer (HLRCC), a condition that can lead to painful skin bumps, uterine fibroids, and kidney tumors. Researchers will study people with known or suspected HLRCC and their family members to iden…

This study will survey 400 adults with moderate to severe chronic kidney disease in Réunion Island to find out how many use herbal medicines and whether those herbs affect how fast their kidney disease gets worse over one year. Participants will fill out questionnaires about thei…

This study looks at a rare inherited condition called Birt-Hogg-Dube (BHD) syndrome, which raises the risk of kidney cancer. Researchers will collect blood, saliva, and tissue samples from up to 950 participants to find the genes involved and understand how kidney tumors grow. Th…

Researchers in China are building a registry of people diagnosed with lupus nephritis, a kidney complication of lupus. The study plans to enroll 5,000 patients from participating hospitals and follow them with yearly check-ins. By collecting baseline and follow-up information, th…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

Researchers at Sun Yat-sen University are building a registry of people with nephrotic syndrome across hospitals in China. The study aims to enroll 5,000 patients regardless of the underlying cause. By recording baseline and follow-up information, the team will track kidney funct…

Researchers in China are enrolling people with biopsy-confirmed primary IgA nephropathy into a long-term registry. Participants are followed once a year, with baseline and follow-up details recorded in a database. The study tracks deaths from any cause and heart-related deaths, p…

Researchers at Sun Yat-sen University are building a registry of people receiving hemodialysis at hospitals across China. The study plans to enroll about 30,000 adults with end-stage renal disease and follow them every three months. By comparing survival, dialysis access patency,…

Researchers at University Hospital, Strasbourg, are developing 3D tumor models grown from patient tissue to study kidney, bladder, and prostate cancers. The study collects tumor samples and a small blood sample from about 100 adults with these cancers. Scientists use the blood to…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

Researchers at Sun Yat-sen University are building a registry of peritoneal dialysis patients across hospitals in China. The study plans to enroll about 10,000 people and follow them every three months. The team will collect baseline and follow-up information to compare patient s…

Calciphylaxis is a rare disorder where calcium builds up in small blood vessels in the skin, causing painful lesions. Researchers at Massachusetts General Hospital are building a biobank and patient registry to collect samples and health information from up to 300 adults with the…

This study is observing how bladder cancer is treated in Russia and how common certain markers (HER2 and PD-L1) are in different stages. Researchers will look at medical records of 600 people with bladder cancer to see what treatments they receive and how the disease progresses. …

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study looks at how different levels of kidney function affect the way the body handles an experimental drug called RO7795081. Researchers will give a single oral dose to people with various degrees of kidney impairment and compare them to people with normal kidney function. …

This study looks at men with urinary retention who need a catheter before having prostate laser surgery (HoLEP, ThuLEP, or ThuFLEP). Researchers want to see if the length of time with a catheter affects how well the surgery works. They will measure changes in urinary symptoms, fl…

This trial tests five different dialysis approaches in people with end-stage kidney disease to see how each affects salt stored in tissues and the health of small blood vessels. Participants receive each method in random order over four weeks. Researchers use MRI scans and skin p…

Complicated urinary tract infections are hard to treat and often return, and doctors need better data on what drives treatment failure. This observational study follows thousands of patients with confirmed complicated UTIs across multiple sites, collecting information on their sy…

This study will check if a simple ultrasound of the neck vein, done before and right after anesthesia, can predict low blood pressure during surgery and kidney injury afterward. Researchers will observe 150 adults having major abdominal surgery. The goal is to see if changes in t…

This study looks at how two common chemotherapy drugs, vincristine and doxorubicin, affect bladder function and urine composition in children who have finished cancer treatment. Researchers will use simple, non-invasive tests to measure urine flow and check for bladder-related pr…

This study tests whether a 12-week nutrition and kidney health program, called THINK-Well, works well for adults with chronic kidney disease. The program includes group nutrition classes, cooking practice, and food bucks to buy healthy foods. Researchers want to see how many peop…

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This observational study follows 350 adults with pulmonary hypertension to see if certain biomarkers in urine and blood are linked to worsening kidney function. Participants undergo standard tests but receive no experimental treatment. The goal is to better understand how kidney …

This study tests a redesigned surgical tool for removing bladder tumors. Researchers will use the device on bladder specimens from 25 patients who need their bladder removed. The goal is to see if the modified device provides better tissue samples for pathology, helping doctors a…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study screens adults with certain cancers (like melanoma, lung, or colorectal cancer) to see if they qualify for experimental treatments being tested by the NCI Surgery Branch. These treatments involve taking a patient's own immune cells, growing them in a lab, and giving th…

This study will follow 300 adults and children with kidney failure who use a specific type of catheter for peritoneal dialysis. Researchers will track infections, complications, and how well the catheter works over time. The goal is to see if these catheters are safe and effectiv…

This early-stage trial is testing whether hemodialysis—a treatment that filters waste from the blood when kidneys fail—changes how the body processes a combination drug called balcinrenone/dapagliflozin. The study will give a single dose of the drug to about 10 people with kidney…

This study tests whether a bedside ultrasound tool called the VExUS score can predict acute kidney injury after open-heart surgery. The score measures fluid buildup in the veins, which may stress the kidneys. Researchers will follow 135 adults undergoing heart surgery with a hear…

This study will include 2,600 adults scheduled for bladder tumor surgery. Half will get a standard urine culture before surgery; the other half will not. The goal is to see if skipping the test leads to more fevers or infections in the month after surgery. If it's safe, it could …

This study looks at whether people who carry one copy of the cystic fibrosis gene (CF carriers) have early signs of kidney or pancreas problems. Researchers will compare 1250 CF carriers and non-carriers using blood tests, urine and stool samples, and surveys. The goal is to see …

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study tracks 230 adults having planned heart surgery to see if unstable blood pressure during the operation raises the risk of serious problems like confusion, kidney injury, stroke, or death within 30 days. Researchers will monitor blood pressure dips and use of pressure-ra…

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

Researchers are testing whether hyperspectral imaging, a camera technique that captures hundreds of light bands invisible to the eye, can map blood flow and identify tumor types during robot-assisted partial nephrectomy. The study will enroll 60 adults with kidney tumors up to 7 …

This study is observing 223 people with active lupus (including kidney inflammation) who haven't gotten better with steroids and at least two immunosuppressants. Researchers want to see how well today's standard treatments work for these tough cases. The goal is to measure how ma…

This early-stage study is testing a new oral drug called SK-09 in 72 healthy adults to see if it is safe and how the body processes it. The study is split into two parts: one where participants get a single dose, and another where they get multiple doses. No one knows who gets th…

This study compares two levels of patient navigation—high-intensity versus low-intensity—to see which helps more people with prostate or kidney cancer enroll in clinical trials. About 90 participants will be randomly assigned to receive either extra support from a patient navigat…

This study tests whether a device called FIZE kUO®, which tracks urine output every minute, can help doctors manage fluids and diuretics in patients recovering from heart surgery. Researchers will monitor 45 adults in the intensive care unit and compare urine output before and af…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This early-stage trial is testing an experimental oral drug called TUL321 in healthy adults to see if it is safe and tolerable. The study will also measure how the drug moves through the body and whether food affects its absorption. TUL321 is being developed as a potential treatm…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goa…

This study follows up to 2000 people with immune-related kidney diseases, such as nephrotic syndrome and lupus nephritis. Researchers will collect medical history, lab tests, and blood or urine samples to better understand these conditions. The goal is to learn more about causes …

This study looks back at medical records of 250 people in Portugal diagnosed with high-risk non-muscle-invasive bladder cancer between 2016 and 2020. The goal is to see how these patients are actually diagnosed, treated, and followed in everyday practice—including which surgeries…

This study creates a biorepository of blood and urine samples from adults of African ancestry, including those with end-stage kidney disease and healthy controls. The goal is to support research on APOL1 gene mutations, which are linked to kidney disease and are only found in peo…

This study explores whether a special type of MRI, called multiparametric MRI, can detect kidney scarring (fibrosis) without the need for an invasive biopsy. Researchers will follow living kidney donors, transplant recipients, and healthy volunteers over two years, comparing MRI …

This study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matt…

This study investigates whether signs of complement activation in the blood can serve as a biomarker for the severity and progression of IgA nephropathy, a kidney disease. Researchers will follow 400 adults with biopsy-proven IgA nephropathy, including those with or without a kid…

This observational study tests a new ultrasound-based measure called the Pelvic Floor Fatigue Index (PFFI), which gauges how quickly pelvic floor muscles tire. Researchers will measure PFFI in 75 adults before they undergo ureteroscopy or retrograde intrarenal surgery for kidney …

This study investigates whether the gut microbiome and its byproducts influence chronic pain in people who have received a kidney transplant. Many transplant recipients experience persistent pain, which can affect their quality of life and treatment adherence. Researchers will tr…

This study investigates why arteries stiffen and harden faster in children and young people with chronic kidney disease (CKD) and high blood pressure. Researchers will use non-invasive tests to compare arterial stiffness between those with CKD and matched controls, including heal…

This study is collecting blood, urine, and tumor tissue samples from about 400 adults with suspected high-risk non-muscle invasive bladder cancer. The goal is to find biological markers that could lead to new tests for detecting and monitoring this type of cancer. Participants wi…

This study is testing whether a blood test can find tiny pieces of tumor DNA in people with muscle-invasive bladder cancer or upper tract urothelial cancer. Researchers will compare DNA from tumor tissue with DNA in blood samples taken during routine care. The goal is to see how …

This study follows people with rare inherited forms of kidney stones and chronic kidney disease, such as primary hyperoxaluria, cystinuria, and Dent disease, to learn how these conditions develop over time. Researchers will measure markers of inflammation in blood and urine and t…

This study analyzes data from over 6,000 French patients with non-metastatic kidney cancer to understand how the disease progresses after surgery. The goal is to identify which patients are at high risk of recurrence and might benefit from adjuvant immunotherapy, while avoiding u…

This study aims to understand the quality of life of school-aged children who were treated for posterior urethral valves (PUV) in their first year of life. PUV is a rare birth defect that can affect kidney and bladder function. Researchers will use a standard questionnaire called…

This study follows people with SPLIS, a rare inherited metabolic condition, to map its natural history—how the disease unfolds over time. Researchers will track growth, organ function, quality of life, and survival in about 28 participants. The goal is to understand the full rang…

This trial asks whether five advanced AI models can match the treatment recommendations of expert tumor boards for cancer patients. Using 100 standardized synthetic cases across breast, lung, urological, digestive, and gynecological cancers, each AI and two independent tumor boar…

This study looks at whether levels of a molecule called inorganic pyrophosphate (PPi) in the blood are linked to blood vessel damage in children with chronic kidney disease (CKD). Researchers will compare PPi levels in children with CKD (including those on dialysis or with a kidn…

This study tests whether ultrasound images can consistently measure pelvic floor structures in women while they rest and perform squats and deadlifts. Researchers will compare measurements taken by different raters and by the same rater at different times. The goal is to see if t…

This study tests whether nurses can accurately identify depression in people on hemodialysis. About 450 patients will have their depression symptoms assessed both by a nurse and by themselves using a standard questionnaire. The goal is to see if nurse assessments can be a reliabl…

This study will enroll 200 adults aged 60 or older who are scheduled for major surgery for urologic cancer. Researchers want to see if an artificial intelligence analysis of a standard heart test (ECG) taken before surgery can predict whether a patient will suffer heart injury or…

This study explores the personal experiences of young women with chronic kidney disease (CKD) who are not yet on dialysis or transplant. Researchers aim to understand how the disease impacts daily life, fertility, and life plans, and whether the cause (genetic vs. non-genetic) ma…

This study tests whether having a specialist review genetic test results and guide treatment decisions can increase the use of targeted therapies for people with advanced solid tumors, including breast, lung, colorectal, and bladder cancers. Participants will have their tumor or …

This study collects medical information from people around the world who have one of four rare hereditary kidney stone diseases: primary hyperoxaluria, Dent disease, cystinuria, or APRT deficiency. By gathering data from many patients, researchers hope to better understand how th…

This study will observe 128 critically ill patients with acute kidney injury who need dialysis to remove excess fluid. Researchers want to understand why some patients become unstable during fluid removal. They will monitor heart function, blood flow, and other signs before and d…

This study investigates how changes in kidney cell metabolism relate to the rate of kidney function decline in people with ANCA vasculitis and other kidney diseases. Researchers will analyze kidney biopsy samples and blood/urine tests from 146 participants over one year. The goal…

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and pover…

This study follows 500 adults with lupus to see if blood and urine tests can reliably detect kidney inflammation (lupus nephritis). Participants give samples during routine visits, and doctors track their kidney health over time. The goal is to find simple, non-invasive markers t…

This observational study will compare blood fat (lipid) levels in 200 adults with chronic kidney disease—half with diabetes and half without. Researchers want to find out if having diabetes leads to worse fat problems in these patients. Participants will fast for 10 hours before …

This study is collecting blood, urine, and fecal samples from 100 people with ANCA-associated vasculitis, a rare autoimmune disease. Researchers will follow participants for up to 5 years, tracking relapses and complications. The goal is to identify factors that predict disease f…

This study is collecting blood, urine, and kidney tissue samples from 144 children and adults with a kidney condition called nephrotic syndrome. The goal is to build a large database and sample collection to study how the immune system and kidney cells interact. Researchers hope …

This study looks at a type of immune cell called memory B cells in people waiting for a kidney transplant who have certain antibodies. Researchers want to understand why some of these cells cause rejection while others don't. They will analyze blood samples from 51 patients to fi…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study is testing three different low doses of the blood thinner rivaroxaban in 10 adults on chronic hemodialysis. The goal is to see how the drug behaves in the body and how much it thins the blood, to find a dose that might lower bleeding risks. Participants will take each …

This study looks at how other medical conditions (comorbidities) affect recovery and survival in 500 bladder cancer patients after bladder removal surgery. Researchers will use artificial intelligence to analyze patient data and find patterns that could help doctors make better t…

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study creates a registry to collect health information from people with Autosomal Dominant Polycystic Kidney Disease (ADPKD), the most common genetic cause of kidney failure. While ADPKD was once thought to only affect adults, researchers now know it begins in childhood, but…

This study is creating a central database and tissue bank for rare diseases affecting the kidneys and liver, such as ARPKD and Joubert syndrome. Researchers will collect medical information, genetic samples, and tissues from 200 participants to help doctors and scientists better …

This study is gathering information from 400 adults in France diagnosed with membranous nephropathy, a rare kidney condition. Researchers will track how the disease progresses over one year, looking at remission rates and possible environmental or genetic risk factors. The goal i…

This study aims to find out if chronic pelvic pain conditions like prostatitis and interstitial cystitis can be inherited. Researchers will collect DNA and urine from 500 participants, including family members, to look for genetic links. The goal is to better understand the cause…

This study is for people with rare kidney diseases like Minimal Change Disease, Focal Segmental Glomerulosclerosis, and Membranous Nephropathy. Researchers will collect health information and biological samples from 1,200 participants over many years. The goal is to better unders…

This study measures hip muscle strength in 50 adults on hemodialysis using a handheld device. The goal is to create reference values for lower-limb strength in this group. Researchers will also check how strength relates to handgrip, walking speed, and quality of life.

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study is testing whether a blood test that looks at tiny genetic molecules called microRNAs can accurately detect bone problems in people with chronic kidney disease. Currently, doctors rely on a bone biopsy, which is invasive and not practical for most patients. The researc…

This study watches how blood flows to the kidneys in 51 adults having elective minimally invasive abdominal surgery. Researchers use two non-invasive tools—ultrasound and light sensors—to measure kidney function at key times during and after surgery. The goal is to see if these t…

This pilot study is looking at whether levels of a common virus called TTV can help predict how well immunotherapy works in people with advanced kidney cancer. Researchers will measure TTV levels in 20 patients before and during their first immunotherapy treatment. The goal is to…

This study follows 100 adults with end-stage kidney disease who need long-term dialysis but have no working access sites left. Researchers are watching how well the HeRO and Super HeRO grafts perform over two years, checking for infections, blockages, and overall safety. The goal…