Gene therapy instilled directly into kidney shows promise for rare cancer
NCT ID NCT06668493
First seen Jan 09, 2026 · Last updated May 25, 2026 · Updated 22 times
Summary
This early-stage trial tests a gene therapy drug called nadofaragene firadenovec, which is instilled directly into the kidney's drainage system. It aims to treat low-grade upper tract urothelial cancer (LG-UTUC) by delivering a gene that helps the body fight cancer cells. The study involves 20 adults with confirmed LG-UTUC and will check for safety and whether the tumors disappear at 3 or 6 months.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baylor College of Medicine (Houston)
RECRUITINGHouston, Texas, 77030, United States
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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MD Anderson Cancer Center - Genitourinary (GU) Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Mayo Clinic
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic - Rochester Minnesota
RECRUITINGRochester, Minnesota, 55905, United States
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Mayo Clinic - Scottsdale Arizona
RECRUITINGScottsdale, Arizona, 85054, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Providence Saint John's Cancer Institute
RECRUITINGSanta Monica, California, 90404, United States
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University of Pennsylvania - Perelman Center for Advanced Medicine - Penn Urology
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Conditions
Explore the condition pages connected to this study.