Pig kidney transplant trial aims to free patients from dialysis

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * ESRD receiving hemodialysis or peritoneal dialysis for ≥6 months * Eligible for kidney transplantation per site criteria * \<50% likelihood of receiving a standard deceased-donor kidney transplant within 12 months * Blood type and immunologic compatibility with study transplant confirmed by testing * EBV seropositive * Up to date on recommended vaccinations for immunocompromised individuals * Willing to use protocol-required contraception * Able to provide informed consent and comply with lifelong follow-up Exclusion Criteria: * Requirement for multi-organ transplantation * Living donor available who is ABO-incompatible * Kidney disease with high risk of post-transplant recurrence * Polycystic kidney disease without prior native nephrectomy * Unable or unwilling to comply with study procedures * History of non-adherence to medical treatment * Identified as vulnerable by psychological assessment * Significant uncontrolled psychiatric illness * Inadequate social support or caregiver unavailable/unwilling * Current drug or alcohol misuse * Serious non-renal illness with life expectancy \<1 year * BMI \<16 or \>35 kg/m² * Known hypercoagulable disorder * Uncontrolled hypertension or hemodynamic instability at enrollment * Clinically significant cardiovascular disease, including poorly controlled coronary artery disease, reduced left ventricular function, recent myocardial infarction or cardiac intervention, or clinically significant arrhythmia requiring treatment * Serious liver disease or impaired liver function * Diabetes mellitus with poor glycemic control (HbA1c \>10%) * Active infection at time of transplantation * Positive serology for hepatitis B, hepatitis C, or HIV * Current, active, or untreated tuberculosis * Malignancy within 5 years prior to enrollment, excluding adequately treated non-melanoma skin cancer * Current systemic immunosuppressive therapy (excluding permitted corticosteroids) * Participation in another interventional drug trial within 60 days prior to enrollment * Pregnant or breastfeeding * Known severe hypersensitivity to a required study medication with no acceptable alternative