Sohag University

This study compares two treatments for stable vitiligo: microneedling with a topical solution (minoxidil 5%) alone versus the same treatment plus narrow-band UVB phototherapy. Thirty adults with stable non-segmental vitiligo will be enrolled. The goal is to see if adding UV light…

This early-stage study tests a daily mixture of saline and glycerin given as an enema to children aged 3 to 16 who have fecal incontinence (at least one accident per week). The goal is to help them stay clean and avoid stool accidents the next day. The study will enroll 30 childr…

This study will compare two add-on treatments—platelet-rich plasma (PRP) and nanofat injections—given alongside standard hair transplants in 30 men with stable male pattern baldness. The goal is to see which method better improves graft survival, hair density, and thickness. Part…

This study compares two surgical techniques (screws vs. plates) to correct bow legs or knock-knees in children aged 3 and older who are still growing. The goal is to improve leg alignment, reduce pain, and lower the risk of early knee arthritis. Sixty children will be enrolled an…

This study tests whether SGLT2 inhibitors, a type of diabetes medicine, can improve anemia in people with chronic kidney disease (CKD). Anemia is a common and serious complication of CKD that can lower quality of life. The study will enroll 60 adults with mild to moderate CKD and…

This study compares two surgical techniques for repairing a common finger injury called volar plate injury. The mini-anchor method uses an internal fixation device, while the pull-out suture method uses an external stitch. The goal is to see which approach leads to better finger …

This study tests whether a combination of three drugs—glucose-insulin-potassium, hydrocortisone, and sevelamer—can reduce deaths from severe aluminum phosphide poisoning, a common suicide method in some countries. The trial will enroll 74 poisoned adults admitted to the ICU withi…

This study will test whether a modified Atkins diet can help control seizures and improve quality of life in 40 children aged 1-18 with drug-resistant epilepsy. The diet is a special high-fat, low-carb plan. Researchers will track seizure frequency, thinking skills, growth, and h…

This study tests two injection treatments for common warts: platelet-rich fibrin (PRF) and vitamin D. PRF is made from the patient's own blood and may help the body heal and fight the wart virus. The trial will enroll 70 adults and measure how much the warts shrink and whether pa…

This study tests a surgery to fix a rare condition where the two bones in a child's forearm are fused together, limiting arm rotation. The procedure uses Kirschner wires to hold the bones in the correct position after cutting and rotating them. The goal is to improve arm function…

This study tests two different laser settings (5% vs 15% duty cycle) to treat diabetic macular edema, a swelling in the back of the eye caused by diabetes. About 50 adults with mild vision loss and moderate swelling will receive one of the two laser treatments. The main goal is t…

This study looks at whether using an endoscope (a small camera) during stapes surgery helps people with otosclerosis hear better. Otosclerosis causes a bone in the ear to harden, leading to hearing loss. The surgery aims to replace that bone with a tiny device to restore sound. R…

This study looks at whether repeated measurements of a blood marker called the Systemic Immune Inflammation Index (SII) can help diagnose and predict acute kidney injury (AKI) in people with liver cirrhosis. AKI is a common and serious complication in cirrhosis, but current tests…

This study aims to see how well MRI can detect and describe perianal fistulas—abnormal tunnels that form near the anus. Researchers will compare MRI results with actual surgical findings in 30 patients to measure the test's accuracy. The goal is to improve diagnosis and help surg…

This study looks at whether a non-invasive stool test (qFIT) can accurately detect colorectal cancer and precancerous lesions in adults aged 40–75 who are already scheduled for a colonoscopy. Researchers will compare the test results with colonoscopy findings to see how well qFIT…

This study looks at two substances in the blood, IL-6 and MMP-7, to see if they can help doctors diagnose and predict the course of a rare lung disease in children. The disease causes inflammation and scarring in the lungs. Researchers will measure these markers in 60 children wi…

This study will check how well MRI and ultrasound can correctly identify superficial soft tissue masses. About 50 people with these lumps will be scanned, and the results will be compared to the final diagnosis. The goal is to see which imaging method is more accurate for guiding…

This study will check how well a specific ultrasound finding called the 'rail sign' can detect placenta accreta, a serious condition where the placenta grows too deeply into the womb. Researchers will scan 90 pregnant women with placenta previa during their second and third trime…

This study looks at whether a hormone called irisin can be used to detect diabetic kidney disease early and track its progression. Researchers will measure irisin levels in 200 people with type 2 diabetes and compare them to healthy individuals. The goal is to find a simple blood…

This study will check if a type of MRI called diffusion-weighted imaging can accurately tell the difference between harmless and cancerous growths in the lining of the uterus. About 30 women with abnormal bleeding or suspicious ultrasound findings will get this MRI, and the resul…

This study aims to see how well MRI scans can tell the difference between harmless and potentially cancerous ovarian cysts. Researchers will enroll 50 women with unclear ultrasound results and compare MRI findings with surgery results or follow-up scans. The goal is to improve di…

This study tests whether breathing in a mist of ketamine or magnesium sulfate before surgery can prevent sore throat afterward. It will include 150 adults having planned surgery with a breathing tube. The goal is to find a simple, safe way to reduce throat pain after general anes…

This study compares adding either midazolam or cisatracurium to the standard numbing medicine (lidocaine) for eye injections before retinal surgery. The goal is to see if these additives help paralyze the eye muscles faster, making the procedure more comfortable. 90 adults schedu…

This study tests whether adding salt water (sodium chloride 5%) eye drops to standard antibiotic treatment helps heal bacterial eye infections faster. Researchers want to see if it speeds up healing of the cornea, kills bacteria better, and improves eyesight. The study will invol…

This study compares two minimally invasive treatments for carpal tunnel syndrome: pulsed radiofrequency (using electrical pulses) and hyaluronidase hydrodissection (injecting an enzyme to free the nerve). Researchers will enroll 56 adults aged 20-80 with mild to moderate carpal t…

This study compares three medications—magnesium sulphate, ondansetron, and dexmedetomidine—to see which works best for stopping shivering after spinal anesthesia. Sixty adults having lower abdominal or leg surgery will take part. The main goal is how quickly shivering stops, and …

This study compares two types of nerve blocks to see which provides better pain relief after open gallbladder removal. Sixty-six adults having this surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure pain levels two hours after surgery,…

This study compares two anesthesia methods for strabismus (crossed eyes) surgery in adults: general anesthesia (being fully asleep) versus a combination of sedation with a numbing injection around the eye. The goal is to see which method leads to higher patient and surgeon satisf…

This study looks at common problems inside the nose, like a crooked septum or narrow airways, in people getting nose surgery (septorhinoplasty). Researchers will describe these issues and test ways to fix them. The goal is to help patients breathe better and have a straighter, mo…

This study compares two minimally invasive surgical techniques (uniportal vs. biportal endoscopy) for treating a single-level herniated lumbar disc. Sixty adults aged 18-70 who have not improved with at least 6 weeks of non-surgical care will be enrolled. The main goal is to meas…

This study compares two types of nerve blocks (ESP and TAP) to see which provides better pain relief after a C-section. Sixty women will receive one of the blocks after surgery, and their pain levels, morphine use, and satisfaction will be tracked for 24 hours. The goal is to fin…

This study tests if a special type of pulsed radiofrequency (STP) works better than the regular type for treating long-lasting nerve pain after shingles. About 100 adults whose pain has lasted more than a month and hasn't responded to standard treatments will be enrolled. The mai…

This study tests whether microneedling (tiny needles that prick the skin) combined with either tretinoin or timolol cream can improve the look of early red stretch marks. About 300 adults with these marks will receive the treatment, and doctors will track changes through photos a…

This study compares two common anesthesia drugs—propofol and sevoflurane—during a type of eye surgery called cyclophotocoagulation. The goal is to see which one keeps eye pressure more stable and causes fewer heart-related side effects. Forty adults with cataracts will take part,…

This study compares two common surgeries for fixing a broken ankle bone (lateral malleolus). About 52 adults with certain types of ankle fractures will get either a metal plate and screws or a single screw placed inside the bone. The goal is to see which method leads to faster he…

This study compares two treatments for chronic migraine: a nerve block injection and a procedure called pulsed radiofrequency. About 70 adults with frequent migraines who haven't improved with standard care will be randomly assigned to one treatment. The goal is to see which bett…

This study tests if a new type of pulsed radiofrequency (irregular STP) is safer and better at reducing severe facial pain from trigeminal neuralgia compared to the standard method. About 62 adults aged 18-75 who still have severe pain despite medication will receive one of the t…

This study looks at whether certain fat molecules (ceramides and S1P) in the blood are different in people with acne compared to healthy people. Researchers will collect blood samples from 80 participants (40 with acne, 40 without) and measure these molecules. The goal is to lear…

This study will look at medical records of 40 children under 18 who came to the hospital with traumatic injuries. Researchers want to find patterns in the types of injuries, how severe they are, and what happens to the children afterward. The goal is to learn more so doctors can …

This study aims to find a specific gene change called Notch1 in the blood or bone marrow of 80 people with either chronic lymphocytic leukemia (CLL) or non-Hodgkin's lymphoma (NHL). Researchers will compare how often the mutation appears in each cancer type. The goal is to better…

This study compares two types of nerve blocks used during shoulder surgery to see which one is less likely to cause temporary diaphragm paralysis, which can make breathing harder. Sixty adults scheduled for shoulder surgery will be randomly assigned to receive either a standard i…

This study looks at how local anesthesia given before cataract surgery changes blood flow in the retina, the light-sensitive tissue at the back of the eye. Researchers will use a special imaging technique called OCT angiography to compare blood vessel density before and after the…

This study will look at blood test results from 60 pregnant women with HELLP syndrome, a rare but serious condition. The goal is to see if certain markers in the blood can help predict which women and their babies are at higher risk for severe complications. This is an observatio…

This study will review medical records of 100 adults with locally advanced rectal cancer treated between 2018 and 2025 at hospitals in Egypt. The goal is to understand which treatments were used and how patients fared, including survival and side effects. No new treatments are gi…

This study looks at 100 adults with advanced rectal cancer who received total neoadjuvant therapy (a combination of chemotherapy and radiation before surgery). Researchers want to see whether the status of lymph nodes after treatment or the shrinkage of the main tumor better pred…

This study looks at a dangerous superbug called carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). Researchers will collect 100 samples from infected patients to test whether certain bacterial genes (siderophore genes) make the bug resistant to a powerful antibio…

This study will measure a blood protein called FAP, which is linked to tissue scarring and inflammation, in people with rheumatoid arthritis or systemic sclerosis and in healthy volunteers. Researchers want to see if FAP levels relate to disease activity and lung involvement. Par…

This study will test 250 people with tuberculosis (TB) to find out how many have drug-resistant forms of the disease. Using special tests called GeneXpert, researchers will look for resistance to key medicines like Rifampicin. They will also check if things like diabetes or drug …

This study collects urine, pus, and sputum samples from 100 hospital patients with multidrug-resistant Klebsiella pneumoniae infections. Researchers will test the bacteria for their ability to form biofilms and pump out antibiotics, and look for specific genes linked to these tra…

This study will compare 200 adults with psychosis to see if their condition is caused by methamphetamine use or by schizophrenia. Researchers will track symptoms, treatment response, and recovery over three months. The goal is to better understand the differences between these tw…

This study looks at how well the antibiotic combination ceftazidime-avibactam works against a hard-to-treat bacteria called Klebsiella pneumoniae that produces carbapenemases (enzymes that break down many antibiotics). Researchers will collect samples from 100 hospitalized patien…

This study looks at how iron buildup from blood transfusions affects hormones and reproductive health in boys aged 10 to 18 with beta thalassemia major. Researchers will measure key hormones like inhibin B and testosterone to catch problems early. The goal is to better understand…

This study looks at whether certain blood test results can help predict how severe a stroke is and how well a person might recover. Researchers will check three different blood ratios in 60 adults with acute ischemic stroke. The goal is to see if these simple, routine tests can g…

This study will look at 100 people who have a colonoscopy for lower gut symptoms like chronic diarrhea, blood in stool, or belly pain. The goal is to find out which types of colon inflammation are most common and what causes them. The results may help doctors diagnose and treat t…

This study will test 200 adults on regular hemodialysis for latent tuberculosis infection (LTBI) using a simple skin test. The goal is to find out how many dialysis patients carry the bacteria without symptoms, so doctors can better prevent active TB in this vulnerable group. No …

This study looks at 100 adults with obstructive jaundice (blocked bile ducts) to see if the type of anesthesia used during a therapeutic ERCP procedure affects how well it works and how safe it is. Researchers will measure technical success, complications, and satisfaction of bot…

This observational study looks at whether different types of anemia (like iron deficiency or thalassemia) can cause HbA1c levels to be falsely high or low in non-diabetic adults. Researchers will compare HbA1c results between 100 anemic participants and a non-anemic control group…

This study looks at two genes (IL-1β and IL-33) in 300 adults with low platelets caused by either primary ITP or lupus. Researchers want to see if these gene activity levels can help tell the two conditions apart and improve diagnosis. Participants give a blood sample, but no tre…

This study will check vitamin D levels in 160 adults to see if a deficiency is more common in people with benign paroxysmal positional vertigo (BPPV), a condition that causes brief dizzy spells. Participants include those with confirmed BPPV and a control group without vertigo. T…

This study will ask 160 adults on regular hemodialysis about their anxiety and depression symptoms. Researchers want to find out how many patients are affected and what personal or medical factors play a role. The goal is to better understand the emotional challenges faced by peo…

This study aims to find out how common diastolic dysfunction (a type of heart failure) is in people with end-stage kidney disease who are on regular hemodialysis. Researchers will use echocardiograms to check heart function and look for links with dialysis-related factors. The st…

This study looks at why some children have persistent low blood sugar (hypoglycemia) that doesn't go away easily. Researchers will check for hormone problems, metabolic disorders, and genetic factors in 50 children from birth to age 18. The goal is to find the root cause so docto…

This study will examine whether the biology of breast cancer changes when it comes back after treatment. Researchers will review medical records of 200 patients treated between 2015 and 2025 at hospitals in Egypt. The goal is to see how often key markers differ between the first …

This study will use a special, non-invasive eye scan called OCTA to look for early signs of damage in the retina of people who have been taking hydroxychloroquine for at least a year. Hydroxychloroquine is a medicine used for autoimmune diseases like lupus and rheumatoid arthriti…

This study aims to understand if dry eye disease is connected to diabetic macular edema, a serious eye condition in people with diabetes. Researchers will assess 50 adults with diabetes using eye exams and questionnaires. The goal is to improve knowledge about how these two condi…

This study aims to find out if certain substances in the blood (CCR6 and CCL20) can serve as markers for rheumatoid arthritis (RA). Researchers will compare 60 adults with RA to healthy individuals by measuring gene activity and protein levels. The goal is to better understand th…

This study aims to find out how common body dysmorphic disorder (BDD) is in children with chronic skin diseases compared to healthy children. Researchers will also measure how skin conditions affect the children's quality of life. The study will include 250 children aged 6 to 18 …

This study looks at how ups and downs in blood sugar levels affect the health of diabetic patients with heart disease while they are in the coronary care unit. Researchers will track 120 adults to see if unstable glucose leads to more deaths or serious heart events like heart att…

This study checks if a formula called fullPIERS can accurately predict serious health problems in pregnant women with preeclampsia. Researchers will collect information like blood pressure and lab results from 50 women in Egypt. The goal is to see if this tool can help doctors id…

This study looks at how period pain (primary dysmenorrhea) impacts the academic performance and quality of life of 402 female medical students at Sohag University. Researchers will use two questionnaires to measure pain severity and its effects on schoolwork, relationships, and d…

This study will compare the quality of life of 50 children aged 6 to 18 who have inborn errors of immunity (a type of primary immune disorder) with that of healthy children. Researchers will use a questionnaire to assess physical, emotional, social, and school functioning. The go…

This study aims to find out how common depression is among medical students at Sohag University. Researchers will survey 300 students aged 18 to 25 to measure depression rates and understand the factors that contribute to it. The goal is to raise awareness and improve mental heal…

This study aims to better understand lupus when it shows up in unusual ways, such as with rare symptoms, late in life, or without the typical ANA antibody. Researchers will compare 400 people with typical and atypical lupus to see how these differences affect disease activity, or…

This study will follow 300 people with non-spreading bladder cancer who receive high-dose radiation therapy, sometimes with chemotherapy. Researchers will track how long patients live, whether the cancer comes back, and what side effects occur. The goal is to learn from real-worl…

This study looks at 50 adults with acute pulmonary embolism (a blood clot in the lung) to compare different tools doctors use for diagnosis and risk assessment. Researchers will analyze clinical scores, lab tests, and CT scans to see which methods work best. The goal is to improv…

This study will observe 50 children (ages 1 month to 18 years) who come to the emergency room with kidney-related symptoms. Researchers want to learn what types of kidney problems are most common and how children respond to initial treatment. The goal is to improve early recognit…

This study watches 200 adults with intermediate-stage liver cancer to see which treatments they actually receive and how long they live. No new medicine is tested—researchers simply collect data from medical records. The goal is to understand real-world survival and side effects,…

This observational study will check how often left ventricular hypertrophy (thickening of the heart muscle) occurs in people with chronic kidney disease. It will also test whether erythropoietin, a drug used to treat anemia, can reduce that thickening. About 100 adults with advan…

This study observes 200 pregnant women with placenta accreta (a condition where the placenta grows too deeply into the uterus) to see how often it invades the cervix and whether a short cervix leads to early labor. Researchers will use extra ultrasound scans during routine care—n…

This study looks at whether a simple calculation using heart rate and blood pressure (called the Modified Shock Index) can help predict how serious sepsis is for patients arriving at the emergency department. Researchers will follow 70 adults with sepsis to see if this score rela…

This study involves 100 university students with type 1 diabetes. Researchers will test their carb counting knowledge and give a short education session, then check blood sugar control (HbA1c) after three months. The goal is to see if better carb counting leads to improved diabet…

This observational study looks at whether toxins from gut bacteria (intestinal endotoxemia) are linked to early beta-cell dysfunction in lean people with prediabetes. Researchers will measure blood markers and compare 120 lean prediabetic adults to healthy controls. The goal is t…

This study will observe 40 people with sigmoid colon volvulus, a condition where the lower bowel twists and blocks the intestine. The goal is to show that this problem can happen in young adults as well as the elderly, helping doctors diagnose it earlier and avoid serious complic…

This observational study will follow 200 adults with well-controlled rheumatoid arthritis to find ways to predict when a disease flare might happen. Researchers will track symptoms, disease history, and specific blood markers every 3 months. The goal is to help doctors make bette…

This study looks at whether a routine blood test called mean platelet volume (MPV) can help predict heart attacks in people with metabolic fatty liver disease. Researchers will compare MPV levels between two groups: those with fatty liver who have had a heart event and those who …

This study will survey 380 breastfeeding mothers in Sohag, Egypt, to learn how many exclusively breastfeed and what factors influence their choices. Researchers will also measure mothers' knowledge and confidence about breastfeeding. The goal is to identify gaps and improve suppo…

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and a gene (HLA-B27) in 84 people with ankylosing spondylitis and healthy volunteers. The goal is to see if these markers are linked to disease activity and severity. No treatment is giv…

This study checks if a set of thinking and drawing tests (called PHES) can find minimal hepatic encephalopathy—a mild form of brain fog—in people with stable liver cirrhosis. About 150 patients and 150 healthy volunteers will take the tests to see how well they detect early cogni…

This study looks at hormone levels in children aged 1 to 12 who have dilated cardiomyopathy, a condition where the heart is enlarged and weak. Researchers will compare these children to healthy kids to see if hormone problems are linked to heart failure severity. No treatments or…

This study looks at how diabetes and related metabolic problems affect hospitalized patients with chronic kidney disease. Researchers will collect medical information from 200 adults to see if diabetes increases the risk of death, need for dialysis, or serious heart problems duri…

This study follows 100 newly diagnosed breast cancer patients in Egypt to see how chemotherapy affects their thinking, memory, and nerves. Researchers will test participants before treatment and one year after using questionnaires and exams. The goal is to better understand these…

This study will measure Omega-6 fatty acid levels in the blood of 100 adults — half with liver cancer and half without — to see if there is a connection. Researchers want to learn if these fatty acids are linked to the presence or severity of the disease. This is an observational…

This study aims to find out which method of helping children breathe during anesthesia is best for keeping their eye pressure stable during congenital glaucoma surgery. Researchers will compare three different airway management techniques in 75 children. The goal is to see which …

This study aims to understand why some adults with bronchiectasis have worse outcomes when their lung condition suddenly gets worse. Researchers will look at 100 hospitalized patients to see if having other health problems like COPD, diabetes, or heart disease leads to longer hos…