Sohag University

This study compares two surgical techniques for removing very hard cataracts, which are tough to break apart and can lead to complications like corneal swelling or lens rupture. The new method, called 'divide and conquer with debulking,' aims to make the procedure safer. Research…

This study tests if injecting polidocanol (a medicine that reduces blood flow) into keloids and hypertrophic scars can make them flatter and less noticeable. About 90 people with scars that are less than a year old will receive either polidocanol or a standard steroid injection. …

This study compares two treatments for stable vitiligo: microneedling with a topical solution (minoxidil) alone versus microneedling with the same solution plus narrow-band UV light therapy. Thirty adults with stable non-segmental vitiligo will be enrolled. The goal is to see if …

This study looks at 60 children with bow legs or knock-knees to see which surgery works better: using screws or plates to guide bone growth. The goal is to straighten the leg and prevent future pain or arthritis. Children must be at least 3 years old and still growing to join.

This study compares two surgical techniques for fixing a broken ankle bone (the lateral malleolus) in adults aged 18 to 60. One method uses a metal plate and screws, the other uses a single screw placed inside the bone. Researchers will track healing time, pain, and function in 5…

This study will test whether adding a salt water (sodium chloride 5%) eye drop to standard antibiotic treatment helps heal bacterial eye infections faster. About 40 adults with bacterial keratitis will receive either antibiotics plus the salt drop or antibiotics alone. The goal i…

This trial tests a combination of three drugs—glucose-insulin-potassium (GIK), hydrocortisone, and sevelamer—in 74 people with severe aluminum phosphide poisoning. The goal is to see if this mix can lower death rates by countering shock and directly neutralizing the toxic gas. Pa…

This study will look at problems with the side wall of the nose and the nasal septum in 25 people scheduled for septorhinoplasty (nose reshaping surgery). Surgeons will use different techniques to fix each issue, such as trimming enlarged turbinates or using grafts to support wea…

This early study tests whether a daily enema made of salt water and glycerin can help children with fecal incontinence stay clean. The trial will include 30 children aged 3 to 16 who have bowel accidents at least once a week due to conditions like corrected anorectal malformation…

This study will test whether SGLT2 inhibitors, a type of diabetes drug, can help correct anemia in people with chronic kidney disease (CKD). Anemia is common in CKD and often requires iron or hormone injections, which have side effects. The trial will enroll 60 adults with CKD st…

This study tests a surgical procedure called endoscopic stapedotomy for people with otosclerosis, a condition that causes progressive hearing loss. Surgeons will use a tiny camera to place a small artificial device in the middle ear to improve sound transmission. The study will f…

This study tests whether adding platelet-rich plasma (PRP) or nanofat injections to standard hair transplants helps more hair grafts survive and grow thicker. Thirty men with stable male pattern baldness will receive both treatments on different scalp areas, and doctors will meas…

This study will test whether a modified Atkins diet can help children aged 1-18 with drug-resistant epilepsy. Researchers will track seizure control, quality of life, thinking skills, and growth in 40 children who follow the diet for at least 6 months. The goal is to see if this …

This study tests two different laser pulse settings (5% vs 15% duty cycle) in 50 adults with diabetic macular edema, a common cause of vision loss in diabetes. The goal is to see which setting is safer and more effective at reducing retinal swelling. Participants must have mild t…

This study compares two surgical techniques for repairing a torn volar plate in the finger. The older method uses a suture that exits the skin, which can cause irritation and delay movement. The newer method uses a small internal anchor. The trial will enroll 12 adults aged 18-55…

This study tests a surgical procedure to correct a rare condition where the two bones in the forearm are fused together, limiting rotation. The surgery involves cutting and repositioning the bones, then using Kirschner wires to hold them in place. The study will enroll one child …

This study looks at whether a detailed MRI scan (called multiparametric DCE-MRI) can improve the detection of breast lesions that don't form a clear lump on ultrasound. Researchers will compare the MRI results with ultrasound findings in 60 women to see if the MRI provides a more…

This study will check how well MRI can find and map perianal fistulas before surgery. Thirty patients with suspected fistulas will get an MRI, and the results will be compared to what surgeons find during the operation. The goal is to see if MRI can help doctors plan better surge…

This study looks at whether measuring a hormone called irisin in the blood can help find diabetic kidney disease early and track how it gets worse. Researchers will compare irisin levels in 200 adults with type 2 diabetes to healthy people. The goal is to see if irisin can be a s…

This study tests whether a simple blood test called the Systemic Immune Inflammation Index (SII) can help diagnose and predict acute kidney injury (AKI) in people with liver cirrhosis. AKI is a common and serious complication in cirrhosis, but current tests are often unreliable. …

This study will check how well a non-invasive stool test (quantitative fecal immunochemical test, or qFIT) can detect colorectal cancer and precancerous lesions like adenomas and serrated polyps. Researchers will compare the test results with colonoscopy findings in 150 adults ag…

This study will test whether a special type of MRI called diffusion-weighted imaging can accurately tell the difference between benign (non-cancerous) and malignant (cancerous) growths in the lining of the uterus. Researchers will compare the MRI results with the standard method—…

This study will test how well MRI can tell if ovarian cysts are benign or malignant. Fifty women with cysts seen on ultrasound will get an MRI, and the results will be compared with surgery findings or follow-up scans. The goal is to improve diagnosis and help doctors choose the …

This observational study will check how well MRI and ultrasound can identify superficial soft tissue masses (lumps just under the skin). Researchers will compare the scan results with the final diagnosis to see how accurate the imaging is. The goal is to find a reliable, non-inva…

This study will check if a specific ultrasound finding called the 'rail sign' can accurately detect placenta accreta, a condition where the placenta grows too deeply into the womb. Researchers will scan 90 pregnant women with placenta previa (low-lying placenta) during their seco…

This study tests whether inhaling ketamine or magnesium sulfate before surgery can prevent the sore throat that often follows general anesthesia with a breathing tube. 150 adults having elective surgery will be randomly assigned to receive one of these treatments or a placebo. Th…

This study compares sound therapy, cognitive behavioral therapy (CBT), and their combination to help people with chronic tinnitus (ringing in the ears). Sixty adults aged 18-65 with stable health will be randomly assigned to one of three groups for six weeks. The goal is to see w…

This study compares two types of nerve blocks—lumbar erector spinae plane block and fascia iliaca plane block—for pain relief after hip surgery. 200 adults undergoing hip surgery will receive one of the blocks, and their pain will be checked every 2 hours using a simple pain scal…

This study tests two different medicines to see which one better prevents confusion and agitation in children after eye surgery with sevoflurane anesthesia. 200 children aged 2-8 will be randomly assigned to receive either dexmedetomidine or a propofol-lidocaine mixture. The goal…

This study compares two types of nerve blocks—retrolaminar block and erector spinae plane block—for pain control after laparoscopic gallbladder removal. One hundred adults aged 20 to 60 will receive one of the two blocks during surgery. The main goal is to see which block delays …

This study compares two types of nerve blocks—erector spinae plane (ESP) block and transversus abdominis plane (TAP) block—for pain relief after cesarean section. Sixty women will receive one of the two blocks after surgery, and their pain levels and need for morphine will be tra…

This study tests two injection treatments for common warts: one using a patient's own blood components (platelet-rich fibrin) and the other using vitamin D. About 70 adults with warts will receive one of the two injections. The goal is to see which treatment shrinks warts more an…

This study compares two types of nerve blocks to see which one controls pain better after open gallbladder removal. Sixty-six adults will receive either an erector spinae plane block or an external oblique intercostal plane block before surgery. Researchers will measure pain scor…

This study compares adding midazolam or cisatracurium to lidocaine for numbing the eye during vitreoretinal surgery. The goal is to see if these additives help the eye muscles paralyze faster. 90 adults having elective eye surgery will be randomly assigned to one of three groups.…

This study compares two procedures—a nerve block and a pulsed radiofrequency treatment—to see which works better for people with chronic migraine. About 70 adults who have not found relief from standard treatments will take part. The goal is to reduce headache pain and improve qu…

This study compares two anesthesia methods for strabismus (eye muscle) surgery in adults: general anesthesia (being fully asleep) versus a combination of sedation with a local numbing injection around the eye. Researchers will measure patient and surgeon satisfaction with each ap…

This trial tests three common drugs—dexmedetomidine, magnesium sulfate, and ondansetron—to see which one stops shivering fastest after spinal anesthesia. Sixty adults having lower body surgery will receive one of the drugs, and researchers will measure how quickly shivering stops…

This study tests two types of pulsed radiofrequency treatments for people with severe trigeminal neuralgia, a condition causing intense facial pain. 62 adults who haven't found relief from medication will receive either a standard or a new irregular-pulse technique. The goal is t…

This study compares two minimally invasive treatments for carpal tunnel syndrome: pulsed radiofrequency (using heat pulses) and hyaluronidase hydrodissection (injecting a fluid to free the nerve). About 56 adults with mild to moderate carpal tunnel will be randomly assigned to on…

This study compares two types of pulsed radiofrequency treatments for postherpetic neuralgia, the long-lasting nerve pain that can follow a shingles infection. One hundred adults whose pain has not responded to standard care will receive either the regular or a new 'STP' irregula…

This early-stage trial tests whether microneedling combined with either tretinoin 0.025% or timolol 0.5% can improve the appearance of red stretch marks (stria rubra). Researchers will enroll 300 adults and track changes through photos and skin checks. The goal is to see if these…

This study uses questionnaires to measure how much gastroenterology clinicians and their patients know about artificial intelligence (AI), how much they trust it, and what barriers they see to using it in digestive health care. About 100 participants will answer questions about t…

This study will use a special imaging device (AS-OCT) to measure the thickness of the cornea's outer layer in 360 adults with nearsightedness, farsightedness, astigmatism, or normal vision. The goal is to see if different vision problems have unique thickness patterns. Participan…

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study will check if certain blood-based inflammation markers are linked to fatty liver disease (MASLD) in 100 adults. Participants will have their blood tested and their liver health assessed. The goal is to better understand the role of inflammation in this condition, not t…

This study will follow 200 adults hospitalized with upper gastrointestinal bleeding to see how many develop acute kidney injury. Researchers will also look for factors that make kidney damage more likely, such as the cause of bleeding. No new treatments are being tested—patients …

This study will measure how common and severe depression, anxiety, and sleep disorders are in 100 people with idiopathic Parkinson's disease. Researchers will use standard rating scales to assess these symptoms and see how they relate to the disease. The goal is to help doctors r…

This study looks at 150 injured children to see which scoring system—the BIG score or the Pediatric Trauma Score—better predicts who might die from their injuries. Researchers will check vital signs, lab results, and outcomes during the hospital stay. The goal is to find the most…

This study looks at how internet addiction affects sleep quality and academic performance in medical students at Sohag University. Researchers will survey 499 students using standard tests for internet addiction, sleep quality, and grades. The goal is to understand the problem, n…

This study will survey 400 medical students at Sohag University in Egypt to understand how health anxiety impacts their quality of life. Participants will fill out two questionnaires: one measuring health anxiety and another assessing physical and mental well-being. The results c…

This study looks at whether a blood test measuring the ratio of two substances (IGF-1 and albumin) can help identify muscle loss (sarcopenia) in people with end-stage kidney disease on dialysis. Researchers will compare the test results to standard muscle assessments in 110 adult…

This study will check if a routine blood measure called mean platelet volume (MPV) can predict acute coronary syndrome (heart attack or unstable angina) in people with metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare MPV levels between 60…

This study looks at 50 adults with acute pulmonary embolism (a blood clot in the lungs) to compare different methods used to diagnose and predict outcomes. Researchers will analyze clinical scores, lab tests, and CT scans from patients in various hospital departments. The goal is…

This observational study aims to understand if toxins from gut bacteria are linked to early signs of diabetes in lean people with prediabetes. Researchers will measure blood markers of gut toxins and insulin-producing cell function in 120 participants. The goal is to find new way…

This study will measure hormone levels in 100 children aged 1 to 12 who have dilated cardiomyopathy, a condition where the heart is enlarged and weakened. Researchers will collect blood samples to check hormones like thyroid, cortisol, and growth factors, and compare them to heal…

This study looks at 100 adults with obstructive jaundice to see if the type of anesthesia used during a procedure called ERCP affects how well it works and how safe it is. The goal is to find out which anesthesia leads to better success rates, fewer complications, and higher sati…

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study looks at 100 adults with advanced rectal cancer who received total neoadjuvant therapy (a combination of chemotherapy and radiation before surgery). Researchers want to see whether the response in the lymph nodes or the primary tumor better predicts how long patients s…

This study aims to find out how often multi-drug resistant Klebsiella pneumoniae bacteria carry genes that help them form biofilms (sticky layers) and pump out antibiotics. Researchers will collect urine, pus, and sputum samples from 100 hospital patients with these infections. T…

This study will observe 50 children (ages 1 month to 18 years) who come to the emergency room with kidney-related symptoms like swelling, blood in urine, or high blood pressure. Researchers want to learn which kidney diseases are most common and how children respond to initial tr…

This study will look at 50 children from birth to age 18 who have persistent or repeated low blood sugar. Researchers at Sohag University Hospital will use a step-by-step approach to find endocrine, metabolic, or genetic reasons for the condition. The goal is to improve early dia…

This study will compare 250 children aged 6 to 18 with chronic skin diseases to 250 healthy children to see how common body dysmorphic disorder (BDD) is in each group. Researchers will use a simple questionnaire to spot BDD symptoms and another to measure how skin problems affect…

This study will examine 100 patients with lower gut symptoms like chronic diarrhea, blood in stool, or abdominal pain who are having a colonoscopy. Researchers want to see which types of colon inflammation (colitis) are most common and how they appear during the procedure. The go…

This study looks at how ups and downs in blood sugar affect diabetic patients admitted to the coronary care unit. Researchers will track 120 adults with diabetes and heart disease to see if glucose variability increases the risk of death or major heart problems like heart attack …

This study will follow 300 people with non-spreading bladder cancer who receive high-dose radiation therapy (with or without a chemotherapy booster). Researchers want to see how long patients live, how often the cancer returns in the bladder or elsewhere, and what side effects oc…

This study will survey 160 adults on long-term hemodialysis at Sohag University Hospital to find out how many experience anxiety or depression. Researchers will also look for links to age, gender, and other health factors. The goal is to better understand the mental health needs …

This study looks at how different ways of managing a child's airway during anesthesia affect eye pressure and heart rate in children having surgery for congenital glaucoma. 75 children will be split into three groups, each receiving a different airway device. The goal is to find …

This study will compare two common anesthesia methods—propofol and sevoflurane—in 40 people having cataract surgery. The goal is to see which one keeps eye pressure more stable and causes fewer heart-related side effects. Researchers will measure eye pressure repeatedly during th…

This study looks at whether certain genes in a dangerous superbug (carbapenem-resistant hypervirulent Klebsiella pneumoniae) make it resistant to the powerful antibiotic cefiderocol. Researchers will collect samples from 100 infected patients and test the bacteria in the lab. The…

This study looks at whether certain blood test results can help predict how severe a stroke is and how well a person might recover. Researchers will check three different ratios in the blood of 60 adults with acute ischemic stroke. The goal is to see if these simple, routine test…

This study will check if a simple calculation called the Modified Shock Index (heart rate divided by mean arterial pressure) can predict how serious sepsis is in 70 adults coming to the emergency department. Researchers will see if a higher index is linked to needing ICU care, br…

This study looks at how different types of anemia—like iron deficiency or thalassemia—can change HbA1c levels, a common test for diabetes, in people who do not have diabetes. Researchers will compare HbA1c results between 100 non-diabetic adults with various anemias and a healthy…

This study watches 200 adults with intermediate-stage liver cancer to see which treatments doctors actually use and how long patients survive. It does not test a new drug or procedure. The goal is to learn from real-world care to help guide future treatment decisions.

This observational study will follow 200 pregnant women with placenta accreta spectrum (PAS) at Sohag University Hospital in Egypt. Researchers will use ultrasound to measure how deeply the placenta invades the cervix and the length of the cervix. The goal is to understand how co…

This study aims to find out how common depression is among medical students at Sohag University. Researchers will survey 300 students aged 18 to 25 to measure depression rates and understand the factors that contribute to it. The goal is to raise awareness and improve mental heal…

This study will use a non-invasive eye scan called OCTA to look for tiny blood vessel changes in the retina of 90 adults who have taken hydroxychloroquine for at least a year. Hydroxychloroquine, used for autoimmune diseases, can sometimes harm the retina with long-term use. The …

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and the HLA-B27 gene in 84 people with ankylosing spondylitis and a healthy control group. The goal is to see if these markers are linked to disease activity and severity. No treatment i…

This study aims to see if certain markers in the blood (CCR6 and CCL20) are linked to rheumatoid arthritis. Researchers will compare 60 adults with RA to healthy people. The goal is to learn more about the disease, not to test a new treatment.

This study compares two types of nerve blocks used during shoulder surgery to see which one causes less diaphragm paralysis (temporary trouble breathing). Sixty adults scheduled for shoulder surgery will receive either a standard interscalene block or a combination block. Researc…

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis and systemic sclerosis, as well as healthy volunteers, and compare them with standard tests and lung functi…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This observational study will check how common left ventricular hypertrophy (thickening of the heart muscle) is in people with chronic kidney disease. It will also look at whether treating anemia with erythropoietin can reduce that thickening. About 100 adults with moderate to se…

This study will check if certain blood markers (like platelet counts and inflammation levels) can help predict serious complications in pregnant women with HELLP syndrome, a rare but dangerous condition. Researchers will follow 60 women to see how these markers relate to problems…

This study will test the antibiotic combination ceftazidime-avibactam on 100 patients with healthcare-associated infections caused by carbapenem-resistant Klebsiella pneumoniae. Researchers will collect samples from blood, urine, and other sites to identify the bacteria and check…

This study looks at whether breast cancer's biology changes when it returns after treatment. Researchers will review medical records of 200 patients treated between 2015 and 2025. The goal is to see how often key markers differ between the first tumor and the recurrence, which co…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study will review medical records of 100 adults with locally advanced rectal cancer treated between 2018 and 2025 at hospitals in Egypt. Researchers will look at which treatments patients received and how they fared, including survival and side effects. The goal is to unders…

This study looks at 400 people with lupus to compare those with typical symptoms versus those with unusual or 'atypical' symptoms. The goal is to understand how these differences affect disease activity, organ damage, and treatment needs over time. By identifying these patterns, …

This observational study will follow 200 hospitalized adults with chronic kidney disease to see how diabetes and related metabolic problems affect their outcomes. Researchers will track deaths, need for dialysis, and major heart events during the hospital stay. The goal is to bet…

This study will survey 402 female medical students at Sohag University to understand how period pain (primary dysmenorrhea) impacts their academic performance and quality of life. Participants will fill out two questionnaires about their pain and its effects. The goal is to gathe…

This study looks at how well university students with type 1 diabetes can estimate carbohydrates in their meals and whether that affects their blood sugar control. Researchers will give a one-time educational session on carb counting and insulin adjustment, then check blood sugar…

This study will follow 100 adults hospitalized for a sudden worsening of bronchiectasis. Researchers will track how conditions like COPD, diabetes, and heart disease, along with disease severity, affect the need for intensive care, length of hospital stay, and risk of death. The …

This study will survey 380 mothers with children up to 24 months old in Sohag, Egypt, to find out how many breastfeed exclusively and what factors influence their choices. Researchers will also measure mothers' knowledge and confidence about breastfeeding. The goal is to identify…

This study will test whether a formula called fullPIERS can accurately predict serious complications in 50 pregnant women with preeclampsia. The formula uses information like blood pressure, kidney function, and symptoms to estimate risk. If it works well, doctors could use it to…

This study looks at how local anesthesia around the eye changes tiny blood vessels in the retina during cataract surgery. Researchers will use a special camera (OCT angiography) to take pictures before and after the numbing injection. The goal is to understand these changes bette…

This study looks at two genes (IL-1β and IL-33) in 300 adults with low platelet counts caused by either primary immune thrombocytopenia (ITP) or lupus (SLE). Researchers will measure gene activity from a blood sample to see if these genes can help tell the two conditions apart. T…

This study will measure certain hormones in 80 boys aged 10 to 18 who have transfusion-dependent beta thalassemia. The goal is to see how iron buildup from repeated blood transfusions affects the glands that control puberty and fertility. By checking levels of inhibin B, INSL3, a…

This study looks at a thinking and coordination test called PHES to find early, hidden brain problems in people with stable liver cirrhosis. About 150 patients and some healthy volunteers will take the test. The goal is to see how well the test catches these issues before they ge…

This observational study will measure Omega-6 fatty acid levels in the blood of 100 adults — half with liver cancer and half without — to see if there is a connection. No drugs or treatments are given. The goal is to understand if these fats are linked to the presence or severity…

This study looks at how children aged 6 to 18 with inborn errors of immunity (a condition where the immune system doesn't work properly) feel about their quality of life. Researchers will compare their answers to those of healthy children using a special questionnaire. The goal i…

This study will measure three types of fats (ceramides and S1P) in the blood of 40 people with acne and 40 healthy volunteers. The goal is to see if these fats are different in acne patients and if they relate to acne severity. No treatment is given—just a blood draw. The results…

This study will test 200 adults on regular hemodialysis at Sohag University Hospital for latent tuberculosis infection (LTBI) using a simple skin test. The goal is to find out how many dialysis patients carry the bacteria without symptoms, so doctors can better prevent active TB …

This study will follow 200 adults in Egypt who have psychosis to compare two conditions: schizophrenia and psychosis caused by methamphetamine use. Researchers will assess symptoms, treatment response, and recovery over three months. The goal is to improve diagnosis and understan…

This study will follow 100 newly diagnosed breast cancer patients in Egypt to see how chemotherapy affects their thinking, memory, and nerves. Researchers will use questionnaires and exams before treatment and one year later. The goal is to better understand these side effects in…

This study will use echocardiography (ultrasound of the heart) to look at how common and how severe diastolic dysfunction—a type of heart stiffness—is in 100 adults with end-stage kidney disease who are on regular hemodialysis. Researchers will also check if certain clinical fact…

This study will test 250 people with tuberculosis (TB) to see how common drug resistance is. Using special rapid tests called GeneXpert, researchers will look for resistance to key TB drugs like Rifampicin. They also want to find out if things like diabetes or drug addiction make…

This observational study in Sohag, Egypt, will look at 40 people of any age who have a twisted sigmoid colon (sigmoid volvulus). The goal is to show that this condition can cause bowel blockages not only in older adults but also in younger people, helping doctors diagnose it earl…

This study will check for a mutation in the Notch1 gene in blood or bone marrow samples from 80 people with chronic lymphocytic leukemia (CLL) or non-Hodgkin's lymphoma (NHL). The goal is to see how common this mutation is and compare it between the two cancers. This is an observ…

This study compares two minimally invasive surgical techniques—uniportal and biportal endoscopy—for treating a single-level lumbar disc herniation. Sixty adults aged 18-70 with persistent symptoms will be randomly assigned to one of the two procedures. The main goal is to see whi…