Gene hunt in blood cancers: could Notch1 hold clues?

NCT ID NCT07157579

Not yet recruiting Knowledge-focused Sponsor: Sohag University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study will check for a mutation in the Notch1 gene in blood or bone marrow samples from 80 people with chronic lymphocytic leukemia (CLL) or non-Hodgkin's lymphoma (NHL). The goal is to see how common this mutation is and compare it between the two cancers. This is an observational study, meaning it does not test any new treatment, but it may help researchers learn more about these diseases.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors understand how Notch1 mutations affect CLL and NHL, possibly pointing toward better ways to predict or treat these cancers in the future.
What could go wrong: This is an early observational study, not a treatment trial. It only looks for a gene mutation and does not test any new drug or therapy, so it cannot directly improve patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia chronic lymphocytic leukemia/small lymphocytic lymphoma non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)- NON-HODGINS'S LYMPHOMA (NHL)

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