Experimental cocktail aims to neutralize deadly grain fumigant poisoning
NCT ID NCT07451561
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tests a combination of three drugs—glucose-insulin-potassium (GIK), hydrocortisone, and sevelamer—in 74 people with severe aluminum phosphide poisoning. The goal is to see if this mix can lower death rates by countering shock and directly neutralizing the toxic gas. Participants must be between 12 and 60 years old, in shock, and treated within 12 hours of ingestion.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Glucose-insulin-potassium (GIK) infusion, intravenous hydrocortisone, and oral sevelamer
- What this could lead to
- If it works, this could point toward an effective treatment for aluminum phosphide poisoning, which currently has no antidote.
- What could go wrong
- This is a small, early-stage trial with only 74 participants, so results may not apply widely. The combination therapy also carries risks like blood sugar and potassium imbalances.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sohag university hospital
Sohag, 82611, Egypt