Fudan University

This study is testing two different treatment combinations for people with locally advanced rectal cancer that hasn't spread to distant organs. All participants receive chemotherapy and immunotherapy, but one group also gets a short course of radiation beforehand. The main goal i…

This study is testing if adding a type of immunotherapy drug (a PD-1 inhibitor) as a long-term maintenance treatment after standard chemoradiation helps people with locally advanced esophageal cancer live longer without their cancer getting worse. It will involve 452 adults and i…

This study compares two surgical approaches for papillary thyroid cancer that has spread to a limited number of lymph nodes in the neck. It aims to see if a more targeted, less extensive surgery (selective neck dissection) is as safe and effective at preventing cancer recurrence …

This study is comparing two different radiation treatment schedules, both combined with chemotherapy and two other drugs, for people with locally advanced rectal cancer that hasn't spread. The goal is to see which approach leads to better tumor shrinkage and higher rates of avoid…

This study is testing whether different antibody-drug conjugate (ADC) medications can help control advanced breast cancer in patients whose cancer has progressed despite previous ADC treatment. The trial will enroll 160 adults with metastatic breast cancer who have already receiv…

This study is testing a combination of radiation, chemotherapy, immunotherapy, and targeted drugs for rectal cancer that has come back in the pelvic area after previous treatment. It is for patients whose cancer progressed or who could not tolerate a standard chemotherapy drug ca…

This study aims to find the most effective treatment sequence for early-stage NK/T-cell lymphoma, a rare but aggressive cancer often starting in the nasal area. Researchers will compare three different approaches combining chemotherapy, radiation, and immunotherapy in 210 patient…

This study is testing a new, targeted drug for people with advanced esophageal cancer whose first treatment has stopped working. The drug is designed to deliver a powerful cancer-killing agent directly to tumor cells, aiming to slow or stop cancer growth. Researchers want to see …

This study is testing a two-part treatment for cancers that have spread to the liver. First, doctors use a procedure that heats and destroys tumors. Then, patients receive an immunotherapy drug. The goal is to see if this combination is more effective and safe than current option…

This study is testing whether adding chemotherapy delivered directly into the spinal fluid (through a small implanted device called an Ommaya reservoir) works better than standard chemotherapy alone for people with HER2-negative breast cancer that has spread to the membranes surr…

This study is testing whether adding a new immunotherapy drug (SHR-1701) to precise, high-dose radiation (SBRT) can better control advanced prostate cancer that has spread and stopped responding to standard hormone therapy. It will involve about 66 men to see if this combination …

This study is testing five different combinations of chemotherapy and other drugs for people with advanced stomach or gastroesophageal cancer whose initial treatment has stopped working. Researchers will compare how well these different approaches control the cancer and manage si…

This study is for people with colorectal cancer that has spread to the lining of the abdomen (peritoneal metastasis) and has worsened after initial treatment. It tests if using a special PET scan to guide precise abdominal radiation, combined with standard second-line therapy and…

This study is testing if a new blood test can detect the return of colon cancer earlier than current standard methods like CT scans. It will follow 584 people who have had surgery for non-metastatic colon cancer. Half will get the new blood test as part of their follow-up, to see…

This study is testing whether adding a drug called retinoic acid to standard immunotherapy can help control advanced HER2-negative breast cancer that has started growing again during previous immunotherapy. It aims to see if this combination can shrink tumors or stop their growth…

This study is testing whether a combination of two new drugs, SHR-0302 and SHR-2554, can help control a rare and aggressive type of blood cancer called peripheral T-cell lymphoma that has come back or hasn't responded to prior treatments. It will enroll about 25 adult patients to…

This study is testing whether adding a new immunotherapy drug (QL1706) to standard chemotherapy works better for people with advanced pancreatic cancer that cannot be removed by surgery. It will involve 58 adults who have not yet received any treatment for their advanced cancer. …

This study is testing if adding two treatments—a drug called narlumosbart and precise radiation therapy—to standard first-line chemo-immunotherapy can improve results for people with advanced non-small cell lung cancer that has spread to their bones. The goal is to see if this co…

This study is testing whether adding a drug called IL-11 to the standard drug G-CSF helps patients' blood cells recover more quickly after a stem cell transplant for blood cancers like multiple myeloma or lymphoma. The goal is to shorten the time patients have low platelet and re…

This study compares three different surgical techniques for removing very low rectal cancer while trying to preserve the patient's natural bowel control. It will enroll 100 patients to see which method provides the best balance between completely removing the cancer and maintaini…

This study is testing whether adding daily omega-3 fish oil supplements to standard immunotherapy helps people with advanced esophageal cancer. Researchers want to see if the supplements help patients maintain muscle mass and improve their response to treatment. About 140 partici…

This study compares two immunotherapy drugs (serplulimab and nivolumab) when given with chemotherapy before surgery for stage II-IIIa squamous non-small cell lung cancer. Researchers want to see which combination better shrinks tumors and improves surgical outcomes for 116 eligib…

This study is testing whether adding a liver-supporting drug (L-Ornithine L-Aspartate) to two standard breast cancer medications can help control advanced breast cancer that has continued to grow despite previous treatment. It will involve 20 women whose cancer is hormone-sensiti…

This study aims to see if radiation therapy given after surgery helps prevent thyroid cancer from returning in the neck area for patients at high risk of recurrence. It will observe 80 patients whose cancer has features that make it more likely to come back, such as not being ful…

This trial is testing two different intensive treatment combinations given before surgery for locally advanced rectal cancer. One group gets a longer course of radiation with chemotherapy. The other gets a shorter radiation course plus chemotherapy, an immunotherapy drug, and an …

This study is testing whether adding probiotics (beneficial bacteria) to a combination of high-dose radiation, chemotherapy, and an immunotherapy drug called adebrelimab can better control limited-stage small cell lung cancer. It will involve 60 patients to see if this approach h…

This study is testing several different combinations of drugs to see if they can help immunotherapy work again for people with advanced triple-negative breast cancer whose cancer got worse during previous immunotherapy. It will enroll about 80 patients whose cancer has spread and…

This study is testing whether a transplant using umbilical cord blood from an unrelated donor can effectively treat severe diseases caused by the Epstein-Barr virus (EBV). The trial will enroll 80 participants with specific EBV-related conditions that have not responded to standa…

This study is testing whether combining two drugs, MRG003 and pucotenlimab, can help control an aggressive form of thyroid cancer that has spread or cannot be surgically removed. It is for adults whose cancer tests positive for a specific marker called EGFR. The goal is to see if…

This study is testing new drug combinations for people with advanced pancreatic cancer that cannot be removed by surgery. Researchers will give 160 participants either a single new drug or combinations with other treatments to see how safe they are and if they can shrink tumors. …

This study is testing whether using less or no opioid painkillers during anesthesia for colorectal cancer surgery affects cancer cell behavior and patient recovery. Researchers are comparing three different anesthesia plans in 90 patients undergoing surgery. They will measure mar…

This study is testing an oral drug called tunlametinib in people with advanced melanoma that has a specific genetic change (NRAS mutation) and has stopped responding to standard immunotherapy. The goal is to see if the drug can shrink tumors and is safe for long-term use in a rea…

This study is testing how well and how safely the drug sunvozertinib works for adults with advanced non-small cell lung cancer. It is for people who have not had any prior cancer treatment and whose cancer has specific, less common genetic changes (EGFR mutations). The main goal …

This study is testing new, personalized treatment plans for young women with early-stage endometrial (uterine) cancer who want to preserve their ability to have children. Instead of standard surgery, which removes the uterus, doctors will assign treatments based on the unique gen…

This study is testing whether a more targeted radiation treatment is just as good as the standard, broader radiation at keeping breast cancer from coming back. It involves over 1,600 women with early-stage breast cancer who have had surgery and have a small amount of cancer in 1-…

This study is testing whether a personalized approach to palliative care (comfort-focused treatment) helps people with advanced esophageal cancer live longer and feel better compared to standard palliative care. Researchers will enroll 624 adults who are receiving immunotherapy a…

This study is for women with a specific, hard-to-treat type of triple-negative breast cancer who have already had surgery. It aims to see if adding a drug called 'antivascular therapy' to standard chemotherapy is better at preventing the cancer from returning than chemotherapy al…

This study is testing a combination of three drugs—two chemotherapy drugs (GEMOX), a targeted therapy (donafenib), and an immunotherapy (tislelizumab)—for people with advanced bile duct cancer that cannot be removed by surgery. The goal is to see if this combination can shrink tu…

This study is testing whether a new two-drug combination (SKB264 plus inetetamab) can help control advanced HER2-positive breast cancer that has continued to grow despite previous treatment with the standard drug T-DXd. The trial will enroll 48 adults whose cancer has spread and …

This study is testing whether combining two drugs, fruquintinib and serplulimab, can help control advanced colorectal cancer that has spread and is no longer responding to standard therapies. It will involve about 50 patients to see if the combination is effective and safe. Resea…

This study is testing a new combination treatment for people with advanced lung cancer that has a specific genetic change (EGFR mutation) and has stopped responding to their first treatment. It combines four drugs (an immunotherapy, a blood vessel blocker, and two chemotherapies)…

This large study is testing whether adding a CDK4/6 inhibitor drug to standard hormone therapy helps prevent breast cancer from coming back in high-risk patients. It involves about 1,900 women with a specific type of early-stage breast cancer (HR+/HER2+) who have already complete…

This study is testing if a simple blood test can help doctors make better treatment decisions for people with advanced breast cancer that has spread. Researchers will track tiny pieces of cancer DNA in the blood to see if changes can predict how well a treatment is working early …

This study is testing whether adding radiation therapy to the standard treatment helps prevent high-risk thyroid cancer from coming back in the neck area. Patients who have had surgery but still have some cancer cells left will be randomly assigned to receive either the standard …

This study is testing if adding an immunotherapy drug to a new, more targeted form of radiation and standard chemotherapy works better for treating advanced esophageal cancer. Researchers will compare the new three-part combination to just the targeted radiation and chemotherapy …

This study is testing whether adding a new immunotherapy drug called tislelizumab to standard chemotherapy works better for people with advanced soft tissue sarcoma. It will enroll 45 adults with specific types of sarcoma that cannot be removed by surgery or have spread. The main…

This study is testing if a more personalized radiation plan for the neck is as good at preventing cancer from coming back as the standard, broader radiation approach. It will involve 462 adults with nasopharyngeal carcinoma (a type of head and neck cancer) that hasn't spread to d…

This study is testing if the diabetes medication metformin can help control mild memory problems in older adults who are overweight or obese. Researchers will enroll 54 participants aged 60-75 and randomly assign them to receive either metformin plus lifestyle advice or lifestyle…

This study is testing a new targeted drug, VEGFR BP102, combined with standard chemotherapy, against standard chemotherapy alone. It is for people with a specific, aggressive form of advanced triple-negative breast cancer (called the BLIS subtype) that has spread or cannot be sur…

This study tests whether a combination of three drugs can shrink advanced stomach tumors that are currently inoperable, with the goal of making surgery possible. It is for patients whose cancer has a specific protein marker (HER2 1+/2+). The main measure of success is whether the…

This study is testing a new blood test that analyzes DNA fragments to try to detect pancreatic neuroendocrine tumors (pNETs) at an early stage. It will involve 1,000 participants who have been diagnosed with specific pancreatic tumors but have not yet started treatment. The goal …

This study aims to see if a new stool test, which looks for specific markers related to a common stomach bacteria, and a simple risk questionnaire can help detect stomach cancer earlier. It will enroll up to 15,000 adults aged 40 and older. People who test positive on either meth…

This study is testing whether using artificial intelligence (AI) to help read mammograms and breast ultrasounds can improve early breast cancer detection in large-scale screening programs. It will enroll 16,000 women aged 35-69. One group will get AI-assisted screening, while the…

This study aims to see if small tissue samples taken during an endoscopy (a tube with a camera) are just as good as larger samples taken during surgery for identifying important features of stomach cancer. Researchers will compare results from both types of samples from 510 patie…

This study is testing a new screening method to find stomach cancer early. About 15,000 adults aged 40 and older will take a stool DNA test and answer a health questionnaire. People with a positive result from either method will get a follow-up endoscopy to check for cancer.

This large study is testing a new training and support program designed to prevent dangerous bloodstream infections that can occur from central line catheters in Intensive Care Units (ICUs). It involves over 8,000 patients across 23 hospitals in China. The goal is to see if this …

This study is testing if a simple daily eating schedule can help prevent gestational diabetes in pregnant women at high risk for the condition. Researchers will compare two groups of 240 women: one group will eat all their food within a 10-hour window each day, while the other fo…

This study is testing if giving a steroid medication (dexamethasone) can reduce painful skin reactions on the hands and feet caused by a chemotherapy drug called liposomal doxorubicin. It will enroll 182 adults with breast cancer who are scheduled to receive this specific chemo r…

This study aims to learn more about marginal zone lymphoma, a type of blood cancer, by tracking 2,500 newly diagnosed patients over time. Researchers will observe how the disease behaves and how well different treatments work, without testing new drugs. The goal is to gather real…

This study is observing how doctors in China currently treat patients with peripheral T-cell lymphoma (PTCL), a rare type of blood cancer, in real hospital settings. Researchers will follow 3,000 patients to understand which treatments work best, what side effects occur, and how …

This study aims to understand how age influences the body's response to breast cancer treatment. Researchers will compare blood samples from younger and older patients with a specific type of early-stage breast cancer before and during their standard pre-surgery (neoadjuvant) the…

This study aims to understand if people infected with certain high-risk types of H. pylori bacteria are more likely to develop stomach cancer or pre-cancerous changes. Researchers will follow 3,000 adults over 10 years, observing their health through check-ups but not giving any …

This study aims to better understand how often esophageal cancer spreads to a specific set of lymph nodes near the windpipe, and what factors make that spread more likely. It will observe 1100 patients with esophageal cancer who are scheduled for surgery. The goal is to gather ev…

This study is testing whether two types of PET scans can predict if a new class of targeted drugs will work for patients with advanced breast cancer. Researchers will scan 45 patients before they start treatment to see if the scan results match how well the drugs control their ca…

This study aims to understand which types of Human Papillomavirus (HPV) are linked to anal cancer in China and to track the disease's patterns over time. Researchers will collect data from 300 patients already diagnosed with anal cancer across multiple hospitals. The goal is to g…

This study aims to create a large, shared database of patients with a rare pancreatic tumor called Solid Pseudopapillary Neoplasm (SPN). It will collect real-world information from up to 2000 patients across multiple hospitals to better understand this disease. The goal is to gat…

This study aims to understand how a common pain and sedation medication (remifentanil) behaves in the bodies of low-weight patients who are critically ill and on breathing machines. Researchers will measure drug levels in the blood and monitor patients' blood pressure and heart r…

This study is testing if a special blood test can help doctors see how well treatment is working for advanced colorectal cancer and predict if the cancer will come back. Researchers will track nearly 500 patients receiving radiation and chemotherapy, with or without immunotherapy…

This study aims to better understand how often esophageal cancer spreads to a specific set of lymph nodes near the windpipe. Researchers will observe 1,852 patients undergoing surgery to see how common this spread is and identify which patients are most at risk. The goal is to ga…

This study aims to understand why some lung cancers with a specific genetic change (ROS1 fusion) eventually stop responding to the targeted drug entrectinib. Researchers will analyze tissue and blood samples from patients who have taken entrectinib as part of their regular care. …

This study aims to learn more about how common respiratory infections like colds, flu, and pneumonia progress over time. Researchers will observe 1000 adults who visit a fever clinic, collecting information on their symptoms and test results. The goal is to understand the natural…

This study aims to find out if a patient's anxiety or depression levels can influence how well their breast cancer responds to immunotherapy. Researchers will observe 120 women with triple-negative breast cancer who are receiving standard treatment, tracking their mental health a…

This study aims to see if the types of bacteria in a patient's gut can help predict how well their stomach cancer will respond to a combination of immunotherapy and chemotherapy. It will enroll 300 adults with advanced stomach cancer who have not had prior chemotherapy or immunot…

This study aims to discover what factors predict whether a powerful cell therapy (CAR-T) will work for patients with large B-cell lymphoma that has returned or not responded to other treatments. Researchers will follow 80 patients receiving standard CAR-T therapy to analyze their…