Could surgery extend life in advanced stomach cancer after a good response to therapy?
NCT ID NCT07757165
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial asks a key question: for people with advanced metastatic stomach cancer whose tumors shrink significantly after initial medical therapy (called conversion therapy), does adding radical surgery improve their chances of living longer without the disease progressing? The study will compare two approaches: one group receives surgery to remove the primary tumor and any remaining metastatic lesions, while the other group continues with the original medical treatment alone. The main goal is to see whether surgery improves the two-year progression-free survival rate, with secondary goals including overall survival and the rate of complete tumor removal.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Surgical radical resection (removal of the primary tumor and metastatic lesions) compared with continuing medical treatment alone
- What this could lead to
- If surgery improves survival, it could change standard care for metastatic gastric cancer patients who respond well to initial therapy, offering a potential path to longer life.
- What could go wrong
- This is a Phase II trial with a modest number of participants, so results may not be definitive. Surgery carries risks, and the benefit over medical therapy alone is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fudan University Cancer Hospital
RECRUITINGShanghai, 200032, China