Fudan University

This study is for people who have had surgery for stage II or III bile duct cancer. It aims to see if using a lab test to choose personalized chemotherapy drugs is better at preventing the cancer from coming back than using the standard single-drug chemotherapy. About 98 particip…

This study aims to see if adding a nutritional supplement called branched-chain amino acids (BCAAs) to two standard liver cancer drugs helps patients with advanced liver cancer that cannot be surgically removed. Researchers will compare the standard two-drug combination with or w…

This study is testing whether combining two drugs, pucotenlimab and becotatug vedotin, can help control advanced skin cancer that has spread or cannot be removed by surgery. It is for patients who have few other treatment options left. The goal is to see if the combination shrink…

This study is testing whether adding a drug called neratinib to a standard treatment (Trastuzumab Deruxtecan) works better for controlling advanced HER2-positive breast cancer that has spread to the brain. It will involve 202 women in China who will receive one of the two treatme…

This study examines how well eribulin-based treatments work for advanced HER2-negative breast cancer patients who have already received antibody-drug conjugate therapies. Researchers will follow 400 patients who receive eribulin treatment after their previous treatments. The main…

This study compares two different drug combinations for people with advanced colorectal cancer that has spread and has a specific genetic change (RAS mutation). About 224 patients whose cancer has worsened after initial treatment will receive either a newer drug (fruquintinib) pl…

This study is testing whether Huaier Granules, an herbal medicine, can help control a kidney side effect called proteinuria in lung cancer patients. Proteinuria is a common problem for patients taking the cancer drugs Bevacizumab or Anlotinib. The trial will compare patients who …

This study is testing a new two-drug combination for men with advanced penile cancer that has spread and who cannot tolerate or have not responded to standard chemotherapy. The trial will see if the drugs becotatug vedotin and pucotenlimab can help control the cancer. It aims to …

This study is testing whether a traditional Chinese herbal medicine called Huaier granules can help lower elevated tumor marker levels in people who have had surgery for early-stage breast cancer. It will involve 232 participants who have no signs of cancer returning but have hig…

This study is testing a new approach for treating a common type of breast cancer before surgery. Patients first get a two-week course of two targeted drugs. Doctors then check a tumor marker (Ki67) to decide if they should continue with the drug combo or switch to standard chemot…

This early-stage study is testing a combined treatment system for liver cancer that uses tumor ablation along with immune system modulation. The research aims to evaluate safety, effectiveness, and how the treatment affects patients' immune responses. It will enroll 20 adults wit…

This study is testing whether actively treating diabetes helps people with advanced pancreatic cancer live longer while they receive standard chemotherapy. It will enroll 210 adults whose pancreatic cancer has spread and who also have diabetes. Researchers believe that controllin…

This study is testing whether adding a second drug (bevacizumab) to a newer cancer treatment (trastuzumab deruxtecan) works better for controlling a specific type of advanced breast cancer that has spread to the brain. It will involve 140 people whose cancer has a low level of a …

This study will observe how well the immunotherapy drug toripalimab works in real-world treatment for patients with advanced small cell lung cancer. Researchers will follow about 1200 patients already scheduled to receive this drug as their first treatment, tracking how long the …

This study is testing if adding a pill called fluzoparib to standard care helps prevent breast cancer from returning in women who have already had surgery. It is for women with early-stage breast cancer who have specific inherited gene mutations. The goal is to see if taking the …

This study is for people with a specific type of advanced breast cancer that has spread. It will test which of two newer, targeted drugs to try first, and which to try second if the first one stops working. The goal is to find the best order to give these treatments to help contr…

This study is testing a combination of targeted drugs given before surgery to treat a specific type of breast cancer that is both hormone-sensitive and HER2-positive. The goal is to see if this approach can effectively control the cancer while reducing the need for traditional ch…

This study is testing a combination treatment for liver cancer that has grown too much for standard surgery. Patients will receive a targeted chemotherapy procedure (TACE) plus an immunotherapy drug (QL1706) before their tumor is removed, and then continue the immunotherapy after…

This large study aims to find out if a shorter course of hormone therapy (2-3 years) works as well as the standard longer treatment for women with a specific, low-risk type of early-stage breast cancer. It will enroll nearly 3,000 patients who will be randomly assigned to receive…

This study is testing if a very low dose of radiation can make tumors sensitive again to immunotherapy drugs in patients with advanced esophageal cancer that has stopped responding to standard treatment. About 32 adults who have progressed after first-line chemo-immunotherapy wil…

This study aims to see if a new combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy works better than a different immunotherapy (sintilimab) plus the same chemo for people with advanced bile duct cancer inside the liver. It will involv…

This study is testing whether adding a targeted drug called disitamab vedotin to the standard BCG treatment works better for controlling high-risk, early-stage bladder cancer. It will involve about 182 patients whose cancer has been surgically removed but is at high risk of retur…

This study compares three different immunotherapy approaches given before surgery for people with locally advanced colorectal cancer that has specific genetic features (MSI-H/dMMR). Researchers want to see if combining two immunotherapy drugs, or adding radiation to immunotherapy…

This study is testing whether a new drug called RC48, when combined with standard chemotherapy, works better than current standard treatments for advanced HER2-positive breast cancer. It's for people whose cancer has continued to grow despite previous treatment with a specific ty…

This study is testing several new treatment combinations for people with advanced liver cancer whose first treatment stopped working. It uses a flexible design that quickly identifies which treatments show promise and which don't, while also looking for biological markers that mi…

This study is testing a new combination of two drugs, envafolimab and lenvatinib, as the first treatment for people with advanced kidney cancer that has spread to the liver. The goal is to see if this two-drug approach can effectively control the cancer and is safe for patients. …

This study is for women with a specific, hard-to-treat type of advanced breast cancer that has grown despite standard hormone and CDK4/6 inhibitor therapy. It will test if adding a drug called famitinib to another drug (SHR-A1811) works better and is safe compared to using SHR-A1…

This study is for people with a common type of early breast cancer (HR+/HER2-) who have had surgery. It aims to see if a gentler, targeted drug combination (ribociclib plus hormone therapy) works as well as starting with chemotherapy for patients whose blood tests show no signs o…

This study is testing whether combining two targeted drugs (becotatug vedotin and cetuximab) can help control advanced colorectal cancer that has stopped responding to standard treatments. It's for patients with a specific genetic profile (RAS wild-type) who have already tried mu…

This study is testing two different maintenance drug combinations to help control advanced HER2-positive breast cancer after initial treatment. Researchers want to see which approach works better at keeping the cancer from progressing, based on whether patients also have hormone-…

This large study is testing if a new treatment approach can work as well as chemotherapy for a specific group of early breast cancer patients. It will compare a targeted pill (dalpiciclib) plus hormone therapy directly against standard chemotherapy. The goal is to see if patients…

This study is testing if a powerful combination of drug therapy, surgery, and targeted radiation can better control prostate cancer that has spread to a limited number of places in the body. It will compare this aggressive approach to drug therapy alone in 300 men. The main goal …

This study is testing a combination of four different treatments for people with advanced soft tissue sarcoma that has continued to grow after initial therapy. The treatment includes an immunotherapy drug (QL1706), a chemotherapy drug (eribulin), a targeted therapy (anlotinib), a…

This study is testing whether a drug called Vebreltinib can shrink tumors in patients with a specific genetic type of non-small cell lung cancer before they have surgery. About 30 eligible patients will take the drug for 8 weeks prior to their planned operation. The main goal is …

This study is testing a new combination of two immunotherapy drugs (iparomlimab and tuvoraleimab) with three standard chemotherapy drugs for people with advanced acral or mucosal melanoma. The goal is to see if this five-drug combination can better control the cancer and is safe …

This study is testing a new combination of radiation and drug therapy for people with advanced non-small cell lung cancer (NSCLC). Researchers want to see if a new 'high-low' radiation dose strategy, given after two cycles of chemotherapy and immunotherapy drugs, can shrink tumor…

This study is testing whether adding a pill called everolimus after standard chemotherapy helps prevent cancer from coming back in people with early-stage triple-negative breast cancer. About 900 patients who've had surgery and chemotherapy will be randomly assigned to receive ei…

This study is testing whether surgically removing the prostate helps men with advanced prostate cancer that has already spread to other parts of the body. After 6 months of strong hormone-blocking drug therapy, patients whose scans show the cancer has quieted down will be randoml…

This study is testing whether combining two drugs, sacituzumab tirumotecan and furmonertinib, can help control advanced non-small cell lung cancer that has specific genetic changes (EGFR mutations) and has started growing again after initial treatment. It will involve about 45 ad…

This study is testing whether combining two drugs, anlotinib and benmelstobart, can help control advanced thyroid cancer that has continued to grow after initial treatment. It is for adults whose cancer cannot be surgically removed or has spread. The main goal is to see how many …

This study is testing whether using heat therapy on breast cancer tumors that have spread to the liver, combined with immunotherapy drugs, can help control the disease. It is for women with advanced HER2-negative breast cancer whose cancer has continued to grow despite previous t…

This study aims to develop a better way to predict which patients are at high risk of their cancer returning after surgery for colorectal cancer that has spread to the liver. Researchers will combine blood tests, genetic information, and clinical factors to create a personalized …

This study is testing whether adding a specific Chinese herbal formula to standard medical care can improve blood flow in the brain for adults with moyamoya disease. Researchers will compare brain scans and symptom scores in about 66 participants who either receive the herbs or n…

This study is testing a treatment that uses both freezing and heating to destroy liver tumors. It aims to see if this method is safe, controls the cancer, and triggers the body's own immune system to fight the disease. The trial will involve 120 patients with primary liver cancer…

This study is testing if a daily pill called golidocitinib can help keep an aggressive type of blood cancer (peripheral T-cell lymphoma) from coming back after initial chemotherapy. It will involve about 136 adults whose cancer has shrunk or disappeared after first treatment but …

This study aims to see if giving a white blood cell booster drug (Leucogen) alongside a targeted cancer drug (pralsetinib) can prevent a common and serious side effect—low white blood cell counts—in patients with advanced lung cancer. It will enroll 25 adults with a specific gene…

This study is testing whether a three-drug combination can help control triple-negative breast cancer that has worsened despite previous immunotherapy. It will enroll 46 women whose cancer has progressed after standard treatments. The approach adds a mast cell stabilizer (cromoly…

This study is testing whether adding a vitamin A-based drug (all-trans retinoic acid) to standard chemotherapy (VAC regimen) works better against intermediate-to-high-risk rhabdomyosarcoma, a rare but aggressive muscle cancer. It will involve 106 patients aged 14-60 who haven't h…

This study is testing whether adding a traditional Chinese herbal medicine called Huaier Granule to standard medical care can better treat proteinuria (excess protein in urine) in breast cancer patients. Proteinuria is a common side effect of certain cancer treatments like immuno…

This large study is testing if a combination of newer, targeted drugs can effectively control a specific type of early-stage breast cancer, potentially allowing patients to avoid traditional chemotherapy. It will compare the new drug regimen against the standard approach of chemo…

This study is testing whether artificial intelligence can automatically detect and diagnose kidney tumors using standard CT scans that don't require contrast dye. Researchers will analyze CT scans from 10,000 people to see if the AI system can accurately identify kidney cysts, be…

This study is testing if taking a second look at the lower part of the colon using a clear plastic cap on the camera helps doctors find more precancerous growths (polyps) during a routine colonoscopy. It will involve about 614 adults aged 45-75. The goal is to see if this simple …

This study is testing a new diagnostic tool that uses artificial intelligence to analyze the genetic material from a metastatic tumor sample. The goal is to predict where in the body the cancer originally started, which is often unknown in advanced cases. Researchers will enroll …

This study is developing and testing an artificial intelligence (AI) system designed to assess how clean a patient's colon is during a colonoscopy procedure. It uses video from the procedure along with positioning data to make its assessment, aiming to be more reliable and object…

This study tests whether a new program using an AI chatbot and coordinated doctor follow-ups can get more people to complete a colonoscopy for cancer screening. It will involve 400 people in China aged 40-64 who are at higher risk for colorectal cancer. The goal is to see if this…

This study is testing whether an AI-powered chatbot can help more young women in China get vaccinated against HPV. Researchers will compare two groups of 15- to 26-year-old women: one group will use the chatbot to get information, while the other will not. The main goal is to see…

This study aims to prevent stomach cancer by identifying and treating people who carry a high-risk type of the common stomach bacteria H. pylori. It will enroll over 4,800 adults aged 40+ and follow them for 5-10 years to see if this targeted treatment strategy lowers their cance…

This study is testing if adding a traditional Chinese medicine called Yueju Pill to standard chemotherapy helps people with advanced bile duct cancer feel better and live better. About 210 patients will be randomly assigned to take either the real pill or a look-alike placebo pil…

This study aims to find out if a new type of PET/MRI scan using special tracers can predict how well different breast cancer treatments will work. It will enroll 300 women with breast cancer who are about to start either neoadjuvant therapy (before surgery) or salvage therapy. Th…

This study aims to understand if a simple stool test can help predict who is at higher risk for developing stomach cancer. Researchers will follow 3,000 people aged 40 and over for up to 10 years, comparing cancer rates between those with positive and negative test results. The g…

This study aims to understand if diabetic nerve damage changes the risk of a slow-emptying stomach for people taking the diabetes/weight-loss drug semaglutide. Researchers will observe 460 patients with type 2 diabetes who are taking semaglutide and scheduled for an upper endosco…

This study looks back at medical records to see if stopping GLP-1 drugs (like Ozempic or Wegovy) for two weeks before an upper endoscopy lowers the risk of having leftover food in the stomach during the procedure. Researchers will review data from over 16,000 patients who had the…

This study aims to find out if stopping the medication semaglutide for one week before a sedated stomach exam (endoscopy) is enough to clear the stomach and make the procedure safer. Researchers will compare people who stopped the drug for a week to people who never took it, chec…

This study looks back at medical records to compare two surgical approaches for treating infected mesh after hernia repair. Researchers will examine 100 patients who had either complete or partial removal of infected mesh between 2016 and 2025. The goal is to understand which app…