ADVANCED SOLID TUMOR

This is the first time researchers are testing the experimental drug TORL-3-600 in people. The study aims to find a safe dose and see how the body handles the drug in 70 patients with advanced solid tumors, including colorectal cancer. It is an early safety study, not a cure, and…

This study is testing a new oral drug called INCB099280 in people with advanced solid tumors who have not yet received immunotherapy. The main goals are to see if the drug is safe and if it can shrink tumors. It is for patients with specific cancers like liver cancer, melanoma, l…

This early-stage clinical trial is testing a new drug called MHB036C in people with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The study will enroll about 200…

This study is testing a new drug called NUV-1511 in adults with advanced solid tumors that have stopped responding to standard treatments. The first part checks the drug's safety and finds the right dose, while the second part looks at how well it shrinks tumors in specific cance…

This is the first study in people to test a new drug called SHR-4712 for advanced solid tumors. The main goals are to find a safe dose and see how the body processes the drug. A small group of patients will receive the drug until side effects become too severe or their cancer get…

This early-stage study is testing a new drug called TTX-MC138 in people with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Participants will receive the drug through an…

This early-stage study is testing a new treatment called RP3, which is a genetically modified virus designed to attack cancer cells and boost the immune system. It will be given to about 123 adults with advanced solid tumors that have not responded to standard treatments, both by…

This study is testing a new oral drug called ART6043 for people with advanced or metastatic solid tumors. It will check the safety and early signs of effectiveness of ART6043 when taken by itself and when combined with an existing cancer drug, olaparib. The trial will enroll abou…

This is the first time a new drug called TORL-2-307-ADC is being tested in people. The main goal is to find a safe dose and see how the body handles it in 163 patients with advanced solid tumors, including stomach and pancreatic cancer. Researchers will also look for early signs …

This early-stage study is testing a new cancer drug called M9466, both alone and in combination with other therapies, in 141 people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check if the drug is safe and how the body proce…

This early-stage study is testing a new oral medication called IMM-1-104 in people with advanced solid tumors that have spread. The main goals are to find a safe dose and see if the drug can shrink tumors in cancers like pancreatic, melanoma, and lung cancer. The drug is being te…

This is the first study in people testing a new drug called DM919, which is designed to help the immune system fight cancer. Researchers want to find safe and effective doses when DM919 is given alone or combined with another cancer drug (pembrolizumab) to 160 adults with advance…

This early-stage study is testing a new drug called BT8009 in people with advanced solid tumors that have a specific marker called Nectin-4. The main goals are to find a safe dose, see how the body processes the drug, and get a first look at whether it can shrink tumors. The drug…

This clinical trial is testing a new drug called YL201 in people with advanced solid tumors that have spread. The study aims to find the safest and most effective dose and see if the drug can shrink tumors or slow their growth. It will involve about 990 adults with specific cance…

This study is testing a new antibody drug called LM-108, given alone or with other cancer treatments, in people with advanced solid tumors that have stopped responding to standard therapies. The main goals are to find a safe dose and see if the treatment can shrink tumors. It inv…

This study is testing whether the drug erdafitinib can shrink tumors in adults and children with advanced solid tumors that have specific changes in a gene called FGFR. The goal is to see how well the drug works by measuring tumor shrinkage and how long the response lasts. The tr…

This study is testing an investigational drug called TYRA300 for people with advanced bladder cancer and other solid tumors that have specific changes in a gene called FGFR3. The main goals are to find a safe and effective dose and to see if the drug can shrink or control the tum…

This is a first-in-human study to find a safe dose and see if a new drug called CLN-619 can help control advanced solid tumors. It will test CLN-619 by itself and combined with other approved cancer drugs. The study is for adults with cancers like advanced lung, cervical, or endo…

This early-stage trial is testing a new drug called GEN1286 in adults with advanced solid tumors that have spread or returned after other treatments. The main goals are to find a safe dose and see if the drug can help shrink tumors. The study is divided into two parts: first find…

This early-stage study is testing a new drug called DCC-3116, both by itself and combined with other cancer drugs, for people with advanced solid tumors that have specific genetic changes. The main goals are to find safe doses and see if the treatments can shrink tumors. It is fo…

This is the first-ever study in humans of a new oral medication called PRJ1-3024 for people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how the body handles the drug. Researchers will also look for…

This is the first study in humans testing an experimental oral medication called BB3008 for advanced solid tumors. The main goal is to find a safe dose and understand how the body processes the drug in 42 patients whose cancers have progressed despite standard treatments. Researc…

This clinical trial is testing a new drug called JSKN003 in Chinese patients with advanced solid tumors that cannot be surgically removed. The study aims to find the safest and most effective dose while checking if the drug helps shrink tumors. It involves 725 participants and is…

This early-stage study is testing a new drug called BT7480, both by itself and combined with an existing immunotherapy (nivolumab), in people with advanced solid tumors. The main goals are to find the safest and most effective dose and to learn about the drug's side effects and h…

This study is testing an investigational capsule called KL590586 for adults with advanced solid tumors that have specific changes in a gene called RET. The main goals are to find a safe dose and see if the treatment can shrink tumors. It is for people whose cancer has progressed …

This is an early-stage study to test the safety and find the right dose of a new experimental drug called BGB-15025. It is being tested alone and in combination with an existing immunotherapy drug (tislelizumab) in 157 patients with advanced solid tumors that have spread or canno…

This is an early-stage study testing the safety of a combination of three existing drugs—metformin, digoxin, and simvastatin—in people with advanced pancreatic cancer or other solid tumors that have worsened despite standard treatment. The main goal is to find the highest dose pa…

This early-stage study is testing a new personalized cell therapy called KSQ-001EX in people with advanced melanoma, lung cancer, or head and neck cancer. Doctors take a patient's own immune cells from a tumor, genetically modify them to potentially be more powerful, and then inf…

This study is testing a new drug called MHB039A for people with advanced solid tumors that haven't responded to standard treatments. Researchers will first find the safest dose, then test how well the drug works against specific cancer types. The main goals are to check side effe…

This is the first human study of an experimental drug called SON-1010 for adults with advanced solid tumors that have stopped responding to standard treatments. Researchers will test increasing doses in 42 patients to find the safest amount and understand how the drug works in th…

This early-stage trial is testing a new long-acting immunotherapy drug called TransCon IL-2 β/γ in adults with advanced solid tumors that have spread or cannot be removed by surgery. The study aims to find safe doses and see if the drug, given alone or with other cancer treatment…

This is an early-stage study to test a new oral drug called TPX-0022 (elzovantinib) in adults with advanced or spreading cancers that have specific changes in a gene called MET. The main goals are to find a safe dose, see how the body processes the drug, and get a first look at w…

This early-stage study is testing a new oral medication called ATRN-119 in patients with advanced solid tumors that have specific genetic mutations. The main goals are to check the drug's safety, how it moves through the body, and see if it shows any early signs of effectiveness …

This study is testing whether combining two drugs, lurbinectedin and berzosertib, can shrink tumors in people with aggressive small cell lung cancer or high-grade neuroendocrine cancers that have returned after prior treatment. The first part of the trial aims to find the safest …

This is an early-stage trial to test the safety and determine the right dose of a new experimental drug called LY4066434. The drug is designed to block a common cancer-driving protein called KRAS in people with advanced solid tumors, including pancreatic, lung, and colorectal can…

This is a first-in-human study to test the safety and early effectiveness of a new investigational drug called WTX-124. It will be given alone and in combination with an existing immunotherapy (pembrolizumab) to about 150 adults with advanced or metastatic solid tumors that have …

This is the first study in people to test a new cancer drug called BGB-C354. Researchers want to see if it is safe, how the body processes it, and if it shows early signs of fighting cancer, both by itself and when combined with another immunotherapy drug. The study will enroll a…

This study is testing a video-based therapy program designed to help people with advanced cancer manage their pain. The program teaches coping skills and focuses on helping patients find meaning and purpose despite their illness. About 210 adults with advanced solid tumors and si…

This study is testing two drugs, rituximab or tocilizumab, to help people with advanced cancer who develop severe, long-lasting side effects from their immunotherapy treatment. These side effects often require patients to take high doses of steroids, which can cause serious healt…

This study is testing how well a blood test, called a liquid biopsy, can be used to monitor cancer during a patient's regular care. It involves 159 adults with advanced solid tumors who are starting their first treatment. Researchers will see if the blood test results help guide …