Experimental vaccine trains immune system to fight Hard-to-Treat cancers
NCT ID NCT05631899
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a personalized vaccine made from a patient's own immune cells, designed to target specific cancer markers (EphA2 and KRAS mutations). The vaccine is given along with chemotherapy and two immunotherapy drugs. The study includes 9 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and see if the vaccine can boost the immune system's ability to fight the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- personalized dendritic cell vaccine (KRAS-EphA-2-CAR-DC) combined with chemotherapy and immune checkpoint inhibitors
- What this could lead to
- If successful, this approach could offer a new treatment option for people with advanced solid tumors that have specific genetic markers.
- What could go wrong
- This is a very early, small trial (9 participants) focused on safety. The treatment may not shrink tumors or improve survival, and side effects like cytokine release syndrome are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Biotherapeutic Department of Chinsese PLA Gereral Hospital
Beijing, Beijing Municipality, 100853, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a Custom-Made immune cell vaccine turn the tide against solid tumors?