Personalized cancer attack: new trial matches drugs to tumor genes

NCT ID NCT04589845

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This phase II trial tests whether giving cancer drugs based on a tumor's genetic makeup can help people with advanced solid tumors that cannot be removed by surgery or have spread. About 920 participants will receive a drug or drug combination tailored to their tumor's specific gene changes. The main goal is to see how many participants have their tumors shrink or disappear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Entrectinib (Rozlytrek) and other targeted therapies or immunotherapies
What this could lead to: If successful, this trial could show that matching cancer treatment to a tumor's genetic profile helps shrink or control advanced solid tumors that have not responded to standard therapy.
What could go wrong: This is an early-phase (phase II) trial with no control group, so results may not prove effectiveness. The drugs may cause side effects or stop working over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Locations

Alliance Cancer Specialists

Horsham, Pennsylvania, 19044, United States
Asan Medical Center

Seoul, 05505, South Korea
Asst Degli Spedali Civili Di Brescia

Brescia, Lombardy, 25100, Italy
Auckland City Hospital, Cancer and Blood Research

Auckland, 1023, New Zealand
Azienda Ospedaliera Universitaria Senese, U.O.C. Immunoterapia Oncologica

Siena, Tuscany, 53100, Italy
BC Cancer ? Vancouver

Vancouver, British Columbia, V5Z 1J3, Canada
Barrett Cancer Center

Cincinnati, Ohio, 45219, United States
Beatson West of Scotland Cancer Centre

Glasgow, G12 0YN, United Kingdom
Beijing Cancer Hospital

Beijing, 100142, China
Beijing Children's Hospital, Capital Medical University

Beijing, China
Cancer Treatment Centers of America

Philadelphia, Pennsylvania, 19124, United States
Centre Leon Berard

Lyon, 69373, France
Centre Oscar Lambret

Lille, 59020, France
Chang Gung Memorial Hospital-Linkou

Taoyuan County, 333, Taiwan
Clinica Universidad de Navarra Madrid

Madrid, 28027, Spain
Cliniques Universitaires St-Luc

Brussels, 1200, Belgium
Clínica Onco Star - Rede D'Or

São Paulo, São Paulo, 04543-000, Brazil
Consultants in Medical Oncology and Hematology

Broomall, Pennsylvania, 19008, United States
Dipartimento di Scienze Pediatriche Adolescenza

Turin, Piedmont, 10126, Italy
First Affiliated Hospital of Medical College of Xi'an Jiaotong University

Xi'an, 710061, China
Froedtert and The Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
GHdC Site Les Viviers

Charleroi, 6060, Belgium
Georg-August-Uniklinik

Göttingen, 37075, Germany
Hadassah University Hospital - Ein Kerem

Jerusalem, 9112001, Israel
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hoag Memorial Hospital

Newport Beach, California, 92658, United States
Hong Kong Children's Hospital

Hong Kong, Hong Kong
Hopital de la Timone

Marseille, 13005, France
Horizon Oncology Research, Inc.

Lafayette, Indiana, 47905, United States
Hospital A. C. Camargo

São Paulo, São Paulo, 01509-010, Brazil
Hospital Infantil Universitario Nino Jesus

Madrid, 28009, Spain
Hospital Sant Joan De Deu

Esplugues de Llobregas, Barcelona, 08950, Spain
Hospital Sírio-Libanês

São Paulo, São Paulo, 01308-050, Brazil
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario la Fe

Valencia, 46026, Spain
IPO do Porto

Porto, 4200-072, Portugal
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Inselspital, Klinik und Poliklinik für Medizinische Onkologie

Bern, 3010, Switzerland
Institut Bergonie

Bordeaux, 33076, France
Institut Universitaire du Cancer de Toulouse-Oncopole

Toulouse, 31059, France
Institut de Cancerologie Gustave-Roussy (IGR)

Villejuif, 94805, France
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana

Billings, Montana, 59102, United States
Irccs Istituto Nazionale Dei Tumori (Int)

Milan, Lombardy, 20133, Italy
Istituto Nazionale Tumori di Milano

Milan, Lombardy, 20133, Italy
Kaiser Permanente Los Angeles

Los Angeles, California, 90027, United States
Kindai University Hospital

Osaka, 589-8511, Japan
Kinghorn Cancer Centre

Darlinghurst, New South Wales, 2010, Australia
Mary Crowley Medical Research Center

Dallas, Texas, 75230, United States
Maryland Hematology & Oncology. P.A.

Silver Spring, Maryland, 20904, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 11101, United States
Metro-Minnesota Community Oncology Research Consortium

Saint Louis Park, Minnesota, 55416, United States
Midwestern Regional Med Center

Zion, Illinois, 60099, United States
Montefiore Einstein Center for Cancer Care

The Bronx, New York, 10461, United States
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad

Warsaw, 02-781, Poland
National Cancer Center Hospital

Tokyo, 104-0045, Japan
National Cancer Centre

Singapore, 168583, Singapore
National Cheng Kung University Hospital

Tainan, 00704, Taiwan
National Taiwan University Hospital

Zhongzheng Dist., 10048, Taiwan
National University Hospital

Singapore, 119228, Singapore
Northwest Medical Specialties, PLLC

Tacoma, Washington, 98405, United States
Oncology Hematology Care Inc

Cincinnati, Ohio, 45242, United States
Ospedale Pediatrico Bambino Gesù - IRCCS

Rome, Lazio, 00165, Italy
PanOncology Trials

San Juan, 00935, Puerto Rico
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Policlinico Universitario Agostino Gemelli IRCCS

Rome, Lazio, 00168, Italy
Praxis für Hämatologie, Onkologie und Palliativmedizin

Mönchengladbach, 41066, Germany
Prince of Wales Hospital

Shatin, Hong Kong
Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia
Rabin MC

Petah Tikva, 4941492, Israel
Rigshospitalet

København Ø, 2100, Denmark
Royal Children's Hospital

Parkville, Victoria, 3052, Australia
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08901, United States
SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III

Heilbronn, 74078, Germany
START Madrid-FJD, Hospital Fundacion Jimenez Diaz

Madrid, 28040, Spain
START Madrid. Centro Integral Oncologico Clara Campal

Madrid, 28050, Spain
Samsung Medical Center- Adult Site

Seoul, 06351, South Korea
Samsung Medical Center- Pediatric Site

Seoul, 06351, South Korea
Seoul National University Bundang Hospital

Gyeonggi-do, 13620, South Korea
Seoul National University Hospital- Adult Site

Seoul, 03080, South Korea
Seoul National University Hospital- Pediatric Site

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Sheba Medical Center

Ramat Gan, 5262100, Israel
Sourasky / Ichilov Hospital

Tel Aviv, 6423906, Israel
St. Alphonsus

Boise, Idaho, 83706, United States
St. Jude Children'S Research Hospital

Memphis, Tennessee, 38105, United States
Taipei Veterans General Hospital

Taipei, 112201, Taiwan
Texas Oncology - Baylor Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States
Texas Oncology - Central South

Austin, Texas, 78731, United States
Texas Oncology- Northeast Texas

Tyler, Texas, 75702, United States
The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom
The Hospital for Sick Children

Toronto, Ontario, M5G 1H3, Canada
The Ottawa Hospital - General Campus

Ottawa, Ontario, K1H 8L6, Canada
The West Clinic

Germantown, Tennessee, 38138, United States
Tianjin Cancer Hospital

Tianjin, 300060, China
UC Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
USC Norris Cancer Center

Los Angeles, California, 90033, United States
UZ Antwerpen

Edegem, 2650, Belgium
UZ Gent

Ghent, 9000, Belgium
UZ Leuven Gasthuisberg

Leuven, 3000, Belgium
Uniklinik Essen

Essen, 45122, Germany
University Cancer & Blood Center, LLC

Athens, Georgia, 30607, United States
University College London Hospital

London, NW1 - 2PG, United Kingdom
University of New Mexico

Albuquerque, New Mexico, 87131, United States
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii

Gda?sk, 80-214, Poland
Vall d'Hebron Institute of Oncology (VHIO), Barcelona

Barcelona, 08035, Spain
Vall d?Hebron Institute of Oncology (VHIO), Barcelona

Barcelona, 08035, Spain
Virginia Cancer Specialists - Leesburg

Leesburg, Pennsylvania, 20176, United States
West China Hospital - Sichuan University

Chengdu, 610047, China
Western Regional Medical Center at Cancer Treatment Centers of America

Goodyear, Arizona, 85338, United States
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, 200092, China
Zhongshan Hospital Fudan Unvierstiy

Shanghai, China

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