New drug combo shows promise in early cancer trial

NCT ID NCT05479812

Ongoing Disease control Sponsor: Werewolf Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called WTX-124, given alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. About 150 adults with certain types of cancer will take part. This is not a cure, but a step toward better disease control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma Melanoma, Cutaneous Malignant metastatic malignant neoplasm neoplasm Neoplasm Metastasis non-small cell lung carcinoma renal cell carcinoma skin squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR METASTATIC SOLID TUMOR

Contacts and locations

Locations

Emory Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
HonorHealth

Scottsdale, Arizona, 85258, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Indianapolis, Indiana, 46202, United States
Minnesota Oncology Hematology, P.A.

Maple Grove, Minnesota, 55369, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
NEXT Oncology

Houston, Texas, 77054, United States
NEXT Oncology

San Antonio, Texas, 78229, United States
Northwestern University

Chicago, Illinois, 60611, United States
Providence Cancer Institute Franz Clinic

Portland, Oregon, 97213, United States
Roswell Park Comprehensive Cancer Care

Buffalo, New York, 14203, United States
Texas Oncology - Austin Midtown

Austin, Texas, 78705-1165, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390-8852, United States
Westchester Medical Center

Hawthorne, New York, 10532, United States

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