New cancer drug CHS-114 enters first human tests
NCT ID NCT05635643
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a new drug called CHS-114, alone or with another immunotherapy (toripalimab), in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see how the body handles the drug. About 87 adults with advanced solid tumors or head and neck cancer will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CHS-114 (a monoclonal antibody targeting CCR8) and toripalimab (an immunotherapy drug)
What this could lead to
If successful, this could lead to a new treatment option for advanced solid tumors that have stopped responding to standard therapies.
What could go wrong
This is a very early Phase 1 trial with only 87 participants, so it is primarily testing safety and dosing. The drug may not shrink tumors or may cause side effects, and it will take years before any potential treatment is available.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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Barbara Ann Karmanos Cancer Institute - Karmanos Cancer Center
RECRUITINGDetroit, Michigan, 48201, United States
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Emory Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30308, United States
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FOMAT Medical Research
RECRUITINGOxnard, California, 93030, United States
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Hoag Memorial Hospital
RECRUITINGNewport Beach, California, 92663, United States
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Hope & Healing Cancer Services
RECRUITINGHinsdale, Illinois, 60521, United States
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SCRI Lake Nona DDU (FL Cancer Specialists)
RECRUITINGOrlando, Florida, 32827, United States
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START Mountain
RECRUITINGWest Valley City, Utah, 84119, United States
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START- San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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Stanford Cancer Center
RECRUITINGPalo Alto, California, 94305, United States
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45219, United States
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University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
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University of Maryland Greenebaum Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21201, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48104, United States
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University of Washington/Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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Vanderbilt-Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37203, United States
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Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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