New drug combo aims to tackle Hard-to-Treat cancers

NCT ID NCT05163041

Ongoing Disease control Sponsor: BicycleTx Limited Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called BT7480, given alone or with another drug (nivolumab), in 200 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug shrinks tumors. It is an early-stage trial, so results will show if further testing is worthwhile.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BT7480 (a drug given by IV) and nivolumab (an immunotherapy drug)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 200 participants, so the drug may not prove effective or safe enough for wider use. Side effects are unknown and could be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

Columbia University Irving Medical Center

New York, New York, 10032, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
START Center for Cancer Care

San Antonio, Texas, 78229, United States
State University of Iowa

Iowa City, Iowa, 52242, United States
The Beatson West of Scotland Cancer Centre

Glasgow, G12 0YN, United Kingdom
The Royal Marsden NHS Foundation Trust

Sutton, Surrey, SM2 5PT, United Kingdom
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States

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